DK3914736T3 - Detektering af cancer, canceroprindelsesvæv og/eller en cancercelletype - Google Patents

Detektering af cancer, canceroprindelsesvæv og/eller en cancercelletype Download PDF

Info

Publication number
DK3914736T3
DK3914736T3 DK20710332.6T DK20710332T DK3914736T3 DK 3914736 T3 DK3914736 T3 DK 3914736T3 DK 20710332 T DK20710332 T DK 20710332T DK 3914736 T3 DK3914736 T3 DK 3914736T3
Authority
DK
Denmark
Prior art keywords
cancer
detection
cell type
tissue
cancer cell
Prior art date
Application number
DK20710332.6T
Other languages
English (en)
Inventor
Oliver Claude Venn
Alexander P Fields
Samuel S Gross
Qinwen Liu
Jan Schellenberger
Joerg Bredno
John F Beausang
Seyedmehdi Shojaee
Onur Sakarya
M Cyrus Maher
Arash Jamshidi
Original Assignee
Grail Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grail Llc filed Critical Grail Llc
Application granted granted Critical
Publication of DK3914736T3 publication Critical patent/DK3914736T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/204—Modifications characterised by specific length of the oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Bioethics (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
DK20710332.6T 2019-01-25 2020-01-24 Detektering af cancer, canceroprindelsesvæv og/eller en cancercelletype DK3914736T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962797174P 2019-01-25 2019-01-25
US201962797176P 2019-01-25 2019-01-25
US201962797170P 2019-01-25 2019-01-25
PCT/US2020/015082 WO2020154682A2 (en) 2019-01-25 2020-01-24 Detecting cancer, cancer tissue of origin, and/or a cancer cell type

Publications (1)

Publication Number Publication Date
DK3914736T3 true DK3914736T3 (da) 2024-03-25

Family

ID=69780286

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20710332.6T DK3914736T3 (da) 2019-01-25 2020-01-24 Detektering af cancer, canceroprindelsesvæv og/eller en cancercelletype

Country Status (10)

Country Link
US (2) US20220090207A1 (da)
EP (2) EP4353834A3 (da)
CN (1) CN113728115A (da)
AU (1) AU2020212057A1 (da)
CA (1) CA3127762A1 (da)
DK (1) DK3914736T3 (da)
FI (1) FI3914736T3 (da)
IL (1) IL285126A (da)
PT (1) PT3914736T (da)
WO (1) WO2020154682A2 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019351130A1 (en) 2018-09-27 2021-04-08 Grail, Llc Methylation markers and targeted methylation probe panel
AU2020217719A1 (en) * 2019-02-05 2021-08-19 Grail, Llc Detecting cancer, cancer tissue of origin, and/or a cancer cell type
US11869661B2 (en) 2019-05-22 2024-01-09 Grail, Llc Systems and methods for determining whether a subject has a cancer condition using transfer learning
CA3156589A1 (en) 2019-11-06 2021-05-14 David M. Kurtz Methods and systems for analyzing nucleic acid molecules
EP4078594A1 (en) 2019-12-18 2022-10-26 Grail, LLC Systems and methods for estimating cell source fractions using methylation information
CA3167633A1 (en) 2020-02-28 2021-09-02 Pranav Parmjit SINGH Systems and methods for calling variants using methylation sequencing data
CN115443507A (zh) 2020-02-28 2022-12-06 格里尔公司 鉴定可鉴别或指示癌症病状的甲基化模式
US20210358626A1 (en) 2020-03-04 2021-11-18 Grail, Inc. Systems and methods for cancer condition determination using autoencoders
CA3207988A1 (en) * 2021-04-06 2022-10-13 Oliver Claude VENN Conditional tissue of origin return for localization accuracy
CN117858954A (zh) * 2021-04-21 2024-04-09 赫利奥健康公司 细胞异质性调整的克隆甲基化(chalm)：甲基化定量方法
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
US20230057154A1 (en) 2021-08-05 2023-02-23 Grail, Llc Somatic variant cooccurrence with abnormally methylated fragments
EP4299764A1 (en) * 2022-06-28 2024-01-03 Universal Diagnostics, S.A. Methods for detecting pancreatic cancer using dna methylation markers
US20240136018A1 (en) * 2022-10-19 2024-04-25 Grail, Llc Component mixture model for tissue identification in dna samples

