US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
US4486414A
(en)
|
1983-03-21 |
1984-12-04 |
Arizona Board Of Reagents |
Dolastatins A and B cell growth inhibitory substances
|
US4486444A
(en)
|
1983-06-20 |
1984-12-04 |
Merck & Co., Inc. |
(Hydroxybenzoyl)thiophenesulfonamide and acyl derivatives thereof for the topical treatment of elevated intraocular pressure
|
US4816444A
(en)
|
1987-07-10 |
1989-03-28 |
Arizona Board Of Regents, Arizona State University |
Cell growth inhibitory substance
|
US5076973A
(en)
|
1988-10-24 |
1991-12-31 |
Arizona Board Of Regents |
Synthesis of dolastatin 3
|
US4978744A
(en)
|
1989-01-27 |
1990-12-18 |
Arizona Board Of Regents |
Synthesis of dolastatin 10
|
US4879278A
(en)
|
1989-05-16 |
1989-11-07 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
|
US4986988A
(en)
|
1989-05-18 |
1991-01-22 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
|
US5187186A
(en)
|
1989-07-03 |
1993-02-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Pyrroloindole derivatives
|
JP2510335B2
(ja)
|
1989-07-03 |
1996-06-26 |
協和醗酵工業株式会社 |
Dc―88a誘導体
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
US5138036A
(en)
|
1989-11-13 |
1992-08-11 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
|
DE4006203C1
(da)
|
1990-02-28 |
1991-05-02 |
Rehm Schweisstechnik Gmbh & Co., 7321 Wangen, De |
|
US5198560A
(en)
|
1990-04-27 |
1993-03-30 |
Bristol-Myers Squibb Company |
Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof
|
CA2076465C
(en)
|
1992-03-25 |
2002-11-26 |
Ravi V. J. Chari |
Cell binding agent conjugates of analogues and derivatives of cc-1065
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
US6034065A
(en)
|
1992-12-03 |
2000-03-07 |
Arizona Board Of Regents |
Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
|
US5410024A
(en)
|
1993-01-21 |
1995-04-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
US5994341A
(en)
|
1993-07-19 |
1999-11-30 |
Angiogenesis Technologies, Inc. |
Anti-angiogenic Compositions and methods for the treatment of arthritis
|
ES2233928T3
(es)
|
1993-10-01 |
2005-06-16 |
Teikoku Hormone Mfg. Co., Ltd. |
Derivados de dolastatina.
|
GB9320575D0
(en)
|
1993-10-06 |
1993-11-24 |
Amp Gmbh |
Coaxial connector having improved locking mechanism
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
US5504191A
(en)
|
1994-08-01 |
1996-04-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide methyl esters
|
US5530097A
(en)
|
1994-08-01 |
1996-06-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory peptide amides
|
US5521284A
(en)
|
1994-08-01 |
1996-05-28 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides and esters
|
US5554725A
(en)
|
1994-09-14 |
1996-09-10 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Synthesis of dolastatin 15
|
US5599902A
(en)
|
1994-11-10 |
1997-02-04 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Cancer inhibitory peptides
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
EP0862553A4
(en)
|
1995-10-03 |
1999-02-03 |
Scripps Research Inst |
CBI ANALOG OF CC-1065 AND THE DUOCARMYCINES
|
ES2218328T5
(es)
|
1995-11-17 |
2011-11-11 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Derivados de epotilón, su preparación y utilización.
|
EP0923583A1
(de)
|
1996-08-30 |
1999-06-23 |
Novartis AG |
Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens
|
US5969145A
(en)
|
1996-08-30 |
1999-10-19 |
Novartis Ag |
Process for the production of epothilones and intermediate products within the process
|
US6680311B1
(en)
|
1996-08-30 |
2004-01-20 |
Eli Lilly And Company |
Cryptophycin compounds
|
HU229833B1
(en)
|
1996-11-18 |
2014-09-29 |
Biotechnolog Forschung Gmbh |
Epothilone d production process, and its use as cytostatic as well as phytosanitary agents
|
EP1386922B1
(en)
|
1996-12-03 |
2012-04-11 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereof, analogues and uses thereof
|
US6441186B1
(en)
|
1996-12-13 |
2002-08-27 |
The Scripps Research Institute |
Epothilone analogs
|
ZA981575B
(en)
|
1997-02-25 |
1998-09-08 |
Biotechnolog Forschung Gmbh |
Epothilones which are modified in the side chain
|
WO1998036765A1
(en)
|
1997-02-25 |
1998-08-27 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18
|
US6117659A
(en)
|
1997-04-30 |
2000-09-12 |
Kosan Biosciences, Inc. |
Recombinant narbonolide polyketide synthase
|
US6605599B1
(en)
|
1997-07-08 |
2003-08-12 |
Bristol-Myers Squibb Company |
Epothilone derivatives
|
DE59805727D1
(de)
|
1997-07-16 |
2002-10-31 |
Schering Ag |
Thiazolderivate, verfahren zur herstellung und verwendung
|
EP1005465B1
(de)
|
1997-08-09 |
2007-07-25 |
Bayer Schering Pharma Aktiengesellschaft |
Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
|
US6365749B1
(en)
|
1997-12-04 |
2002-04-02 |
Bristol-Myers Squibb Company |
Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
|
CA2311929A1
(en)
|
1997-12-04 |
1999-06-10 |
Bristol-Myers Squibb Company |
A process for the reduction of oxiranyl epothilones to olefinic epothilones
|
US6096757A
(en)
|
1998-12-21 |
2000-08-01 |
Schering Corporation |
Method for treating proliferative diseases
|
US20020103136A1
(en)
|
1998-03-05 |
2002-08-01 |
Dong-Mei Feng |
Conjugates useful in the treatment of prostate cancer
|
US6121029A
(en)
|
1998-06-18 |
2000-09-19 |
Novartis Ag |
Genes for the biosynthesis of epothilones
|
US6323315B1
(en)
|
1999-09-10 |
2001-11-27 |
Basf Aktiengesellschaft |
Dolastatin peptides
|
US7303749B1
(en)
|
1999-10-01 |
2007-12-04 |
Immunogen Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
EP2289549A3
(en)
|
1999-10-01 |
2011-06-15 |
Immunogen, Inc. |
Immunoconjugates for treating cancer
|
US6956036B1
(en)
|
2000-03-17 |
2005-10-18 |
Alcon, Inc. |
6-hydroxy-indazole derivatives for treating glaucoma
|
US6608053B2
(en)
|
2000-04-27 |
2003-08-19 |
Yamanouchi Pharmaceutical Co., Ltd. |
Fused heteroaryl derivatives
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
DE60115265T2
(de)
|
2000-09-19 |
2006-08-10 |
Lee, Moses, Holland |
Zusammensetzungen und verfahren zur verwendung achiraler analoge von cc-1065 und den duocarmycinen
|
US6747021B2
(en)
|
2000-10-02 |
2004-06-08 |
Eli Lilly And Company |
Cryptophycin compound
|
JP2005500974A
(ja)
|
2000-10-13 |
2005-01-13 |
ザ ユニバーシテイ オブ ミシシッピー |
エポシロン類及び関連類似体の合成
|
US20030083263A1
(en)
|
2001-04-30 |
2003-05-01 |
Svetlana Doronina |
Pentapeptide compounds and uses related thereto
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
US6534660B1
(en)
|
2002-04-05 |
2003-03-18 |
Immunogen, Inc. |
CC-1065 analog synthesis
|
US6756397B2
(en)
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
WO2004010957A2
(en)
|
2002-07-31 |
2004-02-05 |
Seattle Genetics, Inc. |
Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
|
AU2003282624A1
(en)
|
2002-11-14 |
2004-06-03 |
Syntarga B.V. |
Prodrugs built as multiple self-elimination-release spacers
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
BR122018071808B8
(pt)
|
2003-11-06 |
2020-06-30 |
Seattle Genetics Inc |
conjugado
|
EP1718667B1
(en)
|
2004-02-23 |
2013-01-09 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
JP4490703B2
(ja)
|
2004-02-26 |
2010-06-30 |
出光興産株式会社 |
ポリカーボネートの製造方法
|
WO2009017394A1
(en)
|
2007-08-01 |
2009-02-05 |
Syntarga B.V. |
Substituted cc-1065 analogs and their conjugates
|
PL2842575T3
(pl)
|
2008-03-18 |
2018-02-28 |
Seattle Genetics, Inc. |
Koniugaty aurystatyny lek łącznik
|
CN102448469A
(zh)
|
2009-05-28 |
2012-05-09 |
摩萨纳医疗有限公司 |
包括具有可变的释放速率的连接物的聚缩醛(酮)-药物共轭物
|
WO2011038159A2
(en)
|
2009-09-24 |
2011-03-31 |
Seattle Genetics, Inc. |
Dr5 ligand drug conjugates
|
AU2012257417B2
(en)
|
2011-05-16 |
2017-09-14 |
Tagworks Pharmaceuticals B.V. |
Bio-orthogonal drug activation
|
US8815226B2
(en)
|
2011-06-10 |
2014-08-26 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
US10927139B2
(en)
|
2012-11-22 |
2021-02-23 |
Tagworks Pharmaceuticals B.V. |
Chemically cleavable group
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
MX367851B
(es)
|
2013-10-11 |
2019-09-09 |
Mersana Therapeutics Inc |
Conjugados de proteína-polímero-fármaco.
|
WO2016025480A1
(en)
|
2014-08-11 |
2016-02-18 |
The General Hospital Corporation |
Cyclooctenes for bioorthogonol reactions
|
US11617799B2
(en)
*
|
2016-06-27 |
2023-04-04 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
AU2019262521B2
(en)
|
2018-05-04 |
2024-04-18 |
Tagworks Pharmaceuticals B.V. |
Compounds comprising a linker for increasing transcyclooctene stability
|
IL289095A
(en)
|
2019-06-17 |
2022-02-01 |
Tagworks Pharmaceuticals B V |
Activating components to cleave labels from biomolecules in vivo
|
US20230121556A1
(en)
|
2019-06-17 |
2023-04-20 |
Tagworks Pharmaceuticals B.V. |
Compounds for fast and efficient click release
|
IL289094A
(en)
|
2019-06-17 |
2022-02-01 |
Tagworks Pharmaceuticals B V |
Tetrazines for increasing the speed and yield of the "click release" reaction
|
EP4126972A4
(en)
*
|
2020-03-23 |
2024-05-01 |
Zymeworks BC Inc. |
MASKED IL12 FUSION PROTEINS AND METHODS OF USE THEREOF
|
IL298295A
(en)
|
2020-05-19 |
2023-01-01 |
Werewolf Therapeutics Inc |
Activatable il-12 polypeptides and methods of using them
|
CN116096730A
(zh)
*
|
2020-06-25 |
2023-05-09 |
阿穆尼克斯制药公司 |
细胞因子结合物
|
IL305979A
(en)
|
2021-03-16 |
2023-11-01 |
Tagworks Pharmaceuticals B V |
Methods for the preparation of cycloethanes and their conjugates
|