DK3143018T3 - Carboxamidderivater - Google Patents

Carboxamidderivater Download PDF

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Publication number
DK3143018T3
DK3143018T3 DK15725195.0T DK15725195T DK3143018T3 DK 3143018 T3 DK3143018 T3 DK 3143018T3 DK 15725195 T DK15725195 T DK 15725195T DK 3143018 T3 DK3143018 T3 DK 3143018T3
Authority
DK
Denmark
Prior art keywords
carboxamide derivatives
carboxamide
derivatives
Prior art date
Application number
DK15725195.0T
Other languages
English (en)
Inventor
Anne-Marie D'souza
Mahbub Ahmed
Robert Alexander Pulz
Lisa Ann Rooney
Nichola Smith
Thomas Josef Troxler
Kamlesh Jagdis Bala
Andrew Brearley
James Dale
David Porter
David Andrew Sandham
Duncan Shaw
Jessica Louise Taylor
Roger John Taylor
Joe Wrigglesworth
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50735903&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3143018(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK3143018T3 publication Critical patent/DK3143018T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK15725195.0T 2014-05-14 2015-05-14 Carboxamidderivater DK3143018T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14168303 2014-05-14
PCT/US2015/030817 WO2015175796A1 (en) 2014-05-14 2015-05-14 Carboxamide derivatives

Publications (1)

Publication Number Publication Date
DK3143018T3 true DK3143018T3 (da) 2021-05-31

Family

ID=50735903

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15725195.0T DK3143018T3 (da) 2014-05-14 2015-05-14 Carboxamidderivater

Country Status (38)

Country Link
US (6) US9403810B2 (da)
EP (1) EP3143018B1 (da)
JP (1) JP6523338B2 (da)
KR (2) KR20230074827A (da)
CN (1) CN106661012B (da)
AP (1) AP2016009550A0 (da)
AR (1) AR100440A1 (da)
AU (1) AU2015259083B2 (da)
BR (1) BR112016026552B1 (da)
CA (1) CA2948543C (da)
CL (1) CL2016002839A1 (da)
CR (1) CR20160527A (da)
CU (1) CU24434B1 (da)
CY (1) CY1124251T1 (da)
DK (1) DK3143018T3 (da)
EA (1) EA030938B1 (da)
ES (1) ES2874882T3 (da)
HR (1) HRP20210783T1 (da)
HU (1) HUE054590T2 (da)
IL (1) IL248785B (da)
JO (1) JO3610B1 (da)
LT (1) LT3143018T (da)
MA (1) MA39983B1 (da)
MX (1) MX2016014939A (da)
MY (1) MY186598A (da)
PE (1) PE20171443A1 (da)
PH (1) PH12016502246A1 (da)
PL (1) PL3143018T3 (da)
PT (1) PT3143018T (da)
RS (1) RS61874B1 (da)
SG (1) SG11201609217UA (da)
SI (1) SI3143018T1 (da)
SV (1) SV2016005313A (da)
TN (1) TN2016000489A1 (da)
TW (2) TW201946921A (da)
UY (1) UY36124A (da)
WO (1) WO2015175796A1 (da)
ZA (1) ZA201607658B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201946921A (zh) 2014-05-14 2019-12-16 瑞士商諾華公司 甲醯胺衍生物
US9403833B2 (en) 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
CA3081424A1 (en) * 2017-11-01 2019-05-09 Bristol-Myers Squibb Company Spirocyclic compounds as farnesoid x receptor modulators
CN108689976B (zh) * 2018-07-23 2021-12-28 陕西师范大学 5-磺基水杨酸协同二氯二茂钛催化合成4-碘代四氢吡喃衍生物的方法
EP4211171A2 (en) 2020-09-10 2023-07-19 Precirix N.V. Antibody fragment against fap
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655009A1 (de) 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US7354722B1 (en) 1999-06-11 2008-04-08 Signal Pharmaceuticals Modulators of Smurf and BMP/TGFβ signaling pathways
JP2003502064A (ja) * 1999-06-11 2003-01-21 ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク BMPおよびTGFβシグナル伝達経路のアンタゴニスト
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
GB0312368D0 (en) 2003-05-30 2003-07-02 Univ Aston Novel ureido- and amido-pyrazolone derivatives
US20060281803A1 (en) 2003-09-23 2006-12-14 Lindsley Craig W Pyrazole modulators of metabotropic glutamate receptors
US7291743B2 (en) 2005-03-29 2007-11-06 Geneblue Corporation Isoxazole derivatives and methods of treating nitric oxide mediated diseases
WO2008121861A2 (en) 2007-03-28 2008-10-09 Xenon Pharmaceuticals Inc. Pyrazole and pyrrole compounds useful in treating iron disorders
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
CN101796036A (zh) 2007-08-02 2010-08-04 欧加农股份有限公司 作为trpv1调节剂的5-苯基异噁唑-3-甲酰胺衍生物
ES2477878T3 (es) 2007-08-22 2014-07-18 Irm Llc Compuestos y composiciones de 5-(4-(aloalcoxi)fenil)pirimidin-2-amina como inhibidores de quinasas
WO2009086303A2 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2011151361A1 (en) 2010-06-03 2011-12-08 Glaxo Group Limited Novel compounds
CA2823877C (en) 2011-02-18 2020-01-07 Actelion Pharmaceuticals Ltd Novel pyrazole and imidazole derivatives useful as orexin antagonists
US20170088546A1 (en) * 2014-05-14 2017-03-30 Novartis Ag Carboxamide inhibitors
US9403833B2 (en) * 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
MX2016014878A (es) 2014-05-14 2017-03-08 Pfizer Pirazolopiridinas y pirazolopirimidinas.
TW201946921A (zh) 2014-05-14 2019-12-16 瑞士商諾華公司 甲醯胺衍生物

