DK2885639T3 - COMPLEX SPECIFIC ANTIBODIES AND ANTIBODY FRAGMENTS AND THEIR APPLICATION - Google Patents

COMPLEX SPECIFIC ANTIBODIES AND ANTIBODY FRAGMENTS AND THEIR APPLICATION

Info

Publication number
DK2885639T3
DK2885639T3 DK13752873.3T DK13752873T DK2885639T3 DK 2885639 T3 DK2885639 T3 DK 2885639T3 DK 13752873 T DK13752873 T DK 13752873T DK 2885639 T3 DK2885639 T3 DK 2885639T3
Authority
DK
Denmark
Prior art keywords
application
antibody fragments
specific antibodies
complex specific
complex
Prior art date
Application number
DK13752873.3T
Other languages
Danish (da)
Inventor
Christian Frisch
Achim Knappik
Stefan Härtle
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Application granted granted Critical
Publication of DK2885639T3 publication Critical patent/DK2885639T3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2470/00—Immunochemical assays or immunoassays characterised by the reaction format or reaction type
    • G01N2470/04—Sandwich assay format
    • G01N2470/06—Second binding partner specifically binding complex of analyte with first binding partner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK13752873.3T 2012-08-17 2013-08-08 COMPLEX SPECIFIC ANTIBODIES AND ANTIBODY FRAGMENTS AND THEIR APPLICATION DK2885639T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12180835 2012-08-17
US201261684836P 2012-08-20 2012-08-20
PCT/EP2013/066625 WO2014026905A1 (en) 2012-08-17 2013-08-08 Complex-specific antibodies and antibody fragments and its use

Publications (1)

Publication Number Publication Date
DK2885639T3 true DK2885639T3 (en) 2019-07-08

Family

ID=50101254

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13752873.3T DK2885639T3 (en) 2012-08-17 2013-08-08 COMPLEX SPECIFIC ANTIBODIES AND ANTIBODY FRAGMENTS AND THEIR APPLICATION

Country Status (10)

Country Link
US (4) US20150197579A1 (en)
EP (2) EP3540438A1 (en)
JP (1) JP6437913B2 (en)
KR (1) KR102410763B1 (en)
CN (1) CN104995517B (en)
AU (1) AU2013304237B2 (en)
CA (1) CA2878814C (en)
DK (1) DK2885639T3 (en)
ES (1) ES2734130T3 (en)
WO (1) WO2014026905A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9804161B1 (en) * 2012-05-14 2017-10-31 Lawrence Livermore National Security, Llc Detector and related, devices, methods and systems
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
CA2905010A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
ES2699581T3 (en) * 2013-12-20 2019-02-11 Phadia Ab Antibody analysis
EP3485281A1 (en) * 2016-07-15 2019-05-22 H. Hoffnabb-La Roche Ag Method and means for detecting the level of total vegf-a
CN109991405B (en) * 2017-12-29 2023-01-24 上海索昕生物科技有限公司 Immunoassay kit and application thereof
CN108623684B (en) * 2018-08-30 2018-12-18 宝船生物医药科技(上海)有限公司 A kind of monoclonal antibody and its application identifying Avastin
KR102612555B1 (en) 2020-12-18 2023-12-11 한국세라믹기술원 Immunoprecipitation using antibody binding protein-calsequestrin fusion protein

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58177921A (en) * 1982-04-09 1983-10-18 Fujirebio Inc Anti-immune complex antibody and preparation thereof
US4757024A (en) * 1985-05-31 1988-07-12 Biostar Medical Products, Inc. Immune complex detection method and article using immunologically non-specific immunoglobulins
ATE249840T1 (en) 1991-12-13 2003-10-15 Xoma Corp METHOD AND MATERIALS FOR PRODUCING MODIFIED VARIABLE ANTIBODY DOMAIN AND THERAPEUTIC USE THEREOF
CA2149881A1 (en) * 1992-11-19 1994-05-26 Paul T. Jubinsky Antibodies for gm-csf receptor and uses thereof
US6991907B1 (en) * 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US5798273A (en) 1996-09-25 1998-08-25 Becton Dickinson And Company Direct read lateral flow assay for small analytes
US6194220B1 (en) 1996-09-25 2001-02-27 Becton, Dickinson And Company Non-instrumented assay with quantitative and qualitative results
US5998221A (en) 1996-09-25 1999-12-07 Becton, Dickinson And Company Non-instrumented assay with quantitative and qualitative results
JP2000055917A (en) * 1998-08-05 2000-02-25 Mitsubishi Kagaku Bio-Clinical Laboratories Inc Method for detection or measurement using antigen- antibody complex antibody
PT1144607E (en) 1999-07-20 2009-04-22 Morphosys Ag Methods for displaying (poly)peptides/proteins on bacteriophage particles via disulfide bonds
WO2003024993A2 (en) 2001-09-20 2003-03-27 Board Of Regents, The University Of Texas System Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays
CA2467633C (en) 2001-12-03 2012-03-27 Abgenix, Inc. Antibody categorization based on binding characteristics
ES2360369T5 (en) 2004-12-23 2021-12-13 Hoffmann La Roche Detection of a therapeutic antibody in an experimental animal
ES2527428T3 (en) * 2005-05-18 2015-01-23 Morphosys Ag Anti-GM-CSF antibodies and uses thereof
WO2009032128A1 (en) * 2007-08-28 2009-03-12 Abbott Biotechnology Ltd. Compositions and methods comprising binding proteins for adalimumab
US8093018B2 (en) * 2008-05-20 2012-01-10 Otsuka Pharmaceutical Co., Ltd. Antibody identifying an antigen-bound antibody and an antigen-unbound antibody, and method for preparing the same
FR2939431B1 (en) * 2008-12-05 2011-01-28 Valagro Carbone Renouvelable PROCESS FOR PRODUCING AN INTERMEDIATE PRODUCT FOR THE PRODUCTION OF ETHANOL AND INTERMEDIATE PRODUCT OBTAINED
CA2739310C (en) * 2009-07-21 2014-07-08 Sekisui Medical Co., Ltd. Insulin assay

Also Published As

Publication number Publication date
US20240067753A1 (en) 2024-02-29
EP2885639B1 (en) 2019-04-10
US20180134807A1 (en) 2018-05-17
US10774154B2 (en) 2020-09-15
CA2878814C (en) 2023-03-14
KR102410763B1 (en) 2022-06-20
US20200339703A1 (en) 2020-10-29
CN104995517A (en) 2015-10-21
EP3540438A1 (en) 2019-09-18
KR20150041801A (en) 2015-04-17
JP6437913B2 (en) 2018-12-12
JP2015531762A (en) 2015-11-05
CN104995517B (en) 2018-07-17
CA2878814A1 (en) 2014-02-20
AU2013304237B2 (en) 2017-12-21
WO2014026905A1 (en) 2014-02-20
US20150197579A1 (en) 2015-07-16
AU2013304237A1 (en) 2015-01-29
EP2885639A1 (en) 2015-06-24
ES2734130T3 (en) 2019-12-04

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