DK3472183T3 - Variant adeno-associerede virus og fremgangsmåder til anvendelse - Google Patents

Variant adeno-associerede virus og fremgangsmåder til anvendelse Download PDF

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Publication number
DK3472183T3
DK3472183T3 DK17734575.8T DK17734575T DK3472183T3 DK 3472183 T3 DK3472183 T3 DK 3472183T3 DK 17734575 T DK17734575 T DK 17734575T DK 3472183 T3 DK3472183 T3 DK 3472183T3
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methods
associated viruses
variant adeno
adeno
variant
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DK17734575.8T
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English (en)
Inventor
Joshua Dudman
Adam Hantman
Loren Looger
Kimberly Ritola
David Schaffer
Sarada Viswanathan
Dougal Gowanlock Robinson Tervo
Bum-Yeol Hwang
Alla Karpova
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Hughes Howard Med Inst
Univ California
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Publication of DK3472183T3 publication Critical patent/DK3472183T3/da

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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/015Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
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    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/06Methods of screening libraries by measuring effects on living organisms, tissues or cells
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    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14145Special targeting system for viral vectors
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    • C12N2810/00Vectors comprising a targeting moiety
    • C12N2810/50Vectors comprising as targeting moiety peptide derived from defined protein
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    • C12N2830/00Vector systems having a special element relevant for transcription
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
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DK17734575.8T 2016-06-15 2017-06-15 Variant adeno-associerede virus og fremgangsmåder til anvendelse DK3472183T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662350361P 2016-06-15 2016-06-15
US201662404585P 2016-10-05 2016-10-05
PCT/US2017/037781 WO2017218842A1 (en) 2016-06-15 2017-06-15 Variant adeno-associated viruses and methods of using

Publications (1)

Publication Number Publication Date
DK3472183T3 true DK3472183T3 (da) 2023-11-06

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US (2) US10961282B2 (da)
EP (2) EP4268852A3 (da)
JP (2) JP7094277B2 (da)
KR (2) KR20230054754A (da)
CN (2) CN116003532A (da)
AU (2) AU2017286652B2 (da)
BR (1) BR112018076090A2 (da)
CA (1) CA3028113A1 (da)
DK (1) DK3472183T3 (da)
EA (1) EA201990033A1 (da)
ES (1) ES2962611T3 (da)
FI (1) FI3472183T3 (da)
HR (1) HRP20231403T1 (da)
HU (1) HUE063755T2 (da)
IL (2) IL300981A (da)
LT (1) LT3472183T (da)
MA (1) MA44546B1 (da)
MX (2) MX2018015770A (da)
MY (1) MY190221A (da)
PH (1) PH12018502664A1 (da)
PL (1) PL3472183T3 (da)
PT (1) PT3472183T (da)
RS (1) RS64769B1 (da)
SG (1) SG11201811189RA (da)
SI (1) SI3472183T1 (da)
WO (1) WO2017218842A1 (da)
ZA (1) ZA201900278B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6600624B2 (ja) 2013-05-31 2019-10-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アデノ随伴ウイルス変異体及びその使用方法
EP3445773B1 (en) 2016-05-13 2022-12-28 4D Molecular Therapeutics Inc. Adeno-associated virus variant capsids and methods of use thereof
BR112019001815A2 (pt) * 2016-07-29 2019-05-07 The Regents Of The University Of California vírions do vírus adeno-associado com capsídeo variante e seus métodos de uso
WO2019046069A1 (en) 2017-08-28 2019-03-07 The Regents Of The University Of California ADENO-ASSOCIATED VIRUS CAPSID VARIANTS AND METHODS OF USE
SG11202003287UA (en) * 2017-10-16 2020-05-28 Vigeneron Gmbh Aav vectors
CN113301956A (zh) * 2018-07-31 2021-08-24 康奈尔大学 控制器官功能的基因治疗方法
WO2020068990A1 (en) 2018-09-26 2020-04-02 California Institute Of Technology Adeno-associated virus compositions for targeted gene therapy
EP4007609A1 (en) * 2019-08-01 2022-06-08 Cornell University Targeted gene therapy to treat neurological diseases
CN111825772B (zh) * 2020-07-30 2023-10-20 中国科学院精密测量科学与技术创新研究院 具有变异衣壳蛋白的腺相关病毒及其应用
MX2023000968A (es) 2020-08-06 2023-03-01 Fundacion Para La Investig Medica Aplicada Particulas virales para usarse en el tratamiento contra tauopatias tales como enfermedad de alzheimer mediante terapia genica.
EP4263575A1 (en) * 2020-12-16 2023-10-25 Children's Medical Research Institute Adeno-associated virus capsids and vectors
EP4263574A1 (en) * 2020-12-16 2023-10-25 Children's Medical Research Institute Aav capsids and vectors
CA3222723A1 (en) 2021-06-17 2022-12-22 Florian DZIOPA Aav manufacturing methods
KR20240055728A (ko) 2021-07-14 2024-04-29 메이라지티엑스 유케이 Ii 리미티드 Retgc 유전자 요법
WO2023285986A1 (en) 2021-07-14 2023-01-19 Meiragtx Uk Ii Limited Kcnv2 gene therapy
WO2023288184A2 (en) * 2021-07-14 2023-01-19 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for treating chronic pain and for retrograde transduction of neurons
CN118434758A (zh) 2021-12-15 2024-08-02 梅里特斯英国第二有限公司 肠肽的多顺反子表达
WO2023192450A1 (en) * 2022-03-30 2023-10-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Adeno-associated virus vectors for nucleic acid delivery to retinal ganglion cells and/or retinal pigment epithelium cells
WO2024059667A2 (en) * 2022-09-13 2024-03-21 Dyno Therapeutics, Inc. Capsid variants and methods of using the same
WO2024056902A2 (en) 2022-09-16 2024-03-21 Christopher Shaw Compositions and methods for treating neurological diseases
WO2024079531A2 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Nucleic acid regulatory elements for gene expression in the liver and methods of use
WO2024079657A1 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Formulations for aav gene therapy
WO2024079662A1 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Upf1 expression constructs
WO2024079661A1 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Atp7b gene therapy
WO2024079655A1 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Chromatography methods for purification of aav capsids
WO2024126696A1 (en) 2022-12-14 2024-06-20 King's College London Compositions and methods for treating neurological diseases
WO2024161022A2 (en) 2023-02-03 2024-08-08 King's College London Compositions and methods for treating neurological diseases

