DK3312272T3 - Modulering af replikationstilpasning ved brug a mindre optrædende synonyme kodoner - Google Patents
Modulering af replikationstilpasning ved brug a mindre optrædende synonyme kodoner Download PDFInfo
- Publication number
- DK3312272T3 DK3312272T3 DK17205518T DK17205518T DK3312272T3 DK 3312272 T3 DK3312272 T3 DK 3312272T3 DK 17205518 T DK17205518 T DK 17205518T DK 17205518 T DK17205518 T DK 17205518T DK 3312272 T3 DK3312272 T3 DK 3312272T3
- Authority
- DK
- Denmark
- Prior art keywords
- codones
- synonymous
- replication fitness
- less action
- module
- Prior art date
Links
- 230000010076 replication Effects 0.000 title 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16161—Methods of inactivation or attenuation
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- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16661—Methods of inactivation or attenuation
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- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16761—Methods of inactivation or attenuation
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
- C12N2760/16162—Methods of inactivation or attenuation by genetic engineering
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- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18461—Methods of inactivation or attenuation
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- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
- C12N2760/18562—Methods of inactivation or attenuation by genetic engineering
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- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20061—Methods of inactivation or attenuation
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- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
- C12N2770/24162—Methods of inactivation or attenuation by genetic engineering
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
- C12N2770/32161—Methods of inactivation or attenuation
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32711—Rhinovirus
- C12N2770/32761—Methods of inactivation or attenuation
- C12N2770/32762—Methods of inactivation or attenuation by genetic engineering
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36211—Rubivirus, e.g. rubella virus
- C12N2770/36261—Methods of inactivation or attenuation
- C12N2770/36262—Methods of inactivation or attenuation by genetic engineering
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- General Health & Medical Sciences (AREA)
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- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61754504P | 2004-10-08 | 2004-10-08 | |
EP14168068.6A EP2808384B1 (en) | 2004-10-08 | 2005-10-07 | Modulation of replicative fitness by using less frequently used synonymous codons |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3312272T3 true DK3312272T3 (da) | 2019-12-02 |
Family
ID=35636708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17205518T DK3312272T3 (da) | 2004-10-08 | 2005-10-07 | Modulering af replikationstilpasning ved brug a mindre optrædende synonyme kodoner |
Country Status (7)
Country | Link |
---|---|
US (6) | US8846051B2 (da) |
EP (3) | EP1797173B1 (da) |
AU (1) | AU2005294129B2 (da) |
CA (1) | CA2587084C (da) |
DK (1) | DK3312272T3 (da) |
HK (1) | HK1252169B (da) |
WO (1) | WO2006042156A2 (da) |
Families Citing this family (36)
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MX349825B (es) * | 2007-03-30 | 2017-08-15 | Univ New York State Res Found | Virus atenuados utiles para vacunas. |
SG188813A1 (en) * | 2007-12-24 | 2013-04-30 | Id Biomedical Corp Quebec | Recombinant rsv antigens |
CN104080475A (zh) | 2008-04-18 | 2014-10-01 | 法克斯因内特公司 | 鞭毛蛋白的缺失突变体以及使用方法 |
HRP20220756T1 (hr) | 2009-07-15 | 2022-09-02 | Glaxosmithkline Biologicals S.A. | Proteinski pripravci rsv f i postupci za izradu istih |
CN102648285A (zh) | 2009-08-06 | 2012-08-22 | Cmc依科斯生技制品公司 | 用于改进重组蛋白表达的方法 |
WO2011044561A1 (en) * | 2009-10-09 | 2011-04-14 | The Research Foundation Of State University Of New York | Attenuated influenza viruses and vaccines |
CN106987595B (zh) | 2009-11-02 | 2021-07-06 | 宾夕法尼亚大学托管会 | ***病毒病毒(fmdv)共有蛋白质、其编码序列及由其制备的疫苗 |
EP4159232A1 (en) | 2011-01-26 | 2023-04-05 | GlaxoSmithKline Biologicals S.A. | Rsv immunization regimen |
WO2012138774A2 (en) * | 2011-04-04 | 2012-10-11 | University Of Iowa Research Foundation | Methods of improving vaccine immunogenicity |
US20140335117A1 (en) | 2011-10-07 | 2014-11-13 | Skau Aps | Identification and Attenuation of the Immunosuppressive Domains in Fusion Proteins of Enveloped RNA Viruses |
CA2900713A1 (en) * | 2013-02-08 | 2014-08-14 | Steffen Mueller | Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization |
JP6506249B2 (ja) | 2013-03-14 | 2019-04-24 | エモリー ユニバーシティー | サイレント変異を有する組換えrsv、ワクチン、およびそれに関連する方法 |
US10316294B2 (en) | 2013-03-15 | 2019-06-11 | The Research Foundation For The State University Of New York | Attenuated influenza viruses and vaccines |
CN104419687B (zh) * | 2013-09-03 | 2017-03-15 | 中国农业大学 | 重组PRRS病毒HV‑nsp29及其应用 |
