DK420879A - Letspaltelige substrater til kvantitativ bestemmelse af proteaser - Google Patents
Letspaltelige substrater til kvantitativ bestemmelse af proteaserInfo
- Publication number
- DK420879A DK420879A DK420879A DK420879A DK420879A DK 420879 A DK420879 A DK 420879A DK 420879 A DK420879 A DK 420879A DK 420879 A DK420879 A DK 420879A DK 420879 A DK420879 A DK 420879A
- Authority
- DK
- Denmark
- Prior art keywords
- proteases
- quantitative determination
- easy split
- split substrates
- substrates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/20—Coumarin derivatives
- C12Q2337/22—7-Amino-4-methylcoumarin, i.e. AMC, MCA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96444—Factor X (3.4.21.6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/968—Plasmin, i.e. fibrinolysin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/972—Plasminogen activators
- G01N2333/9723—Urokinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/972—Plasminogen activators
- G01N2333/9726—Tissue plasminogen activator
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/802—Chromogenic or luminescent peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7801373A SE7801373L (sv) | 1978-02-07 | 1978-02-07 | Lett spjelkbara substrat for kvantifiering av proteaser |
SE7801373 | 1978-02-07 | ||
SE7900024 | 1979-02-06 | ||
PCT/SE1979/000024 WO1979000602A1 (en) | 1978-02-07 | 1979-02-06 | Easily split substrates for the quantification of proteases |
Publications (3)
Publication Number | Publication Date |
---|---|
DK420879A true DK420879A (da) | 1979-10-05 |
DK147495B DK147495B (da) | 1984-09-03 |
DK147495C DK147495C (da) | 1985-07-15 |
Family
ID=20333883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK420879A DK147495C (da) | 1978-02-07 | 1979-10-05 | Tripeptider til anvendelse som enzymsubstrat til kvantitativ beste mmelse af proteaser og fremgangsmaade til laboratoriediagnosticering af proteaser |
Country Status (18)
Country | Link |
---|---|
US (2) | US4279810A (da) |
EP (1) | EP0004256B1 (da) |
JP (2) | JPS6345397B2 (da) |
AT (1) | AT368773B (da) |
AU (1) | AU4394579A (da) |
CA (1) | CA1136124A (da) |
DD (1) | DD142550A5 (da) |
DE (1) | DE2963358D1 (da) |
DK (1) | DK147495C (da) |
ES (1) | ES477501A1 (da) |
FI (1) | FI790376A (da) |
IL (1) | IL56520A0 (da) |
NO (1) | NO790375L (da) |
PL (1) | PL116682B1 (da) |
SE (1) | SE7801373L (da) |
SU (1) | SU1277904A3 (da) |
WO (1) | WO1979000602A1 (da) |
ZA (1) | ZA79424B (da) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4275153A (en) * | 1978-08-03 | 1981-06-23 | American Hospital Supply Corporation | Analytical fluorogenic substrates for proteolytic enzymes |
US4336186A (en) * | 1978-08-03 | 1982-06-22 | Gargiulo Robert J | Analytical fluorogenic substrates for proteolytic enzymes |
US4409140A (en) * | 1979-04-23 | 1983-10-11 | Smith Robert E | Substrates and method for determining enzymes |
EP0018002B1 (de) * | 1979-04-24 | 1983-02-09 | Marcel Jozefonvicz | Neues Bestimmungsverfahren für Proteasen und Antiproteasen |
DE2936543A1 (de) * | 1979-09-10 | 1981-04-09 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen |
CA1161432A (en) * | 1980-02-12 | 1984-01-31 | Lars G. Svendsen | Tripeptide derivatives and their application in assaying enzymes |
