DK3720433T3 - Bis-cholin-tetrathiomolybdat til behandling af wilsons sygdom - Google Patents
Bis-cholin-tetrathiomolybdat til behandling af wilsons sygdom Download PDFInfo
- Publication number
- DK3720433T3 DK3720433T3 DK18815624.4T DK18815624T DK3720433T3 DK 3720433 T3 DK3720433 T3 DK 3720433T3 DK 18815624 T DK18815624 T DK 18815624T DK 3720433 T3 DK3720433 T3 DK 3720433T3
- Authority
- DK
- Denmark
- Prior art keywords
- cholin
- tetrathiomolybdate
- wilson
- bis
- disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762594184P | 2017-12-04 | 2017-12-04 | |
| US201862646553P | 2018-03-22 | 2018-03-22 | |
| US201862655568P | 2018-04-10 | 2018-04-10 | |
| US201862669095P | 2018-05-09 | 2018-05-09 | |
| US201862741313P | 2018-10-04 | 2018-10-04 | |
| US201862750595P | 2018-10-25 | 2018-10-25 | |
| PCT/EP2018/083551 WO2019110619A1 (en) | 2017-12-04 | 2018-12-04 | Bis-choline tetrathiomolybdate for treating wilson disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3720433T3 true DK3720433T3 (da) | 2022-05-02 |
Family
ID=64661349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18815624.4T DK3720433T3 (da) | 2017-12-04 | 2018-12-04 | Bis-cholin-tetrathiomolybdat til behandling af wilsons sygdom |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11510944B2 (da) |
| EP (2) | EP3720433B1 (da) |
| JP (2) | JP2021505655A (da) |
| KR (1) | KR20200096798A (da) |
| AU (1) | AU2018379255A1 (da) |
| BR (1) | BR112020011055A2 (da) |
| CA (1) | CA3084100A1 (da) |
| DK (1) | DK3720433T3 (da) |
| ES (1) | ES2912306T3 (da) |
| HU (1) | HUE058921T2 (da) |
| IL (1) | IL275115A (da) |
| MX (1) | MX2020006284A (da) |
| PL (1) | PL3720433T3 (da) |
| PT (1) | PT3720433T (da) |
| SI (1) | SI3720433T1 (da) |
| WO (1) | WO2019110619A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11419832B2 (en) * | 2017-12-04 | 2022-08-23 | Alexion Pharmaceuticals, Inc. | Bis-choline tetrathiomolybdate for treating Wilson Disease |
| EP3720433B1 (en) | 2017-12-04 | 2022-02-02 | Alexion Pharmaceuticals, Inc. | Bis-choline tetrathiomolybdate for treating wilson disease |
| EP3749417A1 (en) | 2018-02-06 | 2020-12-16 | Alexion Pharma International Operations Unlimited Company | Crystalline particles of bis-choline tetrathiomolybdate |
| EP4061353A1 (en) | 2019-11-21 | 2022-09-28 | Alexion Pharmaceuticals, Inc. | Methods of reducing neurological damage in wilson disease patients |
| EP4243806A1 (en) | 2020-11-13 | 2023-09-20 | Alexion Pharmaceuticals, Inc. | Methods of treating copper metabolism-associated diseases or disorders |
| CA3172752A1 (en) * | 2021-01-31 | 2022-08-04 | Justin Lockheart Burt | Novel formulation of bis-choline tetrathiomolybdate for treating copper metabolism-associated diseases or disorders |
| EP4387631A1 (en) | 2021-08-17 | 2024-06-26 | Alexion Pharmaceuticals, Inc. | Methods of treating copper metabolism-associated diseases or disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA008683B1 (ru) * | 2002-07-23 | 2007-06-29 | Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган | Тетрапропиламмония тетратиомолибдат и родственные соединения для антиангиогенной терапии |
