DK2802598T3 - Peptider og peptid-derivater baseret på xenin - Google Patents
Peptider og peptid-derivater baseret på xenin Download PDFInfo
- Publication number
- DK2802598T3 DK2802598T3 DK13700347.1T DK13700347T DK2802598T3 DK 2802598 T3 DK2802598 T3 DK 2802598T3 DK 13700347 T DK13700347 T DK 13700347T DK 2802598 T3 DK2802598 T3 DK 2802598T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptide
- xenin
- seq
- insulin
- glucose
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 91
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 21
- 108010006643 xenin 25 Proteins 0.000 title abstract description 105
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Marine Sciences & Fisheries (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (15)
1. Peptid (i) af SEQ ID No. 1, eller (ii) der er en analog af SEQ ID No.l, hvilken er i stand til at stimulere insulinsekretion og der har ikke mere end 7 aminosyre-substitutioner eller -deletioner sammenlignet med den native sekvens (SEQ ID No.l), hvor peptidet har en eller flere lysin-rester substitueret med en lipofil substituent på 8-40 carbonatomer, eventuelt via en spacer.
2. Peptidet ifølge krav 1, hvor nævnte peptid ikke har nogen aminosyre-substitutioner eller -deletioner sammenlignet med den native sekvens.
3. Peptidet ifølge krav 1 eller krav 2, hvor kun en lysin-rest er substitueret med nævnte lipofile substituent og/eller hvor Lysn er substitueret med nævnte lipofile substituent.
4. Peptidet ifølge et hvilket som helst af kravene 1 til 3, hvor nævnte lipofile substituent er afledt fra en fedtsyre, der kan være mættet eller umættet, fortrinsvis hvor nævnte lipofile substituent er afledt fra palmitinsyre.
5. Peptidet ifølge et hvilket som helst af kravene 1 til 4, hvor nævnte lipofile substituent er fastgjort til lysin-resten med en spacer, fortrinsvis hvor nævnte spacer er Glu.
6. Peptidet ifølge et hvilket som helst af kravene 1 til 5, hvor nævnte peptid er SEQ ID No.l med en (y-L-Glutamoyl(N-a-hexadecanoyl))-modifikation på lysin (K) 13.
7. Peptid (i) af SEQ ID No. 1; eller (ii) der er en analog af SEQ ID No.l, hvilken er i stand til at stimulere insulinsekretion og ikke har mere end 7 aminosyre-substitutioner eller -deletioner sammenlignet med den native sekvens (SEQ ID No.l); i hvilken en eller flere af Lys4, Lyse, Argu, Lysi3, Phei7, LyS2o, eller Arg2i er blevet erstattet med en anden aminosyre, der øger peptidets resistens over for enzymatisk nedbrydning.
8. Peptidet ifølge krav 7, hvor erstatnings-aminosyren er glutamin eller isoleucin, fortrinsvis glutamin.
9. Peptidet ifølge krav 7 eller krav 8, hvor en eller flere af Lys4, Lyse, Argu, Lysi3, Lys2o, eller Arg2i er blevet erstattet.
10. Peptidet ifølge et hvilket som helst af kravene 7 til 9, hvor hver af Lys4, Lyse, Argu, Lysi3, Lys2o, og Arg2i er blevet erstattet, fortrinsvis hvor nævnte peptid er SEQ ID No.16.
11. Peptid ifølge krav 7 eller krav 8, hvor nævnte peptid er valgt fra gruppen bestående af SEQ ID No. 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 og 15.
12. Peptid ifølge et hvilket som helst af kravene 7 til 9 eller krav 11, hvor nævnte peptid omfatter en eller flere substituerede lysin-rester som defineret i et hvilket som helst af krav 1 eller krav 3 til 6.
13. Molekyle omfattende et peptid som defineret i et hvilket som helst af kravene 1 til 12, eller en formulering omfattende et eller flere peptider ifølge et hvilket som helst af kravene 1 til 12 eller nævnte molekyler i blanding med en egnet fortynder, bærer eller excipiens.
14. Peptid ifølge et hvilket som helst af kravene 1 til 12 eller et molekyle ifølge krav 13 eller en formulering ifølge krav 13 til anvendelse i terapi, eventuelt hvor behandlingen involverer co-administration med et andet anti-diabetikum, såsom insulin, et inkretin, eller en imitator eller analog deraf, eller med et andet middel til behandlingen af stofskiftesyndrom eller insulinresistens, eller med et andet anti-fedme middel.
15. Peptid ifølge et hvilket som helst af kravene 1 til 12 eller et molekyle ifølge krav 13 eller en formulering ifølge krav 13 til anvendelse i behandling af Type 2-diabetes mellitus, insulinafhængig diabetes mellitus, insulinresistens, stofskiftesyndrom eller fedme, eventuelt involverer behandlingen co-administration med et andet anti-diabetikum, såsom insulin, et inkretin, eller en imitator eller analog deraf, eller med et andet middel til behandlingen af stofskiftesyndrom eller insulinresistens, eller med et andet anti-fedme middel.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1200509.6A GB201200509D0 (en) | 2012-01-12 | 2012-01-12 | Peptides |
| GBGB1207895.2A GB201207895D0 (en) | 2012-05-04 | 2012-05-04 | Peptides |
| PCT/GB2013/050069 WO2013104929A1 (en) | 2012-01-12 | 2013-01-14 | Peptides and peptide derivatives based on xenin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2802598T3 true DK2802598T3 (da) | 2018-03-12 |
Family
ID=47559562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13700347.1T DK2802598T3 (da) | 2012-01-12 | 2013-01-14 | Peptider og peptid-derivater baseret på xenin |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20150025002A1 (da) |
| EP (1) | EP2802598B1 (da) |
| DK (1) | DK2802598T3 (da) |
| WO (1) | WO2013104929A1 (da) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201521442D0 (en) * | 2015-12-04 | 2016-01-20 | Univ Ulster | Polytpeptides and analogues thereof for use in the treatment of diabetes and bone disorders |
| GB201603510D0 (en) * | 2016-02-29 | 2016-04-13 | Univ Ulster | Compositions for use in the treatment of neurological disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2652991A1 (en) * | 2001-07-16 | 2003-11-13 | Caprotec Bioanalytics Gmbh | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions |
| WO2009108621A2 (en) * | 2008-02-25 | 2009-09-03 | The Washington University | Methods and compositions for modulating insulin regulation |
| CA2745499A1 (en) * | 2008-12-05 | 2010-06-10 | Angiochem Inc. | Peptide therapeutic conjugates and uses thereof |
| PE20120332A1 (es) * | 2008-12-19 | 2012-04-14 | Univ Indiana Res & Tech Corp | Profarmacos de peptido de la superfamilia de glucagon basado en amida |
-
2013
- 2013-01-14 EP EP13700347.1A patent/EP2802598B1/en not_active Not-in-force
- 2013-01-14 DK DK13700347.1T patent/DK2802598T3/da active
- 2013-01-14 WO PCT/GB2013/050069 patent/WO2013104929A1/en active Application Filing
- 2013-01-14 US US14/371,878 patent/US20150025002A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150025002A1 (en) | 2015-01-22 |
| EP2802598B1 (en) | 2017-12-06 |
| WO2013104929A1 (en) | 2013-07-18 |
| EP2802598A1 (en) | 2014-11-19 |
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