DK2227234T3 - Fremgangsmåde til induktion af hepatocytproliferering og anvendelserderaf - Google Patents
Fremgangsmåde til induktion af hepatocytproliferering og anvendelserderafInfo
- Publication number
- DK2227234T3 DK2227234T3 DK08840556.8T DK08840556T DK2227234T3 DK 2227234 T3 DK2227234 T3 DK 2227234T3 DK 08840556 T DK08840556 T DK 08840556T DK 2227234 T3 DK2227234 T3 DK 2227234T3
- Authority
- DK
- Denmark
- Prior art keywords
- inputation
- procedure
- application
- hepatocyte proliferation
- hepatocyte
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96079707P | 2007-10-15 | 2007-10-15 | |
PCT/IL2008/001361 WO2009050707A1 (en) | 2007-10-15 | 2008-10-22 | Method for inducing hepatocyte proliferation and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2227234T3 true DK2227234T3 (da) | 2014-08-11 |
Family
ID=40227958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08840556.8T DK2227234T3 (da) | 2007-10-15 | 2008-10-22 | Fremgangsmåde til induktion af hepatocytproliferering og anvendelserderaf |
Country Status (9)
Country | Link |
---|---|
US (2) | US8846635B2 (da) |
EP (1) | EP2227234B1 (da) |
JP (1) | JP5592262B2 (da) |
CN (1) | CN101820883B (da) |
DK (1) | DK2227234T3 (da) |
ES (1) | ES2490606T3 (da) |
IL (1) | IL204063A (da) |
PL (1) | PL2227234T3 (da) |
WO (1) | WO2009050707A1 (da) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0428416D0 (en) * | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
JP6000950B2 (ja) * | 2010-08-12 | 2016-10-05 | アーベーアーゲー フェアヴァルトゥングス ゲーエムベーハーAbag Verwaltungs Gmbh | 肝細胞の特徴を有する細胞を産生するための方法並びに同方法により産生された細胞及びその使用 |
CN107459544B (zh) | 2011-12-22 | 2021-03-16 | 詹森生物制药有限公司 | 取代的核苷、核苷酸及其类似物 |
EP2806878A1 (en) * | 2012-01-23 | 2014-12-03 | Can-Fite Biopharma Ltd. | Treatment of liver conditions |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2014028079A1 (en) * | 2012-08-16 | 2014-02-20 | Thomas Jefferson University | Treatment of prostate cancer |
IL242723B (en) * | 2015-11-23 | 2019-12-31 | Can Fite Biopharma Ltd | A3 adenosine receptor ligand for the treatment of ectopic fat accumulation |
US9789131B1 (en) | 2016-04-21 | 2017-10-17 | Astrocyte Pharmaceuticals, Inc. | Compounds and methods for treating neurological and cardiovascular conditions |
IL276358B1 (en) | 2018-02-09 | 2024-07-01 | Astrocyte Pharmaceuticals Inc | COMPOUNDS AND METHODS FOR THE TREATMENT OF ADDICTION AND RELATED DISORDERS |
MX2021003515A (es) | 2018-09-26 | 2021-05-27 | Astrocyte Pharmaceuticals Inc | Compuestos polimorficos y usos de los mismos. |
IL272078A (en) | 2020-01-16 | 2021-07-29 | Can Fite Biopharma Ltd | Cannabinoids for use in therapy |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5443836A (en) | 1993-03-15 | 1995-08-22 | Gensia, Inc. | Methods for protecting tissues and organs from ischemic damage |
US5688774A (en) | 1993-07-13 | 1997-11-18 | The United States Of America As Represented By The Department Of Health And Human Services | A3 adenosine receptor agonists |
EP0708781B1 (en) * | 1993-07-13 | 2001-10-04 | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services | A 3 adenosine receptor agonists |
AU1399297A (en) | 1996-01-24 | 1997-08-20 | Sumitomo Chemical Company, Limited | Dihalopropene compounds, their use as insecticides/acaricides and intermediates for their production |
US6048865A (en) | 1997-07-29 | 2000-04-11 | Medco Research, Inc. | N6 -substituted-adenosine-5'-uronamides as adenosine receptor modulator |
AU8764398A (en) | 1997-07-29 | 1999-02-22 | Medco Research, Inc. | N6-substituted-adenosine-5'-uronamides as adenosine receptor modulators |
US6329349B1 (en) | 1997-10-23 | 2001-12-11 | Trustees Of The University Of Pennsylvania | Methods for reducing ischemic injury of the heart via the sequential administration of monophosphoryl lipid A and adenosine receptor agents |
DE60203702T2 (de) * | 2001-01-16 | 2006-03-02 | Can-Fite Biopharma Ltd. | Verwendung eines adenosin-a3-rezeptor-agonisten zur hemmung der virenreplikation |
US7141553B2 (en) | 2002-11-19 | 2006-11-28 | Can-Fite Biopharma Ltd. Israel | A3AR agonists for the treatment of inflammatory arthritis |
US20050101560A1 (en) | 2003-11-12 | 2005-05-12 | Can-Fite Biopharma Ltd. | Method of treating an individual with methyl 1-[N6-(3-iodobenzyl)-adenin-9-yl] beta-D-ibofuronamide |
US7825102B2 (en) | 2004-07-28 | 2010-11-02 | Can-Fite Biopharma Ltd. | Treatment of dry eye conditions |
WO2006031505A1 (en) | 2004-09-09 | 2006-03-23 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Purine derivatives as a3 and a1 adenosine receptor agonists |
EP1819349A2 (en) * | 2004-11-22 | 2007-08-22 | King Pharmaceuticals Research and Development Inc. | Enhancing treatment of hif-1 mediated disorders with adenosine a3 receptor agonists |
EP1798233A1 (en) | 2005-12-19 | 2007-06-20 | Faust Pharmaceuticals | Pyrrolo[1,2-a]quinoxaline derivatives as Adenosine A3 receptor modulators and uses thereof |
-
2008
- 2008-10-22 DK DK08840556.8T patent/DK2227234T3/da active
- 2008-10-22 WO PCT/IL2008/001361 patent/WO2009050707A1/en active Application Filing
- 2008-10-22 US US12/682,994 patent/US8846635B2/en active Active
- 2008-10-22 JP JP2010529501A patent/JP5592262B2/ja active Active
- 2008-10-22 CN CN2008801116084A patent/CN101820883B/zh active Active
- 2008-10-22 EP EP08840556.8A patent/EP2227234B1/en active Active
- 2008-10-22 PL PL08840556T patent/PL2227234T3/pl unknown
- 2008-10-22 ES ES08840556.8T patent/ES2490606T3/es active Active
-
2010
- 2010-02-21 IL IL204063A patent/IL204063A/en active IP Right Grant
-
2014
- 2014-08-21 US US14/464,970 patent/US9387220B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2490606T3 (es) | 2014-09-04 |
US20140364388A1 (en) | 2014-12-11 |
CN101820883A (zh) | 2010-09-01 |
IL204063A (en) | 2013-05-30 |
US20100249053A1 (en) | 2010-09-30 |
JP2012506366A (ja) | 2012-03-15 |
PL2227234T3 (pl) | 2014-11-28 |
JP5592262B2 (ja) | 2014-09-17 |
WO2009050707A1 (en) | 2009-04-23 |
CN101820883B (zh) | 2013-03-20 |
EP2227234B1 (en) | 2014-05-07 |
US9387220B2 (en) | 2016-07-12 |
EP2227234A1 (en) | 2010-09-15 |
US8846635B2 (en) | 2014-09-30 |
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