DK3505174T3 - Deoxynukleosidterapi mod sygdomme forårsaget af ubalancerede nukleotid-pools, herunder mitokondrielt dna-depletionssyndromer - Google Patents

Deoxynukleosidterapi mod sygdomme forårsaget af ubalancerede nukleotid-pools, herunder mitokondrielt dna-depletionssyndromer Download PDF

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Publication number
DK3505174T3
DK3505174T3 DK19156021.8T DK19156021T DK3505174T3 DK 3505174 T3 DK3505174 T3 DK 3505174T3 DK 19156021 T DK19156021 T DK 19156021T DK 3505174 T3 DK3505174 T3 DK 3505174T3
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Prior art keywords
mitocondrial
nucleotid
pools
unbalanced
diseases caused
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DK19156021.8T
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English (en)
Inventor
Michio Hirano
Caterina Garone
Ramon Marti
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Univ Columbia
Fundacio Hospital Univ Vall D Hebron Institut De Recerca
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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DK19156021.8T 2015-06-17 2016-06-17 Deoxynukleosidterapi mod sygdomme forårsaget af ubalancerede nukleotid-pools, herunder mitokondrielt dna-depletionssyndromer DK3505174T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562180914P 2015-06-17 2015-06-17
EP16812537.5A EP3310362B1 (en) 2015-06-17 2016-06-17 Deoxynucleoside therapy for diseases caused by unbalanced nucleotide pools including mitochondrial dna depletion syndromes

Publications (1)

Publication Number Publication Date
DK3505174T3 true DK3505174T3 (da) 2020-07-13

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Application Number Title Priority Date Filing Date
DK19156021.8T DK3505174T3 (da) 2015-06-17 2016-06-17 Deoxynukleosidterapi mod sygdomme forårsaget af ubalancerede nukleotid-pools, herunder mitokondrielt dna-depletionssyndromer
DK16812537.5T DK3310362T3 (da) 2015-06-17 2016-06-17 Deoxynukleosidterapi mod sygdomme forårsaget af ubalancerede nukleotid-pools, herunder mitokondrielt dna-depletionssyndromer

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DK16812537.5T DK3310362T3 (da) 2015-06-17 2016-06-17 Deoxynukleosidterapi mod sygdomme forårsaget af ubalancerede nukleotid-pools, herunder mitokondrielt dna-depletionssyndromer

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US (4) US10471087B2 (da)
EP (3) EP3310362B1 (da)
JP (3) JP6599484B2 (da)
KR (2) KR20180039624A (da)
CN (2) CN116726035A (da)
AU (3) AU2016280293B2 (da)
BR (2) BR112017027079B1 (da)
CA (1) CA2989653A1 (da)
CY (2) CY1122605T1 (da)
DK (2) DK3505174T3 (da)
ES (2) ES2748556T3 (da)
HK (1) HK1252133A1 (da)
HR (2) HRP20191794T1 (da)
HU (2) HUE050678T2 (da)
IL (3) IL275256B2 (da)
LT (2) LT3505174T (da)
MX (2) MX2017016425A (da)
PL (2) PL3310362T3 (da)
PT (2) PT3310362T (da)
RS (2) RS60572B1 (da)
RU (2) RU2721492C2 (da)
SI (2) SI3310362T1 (da)
WO (1) WO2016205671A1 (da)

Families Citing this family (18)

