DK3344628T5 - THERAPEUTIC COMPOUNDS AND SYNTHESIS - Google Patents

THERAPEUTIC COMPOUNDS AND SYNTHESIS Download PDF

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Publication number
DK3344628T5
DK3344628T5 DK16842976.9T DK16842976T DK3344628T5 DK 3344628 T5 DK3344628 T5 DK 3344628T5 DK 16842976 T DK16842976 T DK 16842976T DK 3344628 T5 DK3344628 T5 DK 3344628T5
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DK
Denmark
Prior art keywords
synthesis
therapeutic compounds
therapeutic
compounds
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DK16842976.9T
Other languages
Danish (da)
Other versions
DK3344628T3 (en
Inventor
Bart Lieven Daniel Decorte
Jacob Cornelis Russcher
Menno Cornelis Franciscus Monnee
Original Assignee
Janssen Pharmaceutica Nv
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Publication of DK3344628T3 publication Critical patent/DK3344628T3/en
Publication of DK3344628T5 publication Critical patent/DK3344628T5/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. ***e

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
DK16842976.9T 2015-09-04 2016-09-01 THERAPEUTIC COMPOUNDS AND SYNTHESIS DK3344628T5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562214734P 2015-09-04 2015-09-04
US201562214727P 2015-09-04 2015-09-04
PCT/US2016/049885 WO2017040772A1 (en) 2015-09-04 2016-09-01 Therapeutic compounds and synthesis

Publications (2)

Publication Number Publication Date
DK3344628T3 DK3344628T3 (en) 2020-08-03
DK3344628T5 true DK3344628T5 (en) 2021-07-26

Family

ID=58188341

Family Applications (4)

Application Number Title Priority Date Filing Date
DK16842976.9T DK3344628T5 (en) 2015-09-04 2016-09-01 THERAPEUTIC COMPOUNDS AND SYNTHESIS
DK16842971.0T DK3344614T5 (en) 2015-09-04 2016-09-01 THERAPEUTIC COMPOUNDS FOR PAIN AND ITS SYNTHESIS
DK16842973.6T DK3344626T5 (en) 2015-09-04 2016-09-01 THERAPEUTIC COMPOUNDS FOR PAIN AND SYNTHESIS THEREFORE
DK16842975.1T DK3344627T5 (en) 2015-09-04 2016-09-01 THERAPEUTIC COMPOUNDS FOR PAIN AND ITS SYNTHESIS

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK16842971.0T DK3344614T5 (en) 2015-09-04 2016-09-01 THERAPEUTIC COMPOUNDS FOR PAIN AND ITS SYNTHESIS
DK16842973.6T DK3344626T5 (en) 2015-09-04 2016-09-01 THERAPEUTIC COMPOUNDS FOR PAIN AND SYNTHESIS THEREFORE
DK16842975.1T DK3344627T5 (en) 2015-09-04 2016-09-01 THERAPEUTIC COMPOUNDS FOR PAIN AND ITS SYNTHESIS

Country Status (11)

Country Link
US (9) US10040795B2 (en)
EP (5) EP3344628B9 (en)
JP (5) JP6736661B2 (en)
CN (5) CN108349934B (en)
CA (5) CA2997501C (en)
DK (4) DK3344628T5 (en)
ES (4) ES2809703T3 (en)
IL (5) IL257732B (en)
MA (1) MA45011A (en)
TW (11) TWI654188B (en)
WO (5) WO2017040778A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108349934B (en) 2015-09-04 2021-10-22 詹森药业有限公司 Therapeutic compounds for pain and synthesis thereof

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WO2008104955A1 (en) * 2007-02-28 2008-09-04 Ranbaxy Laboratories Limited Azoniatricyclo [3.3.1.0] nonane derivatives as muscarinic receptor antagonists
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WO2009124755A1 (en) * 2008-04-08 2009-10-15 European Molecular Biology Laboratory (Embl) Compounds with novel medical uses and method of identifying such compounds
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CN108349934B (en) * 2015-09-04 2021-10-22 詹森药业有限公司 Therapeutic compounds for pain and synthesis thereof

