DK2398775T3 - Koblet genkendelses-/detekteringssystem til anvendelse in vivo og in vitro - Google Patents
Koblet genkendelses-/detekteringssystem til anvendelse in vivo og in vitroInfo
- Publication number
- DK2398775T3 DK2398775T3 DK10744308.7T DK10744308T DK2398775T3 DK 2398775 T3 DK2398775 T3 DK 2398775T3 DK 10744308 T DK10744308 T DK 10744308T DK 2398775 T3 DK2398775 T3 DK 2398775T3
- Authority
- DK
- Denmark
- Prior art keywords
- vitro
- vivo
- detection system
- connected recognition
- recognition
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20789709P | 2009-02-18 | 2009-02-18 | |
| PCT/US2010/024622 WO2010096584A1 (en) | 2009-02-18 | 2010-02-18 | Coupled recognition/detection system for in vivo and in vitro use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2398775T3 true DK2398775T3 (da) | 2019-06-03 |
Family
ID=42634209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10744308.7T DK2398775T3 (da) | 2009-02-18 | 2010-02-18 | Koblet genkendelses-/detekteringssystem til anvendelse in vivo og in vitro |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10316000B2 (da) |
| EP (1) | EP2398775B1 (da) |
| CN (1) | CN102405212B (da) |
| DK (1) | DK2398775T3 (da) |
| WO (1) | WO2010096584A1 (da) |
Families Citing this family (43)
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| US8406860B2 (en) | 2008-01-25 | 2013-03-26 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
| CN102405212B (zh) | 2009-02-18 | 2016-01-27 | 康奈尔大学 | 在体内外使用的偶联识别/检测*** |
| WO2011050000A2 (en) * | 2009-10-20 | 2011-04-28 | The Regents Of The University Of California | Single molecule nucleic acid nanoparticles |
| US9069130B2 (en) * | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
| ES2395663B1 (es) * | 2011-07-22 | 2013-11-18 | Universidad De Alcalá | Derivados de 5-azolona como inhibidores de calpaina |
| WO2013016694A2 (en) * | 2011-07-27 | 2013-01-31 | Cornell University | Methods for rna detection and quantification |
| EP2863801B8 (en) | 2012-06-21 | 2024-06-12 | Stryker Corporation | Quantification and analysis of angiography and perfusion |
| RU2661101C2 (ru) | 2013-03-13 | 2018-07-11 | Дженевив Биосайнсис, Инк. | Нерепликативные трансдукторные частицы и основанные на трансдукторных частицах репортерные системы |
| US9481903B2 (en) | 2013-03-13 | 2016-11-01 | Roche Molecular Systems, Inc. | Systems and methods for detection of cells using engineered transduction particles |
| US9664676B2 (en) | 2013-09-06 | 2017-05-30 | Cornell University | RNA sequences that induce fluorescence of small molecule fluorophores |
| US20160231324A1 (en) * | 2013-09-24 | 2016-08-11 | The Regents Of The University Of California | Encapsulated sensors and sensing systems for bioassays and diagnostics and methods for making and using them |
| US9540675B2 (en) | 2013-10-29 | 2017-01-10 | GeneWeave Biosciences, Inc. | Reagent cartridge and methods for detection of cells |
| JP6549705B2 (ja) | 2014-09-29 | 2019-07-24 | ノバダック テクノロジーズ ユーエルシー | 自己蛍光の存在下での、生物的物質内のターゲット蛍光体のイメージング |
| JP6487544B2 (ja) | 2014-10-09 | 2019-03-20 | ノバダック テクノロジーズ ユーエルシー | 蛍光媒介光電式容積脈波記録法を用いた組織中の絶対血流の定量化 |
| CA2925053A1 (en) * | 2015-03-24 | 2016-09-24 | Mcmaster University | Biosensors comprising concatemeric nucleic acid molecules |
