DK3016665T3 - Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser - Google Patents

Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser Download PDF

Info

Publication number
DK3016665T3
DK3016665T3 DK14753019T DK14753019T DK3016665T3 DK 3016665 T3 DK3016665 T3 DK 3016665T3 DK 14753019 T DK14753019 T DK 14753019T DK 14753019 T DK14753019 T DK 14753019T DK 3016665 T3 DK3016665 T3 DK 3016665T3
Authority
DK
Denmark
Prior art keywords
treatment
stem cells
conditioned medium
human adult
adult liver
Prior art date
Application number
DK14753019T
Other languages
English (en)
Inventor
Mustapha Najimi
Etienne Sokal
Silvia Berardis
Original Assignee
Univ Catholique Louvain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Catholique Louvain filed Critical Univ Catholique Louvain
Application granted granted Critical
Publication of DK3016665T3 publication Critical patent/DK3016665T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
DK14753019T 2013-07-05 2014-07-07 Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser DK3016665T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13175442 2013-07-05
PCT/EP2014/064437 WO2015001124A1 (en) 2013-07-05 2014-07-07 Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders

Publications (1)

Publication Number Publication Date
DK3016665T3 true DK3016665T3 (da) 2019-11-25

Family

ID=48792979

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14753019T DK3016665T3 (da) 2013-07-05 2014-07-07 Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser

Country Status (6)

Country Link
US (3) US20160129047A1 (da)
EP (1) EP3016665B1 (da)
JP (1) JP6474394B2 (da)
DK (1) DK3016665T3 (da)
ES (1) ES2759228T3 (da)
WO (1) WO2015001124A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2759228T3 (es) 2013-07-05 2020-05-08 Univ Catholique Louvain Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
JP2017530697A (ja) * 2014-08-28 2017-10-19 プロメセラ バイオサイエンシーズ エス．アー．／エンヌ．フェー． 成体肝前駆細胞を作製する方法
CL2015002971A1 (es) * 2015-10-05 2016-06-24 Univ Del Desarrollo Composición biofarmacológica que comprende componentes producidos y/o secretados por células troncales mesenquimales (msc), que permite recuperar la capacidad regenerativa tisular, en una situación de esteatosis hepática, o donde la capacidad de regeneración endógena del tejido hepático se encuentra inhibida
MA45274A (fr) * 2016-03-02 2019-01-09 Univ Catholique Louvain Préparations améliorées de cellules progénitrices hépatiques adultes
WO2017191234A1 (en) * 2016-05-06 2017-11-09 Unicyte Ev Ag Pharmaceutical carriers containing mirnas for use in the treatment of fibrotic diseases caused by hyperglycemia
SG11202110476YA (en) 2019-03-26 2021-10-28 Promethera Therapeutics Sa Adult liver progenitor cells for treating acute-on-chronic liver failure
KR20220081368A (ko) 2019-10-09 2022-06-15 셀라온 에스에이 혈관 과투과성을 특징으로 하는 장애에서 간 전구세포 또는 줄기세포, 이의 용해물 및/또는 조건화 배지의 사용
EP3881853A1 (en) * 2020-03-20 2021-09-22 Promethera Therapeutics Sa Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation
CN113621557A (zh) * 2021-09-02 2021-11-09 中国烟草总公司郑州烟草研究院 一种人肝微粒体与细胞共培养体系及其构建方法和应用
CN114748505A (zh) * 2022-01-17 2022-07-15 桂林医学院 骨髓间充质干细胞外泌体的应用
WO2023180122A1 (en) 2022-03-24 2023-09-28 Université Catholique de Louvain Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2917998B2 (ja) 1988-02-05 1999-07-12 ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ 修飾された肝細胞およびその用途
US6069005A (en) 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
WO1994008598A1 (en) 1992-10-09 1994-04-28 Advanced Tissue Sciences, Inc. Liver reserve cells
US6576434B1 (en) 1998-03-03 2003-06-10 Genaera Corporation Methods for identification of agents which modulate chloride channel activity
US8778899B2 (en) 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
EP1252293B1 (en) 2000-01-19 2012-10-03 University Of North Carolina At Chapel Hill Liver tissue source
GB0014136D0 (en) 2000-06-10 2000-08-02 Astrazeneca Ab Combination therapy
DE60221987T2 (de) 2001-06-22 2008-05-15 Stemcells, Inc., Palo Alto Le-zellen (liver engrafting cells), assays und verwendungen davon
WO2003033697A1 (en) 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
DE10202982A1 (de) 2002-01-26 2003-07-31 Augustinus Bader Verfahren und Vorrichtung zum Einbringen von lebenden Zellen in eine biologische Körperflüssigkeit
EP1624898A1 (en) 2003-05-12 2006-02-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US20050074876A1 (en) 2003-10-03 2005-04-07 Inserm Bipotential liver cell lines from wild-type mammalian liver tissue
WO2005035738A1 (en) 2003-10-07 2005-04-21 Biomaster Inc. Cell differentiation of adipose-derived precursor cells
US20060222640A1 (en) 2005-03-29 2006-10-05 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of thrombosis
JP2008544957A (ja) 2005-05-10 2008-12-11 ユナイテッド ステイツ オブ アメリカ デパートメント オブ ヴェテランズ アフェアーズ 間充織幹細胞による腎疾患及び多臓器不全の治療法と間充織幹細胞馴化培地
WO2006126219A1 (en) * 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
US20070128174A1 (en) 2005-09-21 2007-06-07 Kleinsek Donald A Methods and compositions for organ and tissue functionality
ES2672205T3 (es) 2005-12-21 2018-06-13 Université Catholique de Louvain Células madre hepáticas aisladas
DK2578081T3 (da) 2006-10-11 2016-06-27 Massachusetts Gen Hospital Sammensætninger, fremgangsmåder og anordninger til behandling af leversygdom
WO2008070868A1 (en) 2006-12-07 2008-06-12 American Symbolic, Llc Stem cell secretions and related methods
US8568771B2 (en) 2007-10-29 2013-10-29 Fresenius Medical Care Deutschland G.M.B.H. Use of microvesicles (MVs) derived from stem cells for preparing a medicament for endo/epithellal regeneration of damaged or injured tissues or organs, and related in vitro and in vivo methods
KR101640381B1 (ko) 2008-02-22 2016-07-18 에이전시 포 사이언스, 테크놀로지 앤드 리서치 중간엽 줄기세포 입자
PT2296672E (pt) * 2008-06-11 2016-01-22 Fresenius Medical Care De Gmbh Meio condicionado de células progenitoras de fígado
FI20095409A0 (fi) 2009-04-14 2009-04-14 Helsingin Yliopisto Soluviljelysupplementti
SG10201403202XA (en) 2009-07-23 2014-08-28 Agency Science Tech & Res Pre-natal mesenchymal stem cells
EP2333047A1 (en) 2009-12-09 2011-06-15 Fresenius Medical Care Deutschland GmbH Adult stem cell derived conditioned medium and/or adult stem cells for use in the therapeutic treatment of a tumor disease
US8415149B2 (en) 2010-05-06 2013-04-09 Gwo Xi Stem Cell Applied Technology Co., Ltd. Hepatic progenitor cells and uses thereof
WO2013110354A1 (en) 2012-01-25 2013-08-01 Université Catholique de Louvain Compositions and methods for cell transplantation
US20130302291A1 (en) 2011-01-25 2013-11-14 Universite Catholique De Louvain Compositions and methods for cell transplantation
ES2759228T3 (es) 2013-07-05 2020-05-08 Univ Catholique Louvain Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
MA45274A (fr) 2016-03-02 2019-01-09 Univ Catholique Louvain Préparations améliorées de cellules progénitrices hépatiques adultes

