DK2612859T3 - Fremgangsmåde til fremstilling af 1-triazol-2-butanol-derivat. - Google Patents
Fremgangsmåde til fremstilling af 1-triazol-2-butanol-derivat. Download PDFInfo
- Publication number
- DK2612859T3 DK2612859T3 DK11821851.0T DK11821851T DK2612859T3 DK 2612859 T3 DK2612859 T3 DK 2612859T3 DK 11821851 T DK11821851 T DK 11821851T DK 2612859 T3 DK2612859 T3 DK 2612859T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid
- methylenepiperidine
- reaction
- addition salt
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (6)
1. Fremgangsmåde til fremstilling af (2R,3R)-2-(2,4-difluorphenyl)-3-(4-methylenpiperidin-l-yl)-l-(l/-/-l,2,4-triazol-l-yl)butan-2-ol eller et syreadditionssalt deraf, som omfatter at reagere (2R,3S)-2-(2,4-difluorphenyl)-3-methyl-2-[(l/-/-l,2,4-triazol-l-yl)methyl]oxiran med et syreadditionssalt af 4-methylenpiperidin i et reaktionssolvent under tilstedeværelse af en hydroxid af et alkalimetal eller et alkalijordmetal valgt fra gruppen bestående af lithium og calcium, eller et hydrat deraf.
2. Fremgangsmåde ifølge krav 1, hvor hydroxiden af et alkalimetal eller et alkalijordmetal er lithiumhydroxid.
3. Fremgangsmåde ifølge krav 1 eller 2, hvor syreadditionssaltet af 4-methylenpiperidin er 4-methylenpiperidinhydrobromid eller 4-methylenpiperidinhydroiodid.
4. Fremgangsmåde ifølge krav 3, hvor syreadditionssaltet af 4-methylenpiperidin er 4-methylenpiperidinhydrobromid.
5. Fremgangsmåde ifølge et hvilket som helst af krav 1 til 4, hvor reaktionssolventet er acetonitril, 1,2-dimethoxyethan, cyclopentylmethylether, isopropanol, 1-butanol, eller 4-methyl-2-pentanon.
6. Fremgangsmåde ifølge krav 5, hvor reaktionssolventet er acetonitril eller cyclopentylmethylether.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010194068 | 2010-08-31 | ||
| PCT/JP2011/069733 WO2012029836A1 (ja) | 2010-08-31 | 2011-08-31 | １－トリアゾール－２－ブタノール誘導体の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2612859T3 true DK2612859T3 (da) | 2015-10-19 |
Family
ID=45772914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11821851.0T DK2612859T3 (da) | 2010-08-31 | 2011-08-31 | Fremgangsmåde til fremstilling af 1-triazol-2-butanol-derivat. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8871942B2 (da) |
| EP (2) | EP2966071B1 (da) |
| JP (1) | JP5852573B2 (da) |
| CN (2) | CN106045970B (da) |
| BR (1) | BR112013004827B1 (da) |
| CA (1) | CA2808230C (da) |
| CY (1) | CY1116997T1 (da) |
| DK (1) | DK2612859T3 (da) |
| ES (1) | ES2556782T3 (da) |
| HU (1) | HUE026357T2 (da) |
| PL (1) | PL2612859T3 (da) |
| PT (1) | PT2612859E (da) |
| RS (1) | RS54330B1 (da) |
| TW (1) | TWI518081B (da) |
| WO (1) | WO2012029836A1 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
| US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
| AU2014329421B2 (en) | 2013-10-03 | 2018-08-02 | Dow Pharmaceutical Sciences, Inc. | Stabilized efinaconazole compositions |
| WO2015077729A2 (en) | 2013-11-22 | 2015-05-28 | Dow Pharmaceutical Sciences, Inc. | Anti-infective methods, compositions, and devices |
| CN104292214B (zh) * | 2014-09-24 | 2017-04-05 | 南京华威医药科技开发有限公司 | 艾氟康唑及其中间体的合成方法 |
| CN104327047B (zh) * | 2014-10-17 | 2016-04-06 | 苏州明锐医药科技有限公司 | 艾菲康唑的制备方法 |
| CA2910990C (en) * | 2014-11-23 | 2022-03-22 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of efinaconazole |
| CA2974180A1 (en) * | 2015-01-20 | 2016-07-28 | Itai Adin | Crystalline forms of efinaconazole |
| ITUB20150417A1 (it) * | 2015-05-08 | 2016-11-08 | Dipharma Francis Srl | Procedimento per la preparazione di composti piperidinici |
| US10479776B2 (en) | 2015-05-12 | 2019-11-19 | Lupin Limited | Process for the preparation of Efinaconazole |
| US10125115B2 (en) | 2015-06-04 | 2018-11-13 | Glenmark Pharmaceuticals Limited | Process for the preparation of efinaconazole |
| EP3112360A1 (en) | 2015-06-29 | 2017-01-04 | Dipharma Francis S.r.l. | Process for the preparation of efinaconazole |
| CN106565672A (zh) * | 2015-10-08 | 2017-04-19 | 中美华世通生物医药科技（武汉）有限公司 | 制备艾氟康唑的方法 |