| US7189865B2 (en) * | 2002-07-23 | 2007-03-13 | Attenuon, Llc | Thiomolybdate analogues and uses thereof |
| JP2009523175A (ja) * | 2006-01-10 | 2009-06-18 | パイペックス，インコーポレイテッド | 目標とされる安定な銅状態を達成及び維持して銅関連中枢神経系疾患を予防及び治療するための医薬組成物及び方法 |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US11419832B2 (en) * | 2017-12-04 | 2022-08-23 | Alexion Pharmaceuticals, Inc. | Bis-choline tetrathiomolybdate for treating Wilson Disease |
| EP3720433B1 (en) | 2017-12-04 | 2022-02-02 | Alexion Pharmaceuticals, Inc. | Bis-choline tetrathiomolybdate for treating wilson disease |
| EP3749417A1 (en) | 2018-02-06 | 2020-12-16 | Alexion Pharma International Operations Unlimited Company | Crystalline particles of bis-choline tetrathiomolybdate |
-
2018
- 2018-12-04 EP EP18815624.4A patent/EP3720433B1/en active Active
- 2018-12-04 ES ES18815624T patent/ES2912306T3/es active Active
- 2018-12-04 BR BR112020011055-8A patent/BR112020011055A2/pt unknown
- 2018-12-04 HU HUE18815624A patent/HUE058921T2/hu unknown
- 2018-12-04 PL PL18815624.4T patent/PL3720433T3/pl unknown
- 2018-12-04 KR KR1020207019115A patent/KR20200096798A/ko unknown
- 2018-12-04 AU AU2018379255A patent/AU2018379255A1/en active Pending
- 2018-12-04 CA CA3084100A patent/CA3084100A1/en active Pending
- 2018-12-04 EP EP21215264.9A patent/EP4029498A1/en active Pending
- 2018-12-04 MX MX2020006284A patent/MX2020006284A/es unknown
- 2018-12-04 DK DK18815624.4T patent/DK3720433T3/da active
- 2018-12-04 WO PCT/EP2018/083551 patent/WO2019110619A1/en active Application Filing
- 2018-12-04 PT PT188156244T patent/PT3720433T/pt unknown
- 2018-12-04 SI SI201830650T patent/SI3720433T1/sl unknown
- 2018-12-04 US US16/770,022 patent/US11510944B2/en active Active
- 2018-12-04 JP JP2020547315A patent/JP2021505655A/ja active Pending
-
2020
- 2020-06-04 IL IL275115A patent/IL275115A/en unknown
-
2021
- 2021-02-22 US US17/182,227 patent/US20210177894A1/en not_active Abandoned
-
2022
- 2022-08-23 US US17/821,786 patent/US20230070534A1/en active Pending
-
2023
- 2023-03-13 JP JP2023038205A patent/JP2023075247A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020011055A2 (pt) | 2020-11-17 |
| WO2019110619A1 (en) | 2019-06-13 |
| US20210137972A1 (en) | 2021-05-13 |
| PL3720433T3 (pl) | 2022-07-18 |
| JP2023075247A (ja) | 2023-05-30 |
| EP3720433A1 (en) | 2020-10-14 |
| AU2018379255A1 (en) | 2020-06-25 |
| EP4029498A1 (en) | 2022-07-20 |
| PT3720433T (pt) | 2022-05-03 |
| HUE058921T2 (hu) | 2022-09-28 |
| CA3084100A1 (en) | 2019-06-13 |
| US11510944B2 (en) | 2022-11-29 |
| MX2020006284A (es) | 2021-04-12 |
| US20230070534A1 (en) | 2023-03-09 |
| KR20200096798A (ko) | 2020-08-13 |
| US20210177894A1 (en) | 2021-06-17 |
| SI3720433T1 (sl) | 2022-09-30 |
| RU2020122023A (ru) | 2022-01-10 |
| JP2021505655A (ja) | 2021-02-18 |
| ES2912306T3 (es) | 2022-05-25 |
| EP3720433B1 (en) | 2022-02-02 |
| IL275115A (en) | 2020-07-30 |
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