DK2125899T3 - Biomarkører til forudsigelse af renal sikkerhed samt biomarkørsignaturer til overvågning af nyrefunktion - Google Patents

Biomarkører til forudsigelse af renal sikkerhed samt biomarkørsignaturer til overvågning af nyrefunktion

Info

Publication number
DK2125899T3
DK2125899T3 DK08718189.7T DK08718189T DK2125899T3 DK 2125899 T3 DK2125899 T3 DK 2125899T3 DK 08718189 T DK08718189 T DK 08718189T DK 2125899 T3 DK2125899 T3 DK 2125899T3
Authority
DK
Denmark
Prior art keywords
biomarkers
well
renal
safety
predicting
Prior art date
Application number
DK08718189.7T
Other languages
English (en)
Inventor
Gerard Maurer
Frank Dieterle
Elias Perentes
Frank Staedtler
Andre Cordier
Andreas Mahl
Jacky Vonderscher
Daniel Wahl
Olivier Grenet
Daniel Robert Roth
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK2125899T3 publication Critical patent/DK2125899T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/08Hepato-biliairy disorders other than hepatitis
    • G01N2800/085Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/34Genitourinary disorders
    • G01N2800/347Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK08718189.7T 2007-03-26 2008-03-25 Biomarkører til forudsigelse af renal sikkerhed samt biomarkørsignaturer til overvågning af nyrefunktion DK2125899T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90809407P 2007-03-26 2007-03-26
PCT/EP2008/053504 WO2008116867A1 (en) 2007-03-26 2008-03-25 Predictive renal safety biomarkers and biomarker signatures to monitor kidney function

Publications (1)

Publication Number Publication Date
DK2125899T3 true DK2125899T3 (da) 2013-02-11

Family

ID=39325830

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08718189.7T DK2125899T3 (da) 2007-03-26 2008-03-25 Biomarkører til forudsigelse af renal sikkerhed samt biomarkørsignaturer til overvågning af nyrefunktion

Country Status (15)

