DK246786A - Laegemiddel indeholdende vaevs-plasminogen-aktivator - Google Patents

Laegemiddel indeholdende vaevs-plasminogen-aktivator Download PDF

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Publication number
DK246786A
DK246786A DK246786A DK246786A DK246786A DK 246786 A DK246786 A DK 246786A DK 246786 A DK246786 A DK 246786A DK 246786 A DK246786 A DK 246786A DK 246786 A DK246786 A DK 246786A
Authority
DK
Denmark
Prior art keywords
plasminogen activator
containing pharmaceutical
pharmaceuticals containing
pharmaceuticals
pharmaceutical
Prior art date
Application number
DK246786A
Other languages
English (en)
Other versions
DK163173B (da
DK246786D0 (da
DK163173C (da
Inventor
Michael Denis Johnston
Henry Berger
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521705A external-priority patent/GB8521705D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK246786D0 publication Critical patent/DK246786D0/da
Publication of DK246786A publication Critical patent/DK246786A/da
Publication of DK163173B publication Critical patent/DK163173B/da
Application granted granted Critical
Publication of DK163173C publication Critical patent/DK163173C/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6459Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK246786A 1985-05-28 1986-05-27 Fremgangsmaade til fremstilling af et lyofiliseret farmaceutisk praeparat af vaevs-plasminogenaktivator (t-pa) DK163173C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8513358 1985-05-28
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB858521705A GB8521705D0 (en) 1985-08-31 1985-08-31 Formulation
GB8521705 1985-08-31

Publications (4)

Publication Number Publication Date
DK246786D0 DK246786D0 (da) 1986-05-27
DK246786A true DK246786A (da) 1986-11-29
DK163173B DK163173B (da) 1992-02-03
DK163173C DK163173C (da) 1992-06-22

Family

ID=26289290

Family Applications (1)

Application Number Title Priority Date Filing Date
DK246786A DK163173C (da) 1985-05-28 1986-05-27 Fremgangsmaade til fremstilling af et lyofiliseret farmaceutisk praeparat af vaevs-plasminogenaktivator (t-pa)

Country Status (22)

Country Link
US (2) US4929444A (da)
JP (1) JPH0759517B2 (da)
AU (1) AU567236B2 (da)
BE (1) BE904830A (da)
CA (1) CA1300008C (da)
CH (1) CH665356A5 (da)
DE (1) DE3617752A1 (da)
DK (1) DK163173C (da)
ES (2) ES8800601A1 (da)
FI (1) FI85335C (da)
FR (1) FR2583984B1 (da)
GB (1) GB2176702B (da)
GR (1) GR861366B (da)
HU (1) HU195733B (da)
IL (1) IL78938A (da)
IT (1) IT1191926B (da)
LU (1) LU86444A1 (da)
NL (1) NL8601355A (da)
NO (1) NO171345C (da)
NZ (1) NZ216307A (da)
PT (1) PT82646B (da)
SE (1) SE462016B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH664495A5 (de) * 1985-05-28 1988-03-15 Wellcome Found Pharmazeutische formulierung.
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
NL8701113A (nl) * 1986-05-12 1987-12-01 Wellcome Found Nieuwe farmaceutische toepassing.
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
WO1992011866A1 (en) * 1991-01-14 1992-07-23 Duke University LAMININ SEQUENCE AS tPA ACTIVATOR
CA2129660C (en) * 1992-06-03 2005-06-28 William F. Bennett Tissue plasminogen activator glycosylation variants with improved therapeutic properties
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
KR19990066981A (ko) * 1995-10-23 1999-08-16 윌리엄 뉴우 치료용 맥관형성억제 조성물 및 방법
DK0869970T3 (da) * 1995-12-13 2004-07-05 Abbott Lab Endothelcelleprolifereringsinhibitor og dens anvendelse
US6139838A (en) * 1996-09-06 2000-10-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Tissue plasminogen activator medicinal composition
US20030077682A1 (en) * 2001-09-07 2003-04-24 Hung Paul Porwen Human tissue urokinase type plasminogen activator formulation
US20040091465A1 (en) * 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
JP2007525963A (ja) * 2003-06-20 2007-09-13 イルミナ インコーポレイテッド 全ゲノム増幅および遺伝型決定のための方法および組成物
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
ES2443653T3 (es) * 2005-04-20 2014-02-20 Fred Hutchinson Cancer Research Center Procedimientos, composiciones y artículos de fabricación para mejorar la supervivencia de células, tejidos, órganos y organismos

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (da) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
CH660742A5 (de) * 1982-10-29 1987-06-15 Mitsui Toatsu Chemicals Plasminogen-aktivator, verfahren zu seiner herstellung und diesen enthaltendes thrombolytisches agens.
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法

Also Published As

Publication number Publication date
GR861366B (en) 1986-09-29
NZ216307A (en) 1989-10-27
FI85335C (fi) 1992-04-10
FI862227A0 (fi) 1986-05-27
CH665356A5 (de) 1988-05-13
IT1191926B (it) 1988-03-31
DK163173B (da) 1992-02-03
IT8648065A0 (it) 1986-05-27
AU567236B2 (en) 1987-11-12
JPH0759517B2 (ja) 1995-06-28
AU5796486A (en) 1986-12-04
SE8602405L (sv) 1986-11-29
ES555353A0 (es) 1987-11-16
NO862096L (no) 1986-12-01
FI85335B (fi) 1991-12-31
SE8602405D0 (sv) 1986-05-27
IL78938A0 (en) 1986-09-30
FI862227A (fi) 1986-11-29
PT82646B (pt) 1989-01-30
IL78938A (en) 1993-02-21
NL8601355A (nl) 1986-12-16
GB8612780D0 (en) 1986-07-02
GB2176702B (en) 1989-07-05
LU86444A1 (fr) 1986-12-05
GB2176702A (en) 1987-01-07
DK246786D0 (da) 1986-05-27
NO171345C (no) 1993-03-03
DE3617752C2 (da) 1988-06-30
DE3617752A1 (de) 1986-12-04
CA1300008C (en) 1992-05-05
PT82646A (en) 1986-06-01
US4929444A (en) 1990-05-29
SE462016B (sv) 1990-04-30
FR2583984B1 (fr) 1989-06-02
JPH06183995A (ja) 1994-07-05
ES8800601A1 (es) 1987-11-16
FR2583984A1 (fr) 1987-01-02
HU195733B (en) 1988-07-28
ES557374A0 (es) 1988-06-01
BE904830A (fr) 1986-11-27
US4968617A (en) 1990-11-06
HUT41638A (en) 1987-05-28
DK163173C (da) 1992-06-22
NO171345B (no) 1992-11-23
ES8802439A1 (es) 1988-06-01

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