DK2968173T3 - Heterocykliske forbindelser og anvendelser deraf - Google Patents

Heterocykliske forbindelser og anvendelser deraf Download PDF

Info

Publication number: DK2968173T3
Authority: DK; Denmark
Prior art keywords: heterocyclic compounds; heterocyclic; compounds
Prior art date: 2013-03-14

Application number

DK14719472.4T

Other languages

English (en)

Inventor

Mingda Bi

Robert Kuehl

Original Assignee

Amgen Inc

Cytokinetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-14

Filing date

2014-03-14

Publication date

2020-12-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50549466&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2968173(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-03-14 Application filed by Amgen Inc, Cytokinetics Inc filed Critical Amgen Inc

2020-12-21 Application granted granted Critical

2020-12-21 Publication of DK2968173T3 publication Critical patent/DK2968173T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

DK14719472.4T 2013-03-14 2014-03-14 Heterocykliske forbindelser og anvendelser deraf DK2968173T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361785763P	2013-03-14	2013-03-14
PCT/US2014/027104 WO2014152236A1 (en)	2013-03-14	2014-03-14	Heterocyclic compounds and their uses

Publications (1)

Publication Number	Publication Date
DK2968173T3 true DK2968173T3 (da)	2020-12-21

Family

ID=50549466

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK14720369.9T DK2970123T3 (da)	2013-03-14	2014-03-14	Salt af omecamtiv mecarbil og fremgangsmåde til fremstilling heraf
DK14719472.4T DK2968173T3 (da)	2013-03-14	2014-03-14	Heterocykliske forbindelser og anvendelser deraf

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK14720369.9T DK2970123T3 (da)	2013-03-14	2014-03-14	Salt af omecamtiv mecarbil og fremgangsmåde til fremstilling heraf

Country Status (41)

Country	Link
US (12)	US9988354B2 (da)
EP (3)	EP3821882A1 (da)
JP (5)	JP6498658B2 (da)
KR (2)	KR102374159B1 (da)
CN (3)	CN105209437B (da)
AP (1)	AP2015008789A0 (da)
AR (1)	AR095542A1 (da)
AU (2)	AU2014240049C1 (da)
BR (2)	BR112015023417B1 (da)
CA (3)	CA2902436A1 (da)
CL (1)	CL2015002708A1 (da)
CR (1)	CR20150549A (da)
CY (2)	CY1122695T1 (da)
DK (2)	DK2970123T3 (da)
EA (1)	EA031185B1 (da)
ES (2)	ES2750676T3 (da)
HK (4)	HK1218080A1 (da)
HR (2)	HRP20191728T1 (da)
HU (2)	HUE052355T2 (da)
IL (2)	IL240788B (da)
JO (1)	JOP20140114B1 (da)
LT (2)	LT2970123T (da)
MA (2)	MA38399B2 (da)
ME (1)	ME03566B (da)
MX (3)	MX363347B (da)
MY (1)	MY186048A (da)
NZ (1)	NZ711225A (da)
PE (1)	PE20151786A1 (da)
PH (2)	PH12015501998B1 (da)
PL (2)	PL2970123T3 (da)
PT (2)	PT2970123T (da)
RS (2)	RS61215B1 (da)
RU (1)	RU2663663C2 (da)
SA (1)	SA515361088B1 (da)
SG (2)	SG10201706656RA (da)
SI (2)	SI2968173T1 (da)
TN (1)	TN2015000380A1 (da)
TW (1)	TWI667026B (da)
UA (1)	UA117011C2 (da)
UY (1)	UY35449A (da)
WO (2)	WO2014152236A1 (da)

