DK3087083T3 - Systemisk opdagelse, modning og forlængelse af peptidbindere til proteiner - Google Patents

Systemisk opdagelse, modning og forlængelse af peptidbindere til proteiner Download PDF

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Publication number
DK3087083T3
DK3087083T3 DK14821163.4T DK14821163T DK3087083T3 DK 3087083 T3 DK3087083 T3 DK 3087083T3 DK 14821163 T DK14821163 T DK 14821163T DK 3087083 T3 DK3087083 T3 DK 3087083T3
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DK
Denmark
Prior art keywords
maturation
proteins
extension
peptide binders
systemic
Prior art date
Application number
DK14821163.4T
Other languages
English (en)
Inventor
Victor Lyamichev
Thomas Albert
Jigar Patel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
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Publication of DK3087083T3 publication Critical patent/DK3087083T3/da

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57434Specifically defined cancers of prostate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/36Assays involving biological materials from specific organisms or of a specific nature from bacteria from Actinomyces; from Streptomyces (G)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK14821163.4T 2013-12-27 2014-12-19 Systemisk opdagelse, modning og forlængelse af peptidbindere til proteiner DK3087083T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361921263P 2013-12-27 2013-12-27
US201361921259P 2013-12-27 2013-12-27
PCT/EP2014/078658 WO2015097077A2 (en) 2013-12-27 2014-12-19 Systemic discovery, maturation and extension of peptide binders to proteins

Publications (1)

Publication Number Publication Date
DK3087083T3 true DK3087083T3 (da) 2019-12-16

Family

ID=52273134

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14821163.4T DK3087083T3 (da) 2013-12-27 2014-12-19 Systemisk opdagelse, modning og forlængelse af peptidbindere til proteiner

Country Status (5)

Country Link
US (2) US10161938B2 (da)
EP (1) EP3087083B1 (da)
JP (1) JP6312225B2 (da)
DK (1) DK3087083T3 (da)
WO (1) WO2015097077A2 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016100735A1 (en) 2014-12-19 2016-06-23 Roche Nimblegen, Inc. Microbial transglutaminases, substrates therefor and methods for the use thereof
JP2018513166A (ja) * 2015-04-20 2018-05-24 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 系統的な探索、成熟化および伸長プロセスにより同定した、タンパク質に対する特異的ペプチドバインダー
US10641778B2 (en) 2015-08-25 2020-05-05 Roche Sequencing Solutions, Inc. System and method for analysis of peptide synthesis fidelity
US10427126B2 (en) * 2015-10-28 2019-10-01 Roche Sequencing Solutions, Inc. System and method for longitudinal analysis of peptide synthesis
CA3006617A1 (en) * 2015-11-30 2017-06-08 F. Hoffmann-La Roche Ag System and method for identification of protease substrates
EP3497446B1 (en) 2016-08-15 2021-04-28 F. Hoffmann-La Roche AG Method and composition for detection of peptide cyclization using protein tags
JP6872024B2 (ja) 2016-10-04 2021-05-19 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 合成分類指標の同定のためのシステムおよび方法
JP2020514746A (ja) 2016-12-01 2020-05-21 ノーティラス バイオテクノロジー インコーポレイテッド タンパク質をアッセイする方法
WO2018165328A1 (en) * 2017-03-07 2018-09-13 Recombipure, Inc. Compositions, methods, and systems for affinity-based protein identification and purification
CN111566261A (zh) * 2017-08-18 2020-08-21 诺迪勒思生物科技公司 选择结合试剂的方法
EP3775196A4 (en) 2018-04-04 2021-12-22 Nautilus Biotechnology, Inc. NANOREWAL AND MICROREWAL GENERATION PROCESSES
JP2022512761A (ja) * 2018-10-22 2022-02-07 エフ.ホフマン-ラ ロシュ アーゲー 関節リウマチ自己抗体レパートリーのプロファイリング及びそのためのペプチド分類子
US11993865B2 (en) 2018-11-20 2024-05-28 Nautilus Subsidiary, Inc. Selection of affinity reagents
JP2022538433A (ja) 2019-06-27 2022-09-02 ロシュ シークエンシング ソリューションズ,インコーポレイティド 増強された部分配列多様性を有するペプチドライブラリ及びその使用方法
CN116096405A (zh) * 2020-05-12 2023-05-09 Cue生物制药股份有限公司 多聚体t细胞调节多肽及其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ299048A (en) 1992-03-06 1998-09-24 Innogenetics Sa Nv Modified peptides corresponding to immunologically useful epitopes in hiv, hcv and htlv and their use especially when biotinylated
EP0772773B1 (en) 1994-07-22 2006-04-05 The University Of North Carolina Src SH3 BINDING PEPTIDES AND METHODS OF ISOLATING AND USING SAME
DK0868427T3 (da) * 1995-12-18 2003-09-15 Praecis Pharm Inc Fremgangsmåder til at idenficere forbindelser, der binder til et mål
EP1197755A1 (en) * 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
DE60223922T2 (de) * 2001-05-07 2008-11-27 Hipep Laboratories Peptidimmobilisierte grundplatte und verfahren zum testen eines zielproteins unter verwendung derselben
US20050267020A1 (en) 2001-09-27 2005-12-01 Olivier Faure Polypeptides derived from inducible hsp70 and pharmaceutical compositions containing the same
EP1576172A2 (en) 2002-06-21 2005-09-21 Dyax Corporation Serum protein-associated target-specific ligands and identification method therefor
US20040018886A1 (en) 2002-07-24 2004-01-29 Burrows Bruce D. Temporary golf club shaft-component connection
MXPA06002311A (es) 2003-09-05 2006-05-19 Genencor Int Epitopos de celulas t cd8+ del virus del papiloma humano (vph).
JP2007527539A (ja) * 2004-03-05 2007-09-27 ザ スクリプス リサーチ インスティテュート ハイスループットグリカンマイクロアレイ
WO2010052939A1 (ja) 2008-11-10 2010-05-14 国立大学法人名古屋大学 アレルゲンのエピトープ又はその候補の検出方法及びその利用
WO2013119845A1 (en) * 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
JP5495457B1 (ja) 2013-08-30 2014-05-21 東レバッテリーセパレータフィルム株式会社 電池用セパレータ及びその電池用セパレータの製造方法

Also Published As

Publication number Publication date
EP3087083B1 (en) 2019-10-16
JP6312225B2 (ja) 2018-04-18
US20190086411A1 (en) 2019-03-21
JP2017504795A (ja) 2017-02-09
WO2015097077A3 (en) 2015-08-13
EP3087083A2 (en) 2016-11-02
US10976317B2 (en) 2021-04-13
WO2015097077A2 (en) 2015-07-02
US10161938B2 (en) 2018-12-25
US20150185216A1 (en) 2015-07-02

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