DK2264165T3 - Udvælgelse og selektion af levende celler ved hjælp af mRNA-bindende prober - Google Patents
Udvælgelse og selektion af levende celler ved hjælp af mRNA-bindende proberInfo
- Publication number
- DK2264165T3 DK2264165T3 DK10179993.0T DK10179993T DK2264165T3 DK 2264165 T3 DK2264165 T3 DK 2264165T3 DK 10179993 T DK10179993 T DK 10179993T DK 2264165 T3 DK2264165 T3 DK 2264165T3
- Authority
- DK
- Denmark
- Prior art keywords
- selection
- living cells
- mrna
- cell lines
- well
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16698799P | 1999-11-23 | 1999-11-23 | |
US09/718,448 US6692965B1 (en) | 1999-11-23 | 2000-11-22 | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
EP02807718A EP1546327B1 (en) | 1999-11-23 | 2002-08-28 | Selection and isolation of living cells using rna-binding probes |
EP10179993.0A EP2264165B1 (en) | 1999-11-23 | 2002-08-28 | Selection and isolation of living cells using mRNA-binding probes |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2264165T3 true DK2264165T3 (da) | 2013-08-05 |
Family
ID=36640908
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02807718.8T DK1546327T3 (da) | 1999-11-23 | 2002-08-28 | Udvælgelse og isolation af levende celler ved brug af RNA-bindingssonder |
DK10179993.0T DK2264165T3 (da) | 1999-11-23 | 2002-08-28 | Udvælgelse og selektion af levende celler ved hjælp af mRNA-bindende prober |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02807718.8T DK1546327T3 (da) | 1999-11-23 | 2002-08-28 | Udvælgelse og isolation af levende celler ved brug af RNA-bindingssonder |
Country Status (16)
Country | Link |
---|---|
US (4) | US6692965B1 (da) |
EP (2) | EP1546327B1 (da) |
JP (1) | JP4502808B2 (da) |
KR (1) | KR101257500B1 (da) |
CN (1) | CN1688693B (da) |
AT (1) | ATE541924T1 (da) |
AU (1) | AU2002332768A1 (da) |
CA (1) | CA2496821C (da) |
DK (2) | DK1546327T3 (da) |
ES (2) | ES2379731T3 (da) |
HK (1) | HK1079238A1 (da) |
IL (1) | IL166757A0 (da) |
MX (1) | MXPA05002192A (da) |
NZ (1) | NZ538852A (da) |
PT (1) | PT1546327E (da) |
WO (1) | WO2004020625A1 (da) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US6692965B1 (en) * | 1999-11-23 | 2004-02-17 | Chromocell Corporation | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
DK1725573T3 (da) * | 2004-02-18 | 2012-04-02 | Chromocell Corp | Fremgangsmåde og materialer ved anvendelse af signalsonder |
CN101573454A (zh) * | 2006-10-10 | 2009-11-04 | 米阿科姆诊断有限公司 | 用于荧光原位杂交和芯片技术的核酸信标 |
JP2010511385A (ja) * | 2006-11-30 | 2010-04-15 | クロモセル コーポレイション | タンパク質産生のための至適化された宿主細胞 |
WO2008089396A1 (en) * | 2007-01-19 | 2008-07-24 | Invitrogen Corporation | Compositions and methods for genetic manipulation and monitoring of cell lines |
DK2036989T3 (da) * | 2007-09-12 | 2012-10-22 | Pasteur Institut | Polynukleotid, der er egnet til enkeltcellebaseret reporterassay tilovervågning af genekspressionsmønstre med høj spatiotemporalopløsning |
WO2009094218A2 (en) * | 2008-01-22 | 2009-07-30 | Chromocell Corporation | Novel cell lines expressing nav and methods using them |
US9534035B2 (en) * | 2008-01-25 | 2017-01-03 | Chromocell Corporation | Cell lines expressing ENaC and methods using them |
CA2713885A1 (en) * | 2008-02-01 | 2009-08-20 | Chromocell Corporation | Novel cell lines and methods |
EP2186827A1 (en) | 2008-11-14 | 2010-05-19 | HS LifeSciences Ltd. | Surrogate marker directed cDNA cloning of selectively induced mRNAs |
WO2010088633A2 (en) * | 2009-02-02 | 2010-08-05 | Chromocell Corporation | Novel cell lines and methods |