Country Link
US (2) US8609812B2 (da)
EP (12) EP2479569A3 (da)
JP (2) JP5450375B2 (da)
CN (2) CN101679525B (da)
AU (1) AU2008231738B2 (da)
BR (1) BRPI0809432A2 (da)
CA (1) CA2681792A1 (da)
DK (1) DK2125899T3 (da)
ES (4) ES2532221T3 (da)
HR (1) HRP20130127T1 (da)
PL (1) PL2125899T3 (da)
PT (1) PT2125899E (da)
RU (1) RU2519148C2 (da)
SI (1) SI2125899T1 (da)
WO (1) WO2008116867A1 (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009029046A1 (en) 2007-08-29 2009-03-05 Agency For Science, Technology And Research Sugar-based surfactant microemulsions containing essential oils for cosmetic and pharmaceutical use
CN102187220B (zh) 2008-08-28 2015-08-19 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
CN102187219B (zh) 2008-08-29 2015-08-05 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
US20110207161A1 (en) * 2008-10-21 2011-08-25 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3246707B1 (en) * 2008-10-21 2020-09-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2742113A1 (en) * 2008-11-10 2010-05-14 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2528799T3 (es) * 2008-11-22 2015-02-12 Astute Medical, Inc. Métodos para el pronóstico de insuficiencia renal aguda
MX2011007811A (es) 2009-01-28 2012-03-14 Ind Tech Res Inst Biomarcadores en orina y suero asociados con nefropatia diabetica.
US20120053072A1 (en) * 2009-02-06 2012-03-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US8658351B2 (en) 2009-02-06 2014-02-25 Metabolon, Inc. Determining liver toxicity of an agent using metabolite biomarkers
US9229010B2 (en) 2009-02-06 2016-01-05 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2012525570A (ja) * 2009-04-30 2012-10-22 エフ.ホフマン−ラ ロシュ アーゲー 腎臓損傷の心臓及び糖尿病に基づく原因の識別のための手段及び方法
WO2011000938A1 (de) * 2009-07-02 2011-01-06 Mosaiques Diagnostics And Therapeutics Ag Verfahren und marker zur diagnose eines akuten nierenversagens
EP2462445A1 (en) * 2009-08-07 2012-06-13 Rules-Based Medicine, Inc. Devices for detecting renal disorders
BR112012002711A2 (pt) 2009-08-07 2016-11-01 Astute Medical Inc metodo para avaliar o estado renal em um individuo, e, medicao de proteina
AU2010315008B2 (en) 2009-11-07 2015-12-03 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US8716453B2 (en) 2009-12-17 2014-05-06 School Juridical Person Kitasato Institute Cystatin C, β2 microglobulin, α1 microglobulin and genes for same, antibody, and kit and method for diagnosis of feline nephropathy
KR20120123056A (ko) 2009-12-20 2012-11-07 아스튜트 메디컬 인코포레이티드 신손상 및 신부전을 진단 및 예측하는 방법 및 조성물
DK2666872T3 (da) 2010-02-05 2016-07-25 Astute Medical Inc Fremgangsmåder og sammensætninger til diagnosticering og prognosticering af nyreskade og nyreinsufficiens
EA201290711A1 (ru) * 2010-02-26 2013-10-30 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности
ES2667066T3 (es) 2010-05-24 2018-05-09 The Trustees Of Columbia University In The City Of New York Proteínas NGAL mutantes y usos de las mismas
AU2011261308C1 (en) * 2010-06-03 2016-02-18 Idexx Laboratories, Inc. Markers for renal disease
CA2803498A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2585827A4 (en) 2010-06-23 2013-12-04 Astute Medical Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency
JP5830329B2 (ja) * 2010-09-28 2015-12-09 国立大学法人 岡山大学 腎障害の新規マーカー
CA2811438A1 (en) * 2010-10-07 2012-04-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102147413A (zh) * 2010-12-08 2011-08-10 武汉生之源生物科技有限公司 一种小粒径匀相溶胶颗粒型胱抑素c测定试剂盒及其制备方法
CN102353782A (zh) * 2010-12-31 2012-02-15 上海华谷生物技术有限公司 抗人肾损伤分子1的体外诊断试剂盒及检测方法
CN102243241A (zh) * 2011-04-07 2011-11-16 武汉生之源生物科技有限公司 一种匀相溶胶颗粒型中性粒细胞明胶酶相关脂质运载蛋白测定试剂盒及其制备方法
EP2729803A4 (en) * 2011-07-09 2015-08-05 Astute Medical Inc METHODS AND COMPOSITIONS FOR DIAGNOSING AND PROGNOSING RENAL INJURY AND RENAL FAILURE
EP3489690A1 (en) * 2011-08-26 2019-05-29 Astute Medical, Inc. Methods and compositions for evaluation of the renal status
US20130062516A1 (en) * 2011-09-09 2013-03-14 Hsien-Shou Kuo Diganosis of a renal disease by oxygen and hydrogen isotopes in a biological sample
WO2013067420A1 (en) * 2011-11-03 2013-05-10 Tumlin James A Acth for treatment of kidney disease
US10935548B2 (en) 2011-12-08 2021-03-02 Astute Medical, Inc. Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2
GB201210587D0 (en) * 2012-06-14 2012-08-01 Belfast Health And Social Care Trust Predictive biomarker
US20150177260A1 (en) * 2012-07-23 2015-06-25 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
EP2925337B1 (en) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutant ngal proteins and uses thereof
CA3158996C (en) 2013-01-17 2024-06-04 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104280477B (zh) * 2014-11-03 2016-03-30 天津中医药大学 内源性小分子物质在快速检测肝毒性方面的应用
US11037070B2 (en) * 2015-04-29 2021-06-15 Siemens Healthcare Gmbh Diagnostic test planning using machine learning techniques
EP3316159A4 (en) 2015-06-25 2019-08-14 Advanced Telecommunications Research Institute International PREDICTIVE EQUIPMENT BASED ON A SYSTEM ASSOCIATED WITH SEVERAL INSTITUTIONS AND PREDICTION PROGRAM
US20180265914A1 (en) * 2015-08-31 2018-09-20 Hitachi Chemical Co., Ltd. Molecular methods for assessing post kidney transplant complications
