DK645688A - 3-(4-(1-substitueret 4-piperazinyl)butyl)-4-thiazolidinoner, deres fremstilling og anvendelse - Google Patents

3-(4-(1-substitueret 4-piperazinyl)butyl)-4-thiazolidinoner, deres fremstilling og anvendelse

Info

Publication number: DK645688A
Authority: DK; Denmark
Prior art keywords: loweralkyl; preparation; loweralkoxy; thiopyran; cycloheptane
Prior art date: 1987-11-20

Application number

DK645688A

Other languages

English (en)

Other versions

DK645688D0 (da

Inventor

Nicholas J Hrib

John Gerard Jurcak

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-20

Filing date

1988-11-18

Publication date

1989-05-21

1988-11-18 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1988-11-18 Publication of DK645688D0 publication Critical patent/DK645688D0/da

1989-05-21 Publication of DK645688A publication Critical patent/DK645688A/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK645688A 1987-11-20 1988-11-18 3-(4-(1-substitueret 4-piperazinyl)butyl)-4-thiazolidinoner, deres fremstilling og anvendelse DK645688A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12362287A	1987-11-20	1987-11-20

Publications (2)

Publication Number	Publication Date
DK645688D0 DK645688D0 (da)	1988-11-18
DK645688A true DK645688A (da)	1989-05-21

Family

ID=22409774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK645688A DK645688A (da)	1987-11-20	1988-11-18	3-(4-(1-substitueret 4-piperazinyl)butyl)-4-thiazolidinoner, deres fremstilling og anvendelse

Country Status (20)