Also Published As

Publication number Publication date
EA030938B1 (ru) 2018-10-31
US20230301970A1 (en) 2023-09-28
JO3610B1 (ar) 2020-08-27
HUE054590T2 (hu) 2021-09-28
PH12016502246B1 (en) 2017-01-09
CA2948543A1 (en) 2015-11-19
MA39983B1 (fr) 2021-05-31
MX2016014939A (es) 2017-02-28
CL2016002839A1 (es) 2017-01-27
IL248785B (en) 2020-04-30
EP3143018B1 (en) 2021-03-10
US20200268718A1 (en) 2020-08-27
MY186598A (en) 2021-07-29
HRP20210783T1 (hr) 2021-06-25
CU24434B1 (es) 2019-09-04
CN106661012B (zh) 2019-12-20
CN106661012A (zh) 2017-05-10
US9403810B2 (en) 2016-08-02
CU20160166A7 (es) 2017-03-03
US10195181B2 (en) 2019-02-05
ES2874882T3 (es) 2021-11-05
AU2015259083B2 (en) 2017-09-14
MA39983A (fr) 2017-03-22
PE20171443A1 (es) 2017-09-29
CR20160527A (es) 2017-04-28
BR112016026552A2 (pt) 2017-08-15
KR20230074827A (ko) 2023-05-31
JP2017515853A (ja) 2017-06-15
TW201946921A (zh) 2019-12-16
AP2016009550A0 (en) 2016-11-30
EP3143018A1 (en) 2017-03-22
KR102534033B1 (ko) 2023-05-19
US20170014388A1 (en) 2017-01-19
US11672782B2 (en) 2023-06-13
US20210052554A1 (en) 2021-02-25
IL248785A0 (en) 2017-01-31
NZ725918A (en) 2023-09-29
CY1124251T1 (el) 2022-07-22
BR112016026552B1 (pt) 2023-02-14
LT3143018T (lt) 2021-06-10
SV2016005313A (es) 2018-06-12
JP6523338B2 (ja) 2019-05-29
BR112016026552A8 (pt) 2021-07-06
UY36124A (es) 2016-01-08
AU2015259083A1 (en) 2016-11-24
RS61874B1 (sr) 2021-06-30
EA201692300A1 (ru) 2017-04-28
SI3143018T1 (sl) 2021-08-31
PH12016502246A1 (en) 2017-01-09
PT3143018T (pt) 2021-06-01
US20150329529A1 (en) 2015-11-19
ZA201607658B (en) 2017-09-27
WO2015175796A1 (en) 2015-11-19
CA2948543C (en) 2022-08-16
KR20170003666A (ko) 2017-01-09
SG11201609217UA (en) 2016-12-29
TW201623296A (zh) 2016-07-01
TN2016000489A1 (en) 2018-04-04
PL3143018T3 (pl) 2021-08-30
TWI714528B (zh) 2021-01-01
AR100440A1 (es) 2016-10-05
US20190381011A1 (en) 2019-12-19

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