DZ3368A1 - 3-AZABICYCLO DERIVATIVES [3.1.0] HEXANE HAVING AN AFFINITY FOR THE OPIOID RECEPTOR - Google Patents

3-AZABICYCLO DERIVATIVES [3.1.0] HEXANE HAVING AN AFFINITY FOR THE OPIOID RECEPTOR

Info

Publication number
DZ3368A1
DZ3368A1 DZ013368A DZ013368A DZ3368A1 DZ 3368 A1 DZ3368 A1 DZ 3368A1 DZ 013368 A DZ013368 A DZ 013368A DZ 013368 A DZ013368 A DZ 013368A DZ 3368 A1 DZ3368 A1 DZ 3368A1
Authority
DZ
Algeria
Prior art keywords
hexane
affinity
opioid receptor
azabicyclo derivatives
azabicyclo
Prior art date
Application number
DZ013368A
Other languages
French (fr)
Inventor
Bernard Joseph Banks
Douglas James Critcher
Ashley Edward Fenwick
David Morris Gethin
Stephen Paul Gibson
Graham Lunn
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DZ3368A1 publication Critical patent/DZ3368A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DZ013368A 2000-06-23 2001-06-07 3-AZABICYCLO DERIVATIVES [3.1.0] HEXANE HAVING AN AFFINITY FOR THE OPIOID RECEPTOR DZ3368A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015562.2A GB0015562D0 (en) 2000-06-23 2000-06-23 Heterocycles
PCT/IB2001/001035 WO2001098267A1 (en) 2000-06-23 2001-06-07 3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity

Publications (1)

Publication Number Publication Date
DZ3368A1 true DZ3368A1 (en) 2001-12-27

Family

ID=9894368

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ013368A DZ3368A1 (en) 2000-06-23 2001-06-07 3-AZABICYCLO DERIVATIVES [3.1.0] HEXANE HAVING AN AFFINITY FOR THE OPIOID RECEPTOR

Country Status (34)

Country Link
EP (1) EP1292574A1 (en)
JP (1) JP2004512263A (en)
KR (1) KR20040002386A (en)
CN (1) CN1639121A (en)
AP (1) AP2002002698A0 (en)
AR (1) AR028969A1 (en)
AU (1) AU781837B2 (en)
BG (1) BG107329A (en)
BR (1) BR0111867A (en)
CA (1) CA2412188A1 (en)
CZ (1) CZ20023967A3 (en)
DO (1) DOP2001000187A (en)
DZ (1) DZ3368A1 (en)
EA (1) EA005117B1 (en)
GB (1) GB0015562D0 (en)
HR (1) HRP20020998A2 (en)
HU (1) HUP0301228A3 (en)
IL (1) IL153427A0 (en)
IS (1) IS6637A (en)
MA (1) MA26915A1 (en)
MX (1) MXPA02012878A (en)
NO (1) NO20026168L (en)
NZ (1) NZ523141A (en)
OA (1) OA12293A (en)
PA (1) PA8519401A1 (en)
PE (1) PE20020253A1 (en)
PL (1) PL365956A1 (en)
SK (1) SK17172002A3 (en)
TN (1) TNSN01094A1 (en)
UA (1) UA73176C2 (en)
UY (1) UY26787A1 (en)
WO (1) WO2001098267A1 (en)
YU (1) YU91802A (en)
ZA (1) ZA200210278B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0401884A2 (en) * 2001-10-22 2005-01-28 Pfizer Products Inc. 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists and pharmaceutical compositions containing them
EP2074997A1 (en) * 2002-05-17 2009-07-01 Tioga Pharmaceuticals, Inc. Use of Asimadoline for the treatment of digestive disorders
DE10259245A1 (en) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivatives of asimadolin with covalently bound acids
PL2070922T3 (en) 2004-02-23 2012-01-31 Glaxo Group Ltd Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors
GB0507680D0 (en) * 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
WO2006133945A1 (en) * 2005-06-14 2006-12-21 Glaxo Group Limited Novel compounds
DE602007012531D1 (en) * 2006-04-03 2011-03-31 Glaxo Group Ltd AZABICYCLOA3.1.0 OXIDE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS
EP2136801B1 (en) 2007-03-30 2012-08-29 Tioga Pharmaceuticals, Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
TWI423801B (en) * 2007-08-27 2014-01-21 Theravance Inc 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists
JP5736040B2 (en) 2010-06-11 2015-06-17 ローズ テクノロジーズ Transition metal catalyzed process and its use for the preparation of N-allyl compounds
BR112013007566A2 (en) 2010-09-28 2016-08-02 Panacea Biotec Ltd new bicyclic compounds
ES2774349T3 (en) * 2013-11-20 2020-07-20 Sanwa Kagaku Kenkyusho Co Derived from 3-azabicyclo [3.1.0] hexane and its use for medical purposes
CN113307760A (en) 2015-05-20 2021-08-27 宇部兴产株式会社 Novel crystal of salt of 3-azabicyclo [3.1.0] hexane derivative and medical application thereof
KR20190129867A (en) 2017-02-17 2019-11-20 트레베나, 인코포레이티드. 5-membered aza-heterocycle-containing delta-opioid receptor modulating compounds, and methods of using and preparing the same
CA3052479A1 (en) 2017-02-17 2018-08-23 Trevena, Inc. 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
AU2018229062A1 (en) 2017-03-02 2019-09-26 Ube Industries, Ltd. Therapeutic agent for alcohol use disorders
CN108250088B (en) * 2018-01-04 2020-10-30 四川之江高新材料股份有限公司 Preparation method of N, N, N '-trimethyl-N' -hydroxyethyl bisaminoethylether

