DZ1399A1 - Pyrroles substitués. - Google Patents

Pyrroles substitués.

Info

Publication number
DZ1399A1
DZ1399A1 DZ900033A DZ900033A DZ1399A1 DZ 1399 A1 DZ1399 A1 DZ 1399A1 DZ 900033 A DZ900033 A DZ 900033A DZ 900033 A DZ900033 A DZ 900033A DZ 1399 A1 DZ1399 A1 DZ 1399A1
Authority
DZ
Algeria
Prior art keywords
substituted pyrroles
active substances
derivatives
substances
furandione
Prior art date
Application number
DZ900033A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898904161A external-priority patent/GB8904161D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DZ1399A1 publication Critical patent/DZ1399A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
DZ900033A 1989-02-23 1990-02-21 Pyrroles substitués. DZ1399A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898904161A GB8904161D0 (en) 1989-02-23 1989-02-23 Substituted pyrroles
GB898928210A GB8928210D0 (en) 1989-02-23 1989-12-13 Substituted pyrroles

Publications (1)

Publication Number Publication Date
DZ1399A1 true DZ1399A1 (fr) 2004-09-13

Family

ID=26295005

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ900033A DZ1399A1 (fr) 1989-02-23 1990-02-21 Pyrroles substitués.

Country Status (20)

Country Link
EP (1) EP0384349B1 (fr)
JP (1) JPH06102661B2 (fr)
AT (1) ATE104972T1 (fr)
AU (1) AU633051B2 (fr)
CA (1) CA2010636C (fr)
CZ (1) CZ284587B6 (fr)
DE (1) DE59005491D1 (fr)
DK (1) DK0384349T3 (fr)
DZ (1) DZ1399A1 (fr)
ES (1) ES2052995T3 (fr)
FI (1) FI93447C (fr)
HU (1) HU206351B (fr)
IE (1) IE64184B1 (fr)
IL (1) IL93433A (fr)
MC (1) MC2096A1 (fr)
NO (1) NO174891C (fr)
NZ (1) NZ232589A (fr)
PT (1) PT93246B (fr)
RU (2) RU2014332C1 (fr)
SK (1) SK278711B6 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
CA2046801C (fr) * 1990-08-07 2002-02-26 Peter D. Davis Pyrroles substitues
DE4128015A1 (de) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
WO1993018765A1 (fr) * 1992-03-20 1993-09-30 The Wellcome Foundation Limited Derives d'indole presentant une action antivirale
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
CA2137203C (fr) * 1993-12-07 2006-11-28 William Francis Heath Jr. Inhibiteurs de la proteine kinase c
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
CA2137205A1 (fr) * 1993-12-07 1995-06-08 Margaret Mary Faul Synthese de bisindolymaleimides
WO1995017182A1 (fr) 1993-12-23 1995-06-29 Eli Lilly And Company Inhibiteurs de la proteine-kinase c
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
DE69505470T2 (de) * 1994-08-04 1999-05-12 F. Hoffmann-La Roche Ag, Basel Pyrrolocarbazol
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
PT797575E (pt) * 1994-12-13 2004-02-27 Hoffmann La Roche Derivados de imidazol utilizaveis como inibidores de proteina quinase em particular da tirosina quinase do egf-r
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
CA2268399C (fr) * 1996-10-31 2008-08-19 Harbor Branch Oceanographic Institution, Inc. Composes et compositions inflammatoires antineurogenes et methodes d'utilisation
EP1224932A4 (fr) * 1999-08-20 2002-10-16 Sagami Chem Res Medicaments inhibant la mort cellulaire
IL153851A0 (en) 2000-07-27 2003-07-31 Hoffmann La Roche 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
AU2002230727A1 (en) 2000-12-08 2002-06-18 Ortho-Mcneil Pharmaceutical, Inc. Indazolyl-substituted pyrroline compounds as kinase inhibitors
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
MXPA06001524A (es) 2003-08-08 2006-05-15 Novartis Ag Combinaciones que comprenden estaurosporinas.
EP2270001A1 (fr) * 2004-01-19 2011-01-05 Novartis AG Dérivés d'indolylmaléimide comme inhibiteurs de la PKC
EP1819697B1 (fr) 2004-12-08 2012-08-01 Johannes Gutenberg-Universität Mainz Derives de 3-(indolyl)-4-arylmaleimide et utilisation comme inhibiteurs de l'angiogenese
DK1846406T5 (da) 2005-02-09 2011-10-31 Arqule Inc Maleimidderivater, farmaceutiske sammensætninger og fremgangsmåder til behandling af cancer
EP1904482B1 (fr) 2005-07-11 2011-01-19 Novartis AG Derives d'indolylmaleimide
EP1915372B1 (fr) * 2005-08-12 2013-11-20 Merck Canada Inc. Derives d'indole en tant qu'antagonistes du recepteur crth2
EP1980561B1 (fr) 2007-03-30 2013-10-09 Nerviano Medical Sciences S.R.L. Dérivés de pyridines 1h-pyrazolo[3,4-b] substitués actifs en tant qu'inhibiteurs de kinase
CA2912546A1 (fr) 2007-06-22 2008-12-31 Arqule, Inc. Compositions et procedes de traitement du cancer
JP5425060B2 (ja) * 2007-06-22 2014-02-26 アークル インコーポレイテッド ピロリジノン、ピロリジン−２，５−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法
JP2010530885A (ja) 2007-06-22 2010-09-16 アークル インコーポレイテッド キナゾリノン化合物およびその使用方法
JP2012502927A (ja) 2008-09-22 2012-02-02 メルク カナダ インコーポレイテッド Ｃｒｔｈ２受容体拮抗薬としてのインドール誘導体
EP2343291A1 (fr) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz Composés de 3-(indolyl)- ou 3-(azaindolyl)-4-arylmaléimide et leur utilisation dans le traitement de tumeurs
WO2011082266A2 (fr) 2009-12-30 2011-07-07 Arqule, Inc. Composés hétérocycliques substitués
EP2474541A1 (fr) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Composés conjugués de 3-(indolyl)- et 3-(azaindolyl)-4-arylmaléimide et leur utilisation dans le traitement de tumeurs
RU2660417C2 (ru) * 2013-04-23 2018-07-06 Лабораторьос Дель Др. Эстеве, С.А. СОЕДИНЕНИЯ ПИРАЗИНО[1,2-а]ИНДОЛА, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ЛЕКАРСТВЕННЫХ СРЕДСТВАХ
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (fr) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques de traitement d'infections virales
EP3187495A1 (fr) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz Composés de 3-(5-fluoroindolyl)-4-arylmaléimide et leur utilisation dans le traitement de tumeurs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89167A (en) * 1988-02-10 1994-02-27 Hoffmann La Roche Substituted pyrroles, their manufacture and pharmaceutical compositions containing them
US5049563A (en) * 1988-07-07 1991-09-17 Duphar International Research B.V. Annelated indoleketones with an imidazolylalkyl substituent