Country	Link
US (5)	US4933453A (da)
EP (1)	EP0316723B1 (da)
JP (1)	JP2617546B2 (da)
KR (1)	KR0130976B1 (da)
AT (1)	ATE81123T1 (da)
AU (1)	AU624092B2 (da)
CA (1)	CA1317955C (da)
DE (1)	DE3875073T2 (da)
DK (1)	DK645688A (da)
ES (1)	ES2052675T3 (da)
FI (1)	FI89916C (da)
GR (1)	GR3006698T3 (da)
HU (1)	HU206709B (da)
IE (1)	IE62229B1 (da)
IL (1)	IL88414A (da)
NO (1)	NO176143C (da)
NZ (1)	NZ226999A (da)
PH (1)	PH27330A (da)
PT (1)	PT89020B (da)
ZA (1)	ZA888651B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3875073T2 (de) *	1987-11-20	1993-03-11	Hoechst Roussel Pharma	3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US5801186A (en) *	1987-11-20	1998-09-01	Hoechst Marion Roussel, Inc.	3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
WO1991000863A1 (en) *	1989-07-07	1991-01-24	Pfizer Inc.	Heteroaryl piperazine antipsychotic agents
HU205092B (en) *	1989-11-24	1992-03-30	Richter Gedeon Vegyeszet	Process for producing new thiazolidinone derivatives and pharmaceutical compositions comprising same
US5216002A (en) *	1989-12-21	1993-06-01	Eli Lilly And Company	Method of treating inflammatory bowel disease
US5034392A (en) *	1990-04-16	1991-07-23	Hoechst-Roussel Pharmaceuticals Incorporated	4-(3-(4-oxothiazolidinyl)butynylamines
US5041445A (en) *	1990-05-21	1991-08-20	Hoechst-Roussel Pharmaceuticals Incorporated	3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles
US5045546A (en) *	1990-10-26	1991-09-03	Hoechst-Roussel Pharmaceuticals Inc.	8-azabicyclo[3.2.1]octylalkylthiazolidines
US5194436A (en) *	1991-01-10	1993-03-16	Hoechst-Roussel Pharmaceuticals Inc.	1-piperazinyl-2-butenes and -2-butynes
US5130315A (en) *	1991-01-10	1992-07-14	Raymond R. Wittekind	1-piperazinyl-2-butenes and -2-butynes
US5240927A (en) *	1992-05-19	1993-08-31	Hoechst-Roussel Pharmaceuticals Incorporated	Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
AU664084B2 (en) *	1992-06-03	1995-11-02	Ciba-Geigy Ag	Novel thiosemicarbazonic acid esters
US5272148A (en) *	1992-09-09	1993-12-21	Hoechst-Roussel Pharmaceuticals Incorporated	Heteroarenylpiperazines
CN1050604C (zh) *	1993-02-04	2000-03-22	明治制果株式会社	具有抗精神病作用的化合物
US5391570A (en) *	1993-10-14	1995-02-21	Bristol-Myers Squibb	Aminomethyl-benzodioxane and benzopyran serotonergic agents
CA2157348A1 (en) *	1994-09-01	1996-03-02	Aventis Pharmaceuticals Inc.	3-¬4-(1-substituted-4-piperazinyl)butyl\|-4-thiazolidinone and related compounds
KR960022486A (ko) *	1994-12-29	1996-07-18	김준웅	신규 티아졸리딘-4-온 유도체
DK0732332T3 (da) *	1995-03-17	2002-04-15	Aventis Pharma Inc	Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling deraf
KR970032857A (ko) *	1995-12-29	1997-07-22	김준웅	약제 조성물
US5880121A (en) *	1996-01-05	1999-03-09	Hoechst Marion Roussel Inc.	4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
ZA9711376B (en)	1996-12-20	1998-07-21	Lundbeck & Co As H	Indole or dihydroindole derivatives
US6506751B1 (en)	1999-11-12	2003-01-14	Millennium Pharmaceuticals, Inc.	Thiazolidinone compounds useful as chemokine inhibitors
US7049146B2 (en) *	2000-11-14	2006-05-23	Facet Analytical Services And Technology, Llc	Calibration standards, methods, and kits for water determination
US7122376B2 (en) *	2001-11-01	2006-10-17	Facet Analytical Services And Technology, Llc	Calibration standards, methods, and kits for water determination
US7169782B2 (en) *	2001-07-16	2007-01-30	Euro-Celtique S.A.	Aryl substituted thiazolidinones and the use thereof
AU2003270727A1 (en) *	2002-09-17	2004-04-08	Luna Innovations, Inc.	Remote temperature sensing of small volume and related apparatus thereof
PT2159226T (pt) *	2007-03-29	2016-12-16	Joint-Stock Company Obninsk Chemical Pharmaceutical Company	Agente anti-histamínico e antialérgico e um método para a produção do mesmo
JP2012504640A (ja) *	2008-10-02	2012-02-23	アボット・ラボラトリーズ	カルシウムチャネル遮断薬としての新規な化合物
US8815869B2 (en) *	2010-03-18	2014-08-26	Abbvie Inc.	Lactam acetamides as calcium channel blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2520179A (en) *	1949-02-02	1950-08-29	Sterling Drug Inc	4-thiazolidones and a method for preparation thereof
JPS51125389A (en) *	1975-04-09	1976-11-01	Yoshitomi Pharmaceut Ind Ltd	A process for preparing heterocyclic compovnds
US4456756A (en) *	1981-08-03	1984-06-26	Mead Johnson & Company	Spirothiazolidinyl piperazine derivatives
US4411901A (en) *	1981-12-23	1983-10-25	Mead Johnson & Company	Benzisothiazole and benzisoxazole piperazine derivatives
US4619930A (en) *	1985-01-16	1986-10-28	Bristol-Myers Company	Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
GB8512163D0 (en) *	1985-05-14	1985-06-19	Fujisawa Pharmaceutical Co	Oxothiazolidine compound
DE3875073T2 (de) *	1987-11-20	1993-03-11	Hoechst Roussel Pharma	3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US5041445A (en) *	1990-05-21	1991-08-20	Hoechst-Roussel Pharmaceuticals Incorporated	3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles

