DK3126490T3 - Kunstigt tredimensionalt brystvæv, fedtvæv og tumorsygdomsmodel - Google Patents

Kunstigt tredimensionalt brystvæv, fedtvæv og tumorsygdomsmodel Download PDF

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Publication number
DK3126490T3
DK3126490T3 DK14887943.0T DK14887943T DK3126490T3 DK 3126490 T3 DK3126490 T3 DK 3126490T3 DK 14887943 T DK14887943 T DK 14887943T DK 3126490 T3 DK3126490 T3 DK 3126490T3
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Denmark
Prior art keywords
tissue
artificial
disease model
tumor disease
dimensional breast
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DK14887943.0T
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English (en)
Inventor
Rosalie Sears
Ellen Langer
Shelby Marie King
Deborah Lynn Greene Nguyen
Vivian A Gorgen
Benjamin R Shepherd
Sharon C Presnell
Brittany Allen-Petersen
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Organovo Inc
Univ Oregon Health & Science
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0656—Adult fibroblasts
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1305—Adipocytes
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
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    • C12N2513/00—3D culture
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

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  • Tropical Medicine & Parasitology (AREA)
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  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK14887943.0T 2014-04-04 2014-06-06 Kunstigt tredimensionalt brystvæv, fedtvæv og tumorsygdomsmodel DK3126490T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461975640P 2014-04-04 2014-04-04
US201461976895P 2014-04-08 2014-04-08
PCT/US2014/041419 WO2015152954A1 (en) 2014-04-04 2014-06-06 Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Publications (1)

Publication Number Publication Date
DK3126490T3 true DK3126490T3 (da) 2021-01-04

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DK14887943.0T DK3126490T3 (da) 2014-04-04 2014-06-06 Kunstigt tredimensionalt brystvæv, fedtvæv og tumorsygdomsmodel

Country Status (10)

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US (5) US20170023550A1 (da)
EP (2) EP3126490B1 (da)
JP (1) JP2017518070A (da)
KR (1) KR20170013865A (da)
CN (1) CN106536720B (da)
AU (1) AU2014389440A1 (da)
CA (2) CA3177480A1 (da)
DK (1) DK3126490T3 (da)
IL (1) IL248164A0 (da)
WO (1) WO2015152954A1 (da)

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US9983195B2 (en) 2018-05-29
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US20170023550A1 (en) 2017-01-26
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US20240168010A1 (en) 2024-05-23
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