US10619137B2 (en) * | 2014-06-20 | 2020-04-14 | Université D'aix-Marseille | Method for rapid generation of an attenuated RNA virus |
MX2017002949A (es) * | 2014-09-05 | 2017-12-14 | Univ New York State Res Found | Arbovirus recodificado y vacunas. |
EP3050962A1 (en) | 2015-01-28 | 2016-08-03 | Institut Pasteur | RNA virus attenuation by alteration of mutational robustness and sequence space |
AU2016274770B2 (en) * | 2015-06-09 | 2020-11-12 | Sanofi Pasteur, Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
BR112018008708A2 (pt) | 2015-10-29 | 2018-11-06 | Univ Emory | rsv quimérico, composições imunogênicas e métodos de uso |
US10385319B2 (en) | 2016-09-08 | 2019-08-20 | The Governement of the United States of America, as represented by the Secretary of Homeland Security | Modified foot-and-mouth disease virus 3C proteases, compositions and methods thereof |
EP3515930A1 (en) | 2016-09-23 | 2019-07-31 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes |
CN110225765B (zh) | 2016-11-30 | 2024-03-12 | 勃林格殷格翰动物保健美国公司 | 减毒猪流感疫苗以及其制备和使用方法 |
US10308927B2 (en) | 2017-01-17 | 2019-06-04 | The United States of America, as Represented by the Secretary of Homeland Security | Processing of a modified foot-and-mouth disease virus P1 polypeptide by an alternative protease |
WO2018175518A1 (en) * | 2017-03-22 | 2018-09-27 | The Scripps Research Institute | Mini-protein immunogens displayng neutralization epitopes for respiratory syncytial virus (rsv) |
AR111770A1 (es) | 2017-05-05 | 2019-08-21 | Elanco Us Inc | Vacuna para enfermedad respiratoria bovina |
US11339387B2 (en) | 2018-05-22 | 2022-05-24 | The Government Of The United States Of America As Represented By The Secretary Of Homeland Security | Modified foot-and-mouth disease virus 3C proteases and methods for processing FMDV P1 precursor polypeptide |
US20210198323A1 (en) * | 2018-08-17 | 2021-07-01 | Icahn School Of Medicine At Mount Sinai | Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease |
GB201818084D0 (en) * | 2018-11-06 | 2018-12-19 | Univ Oxford Innovation Ltd | Compositions and methods |
CA3145401A1 (en) * | 2019-06-25 | 2020-12-30 | Codagenix Inc. | Attenuated dengue viruses |
US20230117167A1 (en) * | 2020-01-28 | 2023-04-20 | Codagenix Inc. | DEOPTIMIZED SARS-CoV-2 AND METHODS AND USES THEREOF |
IL295482A (en) * | 2020-02-14 | 2022-10-01 | Geovax Inc | Vaccines and their uses to induce an immune response to sars-cov2 |
IL298481A (en) * | 2020-05-27 | 2023-01-01 | Us Agriculture | Attenuated live strains of foot-and-mouth disease viruses modified by deoptimization, and uses thereof |
US20240102912A1 (en) * | 2020-11-09 | 2024-03-28 | Thrive Bioscience, Inc. | Plaque counting assay method |
AU2022254738A1 (en) * | 2021-04-08 | 2023-09-07 | Codagenix Inc. | Method of eliciting an immune response against respiratory syncytial virus |
WO2022269248A1 (en) * | 2021-06-23 | 2022-12-29 | University Of Lancaster | Virus attenuation |
CN117430664B (zh) * | 2023-10-24 | 2024-04-09 | 暨南大学附属第六医院(东莞市东部中心医院) | 一种甲型流感病毒t细胞抗原表位肽及其应用 |
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-
2005
- 2005-10-07 CA CA2587084A patent/CA2587084C/en active Active
- 2005-10-07 US US11/576,941 patent/US8846051B2/en active Active
- 2005-10-07 EP EP05802766.5A patent/EP1797173B1/en active Active
- 2005-10-07 AU AU2005294129A patent/AU2005294129B2/en active Active
- 2005-10-07 WO PCT/US2005/036241 patent/WO2006042156A2/en active Application Filing
- 2005-10-07 EP EP14168068.6A patent/EP2808384B1/en active Active
- 2005-10-07 DK DK17205518T patent/DK3312272T3/da active
- 2005-10-07 EP EP17205518.8A patent/EP3312272B1/en active Active
-
2014
- 2014-08-20 US US14/464,619 patent/US20140356390A1/en not_active Abandoned
-
2017
- 2017-08-23 US US15/684,355 patent/US20170354727A1/en not_active Abandoned
-
2018
- 2018-05-31 US US15/994,074 patent/US10695414B2/en active Active
- 2018-09-07 HK HK18111562.5A patent/HK1252169B/zh unknown
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2020
- 2020-05-13 US US15/931,336 patent/US11497803B2/en active Active
-
2022
- 2022-10-18 US US18/047,395 patent/US20230270833A1/en active Pending
Also Published As
Publication number | Publication date |
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CA2587084C (en) | 2019-07-16 |
HK1252169B (zh) | 2020-06-05 |
EP3312272A1 (en) | 2018-04-25 |
US11497803B2 (en) | 2022-11-15 |
EP2808384B1 (en) | 2017-12-06 |
US20200268865A1 (en) | 2020-08-27 |
EP2808384A3 (en) | 2014-12-24 |
WO2006042156A3 (en) | 2006-10-12 |
US20180264098A1 (en) | 2018-09-20 |
US20140356390A1 (en) | 2014-12-04 |
US10695414B2 (en) | 2020-06-30 |
EP1797173B1 (en) | 2014-05-14 |
CA2587084A1 (en) | 2006-04-20 |
WO2006042156A9 (en) | 2013-12-27 |
EP3312272B1 (en) | 2019-08-28 |
WO2006042156A2 (en) | 2006-04-20 |
US20170354727A1 (en) | 2017-12-14 |
AU2005294129B2 (en) | 2010-12-23 |
EP2808384A2 (en) | 2014-12-03 |
EP1797173A2 (en) | 2007-06-20 |
AU2005294129A1 (en) | 2006-04-20 |
US20080118530A1 (en) | 2008-05-22 |
HK1252169A1 (zh) | 2019-05-17 |
US8846051B2 (en) | 2014-09-30 |
US20230270833A1 (en) | 2023-08-31 |
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