DK3886813T3 - Farmaceutiske formuleringer af cyclosporinanaloger - Google Patents

Farmaceutiske formuleringer af cyclosporinanaloger Download PDF

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Publication number
DK3886813T3
DK3886813T3 DK19821392.8T DK19821392T DK3886813T3 DK 3886813 T3 DK3886813 T3 DK 3886813T3 DK 19821392 T DK19821392 T DK 19821392T DK 3886813 T3 DK3886813 T3 DK 3886813T3
Authority
DK
Denmark
Prior art keywords
pharmaceutical formulations
cyclosporine analogs
cyclosporine
analogs
formulations
Prior art date
Application number
DK19821392.8T
Other languages
English (en)
Inventor
Daniel Joseph Trepanier
Daren Raymond Ure
Robert Thomas Foster
Original Assignee
Hepion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hepion Pharmaceuticals Inc filed Critical Hepion Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3886813T3 publication Critical patent/DK3886813T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK19821392.8T 2018-11-26 2019-11-22 Farmaceutiske formuleringer af cyclosporinanaloger DK3886813T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862771453P 2018-11-26 2018-11-26
PCT/US2019/062849 WO2020112562A1 (en) 2018-11-26 2019-11-22 Pharmaceutical formulations of cyclosporine analogs

Publications (1)

Publication Number Publication Date
DK3886813T3 true DK3886813T3 (da) 2023-05-01

Family

ID=68916602

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19821392.8T DK3886813T3 (da) 2018-11-26 2019-11-22 Farmaceutiske formuleringer af cyclosporinanaloger

Country Status (26)

Country Link
US (3) US20200163876A1 (da)
EP (1) EP3886813B1 (da)
JP (1) JP7489385B2 (da)
KR (1) KR20210099038A (da)
CN (1) CN113194927B (da)
AR (1) AR117150A1 (da)
AU (1) AU2019386859A1 (da)
BR (1) BR112021009967A2 (da)
CA (1) CA3120015A1 (da)
CY (1) CY1126071T1 (da)
DK (1) DK3886813T3 (da)
ES (1) ES2942473T3 (da)
FI (1) FI3886813T3 (da)
HR (1) HRP20230548T1 (da)
HU (1) HUE061877T2 (da)
IL (1) IL283286A (da)
LT (1) LT3886813T (da)
MX (1) MX2021006010A (da)
PH (1) PH12021551086A1 (da)
PL (1) PL3886813T3 (da)
PT (1) PT3886813T (da)
RS (1) RS64239B1 (da)
SG (1) SG11202105336TA (da)
SI (1) SI3886813T1 (da)
WO (1) WO2020112562A1 (da)
ZA (1) ZA202103090B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210260153A1 (en) 2020-02-19 2021-08-26 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues for treating fibrosis
IL295498A (en) 2020-02-25 2022-10-01 Hepion Pharmaceuticals Inc Use of cyclosporine analogs for cancer treatment
CA3199530A1 (en) 2020-11-29 2022-06-02 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues as antithrombotic agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US6262022B1 (en) * 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
DE69842121D1 (de) * 1997-12-10 2011-03-17 Cyclosporine Therapeutics Ltd Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen
US20030216303A1 (en) * 1998-03-06 2003-11-20 Michael Ambuhl Emulsion preconcentrates containing cyclosporin or a macrolide
ID25908A (id) * 1998-03-06 2000-11-09 Novartis Ag Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida
AU7638300A (en) * 1999-10-20 2001-04-30 Vesifact Ag Microemulsion preconcentrates and microemulsions
TNSN03139A1 (fr) 2001-06-21 2005-12-23 Pfizer Prod Inc Formulations auto-emulsionnables d'inhibiteurs de la proteine de transfert d'ester de cholesteryle
NZ531946A (en) * 2001-10-19 2005-09-30 Isotechnika Inc Preconcentrate formulations comprising cyclosporin analogue microemulsions that reduce adverse effects while maintaining high bioavailability
TW201902507A (zh) * 2017-04-14 2019-01-16 美商康特維爾製藥公司 治療病毒感染之組合療法

Also Published As

Publication number Publication date
ZA202103090B (en) 2023-09-27
PT3886813T (pt) 2023-04-26
CN113194927B (zh) 2023-10-27
IL283286A (en) 2021-07-29
AR117150A1 (es) 2021-07-14
JP7489385B2 (ja) 2024-05-23
CA3120015A1 (en) 2020-06-04
FI3886813T3 (fi) 2023-05-04
PL3886813T3 (pl) 2023-06-19
AU2019386859A1 (en) 2021-05-27
WO2020112562A1 (en) 2020-06-04
EP3886813B1 (en) 2023-03-22
RS64239B1 (sr) 2023-06-30
US20200163876A1 (en) 2020-05-28
MX2021006010A (es) 2021-09-21
PH12021551086A1 (en) 2022-01-03
HUE061877T2 (hu) 2023-08-28
SI3886813T1 (sl) 2023-05-31
TW202038911A (zh) 2020-11-01
US20230390199A1 (en) 2023-12-07
JP2022513635A (ja) 2022-02-09
CN113194927A (zh) 2021-07-30
ES2942473T3 (es) 2023-06-01
US20230390198A1 (en) 2023-12-07
HRP20230548T1 (hr) 2023-08-04
SG11202105336TA (en) 2021-06-29
BR112021009967A2 (pt) 2021-08-17
EP3886813A1 (en) 2021-10-06
CY1126071T1 (el) 2023-11-15
KR20210099038A (ko) 2021-08-11
LT3886813T (lt) 2023-04-11

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