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Application filed by Pfizer Prod IncfiledCriticalPfizer Prod Inc
Priority to DO2003000786ApriorityCriticalpatent/DOP2003000786A/en
Publication of DOP2003000786ApublicationCriticalpatent/DOP2003000786A/en
La invención se refiere a compuestos de formula 1 Y a sales, Pro fármacos y solvatos farmaceuticamente aceptables de los mismos, en la que R1, R2, R3 y R4 son como se definen en la presente memoria, y en la que el compuesto de formula 1 comprende opcionalmente además un sustituyente hidroxi o un acido O-glucuronico. La invención se refiere también a procedimientos de tratamiento del crecimiento celular anormal en mamíferos mediante la administración de los compuestos de formula 1 y a composiciones farmacéuticas para tratar dichos trastornos que contienen los compuestos de formula 1. la invención se refiere también a procedimientos de preparación de los compuestos de formula 1.The invention relates to compounds of formula 1 and pharmaceutically acceptable salts, Pro drugs and solvates thereof, wherein R1, R2, R3 and R4 are as defined herein, and in which the compound of formula 1 optionally further comprises a hydroxy substituent or an O-glucuronic acid. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula 1 and pharmaceutical compositions for treating such disorders containing the compounds of formula 1. The invention also relates to methods of preparing the compounds. compounds of formula 1.
DO2003000786A2003-12-102003-12-10
BICYCLE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH.
DOP2003000786A
(en)
NOVEL 1,4-BENZOTHIEPIN-l,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL GROUPS, METHOD FOR PRODUCING DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF
BENZONE-CONDENSED HETEROARILAMIDE TYENOPIRIDIN DERIVATIVES USED AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS, INCLUDING THEM, AND THEIR APPLICATION
EUROTINONA AND DERIVATIVES OF THE SAME, PROCEDURE FOR THEIR PREPARATION, A MICROORGANISM, PHARMACEUTICAL COMPOSITIONS, PROCEDURE FOR THEIR PRODUCTION, THE USE OF SUCH DERIVATIVES AND COMPOSITIONS FOR THE PREPARATION OF DRUGS, AND USE OF SUCH MICROORGANISM