DK521680A - METHOD FOR PREPARING SUBSTITUTED 2-PHENALAMINO-IMIDAZOLINES - Google Patents

METHOD FOR PREPARING SUBSTITUTED 2-PHENALAMINO-IMIDAZOLINES

Info

Publication number
DK521680A
DK521680A DK521680A DK521680A DK521680A DK 521680 A DK521680 A DK 521680A DK 521680 A DK521680 A DK 521680A DK 521680 A DK521680 A DK 521680A DK 521680 A DK521680 A DK 521680A
Authority
DK
Denmark
Prior art keywords
group
see diagramm
general formula
acid addition
imidazolines
Prior art date
Application number
DK521680A
Other languages
Danish (da)
Inventor
H Staehle
H Koeppe
W Kummer
W Kobinger
C Lillie
L Pichler
W Hoefke
W Gaida
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of DK521680A publication Critical patent/DK521680A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1. Claims for the Contracting state : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P7,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof. 1. Claims for the Contracting state : AT Process for preparing substituted 2-phenylamino-imidazolines-(2) of general formula (I) see diagramm : EP0030616,P8,F1 wherein R represents an n-propyl, cyclopropylmethyl, cyclopentylmethyl, allyl or methallyl group, and the physiologically acceptable acid addition salts thereof, characterised in that a) 2-(2,6-dibromo-4-methylphenyl-imino)-imidazolidine of formula II see diagramm : EP0030616,P8,F2 is reacted with a halide of general formula III Hal-R wherein Hal represents a chlorine, bromine or iodine atom and R is as hereinbefore defined, at 40 degrees C to 150 degrees C, or b) a compound of general formula IV see diagramm : EP0030616,P8,F3 wherein R is as hereinbefore defined and A represents a cyano group or the group see diagramm : EP0030616,P8,F4 wherein Y represents an alkoxy or alkylthio group with up to 4 carbon atoms or a mercapto group or an amino group, is reacted with ethylenediamine or the acid addition salts thereof at 60 to 180 degrees C, and the end product obtained according to one of these processes is optionally converted into a corresponding acid addition salt.
DK521680A 1979-12-07 1980-12-05 METHOD FOR PREPARING SUBSTITUTED 2-PHENALAMINO-IMIDAZOLINES DK521680A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792949287 DE2949287A1 (en) 1979-12-07 1979-12-07 NEW SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF

Publications (1)

Publication Number Publication Date
DK521680A true DK521680A (en) 1981-06-08

Family

ID=6087857

Family Applications (1)

Application Number Title Priority Date Filing Date
DK521680A DK521680A (en) 1979-12-07 1980-12-05 METHOD FOR PREPARING SUBSTITUTED 2-PHENALAMINO-IMIDAZOLINES

Country Status (12)

Country Link
EP (1) EP0030616B1 (en)
JP (1) JPS5692274A (en)
AT (1) ATE5818T1 (en)
AU (1) AU533756B2 (en)
DE (2) DE2949287A1 (en)
DK (1) DK521680A (en)
ES (1) ES497480A0 (en)
FI (1) FI69068C (en)
IE (1) IE50485B1 (en)
IL (1) IL61637A (en)
NO (1) NO151412C (en)
ZA (1) ZA807611B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
US4644007A (en) * 1981-11-20 1987-02-17 Alcon Laboratories, Inc. 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4517199A (en) * 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
HU192986B (en) * 1984-05-23 1987-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of imidasodiline derivatives
DE19514579A1 (en) 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Use of alpha-1-olone agonists for the treatment of urinary incontinence

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT285599B (en) * 1968-06-21 1970-11-10 Boehringer Sohn Ingelheim Process for the preparation of new trisubstituted 2-arylaminoimidazolines and their salts
BE759048A (en) * 1969-11-17 1971-05-17 Boehringer Sohn Ingelheim NEW N-AMINOALCOYL-ARYLAMINO-IMIDAZOLINES- (2) SUBSTITUTES AND METHODS FOR MAKING THEM
DE2259160A1 (en) * 1972-12-02 1974-06-06 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE, THEIR ACID-ADDITIONAL SALTS AND METHOD FOR MANUFACTURING THE SAME AND THEIR USE AS A MEDICINAL PRODUCT
DE2523103C3 (en) * 1975-05-24 1979-11-29 C.H. Boehringer Sohn, 6507 Ingelheim Substituted 2- [N-Progargyl-N- (2-chlorophenyl) amino] -imidazoline- ^), their acid addition salts, processes for their preparation and their use
DE2636732A1 (en) * 1976-08-14 1978-02-16 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLAMINO IMIDAZOLINE (2), THE ACID ADDITION SALTS THEREOF, THE MEDICINAL PRODUCTS CONTAINING THE SAME AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
EP0030616A1 (en) 1981-06-24
EP0030616B1 (en) 1984-01-11
IE802555L (en) 1981-06-07
DE2949287A1 (en) 1981-06-11
AU6513680A (en) 1981-06-18
AU533756B2 (en) 1983-12-08
IE50485B1 (en) 1986-04-30
ZA807611B (en) 1982-08-25
NO803682L (en) 1981-06-09
JPS5692274A (en) 1981-07-25
FI803799L (en) 1981-06-08
IL61637A (en) 1984-11-30
ATE5818T1 (en) 1984-01-15
ES8201978A1 (en) 1982-01-01
FI69068B (en) 1985-08-30
DE3066104D1 (en) 1984-02-16
NO151412B (en) 1984-12-27
IL61637A0 (en) 1981-01-30
FI69068C (en) 1985-12-10
ES497480A0 (en) 1982-01-01
NO151412C (en) 1985-04-10

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Legal Events

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AHS Application shelved for other reasons than non-payment