EA009728B1 - Триазиновые соединения и их применение в медицине - Google Patents
Триазиновые соединения и их применение в медицине Download PDFInfo
- Publication number
- EA009728B1 EA009728B1 EA200400464A EA200400464A EA009728B1 EA 009728 B1 EA009728 B1 EA 009728B1 EA 200400464 A EA200400464 A EA 200400464A EA 200400464 A EA200400464 A EA 200400464A EA 009728 B1 EA009728 B1 EA 009728B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methoxyphenyl
- triazin
- triamine
- methyl
- cycloheptyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/70—Other substituted melamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32414701P | 2001-09-21 | 2001-09-21 | |
| PCT/US2002/030177 WO2003024926A2 (en) | 2001-09-21 | 2002-09-23 | Methods and compositions of novel triazine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200400464A1 EA200400464A1 (ru) | 2005-02-24 |
| EA009728B1 true EA009728B1 (ru) | 2008-02-28 |
Family
ID=23262298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200400464A EA009728B1 (ru) | 2001-09-21 | 2002-09-23 | Триазиновые соединения и их применение в медицине |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1436266A4 (ko) |
| JP (1) | JP2005511509A (ko) |
| KR (1) | KR20040088457A (ko) |
| CN (1) | CN1578773A (ko) |
| BR (1) | BR0212895A (ko) |
| CA (1) | CA2461074A1 (ko) |
| EA (1) | EA009728B1 (ko) |
| IL (1) | IL160984A0 (ko) |
| IS (1) | IS7190A (ko) |
| MX (1) | MXPA04002680A (ko) |
| NO (1) | NO20041187L (ko) |
| NZ (1) | NZ532349A (ko) |
| PL (1) | PL369600A1 (ko) |
| RS (1) | RS34004A (ko) |
| WO (1) | WO2003024926A2 (ko) |
| ZA (1) | ZA200403009B (ko) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2749834C2 (ru) * | 2015-12-24 | 2021-06-17 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа | Кфтр регуляторы и способы их применения |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7112587B2 (en) | 2001-09-21 | 2006-09-26 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US7132423B2 (en) | 2001-09-21 | 2006-11-07 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US7169785B2 (en) | 2001-09-21 | 2007-01-30 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US7163943B2 (en) | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US7173032B2 (en) * | 2001-09-21 | 2007-02-06 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| JP4325402B2 (ja) | 2002-02-05 | 2009-09-02 | アステラス製薬株式会社 | ２，４，６−トリアミノ−１，３，５−トリアジン誘導体 |
| AU2003253735A1 (en) * | 2002-06-25 | 2004-01-06 | The Center For Blood Research, Inc. | Vacuolins |
| WO2005009980A1 (en) * | 2003-07-22 | 2005-02-03 | Neurogen Corporation | Substituted pyridin-2-ylamine analogues |
| CN1629157A (zh) * | 2003-12-19 | 2005-06-22 | 中国科学院上海药物研究所 | 哌嗪三嗪类化合物、其制备方法及药物组合物 |
| US7335770B2 (en) | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
| JP5547487B2 (ja) * | 2006-11-03 | 2014-07-16 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 抗癌化合物の投与方法 |
| KR101314869B1 (ko) * | 2010-07-29 | 2013-10-04 | 광주과학기술원 | 트리아진계 화합물을 유효성분으로 포함하는 당뇨병 예방 또는 치료용 약제학적 조성물 |
| US20120295911A1 (en) | 2010-11-29 | 2012-11-22 | Galleon Pharmaceuticals, Inc. | Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases |
| CA2819333A1 (en) * | 2010-11-29 | 2012-06-07 | Galleon Pharmaceuticals, Inc. | Novel compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU250148A1 (ru) * | , А. Мельникова, Н. Н. Мельников , Ю. А. Баскаков | Способ получения 2-бehзилokcи-4-n-aлkилгидpokcил- амино-6-алкиламино-8-триазинов | ||
| WO1997008156A1 (de) * | 1995-08-24 | 1997-03-06 | Hoechst Schering Agrevo Gmbh | 2,4-diamino-1,3,5-triazine, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
| RU2083568C1 (ru) * | 1994-05-05 | 1997-07-10 | Кубанский государственный аграрный университет | Соли триазинкарбоновых кислот и средство для предпосевной обработки семян сельскохозяйственных культур |
