DK2729578T3 - Biokemiske markører for neurodegenerative lidelser - Google Patents
Biokemiske markører for neurodegenerative lidelser Download PDFInfo
- Publication number
- DK2729578T3 DK2729578T3 DK12733674.1T DK12733674T DK2729578T3 DK 2729578 T3 DK2729578 T3 DK 2729578T3 DK 12733674 T DK12733674 T DK 12733674T DK 2729578 T3 DK2729578 T3 DK 2729578T3
- Authority
- DK
- Denmark
- Prior art keywords
- neurodegenerative disorders
- biochemical markers
- biochemical
- markers
- neurodegenerative
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Neurosurgery (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1111361.0A GB201111361D0 (en) | 2011-07-04 | 2011-07-04 | Biochemical markers for neurodegenerative conditions |
PCT/EP2012/062965 WO2013004717A1 (en) | 2011-07-04 | 2012-07-04 | Biochemical markers for neurodegenerative conditions |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2729578T3 true DK2729578T3 (da) | 2020-03-23 |
Family
ID=44512035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12733674.1T DK2729578T3 (da) | 2011-07-04 | 2012-07-04 | Biokemiske markører for neurodegenerative lidelser |
Country Status (8)
Country | Link |
---|---|
US (1) | US9733260B2 (da) |
EP (1) | EP2729578B1 (da) |
JP (1) | JP6225107B2 (da) |
KR (1) | KR101980925B1 (da) |
CN (1) | CN103827311B (da) |
DK (1) | DK2729578T3 (da) |
GB (1) | GB201111361D0 (da) |
WO (1) | WO2013004717A1 (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2538221A3 (en) * | 2007-11-05 | 2013-04-24 | Nordic Bioscience A/S | Biochemical markers for CVD risk assessment |
JP6457263B2 (ja) | 2011-05-20 | 2019-01-23 | オリゴメリックス インコーポレイテッド | タウプロテアーゼ組成物および使用方法 |
RU2668159C2 (ru) | 2012-07-03 | 2018-09-26 | Вашингтон Юниверсити | Антитела против тау |
BR112015003326A2 (pt) | 2012-08-16 | 2017-07-04 | Ipierian Inc | métodos de tratamento de uma tauopatia |
JP6674888B2 (ja) * | 2013-03-13 | 2020-04-01 | プロセナ バイオサイエンシーズ リミテッド | タウ免疫療法 |
GB201319761D0 (en) * | 2013-11-08 | 2013-12-25 | Nordic Bioscience As | Biomarkers of disease progression |
CA2938152A1 (en) * | 2014-02-10 | 2015-08-13 | Merck Sharp & Dohme Corp. | Antibodies that bind to human tau and assay for quantifying human tau using the antibodies |
US10400018B2 (en) | 2014-02-14 | 2019-09-03 | Ipierian, Inc. | Tau peptides, anti-tau antibodies, and methods of use thereof |
TWI664190B (zh) | 2014-06-27 | 2019-07-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
JP6438573B2 (ja) * | 2014-09-09 | 2018-12-12 | ユーロ−ディアグノスティカ アーベーEuro−Diagnostica AB | 補体成分C4dに対して特異的な抗体、およびその使用 |
US20180050097A1 (en) * | 2015-03-25 | 2018-02-22 | Stc. Unm | Immunotherapy compositions and methods for treatment of tauopathy and transgenic mouse |
FI3452507T3 (fi) | 2016-05-02 | 2022-12-15 | Tau-immuunihoito | |
EA201892417A1 (ru) | 2016-05-02 | 2019-05-31 | Протена Биосайенсис Лимитед | Антитела, распознающие тау |
KR102533675B1 (ko) | 2016-05-02 | 2023-05-22 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
EP3242134A1 (en) * | 2016-05-04 | 2017-11-08 | Euroimmun Medizinische Labordiagnostika AG | Assay for the diagnosis of a neurological disease |