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156303A (en) 1997-06-11 2000-12-05 University Of Washington Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
US9233131B2 (en) * 2003-06-30 2016-01-12 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
US20090215870A1 (en) * 2005-04-29 2009-08-27 Terwilliger Ernest F Compositions and methods for targeting of viral vectors
US20090215879A1 (en) 2008-02-26 2009-08-27 University Of North Carolina At Chapel Hill Methods and compositions for adeno-associated virus (aav) with hi loop mutations
ES2634118T3 (es) 2009-02-11 2017-09-26 The University Of North Carolina At Chapel Hill Vectores de virus modificados y métodos para fabricar y utilizar los mismos
DK3693025T3 (da) * 2011-04-22 2022-01-10 Univ California Adenoassocierede virus-virioner med variant capsid og fremgangsmåder til anvendelse heraf
US9719992B2 (en) 2011-10-07 2017-08-01 Howard Hughes Medical Institute Genetically encoded biosensors
WO2013174760A1 (en) * 2012-05-25 2013-11-28 Deutsches Krebsforschungszentrum Optimized aav-vectors for high transduction rates in dendritic cells
US9518980B2 (en) 2012-10-10 2016-12-13 Howard Hughes Medical Institute Genetically encoded calcium indicators
US9518996B2 (en) 2013-08-05 2016-12-13 Howard Hughes Medical Institute Fluorescent protein-based calcium integrators
WO2015038958A1 (en) * 2013-09-13 2015-03-19 California Institute Of Technology Selective recovery
CN104592364B (zh) * 2013-10-30 2018-05-01 北京大学 定点突变和定点修饰的腺相关病毒、其制备方法及应用
GB201403684D0 (en) * 2014-03-03 2014-04-16 King S College London Vector
US10746742B2 (en) * 2014-04-25 2020-08-18 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping
WO2016054554A1 (en) * 2014-10-03 2016-04-07 University Of Massachusetts Heterologous targeting peptide grafted aavs
CN107532173A (zh) * 2014-11-21 2018-01-02 北卡罗来纳-查佩尔山大学 靶向中枢神经***的aav载体
US9644007B2 (en) 2014-12-23 2017-05-09 Howard Hughes Medical Institute Red genetically encoded calcium indicators and methods of use
EP3445773B1 (en) 2016-05-13 2022-12-28 4D Molecular Therapeutics Inc. Adeno-associated virus variant capsids and methods of use thereof
BR112019001815A2 (pt) * 2016-07-29 2019-05-07 The Regents Of The University Of California vírions do vírus adeno-associado com capsídeo variante e seus métodos de uso

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MX2018015770A (es) 2019-08-29
BR112018076090A2 (pt) 2019-03-26
KR102522661B1 (ko) 2023-04-18
EP4268852A3 (en) 2024-02-07
SG11201811189RA (en) 2019-01-30
EA201990033A1 (ru) 2019-06-28
MA44546A1 (fr) 2019-07-31
HRP20231403T1 (hr) 2024-02-16
KR20190039930A (ko) 2019-04-16
KR20230054754A (ko) 2023-04-25
IL263719B1 (en) 2023-05-01
CN109641939B (zh) 2022-11-08
MA44546B1 (fr) 2021-03-31
HUE063755T2 (hu) 2024-01-28
RS64769B1 (sr) 2023-11-30
WO2017218842A1 (en) 2017-12-21
AU2021225247A1 (en) 2021-09-30
CN109641939A (zh) 2019-04-16
AU2017286652A1 (en) 2019-01-24
SI3472183T1 (sl) 2023-11-30
ES2962611T3 (es) 2024-03-20
LT3472183T (lt) 2023-09-25
PT3472183T (pt) 2023-11-16
US20210230231A1 (en) 2021-07-29
AU2017286652B2 (en) 2021-10-07
PH12018502664A1 (en) 2019-10-07
JP2022126759A (ja) 2022-08-30
PL3472183T3 (pl) 2024-02-12
CA3028113A1 (en) 2017-12-21
MX2024000505A (es) 2024-03-19
FI3472183T3 (fi) 2023-11-03
EP3472183B1 (en) 2023-08-09
US10961282B2 (en) 2021-03-30
US11939355B2 (en) 2024-03-26
ZA201900278B (en) 2022-04-28
JP7094277B2 (ja) 2022-07-01
EP4268852A2 (en) 2023-11-01
CN116003532A (zh) 2023-04-25
IL263719A (en) 2019-01-31
EP3472183A1 (en) 2019-04-24
US20190300579A1 (en) 2019-10-03
JP2019518793A (ja) 2019-07-04
IL263719B2 (en) 2023-09-01
AU2021225247B2 (en) 2023-02-16
MY190221A (en) 2022-04-06
IL300981A (en) 2023-04-01

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