| US20170129874A1 (en) * | 2015-11-10 | 2017-05-11 | Virupaksha Organics Limited | Novel improved process for preparing a triazole antifungal agent |
| CN106810534A (zh) * | 2015-11-30 | 2017-06-09 | 中美华世通生物医药科技（武汉）有限公司 | 艾氟康唑晶型及其制备方法 |
| CN106918672B (zh) * | 2015-12-28 | 2021-02-09 | 中美华世通生物医药科技（武汉）有限公司 | 利用hplc测定艾氟康唑原料药及其制剂中有关物质的方法 |
| CN106928186A (zh) * | 2015-12-29 | 2017-07-07 | 中美华世通生物医药科技（武汉）有限公司 | 化合物及其制备方法和用途 |
| ITUB20159795A1 (it) * | 2015-12-30 | 2017-06-30 | Procos Spa | Processo per la sintesi di efinaconazolo |
| CN106995434A (zh) * | 2016-01-25 | 2017-08-01 | 广东东阳光药业有限公司 | 一种***类抗真菌药的晶型及其制备方法 |
| ITUA20162545A1 (it) * | 2016-04-13 | 2017-10-13 | Laboratorio Chimico Int S P A | Procedimento per la preparazione di intermedi utili nella sintesi di farmaci |
| CN107759565B (zh) * | 2016-08-15 | 2020-10-23 | 苏州旺山旺水生物医药有限公司 | 一种1-***-2-丁醇衍生物的制备方法 |
| CN107778283A (zh) * | 2016-08-26 | 2018-03-09 | 山东特珐曼药业有限公司 | 一种艾氟康唑的制备方法和其晶型m |
| WO2018036416A1 (zh) * | 2016-08-26 | 2018-03-01 | 山东特珐曼药业有限公司 | 一种艾氟康唑的制备方法和其晶型m |
| CN108276381A (zh) * | 2017-01-06 | 2018-07-13 | 上海和博药物研究有限公司 | 一种艾氟康唑的合成方法 |
| IT201700048270A1 (it) * | 2017-05-04 | 2018-11-04 | Seegpharm Sa | Procedimento per la preparazione di un derivato azolico. |
| ES2941251T3 (es) | 2017-05-19 | 2023-05-19 | Kaken Pharma Co Ltd | Métodos de producción y purificación de efinaconazol |
| CN108440390A (zh) * | 2018-03-13 | 2018-08-24 | 上药康丽（常州）药业有限公司 | 一种4-亚甲基哌啶盐的制备方法 |
| WO2020133411A1 (zh) | 2018-12-29 | 2020-07-02 | 山东威智医药工业有限公司 | 一种艾氟康唑的制备方法 |
| CN113929660B (zh) * | 2021-10-18 | 2022-10-04 | 深圳市海滨制药有限公司 | 一种环氧乙烷衍生物开环方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02191262A (ja) | 1988-03-04 | 1990-07-27 | Sankyo Co Ltd | トリアゾール誘導体 |
| ES2110749T3 (es) * | 1993-05-10 | 1998-02-16 | Kaken Pharma Co Ltd | Derivado de azolilamina. |
| CN1125814C (zh) * | 1995-09-28 | 2003-10-29 | 科研制药株式会社 | 4－亚甲基哌啶的制备方法 |
-
2011
- 2011-08-31 JP JP2012531909A patent/JP5852573B2/ja active Active
- 2011-08-31 CA CA2808230A patent/CA2808230C/en active Active
- 2011-08-31 ES ES11821851.0T patent/ES2556782T3/es active Active
- 2011-08-31 HU HUE11821851A patent/HUE026357T2/en unknown
- 2011-08-31 PL PL11821851T patent/PL2612859T3/pl unknown
- 2011-08-31 TW TW100131301A patent/TWI518081B/zh active
- 2011-08-31 US US13/818,897 patent/US8871942B2/en active Active
- 2011-08-31 EP EP15179288.4A patent/EP2966071B1/en active Active
- 2011-08-31 WO PCT/JP2011/069733 patent/WO2012029836A1/ja active Application Filing
- 2011-08-31 BR BR112013004827-1A patent/BR112013004827B1/pt active IP Right Grant
- 2011-08-31 CN CN201610342052.6A patent/CN106045970B/zh active Active
- 2011-08-31 CN CN201180041900.5A patent/CN103080100B/zh active Active
- 2011-08-31 EP EP11821851.0A patent/EP2612859B1/en active Active
- 2011-08-31 PT PT118218510T patent/PT2612859E/pt unknown
- 2011-08-31 RS RS20150697A patent/RS54330B1/en unknown
- 2011-08-31 DK DK11821851.0T patent/DK2612859T3/da active
-
2015
- 2015-11-30 CY CY20151101088T patent/CY1116997T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2556782T3 (es) | 2016-01-20 |
| CN106045970A (zh) | 2016-10-26 |
| BR112013004827B1 (pt) | 2020-03-31 |
| TW201215601A (en) | 2012-04-16 |
| EP2966071B1 (en) | 2017-01-25 |
| EP2966071A1 (en) | 2016-01-13 |
| PT2612859E (pt) | 2015-11-30 |
| PL2612859T3 (pl) | 2016-01-29 |
| US20130150586A1 (en) | 2013-06-13 |
| EP2612859B1 (en) | 2015-09-30 |
| JPWO2012029836A1 (ja) | 2013-10-31 |
| HUE026357T2 (en) | 2016-06-28 |
| US8871942B2 (en) | 2014-10-28 |
| BR112013004827A2 (pt) | 2016-05-31 |
| CN103080100B (zh) | 2016-04-27 |
| RS54330B1 (en) | 2016-02-29 |
| CN103080100A (zh) | 2013-05-01 |
| CA2808230C (en) | 2017-02-28 |
| JP5852573B2 (ja) | 2016-02-03 |
| EP2612859A4 (en) | 2014-01-08 |
| CN106045970B (zh) | 2019-11-08 |
| EP2612859A1 (en) | 2013-07-10 |
| CA2808230A1 (en) | 2012-03-08 |
| WO2012029836A1 (ja) | 2012-03-08 |
| CY1116997T1 (el) | 2017-04-05 |
| TWI518081B (zh) | 2016-01-21 |
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