DK595987D0 - OSMOTIC CONTINUOUS DISPENSING ORAL DELIVERY SYSTEM CONTAINING A MODERATED WATER SOLUBLE METOPROLOL SALT - Google Patents
OSMOTIC CONTINUOUS DISPENSING ORAL DELIVERY SYSTEM CONTAINING A MODERATED WATER SOLUBLE METOPROLOL SALTInfo
- Publication number
- DK595987D0 DK595987D0 DK595987A DK595987A DK595987D0 DK 595987 D0 DK595987 D0 DK 595987D0 DK 595987 A DK595987 A DK 595987A DK 595987 A DK595987 A DK 595987A DK 595987 D0 DK595987 D0 DK 595987D0
- Authority
- DK
- Denmark
- Prior art keywords
- delivery system
- water soluble
- system containing
- core
- oral delivery
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The system having improved formulation properties, such as hardness and resistance to breakage, consists of a) an outer shell composed of a semipermeable material which is permeable to water and impermeable to the components of the core which contains the active ingredient, b) a core with a mixture which is sufficiently soluble in water to generate osmotic pressure and is composed of about 7.5 to about 15 % by weight of poly-N-vinylpyrrolidone, about 5 % by weight of a glidant or lubricant customary in the production of solid dosage forms, and about 80 to 92.5 % of a pharmaceutically acceptable metoprolol salt which is moderately soluble in water, and c) a passage through the shell a) for the transport of the components contained in the core into the surrounding aqueous body fluid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93082886A | 1986-11-14 | 1986-11-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK595987D0 true DK595987D0 (en) | 1987-11-13 |
| DK595987A DK595987A (en) | 1988-05-15 |
Family
ID=25459837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK595987A DK595987A (en) | 1986-11-14 | 1987-11-13 | OSMOTIC CONTINUOUS DISPENSING ORAL DELIVERY SYSTEM CONTAINING A MODERATED WATER SOLUBLE METOPROLOL SALT |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0271438B1 (en) |
| JP (1) | JP2567427B2 (en) |
| KR (1) | KR960002180B1 (en) |
| AT (1) | ATE75394T1 (en) |
| AU (1) | AU598318B2 (en) |
| CA (1) | CA1312016C (en) |
| DE (1) | DE3778662D1 (en) |
| DK (1) | DK595987A (en) |
| ES (1) | ES2032205T3 (en) |
| GR (1) | GR3005132T3 (en) |
| IE (1) | IE60533B1 (en) |
| NZ (1) | NZ222525A (en) |
| PT (1) | PT86119B (en) |
| ZA (1) | ZA878526B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4892739A (en) * | 1988-04-25 | 1990-01-09 | Ciba-Geigy Corporation | Osmotic continuous dispensing oral delivery system containing a pharmaceutically acceptable active agent having a improved core membrane adhesion properties |
| US4859470A (en) * | 1988-06-02 | 1989-08-22 | Alza Corporation | Dosage form for delivering diltiazem |
| KR100733925B1 (en) * | 2005-03-16 | 2007-07-02 | 주식회사 엘지화학 | ECD control apparatus |
| IL210279A0 (en) | 2009-12-25 | 2011-03-31 | Dexcel Pharma Technologies Ltd | Extended release compositions for high solubility, high permeability acdtive pharmaceutical ingredients |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4576604A (en) * | 1983-03-04 | 1986-03-18 | Alza Corporation | Osmotic system with instant drug availability |
| GB8503666D0 (en) * | 1985-02-13 | 1985-03-13 | Shell Int Research | Producing 4-(2-methoxyethyl)-phenylglycidyl ether |
| US5019302A (en) * | 1986-03-12 | 1991-05-28 | Washington University Technology Associates, Inc. | Method for granulation |
-
1987
- 1987-11-09 AT AT87810646T patent/ATE75394T1/en active
- 1987-11-09 ES ES198787810646T patent/ES2032205T3/en not_active Expired - Lifetime
- 1987-11-09 DE DE8787810646T patent/DE3778662D1/en not_active Expired - Lifetime
- 1987-11-09 EP EP87810646A patent/EP0271438B1/en not_active Expired - Lifetime
- 1987-11-12 PT PT86119A patent/PT86119B/en not_active IP Right Cessation
- 1987-11-12 CA CA000551655A patent/CA1312016C/en not_active Expired - Lifetime
- 1987-11-12 NZ NZ222525A patent/NZ222525A/en unknown
- 1987-11-13 IE IE307187A patent/IE60533B1/en not_active IP Right Cessation
- 1987-11-13 ZA ZA878526A patent/ZA878526B/en unknown
- 1987-11-13 JP JP62285627A patent/JP2567427B2/en not_active Expired - Lifetime
- 1987-11-13 KR KR1019870012779A patent/KR960002180B1/en not_active IP Right Cessation
- 1987-11-13 AU AU81192/87A patent/AU598318B2/en not_active Ceased
- 1987-11-13 DK DK595987A patent/DK595987A/en not_active Application Discontinuation
-
1992
- 1992-07-10 GR GR920400683T patent/GR3005132T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0271438A3 (en) | 1989-07-19 |
| IE873071L (en) | 1988-05-14 |
| IE60533B1 (en) | 1994-07-27 |
| CA1312016C (en) | 1992-12-29 |
| ES2032205T3 (en) | 1993-01-16 |
| JP2567427B2 (en) | 1996-12-25 |
| AU8119287A (en) | 1988-05-19 |
| DE3778662D1 (en) | 1992-06-04 |
| ZA878526B (en) | 1988-05-16 |
| PT86119A (en) | 1987-12-01 |
| EP0271438A2 (en) | 1988-06-15 |
| JPS63135329A (en) | 1988-06-07 |
| KR880005944A (en) | 1988-07-21 |
| PT86119B (en) | 1990-08-31 |
| KR960002180B1 (en) | 1996-02-13 |
| DK595987A (en) | 1988-05-15 |
| ATE75394T1 (en) | 1992-05-15 |
| GR3005132T3 (en) | 1993-05-24 |
| EP0271438B1 (en) | 1992-04-29 |
| AU598318B2 (en) | 1990-06-21 |
| NZ222525A (en) | 1989-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |