DK356382A - Fremgangsmaade til fremstilling af 5-aroyl- eller 5-pyrrylforbindelser - Google Patents

Fremgangsmaade til fremstilling af 5-aroyl- eller 5-pyrrylforbindelser Download PDF

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Publication number
DK356382A
DK356382A DK356382A DK356382A DK356382A DK 356382 A DK356382 A DK 356382A DK 356382 A DK356382 A DK 356382A DK 356382 A DK356382 A DK 356382A DK 356382 A DK356382 A DK 356382A
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DK
Denmark
Prior art keywords
pyrryl
loweralkyl
substituted
hydrogen
compounds
Prior art date
Application number
DK356382A
Other languages
English (en)
Inventor
James B Doherty
Michael N Chang
Conrad P Dorn
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK356382A publication Critical patent/DK356382A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Eye Examination Apparatus (AREA)
  • Measurement Of Optical Distance (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Power Steering Mechanism (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DK356382A 1981-08-10 1982-08-09 Fremgangsmaade til fremstilling af 5-aroyl- eller 5-pyrrylforbindelser DK356382A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29168881A 1981-08-10 1981-08-10

Publications (1)

Publication Number Publication Date
DK356382A true DK356382A (da) 1983-02-11

Family

ID=23121395

Family Applications (1)

Application Number Title Priority Date Filing Date
DK356382A DK356382A (da) 1981-08-10 1982-08-09 Fremgangsmaade til fremstilling af 5-aroyl- eller 5-pyrrylforbindelser

Country Status (15)

Country Link
EP (1) EP0072013B1 (da)
JP (1) JPS5838255A (da)
AT (1) ATE19239T1 (da)
AU (1) AU556243B2 (da)
CA (1) CA1209989A (da)
DE (1) DE3270625D1 (da)
DK (1) DK356382A (da)
ES (1) ES514783A0 (da)
FI (1) FI77022C (da)
GR (1) GR77260B (da)
IE (1) IE53667B1 (da)
NO (1) NO157697C (da)
NZ (1) NZ201468A (da)
PT (1) PT75381A (da)
ZA (1) ZA825746B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170244B (it) * 1983-11-14 1987-06-03 Poli Ind Chimica Spa Acidi pirrol-3 carbossilici con attivita' analgesica centrale
DE10331496A1 (de) * 2003-07-01 2005-01-27 Bayer Cropscience Ag Verfahren zum Herstellen von Difluoracetessigsäurealkylestern

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3952012A (en) * 1970-01-26 1976-04-20 Mcneil Laboratories, Incorporated Aroyl-substituted pyrroles
US3998844A (en) * 1975-06-02 1976-12-27 Mcneil Laboratories, Incorporated Uncatalyzed aroylation of 1-alkylpyrrole-2-acetic acid derivatives
GB1592997A (en) * 1977-10-14 1981-07-15 Rolland Sa A Aroyl-pyrrole carboxylic acids and derivatives thereof
EP0006845B1 (en) * 1978-07-10 1982-02-03 McNeilab, Inc. Pharmaceutical composition comprising a 5-aroyl-1-c1-5 alkyl-pyrrole-2-acetic acid compound and acetaminophen or acetylsalicylic acid
EP0032048A1 (en) * 1980-01-08 1981-07-15 Beecham Group Plc Pyrroloylpyrrole derivatives, processes for their preparation and their use
NZ196700A (en) * 1980-04-18 1983-04-12 Smith & Nephew Ass Anti-inflammatory compositions containing 5-benzoyl-1-methylpyrrole-2-acetic acid derivatives

Also Published As

Publication number Publication date
NO157697B (no) 1988-01-25
JPS5838255A (ja) 1983-03-05
ES8402818A1 (es) 1984-02-01
FI822692L (fi) 1983-02-11
NO822706L (no) 1983-02-11
CA1209989A (en) 1986-08-19
FI77022C (fi) 1989-01-10
IE53667B1 (en) 1989-01-04
AU8669082A (en) 1983-02-17
PT75381A (en) 1982-09-01
GR77260B (da) 1984-09-11
EP0072013B1 (en) 1986-04-16
FI77022B (fi) 1988-09-30
FI822692A0 (fi) 1982-08-02
AU556243B2 (en) 1986-10-30
EP0072013A1 (en) 1983-02-16
ES514783A0 (es) 1984-02-01
ZA825746B (en) 1984-03-28
ATE19239T1 (de) 1986-05-15
NZ201468A (en) 1986-02-21
DE3270625D1 (en) 1986-05-22
NO157697C (no) 1988-05-04
IE821915L (en) 1983-02-10

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