DK3684930T3 - Modificering af ikke-kodende plante-RNA-molekylers specificitet for inaktivering af genekspression - Google Patents

Modificering af ikke-kodende plante-RNA-molekylers specificitet for inaktivering af genekspression Download PDF

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Publication number
DK3684930T3
DK3684930T3 DK18786034.1T DK18786034T DK3684930T3 DK 3684930 T3 DK3684930 T3 DK 3684930T3 DK 18786034 T DK18786034 T DK 18786034T DK 3684930 T3 DK3684930 T3 DK 3684930T3
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Denmark
Prior art keywords
inactivation
specificity
modification
gene expression
rna molecules
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DK18786034.1T
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English (en)
Inventor
Eyal Maori
Yaron Galanty
Cristina Pignocchi
Garcia Angela Chaparro
Ofir Meir
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Tropic Biosciences Uk Ltd
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Priority claimed from GBGB1715113.5A external-priority patent/GB201715113D0/en
Priority claimed from GBGB1715116.8A external-priority patent/GB201715116D0/en
Priority claimed from GBGB1719516.5A external-priority patent/GB201719516D0/en
Application filed by Tropic Biosciences Uk Ltd filed Critical Tropic Biosciences Uk Ltd
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Publication of DK3684930T3 publication Critical patent/DK3684930T3/da

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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • A01H1/06—Processes for producing mutations, e.g. treatment with chemicals or with radiation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
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DK18786034.1T 2017-09-19 2018-09-18 Modificering af ikke-kodende plante-RNA-molekylers specificitet for inaktivering af genekspression DK3684930T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1715113.5A GB201715113D0 (en) 2017-09-19 2017-09-19 Modifying the specificity of plant non-coding RNA molecules for silencing of target RNA
GBGB1715116.8A GB201715116D0 (en) 2017-09-19 2017-09-19 Modifying the specificity of non-coding RNA molecules for silencing of target RNA in eukaryotic cells
GBGB1719516.5A GB201719516D0 (en) 2017-11-23 2017-11-23 Modifying the specificity of plant non-coding RNA molecules for silencing of target RNA
PCT/IB2018/057160 WO2019058255A1 (en) 2017-09-19 2018-09-18 MODIFICATION OF THE SPECIFICITY OF VEGETABLE NON-CODANT RNA MOLECULES FOR THE SILENCING OF GENE EXPRESSION

Publications (1)

Publication Number Publication Date
DK3684930T3 true DK3684930T3 (da) 2022-06-07

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DK18786034.1T DK3684930T3 (da) 2017-09-19 2018-09-18 Modificering af ikke-kodende plante-RNA-molekylers specificitet for inaktivering af genekspression

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Country Link
US (4) US11555199B2 (da)
EP (3) EP4170029A3 (da)
JP (3) JP7422069B2 (da)
KR (3) KR102510576B1 (da)
CN (2) CN111373044A (da)
AU (3) AU2018336126A1 (da)
BR (2) BR112020005444A2 (da)
CA (2) CA3074946A1 (da)
DK (1) DK3684930T3 (da)
ES (1) ES2915576T3 (da)
IL (2) IL273460B1 (da)
SG (2) SG11202002479XA (da)
WO (2) WO2019058255A1 (da)

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US11555199B2 (en) 2017-09-19 2023-01-17 Tropic Biosciences UK Limited Modifying the specificity of plant non-coding RNA molecules for silencing gene expression
JP2021523745A (ja) 2018-05-16 2021-09-09 シンテゴ コーポレイション ガイドｒｎａ設計および使用のための方法およびシステム
CN110857438B (zh) * 2018-08-20 2022-05-17 中国烟草总公司黑龙江省公司牡丹江烟草科学研究所 一种高效产生siRNA的烟草花叶病毒基因片段、弱毒疫苗、制备方法及其应用
JP2022522823A (ja) 2019-03-01 2022-04-20 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 天然ｍｉＲＮＡのゲノム編集による標的遺伝子発現の抑制
GB201903519D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest
GB201903520D0 (en) * 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells
GB201903521D0 (en) 2019-03-14 2019-05-01 Tropic Biosciences Uk Ltd No title
CN110551719B (zh) * 2019-07-30 2023-06-02 中山大学 长链非编码rna基因alex1及其在提高水稻白叶枯病抗性中的应用
CN111508558B (zh) * 2020-03-23 2021-12-14 广州赛业百沐生物科技有限公司 一种基于CRISPR-Cas9技术设计点突变模型的方法及***
CN111676220B (zh) * 2020-05-21 2022-03-29 扬州大学 杨树长链非编码RNA lnc11及其应用
WO2022006310A2 (en) * 2020-06-30 2022-01-06 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions for genome editing and methods of use thereof
CN114073760B (zh) * 2020-08-21 2024-02-13 北京大学 Rdr蛋白在肿瘤治疗中的应用
WO2022119881A1 (en) * 2020-12-01 2022-06-09 Emendobio Inc. Differential knockout of a heterozygous allele of lrrk2
CN112359049B (zh) * 2020-12-10 2022-01-28 昆明理工大学 一种岷江百合几丁质酶基因LrCHI2及其应用
CN112795568B (zh) * 2021-01-06 2023-07-18 河南农业大学 一种控制玉米雌穗穗粗杂种优势的非编码基因的应用及其前体序列
GB202103256D0 (en) 2021-03-09 2021-04-21 Tropic Biosciences Uk Ltd Method for silencing genes
CN114134155B (zh) * 2021-06-29 2023-09-12 中国农业科学院油料作物研究所 一种mlo基因突变体及其制备方法与应用
CN113444727B (zh) * 2021-06-30 2022-06-21 中国热带农业科学院热带生物技术研究所 一种LncRNA及其应用
EP4362662A1 (en) 2021-07-02 2024-05-08 Tropic Biosciences UK Limited Delay or prevention of browning in banana fruit
KR102573947B1 (ko) * 2021-08-09 2023-09-01 경상국립대학교산학협력단 콩 유전자교정 효율 증대를 위한 유전자교정 시스템 및 이의 용도
KR102573948B1 (ko) * 2021-08-09 2023-09-01 경상국립대학교산학협력단 Mips1과 이의 상동체 동시 타겟 유전자교정 시스템 및 이의 용도
KR102573952B1 (ko) * 2021-08-09 2023-09-01 경상국립대학교산학협력단 E2와 이의 상동체 동시 타겟 유전자교정 시스템 및 이의 용도
KR102574819B1 (ko) * 2021-08-09 2023-09-04 경상국립대학교산학협력단 P34와 이의 상동체 동시 타겟 유전자교정 시스템 및 이의 용도
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CN114807128B (zh) * 2022-03-24 2023-09-01 四川农业大学 一种lncRNA-BTRL及其应用
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CN116064644B (zh) * 2022-10-10 2023-10-10 中国农业科学院生物技术研究所 SbAGO1b蛋白及其编码基因在调控植物抗虫性中的应用
CN115976050B (zh) * 2022-11-16 2024-06-18 西北农林科技大学 猕猴桃感病基因及其适用的vigs沉默体系构建
CN116103334A (zh) * 2022-11-16 2023-05-12 西北农林科技大学 一种猕猴桃抗溃疡病基因功能筛选专用瞬时转化体系
GB202305021D0 (en) 2023-04-04 2023-05-17 Tropic Biosciences Uk Ltd Methods for generating breaks in a genome

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