DK280085A - 7alfa-acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner samt deresfremstilling og anvendelse - Google Patents

7alfa-acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner samt deresfremstilling og anvendelse Download PDF

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Publication number
DK280085A
DK280085A DK280085A DK280085A DK280085A DK 280085 A DK280085 A DK 280085A DK 280085 A DK280085 A DK 280085A DK 280085 A DK280085 A DK 280085A DK 280085 A DK280085 A DK 280085A
Authority
DK
Denmark
Prior art keywords
9alfa
11alfa
7alfa
spirox
acylthio
Prior art date
Application number
DK280085A
Other languages
English (en)
Other versions
DK173854B1 (da
DK280085D0 (da
Inventor
Michel Biollaz
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK280085D0 publication Critical patent/DK280085D0/da
Publication of DK280085A publication Critical patent/DK280085A/da
Application granted granted Critical
Publication of DK173854B1 publication Critical patent/DK173854B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198502800A 1984-06-21 1985-06-20 7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater DK173854B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH300984 1984-06-21
CH300984 1984-06-21
CH464684 1984-09-28
CH464684 1984-09-28

Publications (3)

Publication Number Publication Date
DK280085D0 DK280085D0 (da) 1985-06-20
DK280085A true DK280085A (da) 1985-12-22
DK173854B1 DK173854B1 (da) 2001-12-27

Family

ID=25691934

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198502800A DK173854B1 (da) 1984-06-21 1985-06-20 7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater

Country Status (16)

Country Link
US (1) US4670551A (da)
EP (1) EP0165902B1 (da)
AR (2) AR242036A1 (da)
AU (1) AU582754B2 (da)
CA (1) CA1239388A (da)
DE (1) DE3569540D1 (da)
DK (1) DK173854B1 (da)
ES (2) ES8704967A1 (da)
FI (1) FI83225C (da)
GR (1) GR851499B (da)
HU (1) HU192232B (da)
IE (1) IE58050B1 (da)
IL (1) IL75569A (da)
NO (1) NO165496C (da)
NZ (1) NZ212492A (da)
PT (1) PT80663B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA009176B1 (ru) 1995-12-11 2007-12-28 Дж.Д.Серл Энд Ко. Способ получения 7-альфа-карбоксил-9,11-эпоксистероидов и промежуточных продуктов, используемых для их получения, и общий способ эпоксидирования по олефиновым двойным связям
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
DK0944644T3 (da) * 1996-12-11 2003-02-03 Searle & Co Fremgangsmåde til fremstilling af 3-keto-7-alfa-alkoxycarbonyl-delta-4,5-steroider og mellemprodukter, som er nyttite derfor
EP1148061B1 (en) * 1996-12-11 2007-10-17 G.D. Searle LLC. Epoxidation process
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
KR20040080439A (ko) 2001-12-12 2004-09-18 파마시아 코포레이션 에폭시-스테로이드성 알도스테론 수용체 길항제에 의한안구 질환의 치료 방법
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2007025780A2 (en) * 2005-09-02 2007-03-08 Recordati Ireland Limited Aldosterone receptor antagonists
EP1945240B1 (en) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
ES2728225T3 (es) 2009-02-20 2019-10-23 2 Bbb Medicines B V Sistema de administración de fármacos a base de glutatión
US8445002B2 (en) 2009-05-06 2013-05-21 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013012A (en) * 1960-12-22 1961-12-12 Searle & Co Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones
US3095412A (en) * 1961-12-19 1963-06-25 Searle & Co 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
GB1041534A (en) * 1963-04-24 1966-09-07 Merck & Co Inc 20-spiroxane compounds
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
ATE51233T1 (de) * 1983-08-17 1990-04-15 Schering Ag 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.

Also Published As

Publication number Publication date
FI83225C (fi) 1991-06-10
EP0165902B1 (de) 1989-04-19
FI83225B (fi) 1991-02-28
HU192232B (en) 1987-05-28
IL75569A0 (en) 1985-10-31
AU582754B2 (en) 1989-04-13
NZ212492A (en) 1989-02-24
FI852430A0 (fi) 1985-06-19
US4670551A (en) 1987-06-02
AR245731A1 (es) 1994-02-28
NO165496C (no) 1991-02-20
NO852501L (no) 1985-12-23
ES557112A0 (es) 1987-08-16
IL75569A (en) 1989-03-31
PT80663B (en) 1987-05-08
ES8707737A1 (es) 1987-08-16
NO165496B (no) 1990-11-12
DK173854B1 (da) 2001-12-27
ES544387A0 (es) 1987-04-16
EP0165902A2 (de) 1985-12-27
GR851499B (da) 1985-11-25
AU4397185A (en) 1986-01-02
EP0165902A3 (en) 1986-10-22
AR242036A1 (es) 1993-02-26
IE851535L (en) 1985-12-21
CA1239388A (en) 1988-07-19
PT80663A (en) 1985-07-01
ES8704967A1 (es) 1987-04-16
IE58050B1 (en) 1993-06-16
FI852430L (fi) 1985-12-22
DK280085D0 (da) 1985-06-20
HUT38367A (en) 1986-05-28
DE3569540D1 (en) 1989-05-24

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PBP Patent lapsed

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