| EP3277845B1 (en) * | 2015-03-30 | 2021-07-07 | Genapsys Inc. | Beads for nucleic acid sequencing |
| US10351893B2 (en) | 2015-10-05 | 2019-07-16 | GeneWeave Biosciences, Inc. | Reagent cartridge for detection of cells |
| EP3211083A1 (en) | 2016-02-26 | 2017-08-30 | Centre National De La Recherche Scientifique | Fluorescent aptamers and their applications |
| CN108069908B (zh) * | 2016-11-15 | 2021-07-27 | 香港科技大学 | 荧光探针及其应用 |
| GB201704766D0 (en) * | 2017-01-05 | 2017-05-10 | Illumia Inc | System and methods for selective effluent collection |
| US11140305B2 (en) | 2017-02-10 | 2021-10-05 | Stryker European Operations Limited | Open-field handheld fluorescence imaging systems and methods |
| US11077444B2 (en) | 2017-05-23 | 2021-08-03 | Roche Molecular Systems, Inc. | Packaging for a molecular diagnostic cartridge |
| EP3642342A4 (en) | 2017-06-23 | 2021-03-17 | Cornell University | RNA MOLECULES, CIRCULAR RNA PRODUCTION METHODS, AND PROCESSING METHODS |
| US11760984B2 (en) | 2017-10-31 | 2023-09-19 | The Broad Institute, Inc. | CRISPR protein inhibitors |
| CA3091814A1 (en) * | 2018-03-07 | 2019-09-12 | The Penn State Research Foundation | Dyes for analysis of soluble protein aggregates or misfolded protein oligomers |
| WO2020041384A1 (en) | 2018-08-20 | 2020-02-27 | The Broad Institute, Inc. | 3-phenyl-2-cyano-azetidine derivatives, inhibitors of rna-guided nuclease activity |
| WO2020068304A2 (en) | 2018-08-20 | 2020-04-02 | The Broad Institute, Inc. | Inhibitors of rna-guided nuclease target binding and uses thereof |
| GB201901675D0 (en) | 2019-02-07 | 2019-03-27 | Univ Strathclyde | Transcriptional inhibition assay |
| WO2020190061A1 (ko) * | 2019-03-19 | 2020-09-24 | 한국생명공학연구원 | 전사 시스템 기반 고감도 센서 |
| CN111593052A (zh) * | 2019-04-28 | 2020-08-28 | 华东理工大学 | 一种rna检测与定量的方法 |
| CN110105342B (zh) * | 2019-05-31 | 2022-03-18 | 周口师范学院 | 检测还原型烟酰胺腺嘌呤二核苷酸及其磷酸酯的荧光探针以及该荧光探针的制备方法和应用 |
| CN112538482A (zh) * | 2019-09-23 | 2021-03-23 | 华东理工大学 | 一种rna检测与定量的方法 |
| US11976382B2 (en) | 2019-10-23 | 2024-05-07 | Boise State University | Nucleic acid based biosensor and methods thereof |
| WO2021216914A2 (en) * | 2020-04-22 | 2021-10-28 | Facible Biodiagnostics Llc | Nucleic acid-based biosensor and associated methods |
| US20240018526A1 (en) * | 2020-07-15 | 2024-01-18 | Facible Biodiagnostics Llc | Deoxyribonucleic acid-based biosensor and associated methods |
| CN114058622A (zh) * | 2020-08-03 | 2022-02-18 | 华东理工大学 | 一种新型rna检测与定量的方法 |
| CN112209883B (zh) * | 2020-09-21 | 2022-07-29 | 杭州师范大学 | 一种与rna特异性结合的荧光素染料及其应用 |
| CN112899395A (zh) * | 2020-12-05 | 2021-06-04 | 南京普济生物有限公司 | 一种新型冠状病毒核酸免提取的实时检测方法及其试剂盒 |
| CN113061114B (zh) * | 2021-03-25 | 2022-07-01 | 江汉大学 | 一种与二苯丙氨酸二肽共组装形成荧光材料的探针及其制备方法和应用 |
| WO2023097013A1 (en) * | 2021-11-23 | 2023-06-01 | Cornell University | Rna sequences that induce fluorescence of small molecule fluorophores, molecular complexes, sensors, and methods of use thereof |
| WO2024031084A2 (en) * | 2022-08-05 | 2024-02-08 | The Texas A&M University System | Compositions and methods for dye-bound cyclized peptides for medical use |
| WO2024073014A1 (en) * | 2022-09-28 | 2024-04-04 | University Of Cincinnati | Method and device for detecting multiple foodborne pathogens |