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EP3821882A1 (en) *	2013-03-14	2021-05-19	Amgen Inc.	Heterocyclic compounds and their uses
TWI829098B (zh)	2015-01-02	2024-01-11	美商梅拉洛伊卡公司	細菌組成物
JP6858716B2 (ja)	2015-06-26	2021-04-14	アムジエン・インコーポレーテツド	心筋ミオシン活性化剤と洞房結節Ｉｆ電流阻害剤の併用療法
MX2020000190A (es) *	2017-06-30	2020-07-22	Amgen Inc	Métodos para tratar la insuficiencia cardíaca con activadores de sarcómero cardíaco.
CN110799503B (zh) *	2017-06-30	2023-06-27	美国安进公司	美卡奥美坎替的合成
EA039850B1 (ru) *	2018-04-30	2022-03-21	Эмджен Инк.	Синтез омекамтива мекарбила
SI3594199T1 (sl)	2018-07-09	2020-10-30	F.I.S.- Fabbrica Italiana Sintetici S.P.A.	Kristalinični 2-fluoro-3-nitrotoluen in postopek za njegovo pripravo
WO2020014406A1 (en) *	2018-07-12	2020-01-16	Assia Chemical Industries Ltd.	Solid state forms of omecamtiv mecarbil & omecamtiv mecarbil dihcl
WO2020037164A1 (en)	2018-08-17	2020-02-20	Amgen Inc.	Salts and crystal forms of omecamtiv mecarbil
MA55299A (fr) *	2019-03-12	2022-01-19	Amgen Inc	Polymorphes et co-cristaux d'un activateur de troponine cardiaque
EP3938042A1 (en) *	2019-03-12	2022-01-19	Amgen Inc.	Polymorphs of a cardiac troponin activator
EP4045492A1 (en)	2019-09-19	2022-08-24	Synthon B.V.	Salts of omecamtiv mecarbil and solid forms thereof
US20220340542A1 (en)	2019-09-19	2022-10-27	Synthon B.V.	Salts of omecamtiv mecarbil and solid forms thereof
EP4041198A4 (en) *	2019-10-09	2023-08-16	Dr. Reddy's Laboratories Limited	SOLID FORMS OF OMECAMTIV MECARBIL DIHYDROCHLORIDE AND PROCESS THEREOF
AU2021221106A1 (en)	2020-02-10	2022-09-22	Amgen Inc.	Omecamtiv mecarbil tablet
TW202233189A (zh)	2020-11-12	2022-09-01	美商安進公司	藉由投與奧美卡替莫卡必爾治療心臟衰竭之方法
WO2022177927A1 (en) *	2021-02-16	2022-08-25	Assia Chemical Industries Ltd	Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt
AU2022232919A1 (en)	2021-03-10	2023-10-19	Amgen Inc.	Synthesis of omecamtiv mecarbil

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SI3594199T1 (sl)	2018-07-09	2020-10-30	F.I.S.- Fabbrica Italiana Sintetici S.P.A.	Kristalinični 2-fluoro-3-nitrotoluen in postopek za njegovo pripravo
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WO2020037164A1 (en)	2018-08-17	2020-02-20	Amgen Inc.	Salts and crystal forms of omecamtiv mecarbil
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EP4045492A1 (en)	2019-09-19	2022-08-24	Synthon B.V.	Salts of omecamtiv mecarbil and solid forms thereof
US20220340542A1 (en)	2019-09-19	2022-10-27	Synthon B.V.	Salts of omecamtiv mecarbil and solid forms thereof
EP4041710A1 (en)	2019-10-09	2022-08-17	Dr. Reddy's Laboratories Limited	Alternate processes for the preparation of omecamtiv mecarbil
EP4041198A4 (en)	2019-10-09	2023-08-16	Dr. Reddy's Laboratories Limited	SOLID FORMS OF OMECAMTIV MECARBIL DIHYDROCHLORIDE AND PROCESS THEREOF
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AU2021221106A1 (en)	2020-02-10	2022-09-22	Amgen Inc.	Omecamtiv mecarbil tablet
TW202233189A (zh)	2020-11-12	2022-09-01	美商安進公司	藉由投與奧美卡替莫卡必爾治療心臟衰竭之方法
WO2022177927A1 (en)	2021-02-16	2022-08-25	Assia Chemical Industries Ltd	Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt
AU2022232919A1 (en)	2021-03-10	2023-10-19	Amgen Inc.	Synthesis of omecamtiv mecarbil

