DK32684D0 - Fremgangsmade til fremstilling af 26,26,26,27,27,27-hexafluorlalfa,25-dihydroxycholesterol og mellemprodukter til brug herfor - Google Patents
Fremgangsmade til fremstilling af 26,26,26,27,27,27-hexafluorlalfa,25-dihydroxycholesterol og mellemprodukter til brug herforInfo
- Publication number
- DK32684D0 DK32684D0 DK0326/84A DK32684A DK32684D0 DK 32684 D0 DK32684 D0 DK 32684D0 DK 0326/84 A DK0326/84 A DK 0326/84A DK 32684 A DK32684 A DK 32684A DK 32684 D0 DK32684 D0 DK 32684D0
- Authority
- DK
- Denmark
- Prior art keywords
- hexafluorlalfa
- dihydroxycholesterol
- intermediates
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nutrition Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38205582 | 1982-05-26 | ||
US06/382,055 US4411833A (en) | 1982-05-26 | 1982-05-26 | Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol |
US8300577 | 1983-04-18 | ||
PCT/US1983/000577 WO1983004256A1 (en) | 1982-05-26 | 1983-04-18 | METHOD FOR PREPARING 26,26,26,27,27,27-HEXAFLUORO-1alpha,25-DIHYDROXYCHOLESTEROL |
Publications (3)
Publication Number | Publication Date |
---|---|
DK32684A DK32684A (da) | 1984-01-25 |
DK32684D0 true DK32684D0 (da) | 1984-01-25 |
DK168539B1 DK168539B1 (da) | 1994-04-18 |
Family
ID=23507359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK032684A DK168539B1 (da) | 1982-05-26 | 1984-01-25 | Speciel fremgangsmåde til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herved |
Country Status (14)
Country | Link |
---|---|
US (1) | US4411833A (da) |
JP (2) | JPH0742305B2 (da) |
AU (1) | AU561182B2 (da) |
BE (1) | BE896830A (da) |
CH (2) | CH662572A5 (da) |
DE (1) | DE3390016C2 (da) |
DK (1) | DK168539B1 (da) |
FR (2) | FR2527615B1 (da) |
GB (2) | GB2121044B (da) |
IE (1) | IE55022B1 (da) |
IL (1) | IL68537A (da) |
IT (1) | IT1203706B (da) |
NL (1) | NL8320153A (da) |
WO (1) | WO1983004256A1 (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4613594A (en) * | 1984-11-16 | 1986-09-23 | Hoffmann-La Roche Inc. | Fluorinated vitamin D3 compounds |
US4749710A (en) * | 1985-05-01 | 1988-06-07 | Hoffmann-La Roche Inc. | Immunosuppressive agents |
US4619920A (en) * | 1985-09-16 | 1986-10-28 | Wisconsin Alumni Research Foundation | 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3 |
JPH0764804B2 (ja) * | 1986-04-25 | 1995-07-12 | 住友製薬株式会社 | 活性型ビタミンd3のフッ素誘導体 |
US5366736A (en) * | 1989-02-16 | 1994-11-22 | University Of Georgia Research Foundation, Inc. | Vitamin D derivative feed compositions and methods of use |
WO1990009179A1 (en) * | 1989-02-16 | 1990-08-23 | University Of Georgia Research Foundation, Inc. | Treatment of tibial dyschondroplasia |
US5316770A (en) * | 1989-02-16 | 1994-05-31 | University Of Georgia Research Foundation, Inc. | Vitamin D derivative feed compositions and methods of use |
US5571802A (en) * | 1993-02-19 | 1996-11-05 | Wisconsin Alumni Research Foundation | Method of treating post menopausal osteoporosis with hexafluro-vitamin D |
EP2001841B1 (en) * | 2006-04-06 | 2012-06-13 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin d3 analogs and uses thereof |
CA2646911A1 (en) | 2006-04-06 | 2008-03-27 | Hector F. Deluca | 2- substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin d analogs and uses thereof |
NZ570814A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
EP2021321B1 (en) * | 2006-04-06 | 2012-06-20 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof |
EP2001860A2 (en) * | 2006-04-06 | 2008-12-17 | Wisconsin Alumni Research Foundation | 19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring |
US7648973B2 (en) * | 2006-04-06 | 2010-01-19 | Wisconsin Alumni Research Foundation | 2-methylene-1α,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
ATE496885T1 (de) * | 2006-04-10 | 2011-02-15 | Wisconsin Alumni Res Found | 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette |
AU2010208323B2 (en) | 2009-01-27 | 2016-03-10 | Berg Llc | Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy |
EP2464357B1 (en) | 2009-08-14 | 2019-05-22 | Berg LLC | Vitamin d3 and analogs thereof for treating alopecia |
KR20160013201A (ko) | 2013-05-29 | 2016-02-03 | 버그 엘엘씨 | 비타민 d를 이용한 화학요법 유발 탈모증의 예방 또는 완화 |
CN113968888B (zh) * | 2020-07-24 | 2023-06-27 | 上海医药工业研究院 | 一种胆甾衍生物的制备方法、其中间体及应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4183852A (en) * | 1977-07-18 | 1980-01-15 | Kaiser Emil T | Process for preparing 25-hydroxycholesterol |
LU80545A1 (de) * | 1978-11-17 | 1980-06-05 | Hoffmann La Roche | Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden |
US4217279A (en) * | 1978-12-18 | 1980-08-12 | Kaiser Emil T | Synthesis of steroids |
JPS5598199A (en) * | 1979-01-17 | 1980-07-25 | Eisai Co Ltd | Preparation of 25-hydroxy cholesta-1,4,6-trien-3-one |
US4269777A (en) * | 1979-05-21 | 1981-05-26 | Wisconsin Alumni Research Foundation | Isotopically labeled vitamin D derivatives and processes for preparing same |
IL60270A0 (en) * | 1979-06-14 | 1980-09-16 | Diamond Shamrock Corp | Preparation of 25-ydroxycholesterol |
US4248791A (en) * | 1980-02-04 | 1981-02-03 | Wisconsin Alumni Research Foundation | 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol |
US4360470A (en) * | 1980-10-22 | 1982-11-23 | Hoffmann-La Roche Inc. | Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid |
US4358406A (en) * | 1981-07-27 | 1982-11-09 | Wisconsin Alumni Research Foundation | 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same |
-
1982
- 1982-05-26 US US06/382,055 patent/US4411833A/en not_active Expired - Lifetime
-
1983
- 1983-04-18 CH CH4413/86A patent/CH662572A5/de not_active IP Right Cessation
- 1983-04-18 AU AU15542/83A patent/AU561182B2/en not_active Ceased
- 1983-04-18 DE DE19833390016 patent/DE3390016C2/de not_active Expired
- 1983-04-18 NL NL8320153A patent/NL8320153A/nl not_active Application Discontinuation
- 1983-04-18 WO PCT/US1983/000577 patent/WO1983004256A1/en active Application Filing
- 1983-04-18 CH CH341/84A patent/CH663212A5/de not_active IP Right Cessation
- 1983-04-29 IL IL68537A patent/IL68537A/xx not_active IP Right Cessation
- 1983-05-24 IE IE1226/83A patent/IE55022B1/en not_active IP Right Cessation
- 1983-05-24 IT IT21261/83A patent/IT1203706B/it active
- 1983-05-25 FR FR8308650A patent/FR2527615B1/fr not_active Expired
- 1983-05-25 BE BE0/210839A patent/BE896830A/fr not_active IP Right Cessation
- 1983-05-26 GB GB08314612A patent/GB2121044B/en not_active Expired
- 1983-11-04 FR FR8317598A patent/FR2533929B1/fr not_active Expired
-
1984
- 1984-01-25 DK DK032684A patent/DK168539B1/da active IP Right Grant
- 1984-06-19 GB GB08415630A patent/GB2140016B/en not_active Expired
-
1992
- 1992-01-23 JP JP4032644A patent/JPH0742305B2/ja not_active Expired - Lifetime
- 1992-01-23 JP JP4032645A patent/JPH0742306B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK168539B1 (da) | 1994-04-18 |
AU1554283A (en) | 1983-12-16 |
JPH0578388A (ja) | 1993-03-30 |
IL68537A0 (en) | 1983-07-31 |
AU561182B2 (en) | 1987-04-30 |
GB2121044A (en) | 1983-12-14 |
BE896830A (fr) | 1983-09-16 |
GB8314612D0 (en) | 1983-06-29 |
IL68537A (en) | 1986-07-31 |
JPH0742306B2 (ja) | 1995-05-10 |
GB2140016B (en) | 1986-01-02 |
IT1203706B (it) | 1989-02-15 |
WO1983004256A1 (en) | 1983-12-08 |
NL8320153A (nl) | 1984-04-02 |
JPH0742305B2 (ja) | 1995-05-10 |
IE831226L (en) | 1983-11-26 |
CH662572A5 (de) | 1987-10-15 |
IT8321261A0 (it) | 1983-05-24 |
DE3390016C2 (de) | 1989-08-10 |
DK32684A (da) | 1984-01-25 |
US4411833A (en) | 1983-10-25 |
GB2121044B (en) | 1986-01-02 |
IE55022B1 (en) | 1990-04-25 |
FR2533929B1 (fr) | 1986-10-31 |
FR2533929A1 (fr) | 1984-04-06 |
FR2527615B1 (fr) | 1986-05-23 |
FR2527615A1 (fr) | 1983-12-02 |
GB8415630D0 (en) | 1984-07-25 |
CH663212A5 (de) | 1987-11-30 |
GB2140016A (en) | 1984-11-21 |
JPH0578387A (ja) | 1993-03-30 |
DE3390016T1 (de) | 1984-05-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) |