| WO1999031088A1 (en) * | 1997-12-12 | 1999-06-24 | Abbott Laboratories | Triazine angiogenesis inhibitors |
| US6150360A (en) * | 1998-03-27 | 2000-11-21 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-Triazine Derivatives |
| WO2001047897A1 (en) * | 1999-12-28 | 2001-07-05 | Pharmacopeia, Inc. | Cytokine, especially tnf-alpha, inhibitors |
| WO2002036578A2 (en) * | 2000-10-31 | 2002-05-10 | Lynn Bonham | Triazine derivatives as lpaat-b inhibitors and uses thereof |
-
2002
- 2002-09-23 EP EP02799019A patent/EP1436266A4/en not_active Withdrawn
- 2002-09-23 CN CNA028232402A patent/CN1578773A/zh active Pending
- 2002-09-23 CA CA002461074A patent/CA2461074A1/en not_active Abandoned
- 2002-09-23 IL IL16098402A patent/IL160984A0/xx unknown
- 2002-09-23 EA EA200400464A patent/EA009728B1/ru not_active IP Right Cessation
- 2002-09-23 RS YU34004A patent/RS34004A/sr unknown
- 2002-09-23 MX MXPA04002680A patent/MXPA04002680A/es active IP Right Grant
- 2002-09-23 KR KR10-2004-7004179A patent/KR20040088457A/ko not_active Application Discontinuation
- 2002-09-23 WO PCT/US2002/030177 patent/WO2003024926A2/en active Application Filing
- 2002-09-23 BR BR0212895-0A patent/BR0212895A/pt not_active IP Right Cessation
- 2002-09-23 PL PL02369600A patent/PL369600A1/xx not_active Application Discontinuation
- 2002-09-23 JP JP2003528774A patent/JP2005511509A/ja active Pending
- 2002-09-23 NZ NZ532349A patent/NZ532349A/en unknown
-
2004
- 2004-03-19 IS IS7190A patent/IS7190A/is unknown
- 2004-03-22 NO NO20041187A patent/NO20041187L/no not_active Application Discontinuation
- 2004-04-20 ZA ZA200403009A patent/ZA200403009B/en unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU250148A1 (ru) * | , А. Мельникова, Н. Н. Мельников , Ю. А. Баскаков | Способ получения 2-бehзилokcи-4-n-aлkилгидpokcил- амино-6-алкиламино-8-триазинов | ||
| RU2083568C1 (ru) * | 1994-05-05 | 1997-07-10 | Кубанский государственный аграрный университет | Соли триазинкарбоновых кислот и средство для предпосевной обработки семян сельскохозяйственных культур |
| WO1997008156A1 (de) * | 1995-08-24 | 1997-03-06 | Hoechst Schering Agrevo Gmbh | 2,4-diamino-1,3,5-triazine, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
| WO1999031088A1 (en) * | 1997-12-12 | 1999-06-24 | Abbott Laboratories | Triazine angiogenesis inhibitors |
| US6150360A (en) * | 1998-03-27 | 2000-11-21 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-Triazine Derivatives |
| WO2001047897A1 (en) * | 1999-12-28 | 2001-07-05 | Pharmacopeia, Inc. | Cytokine, especially tnf-alpha, inhibitors |
| WO2002036578A2 (en) * | 2000-10-31 | 2002-05-10 | Lynn Bonham | Triazine derivatives as lpaat-b inhibitors and uses thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2749834C2 (ru) * | 2015-12-24 | 2021-06-17 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа | Кфтр регуляторы и способы их применения |
| US11230535B2 (en) | 2015-12-24 | 2022-01-25 | The Regents Of The University Of California | CFTR regulators and methods of use thereof |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| IL160984A0 (en) | 2004-08-31 |
| KR20040088457A (ko) | 2004-10-16 |
| EP1436266A4 (en) | 2004-12-22 |
| NZ532349A (en) | 2007-02-23 |
| NO20041187L (no) | 2004-05-19 |
| WO2003024926A2 (en) | 2003-03-27 |
| CA2461074A1 (en) | 2003-03-27 |
| ZA200403009B (en) | 2007-12-27 |
| IS7190A (is) | 2004-03-19 |
| RS34004A (en) | 2006-10-27 |
| JP2005511509A (ja) | 2005-04-28 |
| MXPA04002680A (es) | 2004-06-18 |
| EA200400464A1 (ru) | 2005-02-24 |
| EP1436266A2 (en) | 2004-07-14 |
| WO2003024926A3 (en) | 2003-12-11 |
| CN1578773A (zh) | 2005-02-09 |
| BR0212895A (pt) | 2005-05-10 |
| PL369600A1 (en) | 2005-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |