DK98833C - Method for stabilizing therapeutically useful plasmin solutions. - Google Patents

Method for stabilizing therapeutically useful plasmin solutions.

Info

Publication number
DK98833C
DK98833C DK169161AA DK169161A DK98833C DK 98833 C DK98833 C DK 98833C DK 169161A A DK169161A A DK 169161AA DK 169161 A DK169161 A DK 169161A DK 98833 C DK98833 C DK 98833C
Authority
DK
Denmark
Prior art keywords
stabilizing
therapeutically useful
plasmin
solutions
plasmin solutions
Prior art date
Application number
DK169161AA
Other languages
Danish (da)
Inventor
Johannes Jensen
Original Assignee
Novo Terapeutisk Labor As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Labor As filed Critical Novo Terapeutisk Labor As
Priority to DK169161AA priority Critical patent/DK98833C/en
Priority to NO144057A priority patent/NO123024B/no
Priority to SE04365/62A priority patent/SE327779B/xx
Priority to GB15352/62A priority patent/GB985498A/en
Priority to BE616779A priority patent/BE616779A/en
Priority to FI0828/62A priority patent/FI43764B/fi
Priority to CH497562A priority patent/CH456848A/en
Priority to NL62277635A priority patent/NL147634B/en
Priority to FR904689A priority patent/FR2140M/en
Application granted granted Critical
Publication of DK98833C publication Critical patent/DK98833C/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4826Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6435Plasmin (3.4.21.7), i.e. fibrinolysin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK169161AA 1961-04-25 1961-04-25 Method for stabilizing therapeutically useful plasmin solutions. DK98833C (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DK169161AA DK98833C (en) 1961-04-25 1961-04-25 Method for stabilizing therapeutically useful plasmin solutions.
NO144057A NO123024B (en) 1961-04-25 1962-04-16
SE04365/62A SE327779B (en) 1961-04-25 1962-04-18
GB15352/62A GB985498A (en) 1961-04-25 1962-04-19 Improvements in or relating to plasmin preparations
BE616779A BE616779A (en) 1961-04-25 1962-04-24 Method of stabilizing therapeutically useful plasmin solutions
FI0828/62A FI43764B (en) 1961-04-25 1962-04-25
CH497562A CH456848A (en) 1961-04-25 1962-04-25 A method of preparing a therapeutically useful plasmin complex
NL62277635A NL147634B (en) 1961-04-25 1962-04-25 PROCEDURE FOR PREPARING STABILIZED THERAPEUTICALLY USABLE PLASMINE SOLUTIONS.
FR904689A FR2140M (en) 1961-04-25 1962-07-20 Stabilized plasmin solutions.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK169161AA DK98833C (en) 1961-04-25 1961-04-25 Method for stabilizing therapeutically useful plasmin solutions.

Publications (1)

Publication Number Publication Date
DK98833C true DK98833C (en) 1964-05-25

Family

ID=8107240

Family Applications (1)

Application Number Title Priority Date Filing Date
DK169161AA DK98833C (en) 1961-04-25 1961-04-25 Method for stabilizing therapeutically useful plasmin solutions.

Country Status (9)

Country Link
BE (1) BE616779A (en)
CH (1) CH456848A (en)
DK (1) DK98833C (en)
FI (1) FI43764B (en)
FR (1) FR2140M (en)
GB (1) GB985498A (en)
NL (1) NL147634B (en)
NO (1) NO123024B (en)
SE (1) SE327779B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2750159C3 (en) * 1977-11-09 1980-05-22 Lentia Gmbh, Chem. U. Pharm. Erzeugnisse - Industriebedarf, 8000 Muenchen Infusion solution for the treatment of hepatic encephalopathy and a process for the manufacture thereof
JPH0672105B2 (en) * 1985-10-02 1994-09-14 持田製薬株式会社 Thrombolytic agent and manufacturing method thereof
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US6355243B1 (en) 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
WO2004009773A2 (en) 2002-07-23 2004-01-29 Ludwig Institute For Cancer Research Methods and compositions for activating or inhibiting vegf-d and vegf-c
GB0228409D0 (en) 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
US20060257391A1 (en) * 2005-05-11 2006-11-16 Bausch & Lomb Incorporated Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
AU2009256168B2 (en) 2008-06-04 2014-06-05 Grifols Therapeutics Inc. Composition, method and kit for preparing plasmin
US9206410B2 (en) 2009-03-03 2015-12-08 Grifols Therapeutics Inc. Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom
CN106167797B (en) * 2016-07-28 2019-04-09 国药集团武汉血液制品有限公司 The lyophilized preparation and preparation method thereof of human fibrin dissolution proenzyme

Also Published As

Publication number Publication date
CH456848A (en) 1968-05-31
SE327779B (en) 1970-08-31
NO123024B (en) 1971-09-20
NL147634B (en) 1975-11-17
FR2140M (en) 1963-11-12
BE616779A (en) 1962-10-24
GB985498A (en) 1965-03-10
FI43764B (en) 1971-03-01

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