US11028443B2 (en) 2015-08-31 2021-06-08 Showa Denko Materials Co., Ltd. Molecular methods for assessing urothelial disease
US20190218587A1 (en) * 2016-03-29 2019-07-18 Advanced Telecommunications Research Institute International Screening method for candidate substances for active component to prevent or treat at least one disease selected from the group consisting of renal hypofunction, chronic kidney disease and kidney failure
WO2017170803A1 (ja) 2016-03-29 2017-10-05 株式会社国際電気通信基礎技術研究所 医薬組成物又は食品組成物、及び有効成分の体内での効果の評価方法
EP3465201A4 (en) 2016-06-06 2020-08-26 Astute Medical, Inc. MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR
JP7012033B2 (ja) 2016-06-17 2022-02-10 エフ.ホフマン-ラ ロシュ アーゲー インビトロ腎毒性スクリーニングアッセイ
CN106126972B (zh) * 2016-06-21 2018-10-02 哈尔滨工业大学 一种用于蛋白质功能预测的层级多标签分类方法
AU2018207151B2 (en) 2017-01-12 2024-02-29 Astute Medical, Inc. Methods and compositions for evaluation and treatment of renal injury and renal failure based on C-C motif chemokine ligand 14 measurement
EP3577458A4 (en) 2017-02-06 2021-04-07 Astute Medical, Inc. METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PREDICTION OF RENAL LESION AND RENAL INSUFFICIENCY
RU2687256C1 (ru) * 2018-03-26 2019-05-08 Федеральное Государственное бюджетное образовательное учреждение высшего образования Дагестанский государственный медицинский университет Министерства здравоохранения Российской Федерации Даггосмедуниверситет Способ персонализированного лечения хронической болезни почек у больных с диабетической нефропатией
CN111647670A (zh) * 2019-03-04 2020-09-11 中国医学科学院药物研究所 一种与肾病综合征相关的肠道菌属Faecalitalea及其应用
RU2761730C1 (ru) * 2020-12-25 2021-12-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Способ дифференциальной диагностики уремического панкреатита и деструктивного панкреатита у пациентов, получающих заместительную почечную терапию - программный гемодиализ
RU2761725C1 (ru) * 2020-12-26 2021-12-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Способ дифференциальной диагностики уремического псевдоперитонита и перитонита у пациентов, получающих заместительную почечную терапию - программный гемодиализ
RU2761732C1 (ru) * 2020-12-26 2021-12-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Способ дифференциальной диагностики уремического псевдоперитонита и перитонита у пациентов, получающих заместительную почечную терапию - программный гемодиализ
RU2761733C1 (ru) * 2020-12-28 2021-12-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Способ дифференциальной диагностики уремического панкреатита и деструктивного панкреатита у пациентов, получающих заместительную почечную терапию - программный гемодиализ
CN115469026B (zh) * 2022-07-14 2023-10-20 中日友好医院(中日友好临床医学研究所) 用于检测环孢素a肾毒性相关标志物的检测试剂、试剂盒及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013877A1 (en) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Measurement of gene expression profiles in toxicity determination
WO1999015904A1 (en) 1997-09-26 1999-04-01 University Of Washington Methods and compositions for diagnosing renal pathologies
JP3730919B2 (ja) 1999-10-13 2006-01-05 扶桑薬品工業株式会社 ベロトキシン産生大腸菌に起因する腎障害、溶血性***症候群および腸管出血性大腸菌感染症の検査方法
RU2180965C1 (ru) 2000-07-03 2002-03-27 Габбасова Наталья Вадимовна Способ дифференциальной диагностики заболеваний почек
WO2002006537A2 (en) 2000-07-13 2002-01-24 Curagen Corporation Methods of identifying renal protective factors
WO2003031967A1 (fr) * 2001-10-02 2003-04-17 Ikagaku Co., Ltd. Kits de diagnostic de maladies renales
GB0215509D0 (en) * 2002-07-04 2002-08-14 Novartis Ag Marker genes
AU2003281287A1 (en) * 2002-07-04 2004-01-23 Oxford Glycosciences (Uk) Ltd Toxicity markers
DE602004022150D1 (de) * 2003-03-27 2009-09-03 Childrens Hosp Medical Center Verfahren und kit zum nachweis des frühstadiums einer nierentubuluszellenverletzung
WO2004108964A1 (en) * 2003-06-04 2004-12-16 Agency For Science, Technology And Research Differentially regulated hepatocellular carcinoma genes and uses thereof
UA88879C2 (en) * 2003-09-02 2009-12-10 Эплайд Рисерч Системз Эрс Холдинг Н.В. Fsh glycosylation mutant
US20110071767A1 (en) 2004-04-07 2011-03-24 Ocimum Biosoluntions, Inc. Hepatotoxicity Molecular Models
CA2589291A1 (en) * 2004-09-21 2006-06-01 University Of Manitoba Method of detecting kidney dysfunction
GB0507838D0 (en) * 2005-04-18 2005-05-25 Epsom & St Helier University H A method of measuring the glomerular filtration rate of an human or animal patient, a self-use kit for providing blood samples for use in measuring glomerular
CA2634871A1 (en) * 2005-12-22 2007-11-08 Neurochem (International) Limited Treatment of renal disorders, diabetic nephopathy and dyslipidemias
WO2007106466A2 (en) * 2006-03-11 2007-09-20 The Board Of Trustees Of The Leland Stanford Junior University Beta-2 microglobulin as a biomarker for peripheral artery disease
US7645616B2 (en) * 2006-10-20 2010-01-12 The University Of Hong Kong Use of lipocalin-2 as a diagnostic marker and therapeutic target
WO2008057806A1 (en) * 2006-11-01 2008-05-15 Vermillion, Inc. A panel of biomarkers for peripheral arterial disease

