DK46789A - 3-indolpyrodruesyrederivater og farmaceutisk anvendelse deraf - Google Patents

3-indolpyrodruesyrederivater og farmaceutisk anvendelse deraf

Info

Publication number: DK46789A
Authority: DK; Denmark
Prior art keywords: indolpyrodruic; acid derivatives; pharmaceutical use; derivatives; acid
Prior art date: 1987-06-03

Application number

DK046789A

Other languages

English (en)

Other versions

DK46789D0 (da

DK170438B1 (da

Inventor

Giovanna De Luca

Giovanni Di Stazio

Andrea Margonelli

Mario Materazzi

Vincenzo Politi

Original Assignee

Polifarma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-03

Filing date

1989-02-02

Publication date

1989-03-31

1989-02-02 Application filed by Polifarma Spa filed Critical Polifarma Spa

1989-02-02 Publication of DK46789D0 publication Critical patent/DK46789D0/da

1989-03-31 Publication of DK46789A publication Critical patent/DK46789A/da

1995-09-04 Application granted granted Critical

1995-09-04 Publication of DK170438B1 publication Critical patent/DK170438B1/da

Links

239000002253 acid Substances 0.000 title 1
HCZHHEIFKROPDY-UHFFFAOYSA-N kynurenic acid Chemical compound C1=CC=C2NC(C(=O)O)=CC(=O)C2=C1 HCZHHEIFKROPDY-UHFFFAOYSA-N 0.000 abstract 2
RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical compound C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK046789A 1987-06-03 1989-02-02 3-Indolpyrodruesyrederivater, lægemidler indeholdende sådanne, samt anvendelse af sådanne derivater til fremstilling af lægemidler DK170438B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
IT4801487		1987-06-03
IT8748014A IT1206078B (it)	1987-06-03	1987-06-03	Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
PCT/IT1988/000041 WO1988009789A2 (en)	1987-06-03	1988-06-01	3-indolepyruvic acid derivatives and pharmaceutical use thereof
IT8800041		1988-06-01

Publications (3)

Publication Number	Publication Date
DK46789D0 DK46789D0 (da)	1989-02-02
DK46789A true DK46789A (da)	1989-03-31
DK170438B1 DK170438B1 (da)	1995-09-04

Family

ID=11263959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK046789A DK170438B1 (da)	1987-06-03	1989-02-02	3-Indolpyrodruesyrederivater, lægemidler indeholdende sådanne, samt anvendelse af sådanne derivater til fremstilling af lægemidler

Country Status (13)