Also Published As

Publication number Publication date
SK85590A3 (en) 1998-01-14
IE900647L (en) 1990-08-23
CA2010636A1 (fr) 1990-08-23
NO900855D0 (no) 1990-02-22
RU2142460C1 (ru) 1999-12-10
JPH02264776A (ja) 1990-10-29
ATE104972T1 (de) 1994-05-15
DK0384349T3 (da) 1994-09-05
IL93433A0 (en) 1990-11-29
NO174891C (no) 1994-07-27
IE64184B1 (en) 1995-07-12
EP0384349B1 (fr) 1994-04-27
EP0384349A1 (fr) 1990-08-29
NO174891B (no) 1994-04-18
SK278711B6 (sk) 1998-01-14
CZ284587B6 (cs) 1999-01-13
MC2096A1 (fr) 1991-02-15
IL93433A (en) 1996-11-14
CA2010636C (fr) 1999-12-14
FI93447B (fi) 1994-12-30
DE59005491D1 (de) 1994-06-01
RU2014332C1 (ru) 1994-06-15
HU206351B (en) 1992-10-28
ES2052995T3 (es) 1994-07-16
JPH06102661B2 (ja) 1994-12-14
FI900863A0 (fi) 1990-02-21
PT93246B (pt) 1996-01-31
NZ232589A (en) 1992-09-25
HU900846D0 (en) 1990-04-28
CZ85590A3 (cs) 1998-10-14
PT93246A (pt) 1990-08-31
NO900855L (no) 1990-08-24
HUT53369A (en) 1990-10-28
FI93447C (fi) 1995-04-10
AU5003390A (en) 1990-08-30
AU633051B2 (en) 1993-01-21

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