1988
- 1988-11-09 DE DE8888118614T patent/DE3875073T2/de not_active Expired - Fee Related
- 1988-11-09 EP EP88118614A patent/EP0316723B1/en not_active Expired - Lifetime
- 1988-11-09 ES ES88118614T patent/ES2052675T3/es not_active Expired - Lifetime
- 1988-11-09 AT AT88118614T patent/ATE81123T1/de not_active IP Right Cessation
- 1988-11-17 PT PT89020A patent/PT89020B/pt not_active IP Right Cessation
- 1988-11-17 FI FI885332A patent/FI89916C/fi not_active IP Right Cessation
- 1988-11-18 ZA ZA888651A patent/ZA888651B/xx unknown
- 1988-11-18 AU AU25694/88A patent/AU624092B2/en not_active Ceased
- 1988-11-18 KR KR1019880015210A patent/KR0130976B1/ko not_active IP Right Cessation
- 1988-11-18 DK DK645688A patent/DK645688A/da not_active Application Discontinuation
- 1988-11-18 HU HU885964A patent/HU206709B/hu not_active IP Right Cessation
- 1988-11-18 CA CA000583546A patent/CA1317955C/en not_active Expired - Fee Related
- 1988-11-18 IE IE346388A patent/IE62229B1/en not_active IP Right Cessation
- 1988-11-18 NZ NZ226999A patent/NZ226999A/en unknown
- 1988-11-18 NO NO885152A patent/NO176143C/no not_active IP Right Cessation
- 1988-11-18 JP JP63290346A patent/JP2617546B2/ja not_active Expired - Lifetime
- 1988-11-18 IL IL88414A patent/IL88414A/xx not_active IP Right Cessation
- 1988-11-18 PH PH37834A patent/PH27330A/en unknown
1989
- 1989-10-31 US US07/430,688 patent/US4933453A/en not_active Expired - Lifetime
1990
- 1990-03-02 US US07/487,328 patent/US5037984A/en not_active Expired - Fee Related
1991
- 1991-06-07 US US07/713,247 patent/US5136037A/en not_active Expired - Fee Related
- 1991-11-21 US US07/795,608 patent/US5229388A/en not_active Expired - Fee Related
1992
- 1992-12-30 GR GR920402519T patent/GR3006698T3/el unknown
1993
- 1993-06-29 US US08/085,273 patent/US5371087A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE81123T1 (de)	1992-10-15
JP2617546B2 (ja)	1997-06-04
IL88414A0 (en)	1989-06-30
EP0316723A1 (en)	1989-05-24
DE3875073D1 (da)	1992-11-05
PH27330A (en)	1993-06-08
US4933453A (en)	1990-06-12
HUT54149A (en)	1991-01-28
GR3006698T3 (da)	1993-06-30
US5229388A (en)	1993-07-20
KR0130976B1 (ko)	1998-04-16
IL88414A (en)	1993-07-08
KR890008137A (ko)	1989-07-10
NZ226999A (en)	1991-05-28
NO176143C (no)	1995-02-08
IE883463L (en)	1989-05-20
PT89020B (pt)	1993-02-26
ES2052675T3 (es)	1994-07-16
AU624092B2 (en)	1992-06-04
JPH01160975A (ja)	1989-06-23
ZA888651B (en)	1989-09-27
EP0316723B1 (en)	1992-09-30
FI89916C (fi)	1993-12-10
HU206709B (en)	1992-12-28
NO885152L (no)	1989-05-22
IE62229B1 (en)	1995-01-11
NO176143B (no)	1994-10-31
PT89020A (pt)	1988-12-01
US5037984A (en)	1991-08-06
AU2569488A (en)	1989-05-25
NO885152D0 (no)	1988-11-18
DK645688D0 (da)	1988-11-18
US5371087A (en)	1994-12-06
FI885332A (fi)	1989-05-21
US5136037A (en)	1992-08-04
FI885332A0 (fi)	1988-11-17
CA1317955C (en)	1993-05-18
DE3875073T2 (de)	1993-03-11
FI89916B (fi)	1993-08-31

Legal Events

Date	Code	Title	Description
2003-12-29	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK645688A (da)	1989-05-21	3-(4-(1-substitueret 4-piperazinyl)butyl)-4-thiazolidinoner, deres fremstilling og anvendelse
DK0417584T3 (da)	1998-09-23	N-Substituerede 4-pyrimidinaminer og -pyrimidindiaminer, fremgangsmåde til deres fremstilling og deres anvendelser som læge
NO953305D0 (no)	1995-08-23	Antranilsyrederivat
ES2170080T3 (es)	2002-08-01	Derivados de 2-(1-(1,3-tiazolin-2-il)azetidin-3-il)tio-carbapenem.
DE69418789D1 (de)	1999-07-08	2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren
PT98747A (pt)	1992-07-31	Processo para a preparacao de 6,7-dihidro-3-fenil-1-1,2-benzisoxazol-4(5h)-onase -ois e de composicoes farmaceuticas que os contem
ATE84787T1 (de)	1993-02-15	Prolin-derivate.
HUP9801072A2 (hu)	1999-02-01	Szubsztituált 6-és 7-amino-tetrahidro-izokinolin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
DK0458234T3 (da)	1999-10-11	3-[1-Thiazolidinylbutyl-4-piperazinyl]-1H-indazoler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemi
ATE205209T1 (de)	2001-09-15	Chinolincarbonsäurederivate und ihre salze
EP0779277A4 (en)	1999-03-03	1,4-DIHYDROPYRYDINE DERIVATIVE
AU590748B2 (en)	1989-11-16	Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
DK0401779T3 (da)	1995-10-16	4,5,5a,6-Tetrahydro-3H-isoazolo(5,4,3-kl)acridinderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
MX9504041A (es)	1997-03-29	3-[4-(1-substituido-4-piperazinil)butil]-4-tiazolidinona y compuestos relacionados.