DK3712152T3 - 4,5,6,7-TETRAHYDRO-1H-IMIDAZO [4,5-C] PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO [4,5-D] AZEPINE DERIVATIVES AS JANUS CHINASE INHIBITORS - Google Patents

4,5,6,7-TETRAHYDRO-1H-IMIDAZO [4,5-C] PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO [4,5-D] AZEPINE DERIVATIVES AS JANUS CHINASE INHIBITORS Download PDF

Info

Publication number
DK3712152T3
DK3712152T3 DK20171633.9T DK20171633T DK3712152T3 DK 3712152 T3 DK3712152 T3 DK 3712152T3 DK 20171633 T DK20171633 T DK 20171633T DK 3712152 T3 DK3712152 T3 DK 3712152T3
Authority
DK
Denmark
Prior art keywords
chinase
hexahydroimidazo
janus
imidazo
tetrahydro
Prior art date
Application number
DK20171633.9T
Other languages
Danish (da)
Inventor
Matthew Colin Thor Fyfe
Original Assignee
Topivert Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1519381.6A external-priority patent/GB201519381D0/en
Application filed by Topivert Pharma Ltd filed Critical Topivert Pharma Ltd
Application granted granted Critical
Publication of DK3712152T3 publication Critical patent/DK3712152T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK20171633.9T 2015-11-03 2016-11-02 4,5,6,7-TETRAHYDRO-1H-IMIDAZO [4,5-C] PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO [4,5-D] AZEPINE DERIVATIVES AS JANUS CHINASE INHIBITORS DK3712152T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1519381.6A GB201519381D0 (en) 2015-11-03 2015-11-03 Kinase inhibitors
GB201606968 2016-04-21
EP16793973.5A EP3371184A1 (en) 2015-11-03 2016-11-02 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors

Publications (1)

Publication Number Publication Date
DK3712152T3 true DK3712152T3 (en) 2021-03-22

Family

ID=57256356

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20171633.9T DK3712152T3 (en) 2015-11-03 2016-11-02 4,5,6,7-TETRAHYDRO-1H-IMIDAZO [4,5-C] PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO [4,5-D] AZEPINE DERIVATIVES AS JANUS CHINASE INHIBITORS

Country Status (8)

Country Link
US (1) US10851097B2 (en)
EP (3) EP3371184A1 (en)
CA (1) CA3037243A1 (en)
DK (1) DK3712152T3 (en)
ES (1) ES2864035T3 (en)
PL (1) PL3712152T3 (en)
PT (1) PT3712152T (en)
WO (1) WO2017077283A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3371185T3 (en) 2015-11-03 2020-11-30 Topivert Pharma Ltd 4,5,6,7-TETRAHYDRO-1H-IMIDAZO [4,5-C] PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO [4,5-D] AZEPINE DERIVATIVES AS JANUS CHINASE INHIBITORS
CA3001542C (en) 2015-11-03 2021-02-16 Theravance Biopharma R&D Ip, Llc Jak kinase inhibitor compounds for treatment of respiratory disease
PT3592742T (en) 2017-03-09 2021-07-30 Theravance Biopharma R&D Ip Llc Jak inhibitors containing a 4-membered heterocyclic amide
AR111495A1 (en) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc FUSIONED IMIDAZO-PIPERIDINE COMPOUNDS AS JAK INHIBITORS
RU2764979C2 (en) 2017-05-01 2022-01-24 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Methods for treatment using jak inhibitor compound
TWI808083B (en) 2017-05-01 2023-07-11 美商施萬生物製藥研發 Ip有限責任公司 Crystalline forms of a jak inhibitor compound
JP7098716B2 (en) 2017-08-01 2022-07-11 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Pyrazolo and triazolobicyclic compounds as JAK kinase inhibitors
IL281150B2 (en) * 2018-09-04 2024-03-01 Theravance Biopharma R& D Ip Llc 5 to 7 membered heterocyclic amides as jak inhibitors
SG11202101734RA (en) 2018-09-04 2021-03-30 Theravance Biopharma R&D Ip Llc Dimethyl amino azetidine amides as jak inhibitors
SG11202101785UA (en) 2018-09-04 2021-03-30 Theravance Biopharma R&D Ip Llc Process for preparing jak inhibitors and intermediates thereof
WO2020092019A1 (en) 2018-10-29 2020-05-07 Theravance Biopharma R&D Ip, Llc 2-azabicyclo hexane compound as jak inhibitor
CN113498352A (en) * 2019-01-23 2021-10-12 施万生物制药研发Ip有限责任公司 Imidazo [1,5-A ] pyridines, 1,2, 4-triazolo [4,3-A ] pyridines and imidazo [1,5-A ] pyrazines as JAK inhibitors
CN114075200A (en) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 JAK inhibitor compounds for the treatment of severe pneumonia
KR20210132666A (en) 2019-02-25 2021-11-04 허난 메디노 파마슈티컬 테크놀로지 컴퍼니 리미티드 JAK inhibitor compounds and their use
TW202144343A (en) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Crystalline hydrate of a jak inhibitor compound
CN115043844B (en) * 2021-06-21 2024-05-17 河南迈英诺医药科技有限公司 TRK kinase inhibitor compounds and uses thereof
CN117343063A (en) * 2022-07-04 2024-01-05 河南迈英诺医药科技有限公司 Compounds as TRK inhibitors and/or RET inhibitors and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2445098C2 (en) 2007-07-11 2012-03-20 Пфайзер Инк. Pharmaceutical composition and methods of treating dry-eye syndrome
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
FR2981917B1 (en) 2011-10-26 2013-11-15 Cadorit Ag CONTAINER FOR PACKING A FIRST FLUID AND A SECOND FLUID
EP2864347B1 (en) 2012-06-22 2020-10-28 Mimetogen Pharmaceuticals, Inc. Synthesis of beta-turn peptidomimetic cyclic compounds
SG11201609139WA (en) 2014-05-14 2016-11-29 Pfizer Pyrazolopyridines and pyrazolopyrimidines
CN111362975B (en) 2015-05-28 2022-04-05 施万生物制药研发Ip有限责任公司 Naphthyridine compounds as JAK kinase inhibitors
CA3001542C (en) 2015-11-03 2021-02-16 Theravance Biopharma R&D Ip, Llc Jak kinase inhibitor compounds for treatment of respiratory disease
DK3371185T3 (en) 2015-11-03 2020-11-30 Topivert Pharma Ltd 4,5,6,7-TETRAHYDRO-1H-IMIDAZO [4,5-C] PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO [4,5-D] AZEPINE DERIVATIVES AS JANUS CHINASE INHIBITORS
RS60237B1 (en) 2015-11-24 2020-06-30 Theravance Biopharma R&D Ip Llc Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease
JP6881879B2 (en) 2016-04-28 2021-06-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Pyrimidine compounds as JAK kinase inhibitors