DE3164437D1 (en) * | 1980-08-25 | 1984-08-02 | Kabivitrum Ab | Peptide substrates for determination of protease activity |
FR2497798A1 (fr) * | 1981-01-09 | 1982-07-16 | Pharmindustrie | Nouveaux peptides portant un fluorophore, procede pour leur preparation et leur application au dosage fluorimetrique des endotoxines |
US4388233A (en) * | 1981-05-15 | 1983-06-14 | The Regents Of The University Of California | Synthetic substrates for enzyme analysis |
US4510241A (en) * | 1981-09-03 | 1985-04-09 | Mallinckrodt, Inc. | Peptide-type substrates useful in the quantitative determination of endotoxin |
JPS5863399A (ja) * | 1981-10-14 | 1983-04-15 | Nitto Boseki Co Ltd | 新規なプラスミン測定用基質 |
US4448715A (en) * | 1981-11-02 | 1984-05-15 | University Of Miami | Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein |
DE3211254A1 (de) * | 1982-03-26 | 1983-09-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
US4491541A (en) * | 1982-11-10 | 1985-01-01 | Farmitalia Carlo Erba | Peptides |
DE3244030A1 (de) * | 1982-11-27 | 1984-05-30 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung |
EP0128118B1 (de) * | 1983-06-03 | 1991-08-14 | Pentapharm A.G. | Peptidderivate und deren Verwendung als Substrate zur quantitativen Bestimmung von Enzymen |
JPS6117956A (ja) * | 1984-07-04 | 1986-01-25 | Nitto Boseki Co Ltd | 新規な尿中カリクレイン測定用基質 |
CA1293591C (en) * | 1985-01-11 | 1991-12-24 | Charles A. Kettner | Peptide substrates for detecting virus-specified protease activity |
US4801534A (en) * | 1985-05-28 | 1989-01-31 | Coulter Electronics, Inc. | Water soluble zanthylium derivative substrates |
US4694070A (en) * | 1985-05-28 | 1987-09-15 | Coulter Electronics, Inc. | Water soluble xanthylium derivatives substrates |
US5231006A (en) * | 1986-10-16 | 1993-07-27 | Behringwerke Aktiengesellschaft | Method for the determination of plasminogen |
DE3635191A1 (de) * | 1986-10-16 | 1988-04-21 | Behringwerke Ag | Verfahren zur bestimmung von plasminogen |
SE8701801L (sv) * | 1987-04-30 | 1988-10-31 | Kabivitrum Ab | Foerfarande foer identifiering av mikroorganismer |
US5115099A (en) * | 1988-06-14 | 1992-05-19 | Nitto Boseki Co., Ltd. | Substrates for determination of enzyme activity and intermediates for synthesis of the substrates as well as process for producing the intermediates |
JPH06104079B2 (ja) * | 1988-07-14 | 1994-12-21 | 日東紡績株式会社 | 新規な酵素活性測定用基質 |
US5191065A (en) * | 1988-11-22 | 1993-03-02 | Hoechst Aktiengesellschaft | Process for the preparation of tripeptides |
DE3839379A1 (de) * | 1988-11-22 | 1990-05-23 | Hoechst Ag | Verfahren zur herstellung von tripeptiden |
SE8904188D0 (sv) * | 1989-12-12 | 1989-12-12 | Kabivitrum Ab | Chromogenic substrate |
JP2769243B2 (ja) * | 1990-02-19 | 1998-06-25 | ノボ ノルディスク アクティーゼルスカブ | 溶液、特に発酵溶液から精製epi蛋白質の回収方法 |
US5776720A (en) * | 1995-05-18 | 1998-07-07 | Coulter Corporation | Assay reagent |
US5698411A (en) * | 1995-05-18 | 1997-12-16 | Coulter Corporation | Method for determining activity of enzymes in metabolically active whole cells |
US5871946A (en) * | 1995-05-18 | 1999-02-16 | Coulter Corporation | Method for determining activity of enzymes in metabolically active whole cells |
US5733719A (en) * | 1995-05-18 | 1998-03-31 | Coulter Corporation | Method of making an assay compound |
