DK3039033T3 - Bindende polypeptider, der har et muteret skelet - Google Patents

Bindende polypeptider, der har et muteret skelet Download PDF

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Publication number
DK3039033T3
DK3039033T3 DK14755841.5T DK14755841T DK3039033T3 DK 3039033 T3 DK3039033 T3 DK 3039033T3 DK 14755841 T DK14755841 T DK 14755841T DK 3039033 T3 DK3039033 T3 DK 3039033T3
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DK
Denmark
Prior art keywords
skeld
mutter
binding polypeptides
polypeptides
binding
Prior art date
Application number
DK14755841.5T
Other languages
English (en)
Inventor
Erik Nordling
Joakim Nilsson
Patrik Strömberg
Original Assignee
Affibody Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affibody Ab filed Critical Affibody Ab
Application granted granted Critical
Publication of DK3039033T3 publication Critical patent/DK3039033T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1044Preparation or screening of libraries displayed on scaffold proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Urology & Nephrology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK14755841.5T 2013-08-28 2014-08-28 Bindende polypeptider, der har et muteret skelet DK3039033T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13182022 2013-08-28
PCT/EP2014/068259 WO2015028550A1 (en) 2013-08-28 2014-08-28 C5 binding polypeptides

Publications (1)

Publication Number Publication Date
DK3039033T3 true DK3039033T3 (da) 2019-08-26

Family

ID=49034001

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14755841.5T DK3039033T3 (da) 2013-08-28 2014-08-28 Bindende polypeptider, der har et muteret skelet

Country Status (20)

Country Link
US (2) US9982022B2 (da)
EP (1) EP3039033B1 (da)
JP (2) JP7138411B2 (da)
KR (2) KR20160068744A (da)
CN (3) CN117964710A (da)
AU (1) AU2014314214C1 (da)
BR (1) BR112016003336A2 (da)
CA (1) CA2920005C (da)
DK (1) DK3039033T3 (da)
ES (1) ES2742505T3 (da)
IL (1) IL243849A0 (da)
LT (1) LT3039033T (da)
MX (1) MX367423B (da)
MY (1) MY176200A (da)
PL (1) PL3039033T3 (da)
PT (1) PT3039033T (da)
RU (1) RU2714156C2 (da)
TR (1) TR201911279T4 (da)
WO (1) WO2015028550A1 (da)
ZA (1) ZA201600721B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9808502B2 (en) 2012-02-20 2017-11-07 Swedish Orphan Biovitrum Ab (Publ) Polypeptides binding to human complement C5
BR112015021730A2 (pt) 2013-03-15 2017-08-29 Affibody Ab POLIPEPTÍDEO DE LIGAÇÃO AO FcRn, PROTEÍNA DE FUSÃO OU CONJUGADO, POLINUCLEOTÍDEO QUE CODIFICA UM POLIPEPTÍDEO, COMPOSIÇÃO, POLIPEPTÍDEO DE LIGAÇÃO AO FcRn, PROTEÍNA DE FUSÃO OU CONJUGADO E POLIPEPTÍDEO DE LIGAÇÃO AO FcRn, PROTEÍNA DE FUSÃO, CONJUGADO OU COMPOSIÇÃO PARA USO
PT3038633T (pt) * 2013-08-28 2021-01-14 Ipc Res Llc Polipéptidos estáveis que se ligam ao complemento humano c5
MY180477A (en) * 2014-09-17 2020-11-30 Affibody Ab New polypeptides
CN117327188A (zh) 2017-07-11 2024-01-02 亚力兄制药公司 结合补体成分c5或血清白蛋白的多肽及其融合蛋白
CN114144433A (zh) 2019-03-22 2022-03-04 反射制药有限公司 用于目标蛋白的多价d-肽化合物
CN114989298A (zh) 2019-03-22 2022-09-02 反射制药有限公司 针对vegf的d-肽化合物
WO2021089695A1 (en) * 2019-11-05 2021-05-14 Affibody Ab Polypeptides
US20240124533A1 (en) 2021-02-15 2024-04-18 Affibody Ab New her2-binding polypeptide
AU2022377077A1 (en) * 2021-11-01 2024-05-16 Ipc Research, Llc Administration of c5-binding proteins

