DK418079A - Fremgangsmaade til fremstilling af 3,3-substituerede spiro-1,2,4-benzothiadiaziner - Google Patents

Fremgangsmaade til fremstilling af 3,3-substituerede spiro-1,2,4-benzothiadiaziner

Info

Publication number
DK418079A
DK418079A DK418079A DK418079A DK418079A DK 418079 A DK418079 A DK 418079A DK 418079 A DK418079 A DK 418079A DK 418079 A DK418079 A DK 418079A DK 418079 A DK418079 A DK 418079A
Authority
DK
Denmark
Prior art keywords
benzothiadiazines
preparing
substituted spiro
spiro
substituted
Prior art date
Application number
DK418079A
Other languages
English (en)
Inventor
E J Cragoe
O W Woltersdorf
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK418079A publication Critical patent/DK418079A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DK418079A 1978-10-06 1979-10-05 Fremgangsmaade til fremstilling af 3,3-substituerede spiro-1,2,4-benzothiadiaziner DK418079A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/949,348 US4226867A (en) 1978-10-06 1978-10-06 3,3-Substituted spiro-1,2,4-benzothiadiazines

Publications (1)

Publication Number Publication Date
DK418079A true DK418079A (da) 1980-04-07

Family

ID=25488955

Family Applications (1)

Application Number Title Priority Date Filing Date
DK418079A DK418079A (da) 1978-10-06 1979-10-05 Fremgangsmaade til fremstilling af 3,3-substituerede spiro-1,2,4-benzothiadiaziner

Country Status (4)

Country Link
US (1) US4226867A (da)
EP (1) EP0010234A1 (da)
JP (1) JPS5573674A (da)
DK (1) DK418079A (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872746A (en) * 1996-05-30 1999-02-16 Sanitoy, Inc. Clock timer with clock face transforming from a frowning orientation to a smiling orientation
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
BR112015014178A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida
BR112015014349A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por hidratação mucosa insuficiente
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA694389A (en) * 1964-09-15 M. Sprague James Benzothiadiazine derivatives
CA694388A (en) * 1964-09-15 Edward J. Cragoe, Jr. Benzothiadiazine derivatives
CA694380A (en) 1964-09-15 C. Overhults Wendell Cellular polystyrene
DE1226107B (de) * 1958-09-02 1966-10-06 Leo Pharm Prod Ltd Verfahren zur Herstellung von 6-Trifluormethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazin-1,1-dioxyden
AT258928B (de) * 1958-09-26 1967-12-27 Merck & Co Inc Verfahren zur Herstellung von neuen Sulfamyl-3,4-dihydro-1,2,4-benzothiadiazin-1,1-dioxyden
GB927698A (en) 1959-07-25 1963-06-06 Chinoin Gyogyszer Es Vegyeszet Pharmaceutically useful sulphonylamido derivatives and process of preparing them
GB936075A (en) * 1960-06-09 1963-09-04 Merck & Co Inc Therapeutic hypotensive compositions comprising phenylalanine derivatives and benzothiadiazine-1,1-dioxide derivatives
FR1285301A (fr) * 1960-12-20 1962-02-23 Merlin Gerin Dispositif de contacts électriques pour disjoncteurs
DE1445095A1 (de) * 1961-05-05 1968-10-24 Leo Pharm Prod Ltd Verfahren zur Herstellung von substituierten 3,4-Dihydro-1,2,4-benzothiadiazin-1,1-dioxyden
US3262931A (en) * 1961-05-08 1966-07-26 Merck & Co Inc Derivatives of 3, 3-spiro-substituted-3, 4-dihydro-1, 2, 4-benzothiadiazine-1, 1-dioxides
AT241464B (de) * 1961-05-08 1965-07-26 Merck & Co Inc Verfahren zur Herstellung von neuen Benzothiadiazinverbindungen
AT242144B (de) * 1961-05-08 1965-08-25 Merck & Co Inc Verfahren zur Herstellung von neuen Benzothiadiazinverbindungen
US3340150A (en) * 1961-11-02 1967-09-05 Ciba Geigy Corp Hypertensive compositions
DE2349114C2 (de) * 1973-09-29 1985-11-14 Basf Ag, 6700 Ludwigshafen 3-sek.-Butyl-2,1,3-benzothiadiazin-(4)-on-2,2-dioxid
US4055645A (en) * 1976-02-13 1977-10-25 Merck & Co., Inc. Novel anti-hypertensive compositions

Also Published As

Publication number Publication date
EP0010234A1 (en) 1980-04-30
JPS5573674A (en) 1980-06-03
US4226867A (en) 1980-10-07

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