DK2170050T3 - Korttidsvirkende phenylalkylamin-calciumkanalblokkere og anvendelser deraf - Google Patents
Korttidsvirkende phenylalkylamin-calciumkanalblokkere og anvendelser derafInfo
- Publication number
- DK2170050T3 DK2170050T3 DK08768636.6T DK08768636T DK2170050T3 DK 2170050 T3 DK2170050 T3 DK 2170050T3 DK 08768636 T DK08768636 T DK 08768636T DK 2170050 T3 DK2170050 T3 DK 2170050T3
- Authority
- DK
- Denmark
- Prior art keywords
- short
- calcium channel
- channel blockers
- phenylalkylamine
- acting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93644007P | 2007-06-20 | 2007-06-20 | |
PCT/US2008/007665 WO2008156820A1 (en) | 2007-06-20 | 2008-06-19 | Short acting phenylalkylamine calcium channel blockers and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2170050T3 true DK2170050T3 (da) | 2014-09-29 |
Family
ID=40156562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08768636.6T DK2170050T3 (da) | 2007-06-20 | 2008-06-19 | Korttidsvirkende phenylalkylamin-calciumkanalblokkere og anvendelser deraf |
Country Status (19)
Country | Link |
---|---|
US (16) | US20100190852A1 (da) |
EP (1) | EP2170050B1 (da) |
JP (1) | JP5421908B2 (da) |
KR (1) | KR101541557B1 (da) |
CN (1) | CN101754678B (da) |
AU (1) | AU2008266798B2 (da) |
BR (1) | BRPI0812919B8 (da) |
CA (1) | CA2693627C (da) |
CY (1) | CY1115619T1 (da) |
DK (1) | DK2170050T3 (da) |
ES (1) | ES2498047T3 (da) |
HK (1) | HK1140913A1 (da) |
HR (1) | HRP20140801T1 (da) |
MX (1) | MX347325B (da) |
NZ (1) | NZ582033A (da) |
PL (1) | PL2170050T3 (da) |
PT (1) | PT2170050E (da) |
SI (1) | SI2170050T1 (da) |
WO (1) | WO2008156820A1 (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX347325B (es) | 2007-06-20 | 2017-04-12 | Milestone Pharmaceuticals Inc | Bloqueadores del canal de calcio de fenilalquilamina de accion corta y sus usos. |
KR101052620B1 (ko) * | 2008-08-28 | 2011-07-29 | 한국과학기술연구원 | 신규 페닐아세테이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 t-형 칼슘 이온 채널의 활성에 의해 유발되는 질환의 예방 또는 치료용 조성물 |
PL2482658T3 (pl) * | 2009-09-30 | 2015-10-30 | Microdose Therapeutx Inc | Sposoby i kompozycje do leczenia objawu Raynauda |
WO2015073919A1 (en) * | 2013-11-14 | 2015-05-21 | University Medical Pharmaceuticals Corporation | Microneedles for therapeutic agent delivery with improved mechanical properties |
ME03679B (me) * | 2015-04-14 | 2020-10-20 | Milestone Pharmaceuticals Inc | Soli kratkodelujućeg fenilalkilamina, bloкatora кalcijumsкih кanala, које su visoko rastvorljive u vodi i njihova primena |
EP4119137A1 (en) * | 2021-07-15 | 2023-01-18 | Milestone Pharmaceuticals Inc. | Methods of administration for highly water-soluble salts of a short acting phenylalkylamine calcium channel blocker |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1154810B (de) * | 1961-04-01 | 1963-09-26 | Knoll Ag | Verfahren zur Herstellung basisch substituierter Phenylacetonitrile |
US3957845A (en) * | 1962-04-27 | 1976-05-18 | Knoll A.G. Chemische Fabriken | Trifluoromethyl-substituted phenyl acetonitriles |
DE1493904A1 (de) * | 1965-07-31 | 1969-06-19 | Knoll Ag | Verfahren zur Herstellung basisch substituierter Phenylacetonitrile |
DE2059923C3 (de) * | 1970-12-05 | 1979-01-25 | Knoll Ag, 6700 Ludwigshafen | l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel |
JPS5118940B2 (da) * | 1971-12-25 | 1976-06-14 | ||
DE2631222C3 (de) * | 1976-07-12 | 1979-01-04 | Knoll Ag, 6700 Ludwigshafen | Verfahren zur Herstellung basisch substituierter Phenylacetonitrile |
DE3144150A1 (de) * | 1981-04-10 | 1982-12-09 | Basf Ag, 6700 Ludwigshafen | (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel |
DE3433383A1 (de) * | 1984-09-12 | 1986-03-20 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue phenyl-acetonitril-derivate |
DE3603032A1 (de) * | 1986-01-31 | 1987-08-06 | Basf Ag | Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel |
US4833162A (en) * | 1988-02-03 | 1989-05-23 | American Cyanamid Company | Substituted benzeneacetonitriles and their use as calcium channel blockers |