| CN115896213A (zh) * | 2022-10-18 | 2023-04-04 | 上海绅道生物科技有限公司 | 一种实时监测体外转录合成rna的检测方法 |
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| US4237224A (en) | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| DE69007413T2 (de) | 1989-10-09 | 1994-07-21 | Toshiba Kawasaki Kk | Organisches Material für die nichtlineare Optik und nichtlineare optische Vorrichtung. |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5688670A (en) | 1994-09-01 | 1997-11-18 | The General Hospital Corporation | Self-modifying RNA molecules and methods of making |
| US6766183B2 (en) | 1995-11-22 | 2004-07-20 | Medtronic Minimed, Inc. | Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers |
| US5792613A (en) | 1996-06-12 | 1998-08-11 | The Curators Of The University Of Missouri | Method for obtaining RNA aptamers based on shape selection |
| US6458559B1 (en) | 1998-04-22 | 2002-10-01 | Cornell Research Foundation, Inc. | Multivalent RNA aptamers and their expression in multicellular organisms |
| IL146564A0 (en) * | 1999-05-24 | 2002-07-25 | Mitsubishi Pharma Corp | Phenoxypropylamine derivatives and pharmaceutical compositions containing the same |
| US7125660B2 (en) | 2000-09-13 | 2006-10-24 | Archemix Corp. | Nucleic acid sensor molecules and methods of using same |
| US20030211516A1 (en) | 2001-07-05 | 2003-11-13 | Davis Jonathan H | Compounds and methods for fluorescently labeling nucleic acids |
| AU2003245676A1 (en) | 2002-06-24 | 2004-01-06 | Cornell Research Foundation, Inc. | Exhaustive selection or rna aptamers against complex targets |
| US20060172320A1 (en) | 2004-07-13 | 2006-08-03 | Stojanovic Milan N | Modular aptametric sensors without covalently attached fluorophores |
| JP2006178325A (ja) | 2004-12-24 | 2006-07-06 | Fuji Photo Film Co Ltd | 光重合性組成物および該光重合性組成物を用いた感光性平版印刷版 |
| US8445655B2 (en) | 2006-06-16 | 2013-05-21 | Cornell Research Foundation, Inc. | Functional nucleic acid ligands to fluorescent proteins |
| FR2919608B1 (fr) | 2007-08-01 | 2012-10-05 | Univ Rennes | Derives d'imidazolones,procede de preparation et applications biologiques |
| CN102405212B (zh) * | 2009-02-18 | 2016-01-27 | 康奈尔大学 | 在体内外使用的偶联识别/检测*** |
| WO2013016694A2 (en) | 2011-07-27 | 2013-01-31 | Cornell University | Methods for rna detection and quantification |
| US9664676B2 (en) | 2013-09-06 | 2017-05-30 | Cornell University | RNA sequences that induce fluorescence of small molecule fluorophores |
-
2010
- 2010-02-18 CN CN201080017269.0A patent/CN102405212B/zh active Active
- 2010-02-18 DK DK10744308.7T patent/DK2398775T3/da active
- 2010-02-18 WO PCT/US2010/024622 patent/WO2010096584A1/en active Application Filing
- 2010-02-18 US US13/202,250 patent/US10316000B2/en active Active
- 2010-02-18 EP EP10744308.7A patent/EP2398775B1/en active Active
-
2019
- 2019-02-26 US US16/286,333 patent/US11629131B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11629131B2 (en) | 2023-04-18 |
| US10316000B2 (en) | 2019-06-11 |
| EP2398775A1 (en) | 2011-12-28 |
| US20190185434A1 (en) | 2019-06-20 |
| WO2010096584A1 (en) | 2010-08-26 |
| CN102405212B (zh) | 2016-01-27 |
| EP2398775A4 (en) | 2013-01-02 |
| EP2398775B1 (en) | 2019-04-24 |
| US20120252699A1 (en) | 2012-10-04 |
| CN102405212A (zh) | 2012-04-04 |
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