WO2001094332A1 (en) * | 2000-06-02 | 2001-12-13 | Regents Of The University Of California | Profiling of protease specificity using combinatorial fluorogenic substrate libraries |
GB0208989D0 (en) | 2002-04-19 | 2002-05-29 | Amersham Biosciences Uk Ltd | Methods for measuring enzyme activity |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL42124A (en) * | 1972-05-02 | 1977-02-28 | Kabi Ab | Substrate for the determination of proteolytic enzymes |
SE380257B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser |
DE2527932C2 (de) * | 1974-07-02 | 1983-04-21 | Pentapharm AG, 4052 Basel | Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein |
SE407058B (sv) * | 1974-12-05 | 1979-03-12 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
CH622286A5 (da) * | 1975-06-23 | 1981-03-31 | Pentapharm Ag | |
SE407571B (sv) * | 1975-07-11 | 1979-04-02 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
SE437153B (sv) * | 1976-12-01 | 1985-02-11 | Kabi Ab | Specifika kromogena enzymsubstrat for serinproteaser |
US4215047A (en) * | 1977-06-06 | 1980-07-29 | Ajinomoto Company Incorporated | 7-(Arginylamino)-4-methylcoumarins |
-
1978
- 1978-02-07 SE SE7801373A patent/SE7801373L/xx unknown
-
1979
- 1979-01-29 IL IL56520A patent/IL56520A0/xx unknown
- 1979-01-29 US US06/007,447 patent/US4279810A/en not_active Expired - Lifetime
- 1979-02-01 ZA ZA79424A patent/ZA79424B/xx unknown
- 1979-02-01 CA CA000320702A patent/CA1136124A/en not_active Expired
- 1979-02-02 AT AT0078279A patent/AT368773B/de not_active IP Right Cessation
- 1979-02-05 FI FI790376A patent/FI790376A/fi unknown
- 1979-02-05 AU AU43945/79A patent/AU4394579A/en not_active Abandoned
- 1979-02-05 PL PL1979213217A patent/PL116682B1/pl unknown
- 1979-02-06 JP JP54500302A patent/JPS6345397B2/ja not_active Expired
- 1979-02-06 ES ES477501A patent/ES477501A1/es not_active Expired
- 1979-02-06 NO NO790375A patent/NO790375L/no unknown
- 1979-02-06 WO PCT/SE1979/000024 patent/WO1979000602A1/en unknown
- 1979-02-06 EP EP79850009A patent/EP0004256B1/en not_active Expired
- 1979-02-06 DE DE7979850009T patent/DE2963358D1/de not_active Expired
- 1979-02-07 DD DD79210881A patent/DD142550A5/de unknown
- 1979-10-05 DK DK420879A patent/DK147495C/da not_active IP Right Cessation
-
1980
- 1980-03-06 SU SU802893256A patent/SU1277904A3/ru active
-
1981
- 1981-03-25 US US06/247,488 patent/US4335204A/en not_active Expired - Lifetime
-
1987
- 1987-08-19 JP JP62204293A patent/JPS63173600A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0004256B1 (en) | 1982-07-21 |
US4335204A (en) | 1982-06-15 |
JPS6345397B2 (da) | 1988-09-09 |
ZA79424B (en) | 1980-01-30 |
JPS55500076A (da) | 1980-02-14 |
PL213217A1 (da) | 1980-02-11 |
AU4394579A (en) | 1979-08-16 |
NO790375L (no) | 1979-08-08 |
DE2963358D1 (en) | 1982-09-09 |
DD142550A5 (de) | 1980-07-02 |
JPS63173600A (ja) | 1988-07-18 |
PL116682B1 (en) | 1981-06-30 |
US4279810A (en) | 1981-07-21 |
IL56520A0 (en) | 1979-03-12 |
SE7801373L (sv) | 1979-08-08 |
ATA78279A (de) | 1982-03-15 |
FI790376A (fi) | 1979-08-08 |
DK147495B (da) | 1984-09-03 |
ES477501A1 (es) | 1979-11-16 |
EP0004256A1 (en) | 1979-09-19 |
SU1277904A3 (ru) | 1986-12-15 |
AT368773B (de) | 1982-11-10 |
WO1979000602A1 (en) | 1979-08-23 |
CA1136124A (en) | 1982-11-23 |
DK147495C (da) | 1985-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |