DK3250574T3 - METHOD FOR THE PREPARATION OF OXYMORPHON HYDROCHLORIDE WITH LOW ABUC CONTENT - Google Patents

METHOD FOR THE PREPARATION OF OXYMORPHON HYDROCHLORIDE WITH LOW ABUC CONTENT Download PDF

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Publication number
DK3250574T3
DK3250574T3 DK16703889.2T DK16703889T DK3250574T3 DK 3250574 T3 DK3250574 T3 DK 3250574T3 DK 16703889 T DK16703889 T DK 16703889T DK 3250574 T3 DK3250574 T3 DK 3250574T3
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DK
Denmark
Prior art keywords
oxymorphon
abuc
hydrochloride
preparation
content
Prior art date
Application number
DK16703889.2T
Other languages
Danish (da)
Inventor
Brian Heinrich
Saroop MATHARU
Aniruddh Singh
Mahmoud Mirmehrabi
Original Assignee
Johnson Matthey Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey Plc filed Critical Johnson Matthey Plc
Application granted granted Critical
Publication of DK3250574T3 publication Critical patent/DK3250574T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK16703889.2T 2015-01-29 2016-01-27 METHOD FOR THE PREPARATION OF OXYMORPHON HYDROCHLORIDE WITH LOW ABUC CONTENT DK3250574T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/608,544 US9918979B2 (en) 2015-01-29 2015-01-29 Process of preparing low ABUK oxymorphone hydrochloride
PCT/US2016/015096 WO2016123202A1 (en) 2015-01-29 2016-01-27 Process of preparing low abuk oxymorphone hydrochloride

Publications (1)

Publication Number Publication Date
DK3250574T3 true DK3250574T3 (en) 2020-12-07

Family

ID=55346212

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16703889.2T DK3250574T3 (en) 2015-01-29 2016-01-27 METHOD FOR THE PREPARATION OF OXYMORPHON HYDROCHLORIDE WITH LOW ABUC CONTENT

Country Status (10)

Country Link
US (1) US9918979B2 (en)
EP (1) EP3250574B1 (en)
JP (1) JP6726194B2 (en)
CN (1) CN107428767B (en)
CA (1) CA2975470C (en)
DK (1) DK3250574T3 (en)
ES (1) ES2836446T3 (en)
HR (1) HRP20201818T1 (en)
HU (1) HUE052641T2 (en)
WO (1) WO2016123202A1 (en)

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
DE2530563C2 (en) 1975-07-09 1986-07-24 Bayer Ag, 5090 Leverkusen Analgesic drugs with reduced potential for abuse
US4063064A (en) 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4285987A (en) 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4861598A (en) 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
DE3812567A1 (en) 1988-04-15 1989-10-26 Basf Ag METHOD FOR PRODUCING PHARMACEUTICAL MIXTURES
US5215758A (en) 1991-09-11 1993-06-01 Euroceltique, S.A. Controlled release matrix suppository for pharmaceuticals
US5286493A (en) 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5273760A (en) 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5472712A (en) 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5324351A (en) 1992-08-13 1994-06-28 Euroceltique Aqueous dispersions of zein and preparation thereof
GB9401894D0 (en) 1994-02-01 1994-03-30 Rhone Poulenc Rorer Ltd New compositions of matter
CA2452872A1 (en) 2001-07-06 2003-01-16 Endo Pharmaceuticals, Inc. Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic
ES2292775T3 (en) 2001-07-06 2008-03-16 Penwest Pharmaceuticals Co. FORMULATIONS OF PROLONGED RELEASE OF OXIMORPHONE.
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
TWI365880B (en) * 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
JP5695296B2 (en) 2006-03-02 2015-04-01 マリンクロッド エルエルシー Process for the production of morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
DK2073636T3 (en) 2006-10-17 2012-11-19 Penick Corp PROCEDURE FOR MANUFACTURING OXYMORPHONE
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
CN102116942B (en) * 2009-12-31 2013-02-13 清华大学 Thermal display component and thermal display device
US8563571B2 (en) 2010-07-22 2013-10-22 Noramco, Inc. Crystalline forms of oxymorphone hydrochloride
EP2714695A1 (en) 2011-05-27 2014-04-09 Grünenthal GmbH Crystalline, anhydrous forms of oxymorphone hydrochloride
US9657029B2 (en) * 2012-06-11 2017-05-23 Siegfried Generics International Ag Method of preparing oxymorphone
WO2015015146A1 (en) * 2013-08-02 2015-02-05 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone

Also Published As

Publication number Publication date
CA2975470A1 (en) 2016-08-04
JP6726194B2 (en) 2020-07-22
WO2016123202A1 (en) 2016-08-04
CA2975470C (en) 2023-03-21
HUE052641T2 (en) 2021-05-28
EP3250574A1 (en) 2017-12-06
US20160220560A1 (en) 2016-08-04
CN107428767B (en) 2019-06-18
HRP20201818T1 (en) 2021-01-22
JP2018507193A (en) 2018-03-15
ES2836446T3 (en) 2021-06-25
US9918979B2 (en) 2018-03-20
EP3250574B1 (en) 2020-09-09
CN107428767A (en) 2017-12-01

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