Also Published As

Publication number Publication date
US20160129047A1 (en) 2016-05-12
US10874699B2 (en) 2020-12-29
US20210077537A1 (en) 2021-03-18
JP6474394B2 (ja) 2019-02-27
WO2015001124A1 (en) 2015-01-08
EP3016665A1 (en) 2016-05-11
US20180289747A1 (en) 2018-10-11
JP2016523883A (ja) 2016-08-12
US11793837B2 (en) 2023-10-24
ES2759228T3 (es) 2020-05-08
EP3016665B1 (en) 2019-09-18

Similar Documents

Publication Publication Date Title
DK3016665T3 (da) Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser
HK1216251A1 (zh) 吡唑並吡咯烷衍生物及其治病作用
HK1217439A1 (zh) 與毒性醛相關的疾病和治療
BR112015022854A2 (pt) pró-farmacos de fumaratos e uso do mesmo no tratamento de várias doenças
HK1215868A1 (zh) 雙特異性構建體及其用於治療多種疾病的用途
DK2793929T3 (da) Konditioneret medium opnået fra mesenkymale stamceller fra placenta og anvendelser deraf i den terapeutiske behandling af præeklampsi
DK2996465T4 (da) Fiskeopdrætsanlæg og anvendelse deraf
DK2774616T3 (da) Anvendelse af roseburia i behandling og forebyggelse af fedmerelaterede sygdomme
IL271352B (en) A pharmaceutical preparation containing a derivative of glutarimide and its use in the treatment of eosinophilic diseases
DK3088353T3 (da) Bilirubinpartikler og deres fremstilling til anvendelse i terapi
DK3089707T3 (da) Vævtransplantater og fremgangsmåder til fremstilling og brug af samme
PL3004112T3 (pl) Pochodne pirazolo-pirolidyn-4-onu oraz ich zastosowanie w leczeniu choroby
DK2510085T3 (da) Vokenstamcelle-afledt konditioneret medium og/eller voksenstamceller til anvendelse i den terapeutiske behandling af en tumorsygdom
LTPA2020511I1 (lt) Ciklezonidas, skirtas arklių kvėpavimo takų ligų gydymui
IL245738A0 (en) Oxindole derivatives, ways of their preparation and their therapeutic use in the treatment of ampk-related diseases
DK3722291T3 (da) Indolinonforbindelser og deres anvendelse i behandlingen af fibrotiske sygdomme
DK3049473T3 (da) Dobbeltderivatiserede chitosannanopartikler og fremgangsmåder til fremstilling og anvendelse heraf til genoverførsel in vivo
EP2949651A4 (en) SUBSTITUTED BENZOTHIAZOLES AND THEIR THERAPEUTIC APPLICATIONS FOR THE TREATMENT OF HUMAN DISEASES
DK3153511T3 (da) 2-acylaminothiazolderivat til anvendelse i forebyggelsen eller behandlingen af blære- og urinvejssygdomme
DK3083678T3 (da) Midler og fremgangsmåder til at modvirke myeloproliferative eller lymfoproliferative forstyrrelser
EP2943593A4 (en) DIAGNOSIS AND TREATMENT OF VIRUS DISEASES
SG11201701618SA (en) Use of tetrahydropyridines in the treatment of sodium channel related disease and disorders
EP2954778A4 (en) ANIMAL MODEL FOR EVALUATING THE PERFORMANCE OF A HEMOSTATIC AGENT FOR INDUCING HEMORRHAGE AT THE COMMON CAROTID ARTERY OR SINUS SAGITTAL TOP, AND USE THEREOF
AP2015008849A0 (en) Pyrazolopyrrolidine derivatives and their use in the treatment of disease
DK3190950T3 (da) Forbedringer i og i sammenhæng med oftalmoskoper