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Publication number Publication date
CN108349934A (en) 2018-07-31
CA2997541C (en) 2022-01-11
CN109071540B (en) 2021-06-04
CN108495854A (en) 2018-09-04
CA2997545A1 (en) 2017-03-09
IL257734B (en) 2021-07-29
IL257735A (en) 2018-04-30
CN108495854B (en) 2021-10-15
ES2809703T9 (en) 2022-01-24
JP2018527356A (en) 2018-09-20
EP3344629A1 (en) 2018-07-11
CA2997543C (en) 2022-07-19
WO2017040772A9 (en) 2019-03-07
TW201722954A (en) 2017-07-01
WO2017040778A1 (en) 2017-03-09
IL257740A (en) 2018-04-30
TW201722955A (en) 2017-07-01
TW201722951A (en) 2017-07-01
EP3344626A4 (en) 2019-03-27
ES2808048T9 (en) 2022-02-01
US20180291024A1 (en) 2018-10-11
DK3344627T5 (en) 2021-08-30
US20180327405A1 (en) 2018-11-15
CA2997545C (en) 2022-01-11
TW201811786A (en) 2018-04-01
CN108290890A (en) 2018-07-17
ES2807901T9 (en) 2022-01-31
TW201920176A (en) 2019-06-01
TWI639597B (en) 2018-11-01
EP3344628B1 (en) 2020-07-15
EP3344627A4 (en) 2019-03-27
US10351566B2 (en) 2019-07-16
EP3344614A4 (en) 2019-03-27
TW201722953A (en) 2017-07-01
WO2017040767A1 (en) 2017-03-09
DK3344614T5 (en) 2021-08-30
ES2809703T3 (en) 2021-03-05
TWI636054B (en) 2018-09-21
WO2017040772A1 (en) 2017-03-09
CN108349934B (en) 2021-10-22
IL257732A (en) 2018-04-30
CA2997501C (en) 2022-05-10
US20170066767A1 (en) 2017-03-09
IL257737A (en) 2018-04-30
CA2997430A1 (en) 2017-03-09
EP3344628B9 (en) 2021-06-30
US20190112311A1 (en) 2019-04-18
EP3344628A1 (en) 2018-07-11
TWI641608B (en) 2018-11-21
EP3344626B1 (en) 2020-07-08
JP2018526388A (en) 2018-09-13
DK3344628T3 (en) 2020-08-03
US10351565B2 (en) 2019-07-16
CN109153679B (en) 2022-04-08
DK3344626T5 (en) 2021-09-06
TW201835082A (en) 2018-10-01
US10766898B2 (en) 2020-09-08
JP6868008B2 (en) 2021-05-12
EP3344614B1 (en) 2020-07-08
EP3344629A4 (en) 2019-03-27
TW201843153A (en) 2018-12-16
JP2018527355A (en) 2018-09-20
EP3344614B9 (en) 2021-07-28
EP3344627B9 (en) 2021-08-04
EP3344628A4 (en) 2019-03-27
US20180327406A1 (en) 2018-11-15
TWI695836B (en) 2020-06-11
US10155762B2 (en) 2018-12-18
IL257734A (en) 2018-04-30
TW201819381A (en) 2018-06-01
CA2997430C (en) 2021-05-11
CA2997541A1 (en) 2017-03-09
IL257737B2 (en) 2023-02-01
JP6639651B2 (en) 2020-02-05
US20170066768A1 (en) 2017-03-09
TWI663167B (en) 2019-06-21
JP6736660B2 (en) 2020-08-05
CN109071540A (en) 2018-12-21
US20170066770A1 (en) 2017-03-09
CN109153679A (en) 2019-01-04
DK3344627T3 (en) 2020-07-20
JP2018526387A (en) 2018-09-13
CN108290890B (en) 2021-08-06
JP6736659B2 (en) 2020-08-05
US9994572B2 (en) 2018-06-12
TWI707854B (en) 2020-10-21
TWI654188B (en) 2019-03-21
ES2808048T3 (en) 2021-02-25
ES2812233T9 (en) 2022-02-18
IL257737B (en) 2022-10-01
US20170066760A1 (en) 2017-03-09
ES2812233T3 (en) 2021-03-16
EP3344627A1 (en) 2018-07-11
DK3344626T3 (en) 2020-07-27
TWI672303B (en) 2019-09-21
WO2017040764A1 (en) 2017-03-09
IL257735B (en) 2022-01-01
IL257732B (en) 2020-11-30
US10040795B2 (en) 2018-08-07
TWI683815B (en) 2020-02-01
CA2997543A1 (en) 2017-03-09
TW201833110A (en) 2018-09-16
EP3344627B1 (en) 2020-07-01
JP2018531907A (en) 2018-11-01
JP6736661B2 (en) 2020-08-05
TWI713879B (en) 2020-12-21
US10040797B2 (en) 2018-08-07
DK3344614T3 (en) 2020-07-27
TWI686393B (en) 2020-03-01
EP3344626B9 (en) 2021-08-11
MA45011A (en) 2021-06-02
WO2017040770A1 (en) 2017-03-09
ES2807901T3 (en) 2021-02-24
EP3344626A1 (en) 2018-07-11
CA2997501A1 (en) 2017-03-09
US10040796B2 (en) 2018-08-07
EP3344614A1 (en) 2018-07-11
US20170066769A1 (en) 2017-03-09
TW201716409A (en) 2017-05-16
US10358448B2 (en) 2019-07-23

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