Also Published As

Publication number Publication date
EP3712152A1 (en) 2020-09-23
US10851097B2 (en) 2020-12-01
CA3037243A1 (en) 2017-05-11
EP3712152B1 (en) 2021-01-13
WO2017077283A1 (en) 2017-05-11
PT3712152T (en) 2021-04-15
PL3712152T3 (en) 2021-08-02
EP3865481A1 (en) 2021-08-18
EP3371184A1 (en) 2018-09-12
US20180319791A1 (en) 2018-11-08
ES2864035T3 (en) 2021-10-13

Similar Documents

Publication Publication Date Title
DK3712152T3 (en) 4,5,6,7-TETRAHYDRO-1H-IMIDAZO [4,5-C] PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO [4,5-D] AZEPINE DERIVATIVES AS JANUS CHINASE INHIBITORS
DK3371185T3 (en) 4,5,6,7-TETRAHYDRO-1H-IMIDAZO [4,5-C] PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO [4,5-D] AZEPINE DERIVATIVES AS JANUS CHINASE INHIBITORS
HK1258857A1 (en) Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors
DK3523301T3 (en) Substituted pyrazolo [1,5-A] pyridine compounds as RET kinase inhibitors
DK3523302T3 (en) Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
DK3322706T3 (en) SUBSTITUTED PYRAZOLO [1,5-A] PYRIDINE COMPOUNDS AS RIGHT CHINESE INHIBITORS
DK3194388T3 (en) IMIDAZO [4,5-C] PYRIDINE DERIVED SSAO INHIBITORS
DK3466955T3 (en) PROCEDURE FOR THE PREPARATION OF OXAZOL [4,5-B] PYRIDINE AND THIAZOL [4,5-B] PYRIDINE DERIVATIVES AS IRAQ4 INHIBITORS FOR THE CANCER OF CANCER
CR20160449A (en) INHIBITORS OF THE JAK1 FOR THE TREATMENT OF MYELODISPLASTIC SYNDROMES
DK3478681T3 (en) 1H-PYRAZOLO [4,3-B] PYRIDINES AS PDE1 INHIBITORS
DK3237423T3 (en) THIENO [2,3-C] PYRROL-4-ON DERIVATIVES AS ERK INHIBITORS
DK2970260T3 (en) IMIDAZO- [4,5-C] PYRIDIN AND PYRROLO- [2,3-C] PYRIDIN DERIVATIVES AS SSAO INHIBITORS
HK1255804A1 (en) New imidazo[4,5-b]pyridine derivatives as dual dyrk1/clk1 inhibitors
DK3481827T3 (en) IMIDAZO [1,2-A] PYRIDINE DERIVATIVES, MANUFACTURING METHODS AND USE
SI2991983T1 (en) 2-phenyl or 2-hetaryl imidazol(1,2-a)pyridine derivatives
DK3347356T3 (en) TRICYCLIC CONNECTED PYRIDIN-2-ONE DERIVATIVES AND THEIR USE AS BRD4 INHIBITORS
IL269214B (en) Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors
IL251166A0 (en) Imidazo[4,5-c]pyridine derived ssao inhibitors
DK3472160T3 (en) BICYCLIC PYRIDINE, PYRAZINE AND PYRIMIDINE DERIVATIVES AS PI3K BETA INHIBITORS