DK3019166T3 - A Pharmaceutical Combination for the Treatment of Melanoma - Google Patents

A Pharmaceutical Combination for the Treatment of Melanoma Download PDF

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Publication number
DK3019166T3
DK3019166T3 DK14822283.9T DK14822283T DK3019166T3 DK 3019166 T3 DK3019166 T3 DK 3019166T3 DK 14822283 T DK14822283 T DK 14822283T DK 3019166 T3 DK3019166 T3 DK 3019166T3
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DK
Denmark
Prior art keywords
melanoma
treatment
pharmaceutical combination
pharmaceutical
combination
Prior art date
Application number
DK14822283.9T
Other languages
English (en)
Inventor
Veena Agarwal
Giridharan Periyasamy
Maggie Rathos
Ankita Srivastava
Sreesha Srinivasa
Original Assignee
Piramal Entpr Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piramal Entpr Ltd filed Critical Piramal Entpr Ltd
Application granted granted Critical
Publication of DK3019166T3 publication Critical patent/DK3019166T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK14822283.9T 2013-07-12 2014-07-11 A Pharmaceutical Combination for the Treatment of Melanoma DK3019166T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361845749P 2013-07-12 2013-07-12
PCT/IB2014/063022 WO2015004636A1 (en) 2013-07-12 2014-07-11 A pharmaceutical combination for the treatment of melanoma

Publications (1)

Publication Number Publication Date
DK3019166T3 true DK3019166T3 (da) 2019-07-29

Family

ID=52279411

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14822283.9T DK3019166T3 (da) 2013-07-12 2014-07-11 A Pharmaceutical Combination for the Treatment of Melanoma

Country Status (12)

Country Link
US (4) US11007174B2 (da)
EP (1) EP3019166B1 (da)
JP (5) JP6568060B2 (da)
CN (3) CN111053768B (da)
AR (1) AR096892A1 (da)
AU (1) AU2014288857B2 (da)
CA (1) CA2917742C (da)
DK (1) DK3019166T3 (da)
ES (1) ES2733929T3 (da)
IL (1) IL243572B (da)
TW (2) TWI680760B (da)
WO (1) WO2015004636A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2917742C (en) 2013-07-12 2020-04-14 Piramal Enterprises Limited A pharmaceutical combination for the treatment of melanoma
CN117257802A (zh) * 2015-06-05 2023-12-22 伊利诺伊大学董事会 Pac-1联合疗法
WO2017004122A1 (en) * 2015-06-30 2017-01-05 Genentech, Inc. Immediate-release tablets containing a drug and processes for forming the tablets
CA3017963A1 (en) * 2016-03-16 2017-09-21 Dicerna Pharmaceuticals, Inc. Compositions and methods for the treatment of a beta-catenin-associated disease or disorder
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
AU2018269982A1 (en) * 2017-05-16 2020-01-02 Biomed Valley Discoveries, Inc. Compositions and methods for treating cancer with atypical BRAF mutations
WO2019099873A1 (en) 2017-11-17 2019-05-23 The Board Of Trustees Of The University Of Illinois Cancer therapy by degrading dual mek signaling
CN107827726B (zh) * 2017-11-28 2020-09-15 辽宁中医药大学 马齿苋中化合物Oleracone E及其提取分离方法
CN108591464B (zh) * 2018-06-28 2020-06-23 宁波奥克斯高科技有限公司 一种气体绝缘开关柜用密封结构
AU2020271908A1 (en) * 2019-04-11 2021-11-04 Mei Pharma, Inc. Voruciclib poly morphs and methods of making and using thereof
WO2021229439A1 (en) * 2020-05-12 2021-11-18 Novartis Ag Therapeutic combinations comprising a craf inhibitor
CN112168821B (zh) * 2020-11-09 2022-10-14 中南大学湘雅医院 一种治疗维罗非尼耐药的黑色素瘤的联合用药物及其应用
EP4247806A1 (en) * 2020-11-19 2023-09-27 MEI Pharma, Inc. Treatment of kras mutant cancers

