DK3142672T3 - Amphotericin b-derivat med reduceret toksicitet - Google Patents
Amphotericin b-derivat med reduceret toksicitet Download PDFInfo
- Publication number
- DK3142672T3 DK3142672T3 DK15793421.7T DK15793421T DK3142672T3 DK 3142672 T3 DK3142672 T3 DK 3142672T3 DK 15793421 T DK15793421 T DK 15793421T DK 3142672 T3 DK3142672 T3 DK 3142672T3
- Authority
- DK
- Denmark
- Prior art keywords
- amphotericin
- derivative
- reduced toxicity
- toxicity
- reduced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461994450P | 2014-05-16 | 2014-05-16 | |
| US201462045907P | 2014-09-04 | 2014-09-04 | |
| PCT/US2015/030965 WO2015175875A1 (en) | 2014-05-16 | 2015-05-15 | Amphotericin b derivative with reduced toxicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3142672T3 true DK3142672T3 (da) | 2019-10-21 |
Family
ID=54480735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15793421.7T DK3142672T3 (da) | 2014-05-16 | 2015-05-15 | Amphotericin b-derivat med reduceret toksicitet |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9738677B2 (da) |
| EP (1) | EP3142672B1 (da) |
| JP (1) | JP6543272B2 (da) |
| CA (1) | CA2981288C (da) |
| DK (1) | DK3142672T3 (da) |
| ES (1) | ES2749927T3 (da) |
| WO (1) | WO2015175875A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10087206B2 (en) * | 2014-10-17 | 2018-10-02 | The Board Of Trustees Of The University Of Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin B |
| US9957290B2 (en) | 2015-04-15 | 2018-05-01 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin B |
| AU2019335409A1 (en) | 2018-09-07 | 2021-05-06 | The Board Of Trustees Of The University Of Illinois | Hybrid amphotericin B derivatives with reduced toxicity |
| EP4009984A4 (en) * | 2019-08-08 | 2023-09-06 | The Board Of Trustees Of The University Of Illinois | HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY |
| WO2021030183A1 (en) * | 2019-08-09 | 2021-02-18 | The Board Of Trustees Of The University Of Illinois | Combination treatment of systemic fungal infections |
| WO2024010968A2 (en) * | 2022-07-08 | 2024-01-11 | The Board Of Trustees Of The University Of Illinois | Transfer of c2'-epimerized sugars to the amphotericin b aglycone |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521418B2 (en) | 2003-05-27 | 2009-04-21 | Theravance, Inc. | Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent |
| JP2008503586A (ja) * | 2004-06-21 | 2008-02-07 | ネクター セラピューティクス | アンフォテリシンｂを含む組成物、方法、およびシステム |
| US8513204B2 (en) | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
| WO2014059436A1 (en) * | 2012-10-12 | 2014-04-17 | The Board Of Trustees Of The University Of Illinois | Electronic tuning of site selectivity |
| US10087206B2 (en) * | 2014-10-17 | 2018-10-02 | The Board Of Trustees Of The University Of Illinois | Scalable synthesis of reduced toxicity derivative of amphotericin B |
-
2015
- 2015-05-15 EP EP15793421.7A patent/EP3142672B1/en active Active
- 2015-05-15 ES ES15793421T patent/ES2749927T3/es active Active
- 2015-05-15 US US15/310,815 patent/US9738677B2/en active Active
- 2015-05-15 CA CA2981288A patent/CA2981288C/en active Active
- 2015-05-15 JP JP2016567865A patent/JP6543272B2/ja active Active
- 2015-05-15 WO PCT/US2015/030965 patent/WO2015175875A1/en active Application Filing
- 2015-05-15 DK DK15793421.7T patent/DK3142672T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3142672A4 (en) | 2017-11-15 |
| JP2017518982A (ja) | 2017-07-13 |
| WO2015175875A1 (en) | 2015-11-19 |
| US9738677B2 (en) | 2017-08-22 |
| JP6543272B2 (ja) | 2019-07-10 |
| EP3142672B1 (en) | 2019-09-25 |
| CA2981288C (en) | 2022-12-06 |
| US20170088572A1 (en) | 2017-03-30 |
| ES2749927T3 (es) | 2020-03-24 |
| CA2981288A1 (en) | 2015-11-19 |
| EP3142672A1 (en) | 2017-03-22 |
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