CA2769456A1 (en) * | 2009-07-31 | 2011-02-03 | Chromocell Corporation | Methods and compositions for identifying and validating modulators of cell fate |
WO2011017288A1 (en) | 2009-08-05 | 2011-02-10 | Chromocell Corporation | Improved plants, microbes, and organisms |
US9347934B2 (en) | 2011-10-20 | 2016-05-24 | Chromocell Corporation | Assays for identifying compounds that modulate bitter taste |
US9540684B2 (en) * | 2012-12-14 | 2017-01-10 | Mindera Corporation | Methods and devices for detection and acquisition of biomarkers |
EP2971131A4 (en) * | 2013-03-15 | 2016-11-23 | Chromocell Corp | METHODS AND MATERIALS USING SIGNALING PROBES |
EP2970971B1 (en) | 2013-03-15 | 2020-09-02 | Kambiz Shekdar | Genome editing using effector oligonucleotides for therapeutic treatment |
US9493742B2 (en) | 2013-03-15 | 2016-11-15 | Emory University | Purification of cell mixtures using molecular beacons targeting cell specific RNA |
CN105358983B (zh) | 2013-04-24 | 2018-08-03 | 卓莫赛尔公司 | 用于鉴定调节苦味的化合物的测定 |
US20160177396A1 (en) * | 2014-12-22 | 2016-06-23 | Enzo Biochem, Inc. | Comprehensive and comparative flow cytometry-based methods for identifying the state of a biological system |
MX2019012398A (es) | 2017-04-18 | 2020-09-25 | Broad Inst Inc | Composiciones para detectar secreciones y metodos de uso. |
US20210147831A1 (en) | 2018-04-27 | 2021-05-20 | The Broad Institute, Inc. | Sequencing-based proteomics |
CN110819656B (zh) * | 2019-11-11 | 2021-06-04 | 中国科学院上海高等研究院 | 一种基于同步光源的x-射线多色遗传标记探针及其制备方法以及应用 |
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EP0791659A3 (en) * | 1989-11-13 | 1997-09-17 | Children's Medical Center Corporation | Antigen specific separation of nucleated fetal cells in non-invasive detection of fetal DNA |
EP0662152A1 (en) * | 1992-07-17 | 1995-07-12 | Aprogenex, Inc. | Enriching and identyfying fetal cells in maternal blood for in situ hybridization |
US5629147A (en) * | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
US5925517A (en) * | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
US5641675A (en) | 1994-10-07 | 1997-06-24 | University Of Massachusetts Medical Center | Cis-acting sequences for intracellular localization of RNA |
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US20030215798A1 (en) * | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
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US6416959B1 (en) * | 1997-02-27 | 2002-07-09 | Kenneth Giuliano | System for cell-based screening |
US6750052B1 (en) * | 1997-07-23 | 2004-06-15 | The Brigham And Women's Hospital, Inc. | Lens epithelial cell derived growth factor |
AU9220498A (en) * | 1997-09-04 | 1999-03-22 | Bayer Corporation | Oligonucleotide probes bearing quenchable fluorescent labels, and methods of usethereof |
US6485901B1 (en) * | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
WO1999037806A2 (en) * | 1998-01-27 | 1999-07-29 | Cytocell Limited | Modified nucleic acid probes and uses thereof |
WO1999053017A2 (en) * | 1998-04-15 | 1999-10-21 | Fred Hutchinson Cancer Research Center | Methods and vector constructs for making transgenic non-human animals which ubiquitously express a heterologous gene |
ES2330812T3 (es) * | 1998-07-02 | 2009-12-15 | Gen-Probe Incorporated | Antorchas moleculares. |
US6037130A (en) * | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
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US6692965B1 (en) * | 1999-11-23 | 2004-02-17 | Chromocell Corporation | Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences |
JP3460673B2 (ja) * | 2000-02-04 | 2003-10-27 | 浜松ホトニクス株式会社 | 特定の遺伝子を発現した生細胞の選択的分離方法 |
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US20020129397A1 (en) * | 2000-12-13 | 2002-09-12 | Allen Keith D. | Transgenic mice containing brain-specific membrane-anchored protein gene disruptions |
WO2002051988A2 (en) * | 2000-12-22 | 2002-07-04 | University Of Edinburgh | Thymic epithelial progenitor cells and uses thereof |
US20020090614A1 (en) | 2001-01-09 | 2002-07-11 | Jia Zhang | Direct measurement method for gene expression using single chain antisense array |
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WO2003048346A1 (en) * | 2001-12-04 | 2003-06-12 | Genome Biosciences, Llc | Gene targeting methods and vectors |
CN103966345A (zh) * | 2007-02-09 | 2014-08-06 | 西北大学 | 检测细胞内标靶的颗粒 |
-
2000
- 2000-11-22 US US09/718,448 patent/US6692965B1/en not_active Expired - Lifetime
-
2002
- 2002-08-28 NZ NZ538852A patent/NZ538852A/xx not_active IP Right Cessation
- 2002-08-28 CN CN028296869A patent/CN1688693B/zh not_active Expired - Fee Related
- 2002-08-28 EP EP02807718A patent/EP1546327B1/en not_active Expired - Lifetime
- 2002-08-28 JP JP2004532540A patent/JP4502808B2/ja not_active Expired - Fee Related
- 2002-08-28 PT PT02807718T patent/PT1546327E/pt unknown
- 2002-08-28 ES ES02807718T patent/ES2379731T3/es not_active Expired - Lifetime
- 2002-08-28 IL IL16675702A patent/IL166757A0/xx active IP Right Grant
- 2002-08-28 WO PCT/US2002/027749 patent/WO2004020625A1/en active Application Filing
- 2002-08-28 ES ES10179993T patent/ES2423598T3/es not_active Expired - Lifetime
- 2002-08-28 KR KR1020057003536A patent/KR101257500B1/ko active IP Right Grant
- 2002-08-28 DK DK02807718.8T patent/DK1546327T3/da active
- 2002-08-28 CA CA2496821A patent/CA2496821C/en not_active Expired - Fee Related
- 2002-08-28 AU AU2002332768A patent/AU2002332768A1/en not_active Abandoned
- 2002-08-28 EP EP10179993.0A patent/EP2264165B1/en not_active Expired - Lifetime
- 2002-08-28 MX MXPA05002192A patent/MXPA05002192A/es active IP Right Grant
- 2002-08-28 AT AT02807718T patent/ATE541924T1/de active
- 2002-08-28 DK DK10179993.0T patent/DK2264165T3/da active
-
2003
- 2003-09-02 US US10/654,241 patent/US20060147937A1/en not_active Abandoned
-
2005
- 2005-12-05 HK HK05111073.2A patent/HK1079238A1/xx not_active IP Right Cessation
-
2010
- 2010-04-30 US US12/771,223 patent/US20100212040A1/en not_active Abandoned
-
2015
- 2015-01-16 US US14/599,319 patent/US20150143563A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2264165A2 (en) | 2010-12-22 |
WO2004020625A1 (en) | 2004-03-11 |
US20100212040A1 (en) | 2010-08-19 |
EP2264165A3 (en) | 2011-02-16 |
KR20050084810A (ko) | 2005-08-29 |
CN1688693B (zh) | 2010-12-22 |
US6692965B1 (en) | 2004-02-17 |
KR101257500B1 (ko) | 2013-04-23 |
MXPA05002192A (es) | 2005-08-18 |
HK1079238A1 (en) | 2006-03-31 |
AU2002332768A1 (en) | 2004-03-19 |
ATE541924T1 (de) | 2012-02-15 |
CN1688693A (zh) | 2005-10-26 |
US20060147937A1 (en) | 2006-07-06 |
EP1546327B1 (en) | 2012-01-18 |
US20150143563A1 (en) | 2015-05-21 |
JP4502808B2 (ja) | 2010-07-14 |
CA2496821C (en) | 2012-06-19 |
ES2423598T3 (es) | 2013-09-23 |
ES2379731T3 (es) | 2012-05-03 |
EP1546327A4 (en) | 2005-11-09 |
NZ538852A (en) | 2006-03-31 |
PT1546327E (pt) | 2012-03-12 |
EP1546327A1 (en) | 2005-06-29 |
DK1546327T3 (da) | 2012-03-26 |
JP2005537005A (ja) | 2005-12-08 |
IL166757A0 (en) | 2006-01-15 |
CA2496821A1 (en) | 2004-03-11 |
EP2264165B1 (en) | 2013-05-01 |
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