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164232B (da) 1986-04-11 1989-02-04 Hoechst India
USH1427H (en) 1988-04-06 1995-04-04 Briet; Phillipe Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2
US5116954A (en) 1988-04-06 1992-05-26 Lipha, Lyonnaise Industrielle Pharmaceutique Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety
US5284856A (en) 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5723313A (en) 1995-09-27 1998-03-03 St. Jude Children's Research Hospital ARF-p19, a novel regulator of the mammalian cell cycle
US5733920A (en) 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US5849733A (en) 1996-05-10 1998-12-15 Bristol-Myers Squibb Co. 2-thio or 2-oxo flavopiridol analogs
US6281223B1 (en) 1999-04-13 2001-08-28 Supergen, Inc. Radioenhanced camptothecin derivative cancer treatments
CN100355751C (zh) 2000-03-29 2007-12-19 西克拉塞尔有限公司 2-取代的4-杂芳基-嘧啶、其组合物及其用途
CN1433410A (zh) 2000-05-03 2003-07-30 株式会社Lg生命科学 具有3-羟基色烯-4-酮结构的cdk抑制剂
CN1245974C (zh) 2000-06-28 2006-03-22 特瓦制药工业有限公司 卡维地洛
TWI331034B (en) * 2002-07-08 2010-10-01 Piramal Life Sciences Ltd Inhibitors of cyclin-dependent kinases and their use
US7884127B2 (en) 2002-07-08 2011-02-08 Pirimal Life Sciences Ltd. Inhibitors of cyclin dependent kinases and their use
US7915301B2 (en) 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
US7271193B2 (en) * 2002-07-08 2007-09-18 Nicholas Piramal India, Ltd. Inhibitors of cyclin-dependent kinases and their use
EP1558289A1 (en) 2002-11-06 2005-08-03 Cyclacel Limited Pharmaceutical composition comprising a cdk inhibitor and gemcitabine
GB0328180D0 (en) 2003-12-04 2004-01-07 Cyclacel Ltd Combination
CA2548491A1 (en) 2003-12-08 2005-06-23 The Arizona Board Of Regents On Behalf Of The University Of Arizona Synergistic anti-cancer compositions
WO2006099193A2 (en) 2005-03-11 2006-09-21 The Regents Of The University Of Michigan Chromen-4-one inhibitors of anti-apoptotic bcl-2 family members and the uses thereof
EP1893612B1 (en) * 2005-06-22 2011-08-03 Plexxikon, Inc. Pyrrolo [2, 3-b]pyridine derivatives as protein kinase inhibitors
ES2491140T3 (es) 2006-06-21 2014-09-05 Piramal Enterprises Limited Derivados de flavona enantioméricamente puros para el tratamiento de trastornos proliferativos y procesos para su preparación
US7951961B2 (en) 2006-07-07 2011-05-31 Piramal Life Sciences Limited Enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof
GB0706633D0 (en) 2007-04-04 2007-05-16 Cyclacel Ltd Combination
EP2154971B1 (en) * 2007-05-15 2011-12-28 Piramal Life Sciences Limited A synergistic pharmaceutical combination for the treatment of cancer
US20100152129A1 (en) * 2008-03-31 2010-06-17 Periyasamy Giridharan Novel synergistic combination of gemcitabine with P276-00 or P1446A in treatment of cancer
TWI461194B (zh) * 2009-05-05 2014-11-21 Piramal Entpr Ltd 吡咯啶取代黃酮作為輻射致敏劑
CN103037860A (zh) 2010-02-26 2013-04-10 皮拉马尔企业有限公司 用于治疗炎症性疾病的吡咯烷取代的黄酮
CN101841463B (zh) * 2010-03-05 2012-05-16 清华大学 基于sctp的多路径并发传输方法
EP2608790A4 (en) * 2010-08-26 2014-04-02 Glaxosmithkline Llc PHARMACEUTICAL COMBINATION OF A VEGFR-INHIBITOR AND A MEK-INHIBITOR FOR THE TREATMENT OF CANCER
JP2013543008A (ja) 2010-11-19 2013-11-28 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッド Braf阻害剤による治療方法
CN104220066A (zh) 2010-11-19 2014-12-17 皮拉马尔企业有限公司 紫杉醇和cdk抑制剂药物组合物
TW201242597A (en) * 2011-03-14 2012-11-01 Piramal Life Sciences Ltd A synergistic pharmaceutical combination for the treatment of pancreatic cancer
TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
US20120321637A1 (en) * 2011-06-20 2012-12-20 The Board Of Regents Of The University Of Texas System Combination cancer therapy with herv inhibition
JP2014517063A (ja) 2011-06-24 2014-07-17 ピラマル エンタープライジーズ リミテッド ヒトパピローマウイルスと関連するがんを処置するための化合物
IN2014MN01546A (da) 2012-01-13 2015-05-08 Piramal Entpr Ltd
WO2014049515A1 (en) 2012-09-25 2014-04-03 Piramal Enterprises Limited Pyrrolidine substituted flavones for treatment of renal cystic diseases
WO2014128523A1 (en) 2013-02-19 2014-08-28 Piramal Enterprises Limited A process for preparation of an intermediate of the pyrrolidine substituted flavones
CA2917742C (en) 2013-07-12 2020-04-14 Piramal Enterprises Limited A pharmaceutical combination for the treatment of melanoma
EP3148532B1 (en) 2014-05-28 2021-03-03 Piramal Enterprises Limited Pharmaceutical combination comprising a cdk inhibitor and a thioredoxin reductase inhibitor for the treatment of cancer

Also Published As

Publication number Publication date
CN105530931A (zh) 2016-04-27
AR096892A1 (es) 2016-02-03
TW202233177A (zh) 2022-09-01
ES2733929T3 (es) 2019-12-03
CN111053768A (zh) 2020-04-24
AU2014288857A1 (en) 2016-02-04
JP6568060B2 (ja) 2019-08-28
TW201534297A (zh) 2015-09-16
TWI680760B (zh) 2020-01-01
US20190282544A1 (en) 2019-09-19
WO2015004636A1 (en) 2015-01-15
CA2917742C (en) 2020-04-14
CN105530931B (zh) 2019-11-08
JP2019206565A (ja) 2019-12-05
US20210393589A1 (en) 2021-12-23
CN111053768B (zh) 2023-12-12
JP2016525097A (ja) 2016-08-22
EP3019166A4 (en) 2017-04-19
JP2024037891A (ja) 2024-03-19
JP2022068335A (ja) 2022-05-09
US11839591B2 (en) 2023-12-12
CA2917742A1 (en) 2015-01-15
AU2014288857B2 (en) 2019-03-14
EP3019166A1 (en) 2016-05-18
IL243572B (en) 2019-10-31
CN117731786A (zh) 2024-03-22
US11007174B2 (en) 2021-05-18
JP2021001186A (ja) 2021-01-07
EP3019166B1 (en) 2019-05-08
TW202031253A (zh) 2020-09-01
US20240165076A1 (en) 2024-05-23
US20160136132A1 (en) 2016-05-19
IL243572A0 (en) 2016-02-29

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