Country	Link
US (1)	US5002963A (da)
EP (1)	EP0321516B1 (da)
JP (1)	JPH02500369A (da)
KR (1)	KR960016522B1 (da)
AT (1)	ATE86247T1 (da)
AU (1)	AU609500B2 (da)
CA (1)	CA1328658C (da)
DE (1)	DE3878866T2 (da)
DK (1)	DK170438B1 (da)
FI (1)	FI92055C (da)
IT (1)	IT1206078B (da)
NO (1)	NO890408L (da)
WO (1)	WO1988009789A2 (da)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1224546B (it) *	1988-09-29	1990-10-04	Polifarma Spa	Utilizzatore farmaceutica di acido 3 -indolpiruvico come agente inibitore di patologie degenerative
US4960786A (en) *	1989-04-24	1990-10-02	Merrell Dow Pharmaceuticals Inc.	Excitatory amino acid antagonists
JPH0347123A (ja) *	1989-05-05	1991-02-28	G D Searle & Co	インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
DE3917880A1 (de) *	1989-06-01	1990-12-06	Kali Chemie Ag	Neue acylaminosaeurederivate enthaltende arzneimittel und diaetetika
IT218019Z2 (it) *	1989-09-08	1992-03-05	Enea	Dispositivo protettivo individuale, portatile ad isolamento totale conatmosfera controllata
IT1237472B (it) *	1989-10-04	1993-06-07	Polifarma Spa	Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
US5037846A (en) *	1990-01-02	1991-08-06	Pfizer Inc.	Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters
DK0624569T3 (da) *	1991-02-28	1998-10-26	Merrell Pharma Inc	MMDA-antagonister
US5360814A (en) *	1991-02-28	1994-11-01	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
US5484814A (en) *	1991-02-28	1996-01-16	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
IT1261165B (it) *	1993-01-25	1996-05-09	Polifarma Spa	Agente attivo per ridurre il livello ematico di glucocorticoidi e prevenire disturbi cerebrali da stress e senilita'.
FR2701948B1 (fr) *	1993-02-22	1996-07-26	Exsymol Sa	Produit de couplage de l'histamine ou l'histamine méthyl-substituée et d'un acide aminé, procédé de préparation et applications thérapeutiques, cosmétologiques et agroalimentaires.
US5859031A (en)	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US7056935B2 (en) *	1995-06-07	2006-06-06	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5801187A (en)	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US6242468B1 (en)	1997-02-27	2001-06-05	Jia-He Li	Carbamate and urea compositions and neurotrophic uses
US5846979A (en)	1997-02-28	1998-12-08	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic esters, amides, thioesters, and ketones
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US5945441A (en)	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
US6075150A (en)	1998-01-26	2000-06-13	Cv Therapeutics, Inc.	α-ketoamide inhibitors of 20S proteasome
EP1085853A1 (en)	1998-06-03	2001-03-28	GPI NIL Holdings, Inc.	Heterocyclic ester and amide hair growth compositions and uses
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6331537B1 (en)	1998-06-03	2001-12-18	Gpi Nil Holdings, Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
BR9815882A (pt)	1998-06-03	2002-09-17	Gpi Nil Holding Inc	Sulfonamidas ligadas por n de ácido carboxìlicos n-heterocìclicos ouou de isósteros de ácidos carboxìlicos
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
US7253169B2 (en)	1999-11-12	2007-08-07	Gliamed, Inc.	Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en)	1999-11-12	2002-07-09	Gpi Nil Holdings, Inc.	AZA compounds, pharmaceutical compositions and methods of use
DE60026568D1 (de)	1999-12-21	2006-05-04	Mgi Gp Inc	Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung
US6608196B2 (en)	2001-05-03	2003-08-19	Galileo Pharmaceuticals, Inc.	Process for solid supported synthesis of pyruvate-derived compounds
ES2314100T3 (es)	2001-05-03	2009-03-16	Monsanto Technology Llc	Derivados de piruvato.
DE60239072D1 (de)	2001-12-27	2011-03-10	Ajinomoto Kk	Verfahren zur herstellung von glutaminsäurederivaten
CN102027117B (zh) *	2007-08-24	2012-11-07	味之素株式会社	新的氧化酶基因及使用该基因生产3-吲哚-丙酮酸的方法
KR20120068872A (ko)	2010-10-14	2012-06-27	아지노모토 가부시키가이샤	모나틴의 제조 방법
WO2020012373A1 (en) *	2018-07-10	2020-01-16	Polindols S.R.L.S.	New drugs chronic invalidating pathologies and to slow aging, based on a new metabolic tryptophan route and production process thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1096881A (en) *	1976-10-07	1981-03-03	Roger R. Gaudette	Preparation of aliphatic and heterocyclic alpha-keto carboxylic acids
GR74635B (da) *	1980-08-18	1984-06-29	Merck & Co Inc
DE3177130D1 (de) *	1980-08-30	1990-01-11	Hoechst Ag	Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
GR75019B (da) *	1980-09-17	1984-07-12	Univ Miami
IT1148618B (it) *	1982-10-11	1986-12-03	Polifarma Spa	Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
IT1184282B (it) *	1985-06-28	1987-10-22	Polifarma Spa	Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico

1987
- 1987-06-03 IT IT8748014A patent/IT1206078B/it active
1988
- 1988-05-25 CA CA000567675A patent/CA1328658C/en not_active Expired - Fee Related
- 1988-06-01 US US07/327,804 patent/US5002963A/en not_active Expired - Lifetime
- 1988-06-01 EP EP88904984A patent/EP0321516B1/en not_active Expired - Lifetime
- 1988-06-01 AU AU19433/88A patent/AU609500B2/en not_active Expired
- 1988-06-01 JP JP63504630A patent/JPH02500369A/ja active Pending
- 1988-06-01 KR KR1019890700193A patent/KR960016522B1/ko not_active IP Right Cessation
- 1988-06-01 WO PCT/IT1988/000041 patent/WO1988009789A2/en active IP Right Grant
- 1988-06-01 DE DE8888904984T patent/DE3878866T2/de not_active Expired - Lifetime
- 1988-06-01 AT AT88904984T patent/ATE86247T1/de not_active IP Right Cessation
1989
- 1989-02-01 NO NO89890408A patent/NO890408L/no unknown
- 1989-02-02 FI FI890508A patent/FI92055C/fi active IP Right Grant
- 1989-02-02 DK DK046789A patent/DK170438B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH02500369A (ja)	1990-02-08
NO890408L (no)	1989-03-30
DK46789D0 (da)	1989-02-02
EP0321516A1 (en)	1989-06-28
IT8748014A0 (it)	1987-06-03
NO890408D0 (no)	1989-02-01
AU609500B2 (en)	1991-05-02
DK170438B1 (da)	1995-09-04
ATE86247T1 (de)	1993-03-15
US5002963A (en)	1991-03-26
FI92055C (fi)	1994-09-26
KR890701559A (ko)	1989-12-20
CA1328658C (en)	1994-04-19
DE3878866T2 (de)	1993-09-02
DE3878866D1 (de)	1993-04-08
WO1988009789A2 (en)	1988-12-15
EP0321516B1 (en)	1993-03-03
FI890508A (fi)	1989-02-02
AU1943388A (en)	1989-01-04
IT1206078B (it)	1989-04-14
KR960016522B1 (ko)	1996-12-14
FI890508A0 (fi)	1989-02-02
WO1988009789A3 (en)	1989-02-09
FI92055B (fi)	1994-06-15

Legal Events

Date	Code	Title	Description
1995-09-04	B1	Patent granted (law 1993)
2008-06-16	PUP	Patent expired

Publication	Publication Date	Title
DK46789A (da)	1989-03-31	3-indolpyrodruesyrederivater og farmaceutisk anvendelse deraf
HUT47217A (en)	1989-02-28	Process for producing pharmaceutical compositions containing indol derivatives as active components
ES2139638T3 (es)	2000-02-16	1,4-piperazinas disustituidas para el tratamiento de las enfermedades del sistema nervioso central y de las enfermedades neuroendocrinas.
DK0495982T3 (da)	1996-07-01	Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel
EP0285008A3 (en)	1990-06-06	The use of buspirone for preparing a pharmaceutical composition for the treatment of alcohol abuse
HUT67028A (en)	1995-01-30	Indole derivatives, pharmeceutical compositions comprising them and process for their production
TNSN88096A1 (fr)	1990-07-10	Nouveau n-(1-alkyl-3-hydroxy-4-piperidyl)
EP0451654A3 (en)	1992-07-08	Use of n-alkylated 1,4-dihydropyridine carboxylic acid esters as drugs, new compounds and process for their preparation
DK515489D0 (da)	1989-10-17	Dispergerbar laegemiddelformulering
ES464146A1 (es)	1978-09-01	Procedimiento de preparacion de derivados de la piperidina.
DE68928756D1 (de)	1998-08-27	Topische Zubereitungen enthaltend aliphatische Amine zur Behandlung von Hautkrankheiten
ATE325610T1 (de)	2006-06-15	Xanthinderivative zur behandlung von hirnischämie
HUT50334A (en)	1990-01-29	Process for producing arylpiperazinyl-alkilenephenyl-p-heterocycluc compounds, pharmaceutically acceptable acid addition salts thereof and pharmaceutical compositions comprising the compounds as active ingredient
GR3019774T3 (en)	1996-07-31	Piperidylmethyl substituted chroman derivatives as agents for the treatment of diseases of the central nervous system
DK0571243T3 (da)	1995-12-04	Thiochromanderivater, fremgangsmåder til fremstilling heraf samt farmaceutiske midler indeholdende d isse
DE3261625D1 (en)	1985-01-31	Tricyclic thiazolyl oxamic acids and derivatives, process for their production, and therapeutic agents containing them
ZA891769B (en)	1989-12-27	Heterocyclic compounds
PT85593A (en)	1987-09-01	Process for preparing substituted hexahydroarylquinolizines
ES2055440T3 (es)	1994-08-16	Derivados del acido quinurenico, su preparacion y composiciones farmaceuticas que los contienen.
RU93004689A (ru)	1996-09-20	Производные индола и индазола для лечения и профилактики нарушений мозговой деятельности, их получение и использование
IT1248525B (it)	1995-01-19	Derivati dell'eseridina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.