2014
- 2014-03-14 EP EP20201011.2A patent/EP3821882A1/en active Pending
- 2014-03-14 SI SI201431724T patent/SI2968173T1/sl unknown
- 2014-03-14 JP JP2016502336A patent/JP6498658B2/ja active Active
- 2014-03-14 UA UAA201509685A patent/UA117011C2/uk unknown
- 2014-03-14 EA EA201591728A patent/EA031185B1/ru unknown
- 2014-03-14 JP JP2016502348A patent/JP6783138B2/ja active Active
- 2014-03-14 CN CN201480018405.6A patent/CN105209437B/zh active Active
- 2014-03-14 ME MEP-2019-283A patent/ME03566B/me unknown
- 2014-03-14 CN CN201810812212.8A patent/CN108785265A/zh active Pending
- 2014-03-14 AR ARP140101155A patent/AR095542A1/es not_active Application Discontinuation
- 2014-03-14 MX MX2015012414A patent/MX363347B/es unknown
- 2014-03-14 ES ES14720369T patent/ES2750676T3/es active Active
- 2014-03-14 BR BR112015023417-8A patent/BR112015023417B1/pt active IP Right Grant
- 2014-03-14 LT LT14720369T patent/LT2970123T/lt unknown
- 2014-03-14 HU HUE14719472A patent/HUE052355T2/hu unknown
- 2014-03-14 MY MYPI2015002299A patent/MY186048A/en unknown
- 2014-03-14 US US14/773,436 patent/US9988354B2/en active Active
- 2014-03-14 US US14/210,713 patent/US9951015B2/en active Active
- 2014-03-14 CA CA2902436A patent/CA2902436A1/en active Pending
- 2014-03-14 KR KR1020157025283A patent/KR102374159B1/ko active IP Right Grant
- 2014-03-14 BR BR112015022857-7A patent/BR112015022857B1/pt active IP Right Grant
- 2014-03-14 PL PL14720369T patent/PL2970123T3/pl unknown
- 2014-03-14 KR KR1020227007907A patent/KR102474467B1/ko active IP Right Grant
- 2014-03-14 MX MX2015012429A patent/MX2015012429A/es unknown
- 2014-03-14 CA CA2902646A patent/CA2902646C/en active Active
- 2014-03-14 SG SG10201706656RA patent/SG10201706656RA/en unknown
- 2014-03-14 PT PT147203699T patent/PT2970123T/pt unknown
- 2014-03-14 PL PL14719472T patent/PL2968173T3/pl unknown
- 2014-03-14 AU AU2014240049A patent/AU2014240049C1/en active Active
- 2014-03-14 PE PE2015002000A patent/PE20151786A1/es unknown
- 2014-03-14 ES ES14719472T patent/ES2837038T3/es active Active
- 2014-03-14 PT PT147194724T patent/PT2968173T/pt unknown
- 2014-03-14 EP EP14719472.4A patent/EP2968173B1/en active Active
- 2014-03-14 MA MA38399A patent/MA38399B2/fr unknown
- 2014-03-14 CN CN201480014897.1A patent/CN105120844A/zh active Pending
- 2014-03-14 EP EP14720369.9A patent/EP2970123B1/en active Active
- 2014-03-14 AP AP2015008789A patent/AP2015008789A0/xx unknown
- 2014-03-14 SI SI201431358T patent/SI2970123T1/sl unknown
- 2014-03-14 UY UY0001035449A patent/UY35449A/es active IP Right Grant
- 2014-03-14 RU RU2015143643A patent/RU2663663C2/ru active
- 2014-03-14 WO PCT/US2014/027104 patent/WO2014152236A1/en active Application Filing
- 2014-03-14 HU HUE14720369A patent/HUE046285T2/hu unknown
- 2014-03-14 SG SG11201507258PA patent/SG11201507258PA/en unknown
- 2014-03-14 CA CA3147180A patent/CA3147180A1/en active Granted
- 2014-03-14 AU AU2014239995A patent/AU2014239995B2/en active Active
- 2014-03-14 RS RS20201513A patent/RS61215B1/sr unknown