CN106124770A (zh) * | 2016-06-14 | 2016-11-16 | 同济大学 | 一种高灵敏度可回收纳米生物传感器及其制备方法与应用 |
WO2018152359A1 (en) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
CN110881274A (zh) | 2017-05-02 | 2020-03-13 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
AU2019232630A1 (en) | 2018-03-05 | 2020-09-24 | Janssen Pharmaceutica Nv | Assays to detect neurodegeneration |
PE20211709A1 (es) * | 2019-02-08 | 2021-09-01 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
BR112021016947A2 (pt) | 2019-03-03 | 2021-11-03 | Prothena Biosciences Ltd | Anticorpos que reconhecem tau |
CN114989313B (zh) * | 2022-06-28 | 2024-04-02 | 福建亿彤生物科技有限公司 | p-tau181抗原表位肽及其在阿尔茨海默病检测中的用途 |
CN115894659B (zh) * | 2022-10-19 | 2023-11-10 | 上海优宁维生物科技股份有限公司 | 微管相关蛋白Tau抗原及其制备方法和应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993003369A1 (en) * | 1991-08-01 | 1993-02-18 | Voorheis Paul H | Diagnostic method for alzheimer's disease |
EP0673418B1 (en) * | 1992-12-14 | 1998-05-06 | N.V. Innogenetics S.A. | Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications |
GB9506197D0 (en) * | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
ATE342509T1 (de) * | 2000-01-24 | 2006-11-15 | Innogenetics Nv | Diagnose von tauopathien durch bestimmung des verhältnisses von tau/phospho-tau |
KR100428998B1 (ko) * | 2001-09-10 | 2004-04-28 | 한국과학기술원 | 모체 단백질과는 크기와 서열이 다른 단백질의 변이집단을생산하는 방법 |
US8012936B2 (en) * | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
EP2538221A3 (en) * | 2007-11-05 | 2013-04-24 | Nordic Bioscience A/S | Biochemical markers for CVD risk assessment |
WO2010021755A2 (en) * | 2008-08-20 | 2010-02-25 | Oligomerix, Inc. | Tau protease compositions and methods |
ES2635494T3 (es) * | 2009-03-30 | 2017-10-04 | Nordic Bioscience A/S | Ensayo de biomarcador de fibrosis |
CN106390107B (zh) * | 2009-06-10 | 2019-12-31 | 纽约大学 | 病理tau蛋白的免疫靶向 |
EP2478360B1 (en) * | 2009-09-14 | 2018-06-27 | Banyan Biomarkers, Inc. | Autoantibody markers for diagnosis of traumatic brain injury |
-
2011
- 2011-07-04 GB GBGB1111361.0A patent/GB201111361D0/en not_active Ceased
-
2012
- 2012-07-04 CN CN201280033143.1A patent/CN103827311B/zh not_active Expired - Fee Related
- 2012-07-04 WO PCT/EP2012/062965 patent/WO2013004717A1/en active Application Filing
- 2012-07-04 EP EP12733674.1A patent/EP2729578B1/en active Active
- 2012-07-04 DK DK12733674.1T patent/DK2729578T3/da active
- 2012-07-04 KR KR1020147001378A patent/KR101980925B1/ko active IP Right Grant
- 2012-07-04 JP JP2014517782A patent/JP6225107B2/ja active Active
- 2012-07-04 US US14/130,927 patent/US9733260B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20150064726A1 (en) | 2015-03-05 |
CN103827311B (zh) | 2020-05-12 |
EP2729578B1 (en) | 2020-03-11 |
JP6225107B2 (ja) | 2017-11-01 |
KR101980925B1 (ko) | 2019-05-21 |
US9733260B2 (en) | 2017-08-15 |
JP2014522643A (ja) | 2014-09-08 |
GB201111361D0 (en) | 2011-08-17 |
WO2013004717A1 (en) | 2013-01-10 |
KR20140040243A (ko) | 2014-04-02 |
CN103827311A (zh) | 2014-05-28 |
EP2729578A1 (en) | 2014-05-14 |
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