DK2209518T3 - Udløsningsreducerende højfrekvens-nerveblokade - Google Patents

Udløsningsreducerende højfrekvens-nerveblokade Download PDF

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Publication number
DK2209518T3
DK2209518T3 DK08844728.9T DK08844728T DK2209518T3 DK 2209518 T3 DK2209518 T3 DK 2209518T3 DK 08844728 T DK08844728 T DK 08844728T DK 2209518 T3 DK2209518 T3 DK 2209518T3
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Denmark
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hfac
block
nerve
amplitude
axon
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DK08844728.9T
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English (en)
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Kevin L Kilgore
Niloy Bhadra
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Univ Case Western Reserve
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36103—Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Electrotherapy Devices (AREA)
  • Rehabilitation Therapy (AREA)

Claims (11)

1. Apparatur omfattende: en elektrode; en kurveformsgenerator forbundet med elektroden; og en styring konfigureret til at styre kurveformsgeneratoren til: at påtrykke en jævnstrøm (DC) på en axon for en nerve, hvilken DC har en første DC amplitude, som ikke er tilstrækkelig til at producere en nerveledningsblokade i axonen; derefter at forøge, over en første tidsperiode, den første DC amplitude til en anden DC amplitude, som er tilstrækkelig til at producere en nerveblokade i axonen; efter den anden DC amplitude er nået, at påtrykke en højfrekvens vekselstrøm (HFAC) på axonen, hvilken HFAC har en HFAC amplitude, en HFAC frekvens over 1 kHz, og en HFAC strøm, hvilken HFAC er konfigureret til at producere en nerveledningsblokade i axonen; og derefter at reducere, over en anden tidsperiode, den anden DC amplitude til en tredie DC amplitude, som ikke er tilstrækkelig til at producere en nerveblokade i axonen, hvorved der dannes en rampeformet DC blokeringskurveform; hvor styringen er konfigureret til at påtrykke den anden DC amplitude sammen med HFAC over en forudbestemt tid og at påtrykke HFAC til at strække sig forbi påtrykningen af den rampeformede DC blokeringskurveform.
2. Apparatur ifølge krav 1, hvor styringen omfatter en lukketsløjfestyring og styringen er konfigureret til selektivt at styre påtrykningen af én eller flere af DC og HFAC baseret på et styresignal modtaget fra lukketsløjfestyringen.
3. Apparatur ifølge krav 1, hvor elektroden omfatter en fem-knude-punkts elektrode omfattende et sæt af to indvendige knudepunkter for påtrykning af HFAC og et sæt af tre udvendige knudepunkter for påtrykning af DC.
4. Apparatur ifølge krav 1, hvor elektroden omfatter en tre-knude-punkts elektrode, hvor de tre knudepunkter omfatter et sæt bestående af to udvendige knudepunkter til påtrykning af såvel HFAC som DC sammen, og et midterknudepunkt for påtrykning af HFAC alene.
5. Apparatur ifølge krav 1, hvor HFAC frekvensen er imellem 1 og 100 kHz.
6. Apparatur ifølge krav 1, hvor HFAC frekvensen er imellem 5 og 50 kHz.
7. Apparatur ifølge krav 1, konfigureret til at producere en nerveledningsblokade som er én af: en motorisk nerveblokade, en sensorisk nerveblokade og en autonom nerveblokade.
8. Apparatur ifølge krav 1, konfigureret til at producere en nerveledningsblokade som er én af: en sternocleidomastoid blokade, en mediannerveblokade, en phrenisk nerveblokade, en celiac-plexusnerveblokade og en moduleret spasticitetblokade.
9. Apparatur ifølge krav 1, hvor én eller flere af DC og HFAC indledningsvis er ubalanceret med hensyn til ladning og hvor styringen er konfigureret til at styre kurveformsgeneratoren til at balancere, over en tidsperiode, ladningen for en indledningsvis ubalanceret HFAC.
10. Apparatur ifølge krav 1, hvor styringen er konfigureret til at påtrykke nerveledningsblokaden for behandling af symptomer af ét eller flere af følgende: torticollis, neuroma-smerte, hikke, muskulær dystrofi, cancersmerte, post-operativ smerte og slagtilfælde.
11. Apparatur ifølge krav 1, hvor den forudbestemte tid er fra 100 til 200 millisekunder.
DK08844728.9T 2007-10-29 2008-10-28 Udløsningsreducerende højfrekvens-nerveblokade DK2209518T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98342007P 2007-10-29 2007-10-29
PCT/US2008/012209 WO2009058258A1 (en) 2007-10-29 2008-10-28 Onset-mitigating high-frequency nerve block

Publications (1)

Publication Number Publication Date
DK2209518T3 true DK2209518T3 (da) 2018-05-28

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US (6) US8983614B2 (da)
EP (1) EP2209518B1 (da)
JP (3) JP5425795B2 (da)
AU (1) AU2008319357B2 (da)
CA (1) CA2703867C (da)
DK (1) DK2209518T3 (da)
ES (1) ES2670218T3 (da)
NO (1) NO2209518T3 (da)
PL (1) PL2209518T3 (da)
WO (1) WO2009058258A1 (da)

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JP5425795B2 (ja) 2014-02-26
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JP6087410B2 (ja) 2017-03-01
NO2209518T3 (da) 2018-07-21
EP2209518A1 (en) 2010-07-28
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JP5884252B2 (ja) 2016-03-15
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US20100241190A1 (en) 2010-09-23
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