- 2014-03-14 WO PCT/US2014/027146 patent/WO2014152270A1/en active Application Filing
- 2014-03-14 LT LTEP14719472.4T patent/LT2968173T/lt unknown
- 2014-03-14 TW TW103109296A patent/TWI667026B/zh active
- 2014-03-14 MA MA44637A patent/MA44637B1/fr unknown
- 2014-03-14 NZ NZ711225A patent/NZ711225A/en unknown
- 2014-03-14 DK DK14720369.9T patent/DK2970123T3/da active
- 2014-03-14 RS RS20191313A patent/RS59536B1/sr unknown
- 2014-03-14 DK DK14719472.4T patent/DK2968173T3/da active
- 2014-03-16 JO JOP/2014/0114A patent/JOP20140114B1/ar active
2015
- 2015-08-24 IL IL240788A patent/IL240788B/en active IP Right Grant
- 2015-08-31 TN TN2015000380A patent/TN2015000380A1/en unknown
- 2015-09-03 IL IL24108915A patent/IL241089B/en active IP Right Grant
- 2015-09-08 PH PH12015501998A patent/PH12015501998B1/en unknown
- 2015-09-11 MX MX2021001231A patent/MX2021001231A/es unknown
- 2015-09-14 SA SA515361088A patent/SA515361088B1/ar unknown
- 2015-09-14 CL CL2015002708A patent/CL2015002708A1/es unknown
- 2015-10-13 CR CR20150549A patent/CR20150549A/es unknown
2016
- 2016-06-02 HK HK16106250.4A patent/HK1218080A1/zh unknown
- 2016-06-07 HK HK16106548.6A patent/HK1218512A1/zh unknown
- 2016-06-07 HK HK16106547.7A patent/HK1218544A1/zh unknown
- 2016-06-30 HK HK16107606.3A patent/HK1219484A1/zh unknown
2018
- 2018-03-20 US US15/926,411 patent/US10421726B2/en active Active
- 2018-04-26 US US15/963,529 patent/US20180312469A1/en not_active Abandoned
- 2018-11-15 JP JP2018214801A patent/JP6689942B2/ja active Active
2019
- 2019-01-24 PH PH12019500176A patent/PH12019500176A1/en unknown
- 2019-09-23 US US16/579,360 patent/US11384053B2/en active Active
- 2019-09-24 HR HRP20191728 patent/HRP20191728T1/hr unknown
- 2019-10-15 CY CY20191101080T patent/CY1122695T1/el unknown
- 2019-11-14 US US16/684,216 patent/US20200079736A1/en not_active Abandoned
2020
- 2020-04-08 JP JP2020069487A patent/JP6966590B2/ja active Active
- 2020-07-02 US US16/920,155 patent/US20200331859A1/en not_active Abandoned
- 2020-07-02 US US16/920,144 patent/US11472773B2/en active Active
- 2020-12-08 HR HRP20201967TT patent/HRP20201967T1/hr unknown
- 2020-12-15 CY CY20201101184T patent/CY1123633T1/el unknown
2021
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- 2021-10-21 JP JP2021172324A patent/JP7174132B2/ja active Active
2022
- 2022-06-08 US US17/806,033 patent/US11884630B2/en active Active
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2023
- 2023-11-27 US US18/520,156 patent/US20240101517A1/en active Pending

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CN105209437A (zh)	2015-12-30
JP6783138B2 (ja)	2020-11-11
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PH12019500176A1 (en)	2020-11-04
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CA2902646A1 (en)	2014-09-25
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US20180273479A1 (en)	2018-09-27
EP2970123B1 (en)	2019-08-14
EP3821882A1 (en)	2021-05-19

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