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065230A (en) * 1959-03-16 1962-11-20 Burroughs Wellcome Co Azabicyclohexanes and method of preparing them
CA1321792C (en) * 1987-04-16 1993-08-31 Eli Lilly And Company Piperidine opioid antagonists
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (en) * 1993-12-04 1995-06-08 Basf Ag N-substituted 3-azabicycloalkane derivatives, their preparation and use
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (en) * 1998-12-23 2000-12-18 Pfizer CCR5 MODULATORS

Also Published As

Publication number Publication date
NO20026168D0 (en) 2002-12-20
CZ20023967A3 (en) 2004-02-18
HUP0301228A2 (en) 2003-08-28
PA8519401A1 (en) 2002-12-30
EA005117B1 (en) 2004-10-28
AU781837B2 (en) 2005-06-16
CN1639121A (en) 2005-07-13
IL153427A0 (en) 2003-07-06
HUP0301228A3 (en) 2005-08-29
KR20040002386A (en) 2004-01-07
NZ523141A (en) 2005-06-24
WO2001098267A1 (en) 2001-12-27
OA12293A (en) 2004-03-18
JP2004512263A (en) 2004-04-22
PL365956A1 (en) 2005-01-24
SK17172002A3 (en) 2004-09-08
EA200201269A1 (en) 2003-06-26
MA26915A1 (en) 2004-12-20
UA73176C2 (en) 2005-06-15
YU91802A (en) 2006-05-25
BG107329A (en) 2003-07-31
UY26787A1 (en) 2002-01-31
ZA200210278B (en) 2003-12-19
AU6259101A (en) 2002-01-02
TNSN01094A1 (en) 2005-11-10
GB0015562D0 (en) 2000-08-16
AR028969A1 (en) 2003-05-28
NO20026168L (en) 2003-02-18
HRP20020998A2 (en) 2004-02-29
PE20020253A1 (en) 2002-04-08
BR0111867A (en) 2003-07-01
DOP2001000187A (en) 2002-03-30
EP1292574A1 (en) 2003-03-19
IS6637A (en) 2002-11-28
MXPA02012878A (en) 2003-05-14
AP2002002698A0 (en) 2002-12-31
WO2001098267A8 (en) 2003-02-27
CA2412188A1 (en) 2001-12-27

Similar Documents

Publication Publication Date Title
DZ3368A1 (en) 3-AZABICYCLO DERIVATIVES [3.1.0] HEXANE HAVING AN AFFINITY FOR THE OPIOID RECEPTOR
HK1072052A1 (en) 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
ATE335725T1 (en) 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES AS OPIATE RECEPTORS LIGANDS
MA27032A1 (en) NEW INDOLE AFFINITY DERIVATIVES FOR THE 5-HT6 RECEPTOR
ATE354570T1 (en) 5,6-DIARYL-PYRAZINEAMIDE DERIVATIVES AS CB1 ANTAGONISTS
ZA991413B (en) Substituted quinoxaline derivatives as interleukin-8 receptor antagonists.
CY2010003I2 (en) BETA-2 ADRENOREGIC RECEPTOR ANTAGONISTS
PL365377A1 (en) Amide derivatives as nmda receptor antagonists
DE60214428D1 (en) 1, 4-DIHYDRO-1, 4-DIPHENYLPYRIDINE DERIVATIVES
IL158807A0 (en) 5-ht receptor ligands and uses thereof
GB0113352D0 (en) Adjustable swivel assembly for seat suspension
MXPA03006991A (en) Piperidinee derivatives as neurokinin 1 antagonists.
HK1042699A1 (en) N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists.
HK1060065A1 (en) Use of an aldosterone antagonist for the treatmentor prohpylaxis of aldosteronemediated pathogenic effects
MXPA03003892A (en) Bombesin receptor antagonists.
MXPA03004414A (en) Bombesin receptor antagonists.
NO995081D0 (en) Device for H.323 proxy
NL1022106A1 (en) Base for caravans.
FR2782251B1 (en) BASE FOR FURNITURE
FI20000214A (en) Swiveling device for turning the vehicle seat
ZA99171B (en) Piperazino derivatives as neurokinin antagonists.
FIU20000198U0 (en) SEAT
FI20011745A0 (en) Swiveling device for turning the vehicle seat
FI20000363A (en) Seat swivel seat
ES1049951Y (en) PERFECTED HANGER.