DK3831825T3 - Polymethinforbindelser og anvendelse deraf som fluorescerende markører - Google Patents

Polymethinforbindelser og anvendelse deraf som fluorescerende markører Download PDF

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Publication number
DK3831825T3
DK3831825T3 DK21152134.9T DK21152134T DK3831825T3 DK 3831825 T3 DK3831825 T3 DK 3831825T3 DK 21152134 T DK21152134 T DK 21152134T DK 3831825 T3 DK3831825 T3 DK 3831825T3
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Denmark
Prior art keywords
polymethyne
compounds
fluorescent markers
markers
fluorescent
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Application number
DK21152134.9T
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English (en)
Inventor
Antoine Francais
Xiaohai Liu
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Illumina Cambridge Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C09B23/105—The polymethine chain containing an even number of >CH- groups two >CH- groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10—Detection mode being characterised by the assay principle
    • C12Q2565/102—Multiple non-interacting labels

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK21152134.9T 2015-09-25 2016-09-26 Polymethinforbindelser og anvendelse deraf som fluorescerende markører DK3831825T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1516987.3A GB201516987D0 (en) 2015-09-25 2015-09-25 Polymethine compounds and their use as fluorescent labels
EP20153408.8A EP3663290B1 (en) 2015-09-25 2016-09-26 Polymethine compounds and their use as fluorescent labels

Publications (1)

Publication Number Publication Date
DK3831825T3 true DK3831825T3 (da) 2023-12-11

Family

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Application Number Title Priority Date Filing Date
DK21152134.9T DK3831825T3 (da) 2015-09-25 2016-09-26 Polymethinforbindelser og anvendelse deraf som fluorescerende markører
DK20153408.8T DK3663290T3 (da) 2015-09-25 2016-09-26 Polymethinforbindelser og anvendelse deraf som fluorescerende markører
DK16775846.5T DK3353166T3 (da) 2015-09-25 2016-09-26 Polymethinforbindelser og anvendelser deraf som fluorescerende markeringer

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DK20153408.8T DK3663290T3 (da) 2015-09-25 2016-09-26 Polymethinforbindelser og anvendelse deraf som fluorescerende markører
DK16775846.5T DK3353166T3 (da) 2015-09-25 2016-09-26 Polymethinforbindelser og anvendelser deraf som fluorescerende markeringer

Country Status (23)

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US (3) US10982261B2 (da)
EP (3) EP3353166B1 (da)
JP (1) JP6750006B2 (da)
KR (1) KR102053108B1 (da)
CN (1) CN108290870B (da)
AU (1) AU2016325587B2 (da)
BR (1) BR112018006001A2 (da)
CA (1) CA2998459C (da)
DK (3) DK3831825T3 (da)
ES (3) ES2783851T3 (da)
FI (1) FI3831825T3 (da)
GB (1) GB201516987D0 (da)
HK (1) HK1252747A1 (da)
IL (1) IL258256B (da)
MX (2) MX2018003658A (da)
MY (1) MY190837A (da)
NZ (1) NZ740630A (da)
PL (3) PL3353166T3 (da)
PT (3) PT3353166T (da)
RU (1) RU2696562C1 (da)
TW (1) TWI701236B (da)
WO (1) WO2017051201A1 (da)
ZA (1) ZA201801687B (da)

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Publication number Publication date
MY190837A (en) 2022-05-12
CN108290870A (zh) 2018-07-17
FI3831825T3 (fi) 2023-12-07
GB201516987D0 (en) 2015-11-11
ES2783851T3 (es) 2020-09-18
US20230167486A1 (en) 2023-06-01
KR102053108B1 (ko) 2019-12-06
AU2016325587B2 (en) 2018-11-08
EP3831825A1 (en) 2021-06-09
PT3353166T (pt) 2020-04-09
PL3663290T3 (pl) 2021-07-05
EP3353166B1 (en) 2020-02-19
EP3831825B1 (en) 2023-09-06
ZA201801687B (en) 2019-05-29
HK1252747A1 (zh) 2019-05-31
JP2018528959A (ja) 2018-10-04
RU2696562C1 (ru) 2019-08-06
DK3663290T3 (da) 2021-03-08
PL3353166T3 (pl) 2020-09-07
US11981955B2 (en) 2024-05-14
EP3663290B1 (en) 2021-01-20
DK3353166T3 (da) 2020-04-14
BR112018006001A2 (pt) 2018-10-30
ES2860630T3 (es) 2021-10-05
IL258256B (en) 2020-10-29
CA2998459A1 (en) 2017-03-30
TWI701236B (zh) 2020-08-11
EP3663290A1 (en) 2020-06-10
PT3663290T (pt) 2021-03-03
US20210198724A1 (en) 2021-07-01
US20180282791A1 (en) 2018-10-04
MX2022007933A (es) 2022-07-27
ES2966353T3 (es) 2024-04-22
JP6750006B2 (ja) 2020-09-02
CA2998459C (en) 2020-12-15
PT3831825T (pt) 2023-12-13
NZ740630A (en) 2019-03-29
EP3353166A1 (en) 2018-08-01
AU2016325587A1 (en) 2018-04-05
KR20180057702A (ko) 2018-05-30
MX2018003658A (es) 2019-04-25
US10982261B2 (en) 2021-04-20
TW201726616A (zh) 2017-08-01
WO2017051201A1 (en) 2017-03-30
PL3831825T3 (pl) 2024-02-19
IL258256A (en) 2018-05-31
CN108290870B (zh) 2022-04-26
US11530439B2 (en) 2022-12-20

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