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Publication number Priority date Publication date Assignee Title
US10292996B2 (en) 2015-03-26 2019-05-21 The Trustees Of Columbia University In The City Of New York Deoxyribonucleoside monophospate bypass therapy for mitochondrial DNA depletion syndrome
DK3505174T3 (da) * 2015-06-17 2020-07-13 Univ Columbia Deoxynukleosidterapi mod sygdomme forårsaget af ubalancerede nukleotid-pools, herunder mitokondrielt dna-depletionssyndromer
AU2016379345B2 (en) 2015-12-22 2020-09-17 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
SG11201804811WA (en) 2015-12-22 2018-07-30 Zogenix International Ltd Fenfluramine compositions and methods of preparing the same
JP2019526544A (ja) 2016-08-24 2019-09-19 ゾゲニクス インターナショナル リミテッド ５−ｈｔ２ｂアゴニストの形成を阻害するための製剤およびその使用方法
WO2019051097A1 (en) 2017-09-08 2019-03-14 The Regents Of The University Of California RNA-GUIDED ENDONUCLEASE FUSION POLYPEPTIDES AND METHODS OF USING SAME
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
MX2020010667A (es) * 2018-04-12 2021-01-08 Modis Therapeutics Inc Profarmacos de desoxinucleosidos para el tratamiento de enfermedades causadas por reservas desequilibradas de nucleotidos.
EP3790537A1 (en) 2018-05-11 2021-03-17 Zogenix International Limited Compositions and methods for treating seizure-induced sudden death
US11649259B2 (en) 2019-08-19 2023-05-16 Zogenix Mds, Inc. Polymorphic forms of deoxycytidine, compositions comprising the same and uses
CN114340641A (zh) * 2019-09-05 2022-04-12 米托瑞因博治疗股份有限公司 治疗线粒体dna缺失障碍
JP2023518395A (ja) * 2020-03-19 2023-05-01 インテリア セラピューティクス，インコーポレイテッド 指向性ゲノム編集のための方法及び組成物
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
US20220096514A1 (en) * 2020-09-29 2022-03-31 Zogenix International Limited Methods of treating thymidine kinase 2 deficiency by administering deoxycytidine and deoxythymidine
WO2022145439A1 (ja) * 2020-12-28 2022-07-07 ヤマサ醤油株式会社 筋萎縮抑制剤及び筋萎縮を抑制させる方法
JP2024515025A (ja) * 2021-03-26 2024-04-04 ゾジェニックス，インコーポレイテッド プリン及びピリミジンを含有する水性溶液及びその使用
CN117500510A (zh) * 2021-06-18 2024-02-02 周格尼克斯公司 用于治疗由失衡的核苷酸池引起的线粒体疾病的脱氧核苷的前药
WO2024015453A1 (en) * 2022-07-12 2024-01-18 Zogenix Mds, Inc. Methods for increasing the bioavailability of nucleoside medicinal agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
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CN101120947B (zh) * 1998-08-10 2010-11-24 艾丹尼克斯(开曼)有限公司 用于治疗乙型肝炎的β-L-2′-脱氧-核苷
DK1171137T3 (da) * 1999-02-23 2008-03-31 Univ California Anvendelse af triacetyluridin til behandling af mitochondriale lidelser
KR100854398B1 (ko) * 2000-05-26 2008-08-26 이데닉스 (케이만) 리미티드 베타-ｌ-2'-데옥시-뉴클레오사이드를 이용한 델타형 간염바이러스 감염의 치료방법
WO2012125848A2 (en) * 2011-03-16 2012-09-20 Baylor College Of Medicine A method for comprehensive sequence analysis using deep sequencing technology
US10292996B2 (en) 2015-03-26 2019-05-21 The Trustees Of Columbia University In The City Of New York Deoxyribonucleoside monophospate bypass therapy for mitochondrial DNA depletion syndrome
LT3302499T (lt) * 2015-06-05 2023-05-25 Fundació Hospital Universitari Vall D'hebron - Institut De Recerca Mitochondrinių ligų gydymas
DK3505174T3 (da) * 2015-06-17 2020-07-13 Univ Columbia Deoxynukleosidterapi mod sygdomme forårsaget af ubalancerede nukleotid-pools, herunder mitokondrielt dna-depletionssyndromer

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EP3505174A1 (en) 2019-07-03
LT3505174T (lt) 2020-09-10
PT3505174T (pt) 2020-07-06
US20210244754A1 (en) 2021-08-12
JP2020019792A (ja) 2020-02-06
JP6599484B2 (ja) 2019-10-30
AU2021250841B2 (en) 2023-02-09
SI3310362T1 (sl) 2020-02-28
BR122020021913B1 (pt) 2021-07-06
RS59724B1 (sr) 2020-01-31
CN116726035A (zh) 2023-09-12
JP2020019791A (ja) 2020-02-06
US20230277577A1 (en) 2023-09-07
ES2748556T3 (es) 2020-03-17
HRP20200949T1 (hr) 2020-10-02
PT3310362T (pt) 2019-10-29
JP7036782B2 (ja) 2022-03-15
CY1122605T1 (el) 2021-03-12
CA2989653A1 (en) 2016-12-22
US11110111B2 (en) 2021-09-07
ES2808148T3 (es) 2021-02-25
RU2020112901A (ru) 2020-06-05
AU2021250841A1 (en) 2021-11-04
EP3505174B1 (en) 2020-04-29
EP3569236A1 (en) 2019-11-20
IL275255B (en) 2021-04-29
RU2018101305A (ru) 2019-07-17
KR20180039624A (ko) 2018-04-18
US20180133241A1 (en) 2018-05-17
KR20220018623A (ko) 2022-02-15
PL3505174T3 (pl) 2020-08-24
IL256331B (en) 2020-08-31
IL275256A (en) 2020-07-30
IL256331A (en) 2018-02-28
US11666592B2 (en) 2023-06-06
EP3310362B1 (en) 2019-08-28
HUE050678T2 (hu) 2020-12-28
EP3310362A1 (en) 2018-04-25
RU2721492C2 (ru) 2020-05-19
MX2020000269A (es) 2022-01-03
RU2018101305A3 (da) 2019-10-31
SI3505174T1 (sl) 2021-02-26
AU2020204042B2 (en) 2021-07-15
JP6675037B2 (ja) 2020-04-01
HK1252133A1 (zh) 2019-05-17
IL275256B2 (en) 2023-09-01
US10471087B2 (en) 2019-11-12
AU2016280293B2 (en) 2020-07-02
PL3310362T3 (pl) 2020-04-30
CY1123107T1 (el) 2021-10-29
DK3310362T3 (da) 2019-10-07
AU2020204042A1 (en) 2020-07-09
US20200038424A1 (en) 2020-02-06
HUE046399T2 (hu) 2020-03-30
CN107847512A (zh) 2018-03-27
WO2016205671A1 (en) 2016-12-22
IL275255A (en) 2020-07-30
MX2017016425A (es) 2018-12-11
RS60572B1 (sr) 2020-08-31
BR112017027079B1 (pt) 2021-04-27
EP3310362A4 (en) 2018-12-19
LT3310362T (lt) 2019-11-11
HRP20191794T1 (hr) 2020-02-07
IL275256B1 (en) 2023-05-01
AU2016280293A1 (en) 2018-02-08
JP2018521993A (ja) 2018-08-09
WO2016205671A9 (en) 2018-01-04

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