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9115386B2 (en) 2008-09-26 2015-08-25 Children's Medical Center Corporation Selective oxidation of 5-methylcytosine by TET-family proteins
WO2011127136A1 (en) 2010-04-06 2011-10-13 University Of Chicago Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc)
CA2933514A1 (en) * 2013-12-31 2015-07-09 F. Hoffmann-La Roche Ag Methods of assessing epigenetic regulation of genome function via dna methylation status and systems and kits therefor
WO2015116837A1 (en) 2014-01-30 2015-08-06 The Regents Of The University Of California Methylation haplotyping for non-invasive diagnosis (monod)
EP3126529B1 (en) * 2014-03-31 2020-05-27 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
IL302912A (en) * 2016-12-22 2023-07-01 Guardant Health Inc Methods and systems for analyzing nucleic acid molecules
EP3589371A4 (en) * 2017-03-02 2020-11-25 Youhealth Oncotech, Limited METHYLATION MARKERS FOR THE DIAGNOSIS OF HEPER CELL CARCINOMA AND LUNG CANCER
AU2019234843A1 (en) 2018-03-13 2020-09-24 Grail, Llc Anomalous fragment detection and classification

Also Published As

Publication number Publication date
FI3914736T3 (fi) 2024-03-19
EP4353834A2 (en) 2024-04-17
EP4353834A3 (en) 2024-05-01
WO2020154682A2 (en) 2020-07-30
IL285126A (en) 2021-09-30
US20220090207A1 (en) 2022-03-24
CN113728115A (zh) 2021-11-30
PT3914736T (pt) 2024-03-27
EP3914736B1 (en) 2023-12-20
AU2020212057A1 (en) 2021-08-26
WO2020154682A3 (en) 2020-10-01
EP3914736A2 (en) 2021-12-01
CA3127762A1 (en) 2020-07-30
US20220119890A1 (en) 2022-04-21

Similar Documents

Publication Publication Date Title
DK3914736T3 (da) Detektering af cancer, canceroprindelsesvæv og/eller en cancercelletype
DK3627606T3 (da) Elektrolyt og elektrokemisk indretning
DK3371922T3 (da) Clean-slate synkronisations-signaldesign og cellesøgningsalgoritmer
DK3749181T3 (da) Detektering af vævsbeskadigelse
DK3712424T3 (da) Vindmøllevinge og vindmølle
DK3640208T3 (da) Molekularsi scm-14, syntesefremgangsmåde dertil og anvendelse deraf
DK3328317T3 (da) Tilbagetrækning og/eller understøttelse af periurethralt væv
DK3689076T3 (da) PDCP-UL-opdeling og forbehandling
DK3284816T3 (da) Dyrkningsmedietilsætningsstof, dyrkningsmediesammensætning og fremgangsmåde til at dyrke celler eller væv ved anvendelse af samme
DK3286070T3 (da) Fartøj og bomkonstruktion
DK3704264T3 (da) Anvendelse af nukleinsyrestørrelsesinterval til ikke-invasiv, prænatal test og cancerpåvisning
DK3640207T3 (da) Molekularsi scm-15, syntesefremgangsmåde dertil og anvendelse deraf
IL285316A (en) Cancer detection, the source of the cancer tissue and/or the type of cancer cells
DK3612579T3 (da) Pultrudat, fremstilling og anvendelse heraf
DK3795653T3 (da) Syntetisk materiale til detektering af ultraviolet stråling og/eller røntgenstraling
DK3759083T3 (da) 2,4-diaminoquinazolinderivater og anvendelse deraf til behandling af virusinfektioner, cancer eller allergier
DK3294142T3 (da) System og fremgangsmåde af biologiske vævsstrukturer
DK3790927T3 (da) Fremgangsmåde, indretning og anvendelse til oparbejdning af i det væsentlige polyalkylenterephthalat
DK3347006T3 (da) Deutererede analoger af etifoxin, derivater deraf og anvendelser deraf
DK3517083T3 (da) Høreværnssystem og relateret fremgangsmåde
DK3390364T3 (da) Små molekyler til hæmning af kemokinaktivitet og/eller cancercellevækst
DK3551786T3 (da) Elektropoleringsfremgangsmåde og elektrolyt hertil
DK3545144T3 (da) Knudeelementer, kits og fremgangsmåder
DK3719312T3 (da) Vindmøllevinge og vindmølle
DK3893827T3 (da) Mandlig inkontinensbeskyttelse, kit og fremgangsmåde