US5486539A (en) * | 1989-12-21 | 1996-01-23 | G. D. Searle & Co. | Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives |
IE64870B1 (en) | 1989-12-21 | 1995-09-20 | Searle & Co | Methods of using 2-isopropyl-2-phenylaminovaleronitriles immunosuppressants and vasodilators |
US5162569A (en) | 1989-12-21 | 1992-11-10 | G. D. Searle & Co. | Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives |
US5247119A (en) * | 1990-12-12 | 1993-09-21 | G. D. Searle & Co. | Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives |
US6057344A (en) * | 1991-11-26 | 2000-05-02 | Sepracor, Inc. | Methods for treating hypertension, and angina using optically pure (-) amlodipine |
US5451604A (en) * | 1993-07-26 | 1995-09-19 | G. D. Searle & Co. | Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives |
US5910601A (en) * | 1994-09-26 | 1999-06-08 | Darwin Discovery Limited | Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues |
US5859279A (en) | 1996-09-10 | 1999-01-12 | Darwin Discovery Limited | Compound and process |
US6750238B1 (en) | 2000-05-12 | 2004-06-15 | The University Of Toledo | Aralkyl ester soft drugs |
US7511077B2 (en) * | 2005-02-09 | 2009-03-31 | Neuromed Pharmaceuticals Ltd. | Diamine calcium channel blockers |
GB2435824A (en) | 2006-03-09 | 2007-09-12 | Esteve Labor Dr | Use of nitrile compounds in the treatment of food related and other disorders |
MX347325B (es) | 2007-06-20 | 2017-04-12 | Milestone Pharmaceuticals Inc | Bloqueadores del canal de calcio de fenilalquilamina de accion corta y sus usos. |
-
2008
- 2008-06-19 MX MX2009014052A patent/MX347325B/es active IP Right Grant
- 2008-06-19 DK DK08768636.6T patent/DK2170050T3/da active
- 2008-06-19 KR KR1020107000124A patent/KR101541557B1/ko active IP Right Grant
- 2008-06-19 NZ NZ582033A patent/NZ582033A/en unknown
- 2008-06-19 JP JP2010513245A patent/JP5421908B2/ja active Active
- 2008-06-19 AU AU2008266798A patent/AU2008266798B2/en active Active
- 2008-06-19 PT PT87686366T patent/PT2170050E/pt unknown
- 2008-06-19 EP EP08768636.6A patent/EP2170050B1/en active Active
- 2008-06-19 CA CA2693627A patent/CA2693627C/en active Active
- 2008-06-19 PL PL08768636T patent/PL2170050T3/pl unknown
- 2008-06-19 CN CN200880020979.1A patent/CN101754678B/zh active Active
- 2008-06-19 BR BRPI0812919A patent/BRPI0812919B8/pt active IP Right Grant
- 2008-06-19 SI SI200831291T patent/SI2170050T1/sl unknown
- 2008-06-19 US US12/664,026 patent/US20100190852A1/en not_active Abandoned
- 2008-06-19 ES ES08768636.6T patent/ES2498047T3/es active Active
- 2008-06-19 WO PCT/US2008/007665 patent/WO2008156820A1/en active Application Filing
-
2010
- 2010-08-03 HK HK10107383.8A patent/HK1140913A1/xx unknown
-
2014
- 2014-06-16 US US14/305,626 patent/US9227918B2/en active Active
- 2014-08-22 HR HRP20140801AT patent/HRP20140801T1/hr unknown
- 2014-09-18 CY CY20141100766T patent/CY1115619T1/el unknown
-
2015
- 2015-11-23 US US14/949,107 patent/US9463179B2/en active Active
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2016
- 2016-09-12 US US15/262,567 patent/US9737503B2/en active Active
-
2017
- 2017-07-18 US US15/653,246 patent/US10010522B2/en active Active
- 2017-07-18 US US15/653,367 patent/US10010523B2/en active Active
- 2017-07-20 US US15/655,564 patent/US10010524B2/en active Active
-
2018
- 2018-06-04 US US15/997,229 patent/US20180280339A1/en not_active Abandoned
-
2019
- 2019-01-14 US US16/246,980 patent/US20190142781A1/en not_active Abandoned
- 2019-08-29 US US16/555,766 patent/US20190380993A1/en not_active Abandoned
-
2020
- 2020-04-09 US US16/844,440 patent/US20200230097A1/en not_active Abandoned
- 2020-11-12 US US17/096,498 patent/US20210059972A1/en not_active Abandoned
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2021
- 2021-06-22 US US17/354,288 patent/US20210315855A1/en not_active Abandoned
-
2022
- 2022-01-26 US US17/584,686 patent/US20220142963A1/en not_active Abandoned
-
2023
- 2023-04-24 US US18/138,341 patent/US20230255923A1/en not_active Abandoned
- 2023-12-08 US US18/533,381 patent/US20240115543A1/en active Pending
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