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
AU8957091A (en) 1990-11-26 1992-06-25 Public Health Laboratory Service Board Immunoglobulin-binding proteins and recombinant dna molecules coding therefor
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
SE9901379D0 (sv) * 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
DK1325033T3 (da) 2000-10-10 2010-04-06 Genentech Inc Inhibering af komplement C5 aktivering til behandlingen og forebyggelsen af forsinket xenograf- eller akut vaskulær afstødning
AT410798B (de) 2001-01-26 2003-07-25 Cistem Biotechnologies Gmbh Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
MX342385B (es) 2001-08-17 2016-09-27 Genentech Inc Inhibidores de la ruta del complemento que se unen a c5 y c5a sin evitar la formación de c5b.
ITMI20021527A1 (it) 2002-07-11 2004-01-12 Consiglio Nazionale Ricerche Anticorpi anti componente c5 del complemento e loro uso
WO2005023866A2 (en) 2003-09-10 2005-03-17 Baxter International Inc. Peptides that inhibit complement activation
SE0400274D0 (sv) * 2004-02-09 2004-02-09 Affibody Ab New polypeptide
GB0518443D0 (en) 2005-09-09 2005-10-19 Evolutec Ltd Method of treating myasthenia gravis
EP3167888B1 (en) 2006-03-15 2024-05-01 Alexion Pharmaceuticals, Inc. Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
EP2190863B1 (en) 2007-07-31 2015-09-02 Affibody AB New albumin binding compositions, methods and uses
EP2077272A1 (en) 2007-12-21 2009-07-08 Affibody AB Polypeptide libraries with a predetermined scaffold
US9187535B2 (en) 2007-12-19 2015-11-17 Affibody Ab Polypeptide derived from protein A and able to bind PDGF
EP2231860B1 (en) 2007-12-19 2011-10-05 Affibody AB Polypeptide derived from protein a and able to bind pdgf
EP2072525A1 (en) 2007-12-21 2009-06-24 Affibody AB New polypeptides having affinity for HER2
CN102170906B (zh) 2008-08-05 2014-07-30 诺华股份有限公司 靶定补体蛋白c5的抗体的组合物和方法
WO2011056124A1 (en) 2009-11-04 2011-05-12 Affibody Ab Her3 binding polypeptides
EP2327725A1 (en) 2009-11-26 2011-06-01 InflaRx GmbH Anti-C5a binding moieties with high blocking activity
DK2933262T3 (da) 2010-07-09 2018-06-25 Affibody Ab Polypeptider
US8859726B2 (en) 2010-11-29 2014-10-14 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix
CN102127554B (zh) 2010-12-22 2012-07-25 南京农业大学 一种日本脑炎颗粒疫苗及其制备方法和应用
US9005992B2 (en) * 2011-03-18 2015-04-14 Postech Academy-Industry Foundation Immobilizing fusion protein for effective and oriented immobilization of antibody on surfaces
US9808502B2 (en) 2012-02-20 2017-11-07 Swedish Orphan Biovitrum Ab (Publ) Polypeptides binding to human complement C5
JP5980104B2 (ja) 2012-11-22 2016-08-31 三菱電機株式会社 液晶表示装置の製造方法および液晶表示装置の製造システム
WO2014096163A1 (en) 2012-12-19 2014-06-26 Affibody Ab New polypeptides
PT3038633T (pt) * 2013-08-28 2021-01-14 Ipc Res Llc Polipéptidos estáveis que se ligam ao complemento humano c5

Also Published As

Publication number Publication date
KR102497083B1 (ko) 2023-02-07
AU2014314214B2 (en) 2018-07-12
WO2015028550A1 (en) 2015-03-05
JP2016535061A (ja) 2016-11-10
BR112016003336A2 (pt) 2017-11-21
LT3039033T (lt) 2019-10-25
CN116987154A (zh) 2023-11-03
IL243849A0 (en) 2016-04-21
NZ716426A (en) 2021-10-29
PT3039033T (pt) 2019-09-06
WO2015028550A8 (en) 2015-05-21
US9982022B2 (en) 2018-05-29
JP2020180133A (ja) 2020-11-05
MX2016002208A (es) 2016-06-28
MY176200A (en) 2020-07-24
EP3039033A1 (en) 2016-07-06
AU2014314214C1 (en) 2019-01-24
PL3039033T3 (pl) 2020-01-31
KR20160068744A (ko) 2016-06-15
CA2920005C (en) 2023-11-28
US20160200772A1 (en) 2016-07-14
KR20220021007A (ko) 2022-02-21
CA2920005A1 (en) 2015-03-05
USRE49495E1 (en) 2023-04-18
AU2014314214A1 (en) 2016-03-03
RU2714156C2 (ru) 2020-02-12
TR201911279T4 (tr) 2019-08-21
CN105473606A (zh) 2016-04-06
JP7138411B2 (ja) 2022-09-16
CN117964710A (zh) 2024-05-03
EP3039033B1 (en) 2019-06-19
RU2016108976A (ru) 2017-10-04
ES2742505T3 (es) 2020-02-14
RU2016108976A3 (da) 2018-04-26
ZA201600721B (en) 2020-05-27
MX367423B (es) 2019-08-21

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