Also Published As

Publication number Publication date
CN101679525B (zh) 2013-06-19
EP2479566A3 (en) 2012-09-26
EP2479565A3 (en) 2012-09-26
EP2479574A2 (en) 2012-07-25
US8609812B2 (en) 2013-12-17
EP2479574A3 (en) 2012-09-26
EP2479573A2 (en) 2012-07-25
SI2125899T1 (sl) 2013-02-28
WO2008116867A1 (en) 2008-10-02
EP2125899B1 (en) 2012-11-14
EP2479568A3 (en) 2012-09-26
CN103399155A (zh) 2013-11-20
EP2479564A3 (en) 2012-09-26
EP2479572A3 (en) 2012-09-26
EP2479568A2 (en) 2012-07-25
EP2479567A2 (en) 2012-07-25
EP2479568B1 (en) 2015-01-07
EP2479566B1 (en) 2015-01-07
EP2479570A2 (en) 2012-07-25
PL2125899T3 (pl) 2013-04-30
RU2519148C2 (ru) 2014-06-10
EP2479569A2 (en) 2012-07-25
JP2014074721A (ja) 2014-04-24
EP2479572A2 (en) 2012-07-25
RU2009139295A (ru) 2011-05-10
EP2479573A3 (en) 2012-09-26
BRPI0809432A2 (pt) 2014-09-09
CA2681792A1 (en) 2008-10-02
EP2479571A3 (en) 2012-09-26
ES2532221T3 (es) 2015-03-25
EP2125899A1 (en) 2009-12-02
EP2479571A2 (en) 2012-07-25
JP2010522871A (ja) 2010-07-08
PT2125899E (pt) 2013-01-24
EP2479564A2 (en) 2012-07-25
EP2479572B1 (en) 2014-12-24
CN101679525A (zh) 2010-03-24
EP2479566A2 (en) 2012-07-25
JP5450375B2 (ja) 2014-03-26
EP2479570A3 (en) 2012-09-26
AU2008231738B2 (en) 2012-09-27
EP2479569A3 (en) 2012-09-26
ES2532229T3 (es) 2015-03-25
EP2479565A2 (en) 2012-07-25
HRP20130127T1 (hr) 2013-03-31
EP2479567A3 (en) 2012-09-26
ES2532220T3 (es) 2015-03-25
AU2008231738A1 (en) 2008-10-02
ES2397484T3 (es) 2013-03-07
US20100143956A1 (en) 2010-06-10
US20140171335A1 (en) 2014-06-19

Similar Documents

Publication Publication Date Title
DK2125899T3 (da) Biomarkører til forudsigelse af renal sikkerhed samt biomarkørsignaturer til overvågning af nyrefunktion
WO2013096817A3 (en) A testing cartridge comprising electrochemical sensors and an optical microarray
IL223419A0 (en) Biomarkers for predicting anti-tnf responsiveness or non-responsiveness
DK2557180T3 (da) Fremgangsmåder til påvisning af autoimmune lidelser
DK2438441T3 (da) Nye biomarkører til vurdering af nyresygdomme
DK2232269T3 (da) Fremgangsmåder til biomarkører til diagnosticering og monitorering af psykotiske forstyrrelser
DK2173917T3 (da) Stål til sure servicemiljøer
DK2342220T3 (da) Metoder og systemer til forudsigelse af misfoldede proteinepitoper
EP2272044A4 (en) INFLAMMATION BIOMARKERS FOR MONITORING DEPRESSION DISORDERS
BRPI0816986A2 (pt) Indicador de vida útil do cartucho
BRPI0818789A2 (pt) Medição de rendimento elétrico para centros de dados.
DK3106874T3 (da) Fremgangsmåde til detektering af cancer
BRPI0820127A2 (pt) Posicionamento empregando sinal de piloto melhorado.
DE602006005588D1 (de) Verbesserte Diskriminatorfunktion für GPS-Codeausrichtung
DK2107971T3 (da) Kombineret blækfamilie profilering til en blækpatron
DE112008003444B8 (de) System für Lader
DK2152879T3 (da) RNA antagonistforbindelser til modulering af beta-catenin
IL206631A0 (en) Biomarkers for the prediction of renal injury
DK3130367T3 (da) System til vurdering af insulinfølsomhed
IL212622A0 (en) Biomarkers for assessing atherosclerotic potential
DK2313364T3 (da) Fremgangsmåder til detektering af symmetrisk demethylarginin
GB201102702D0 (en) Predictive biomarkers
DE602004018397D1 (de) Mikrofluidanordnung für optische mikrofluiderfassung
BRPI0911371A2 (pt) método de determinação do prognóstico de funcionamento de um sistema
DK2083686T3 (da) Teknikker til bestemmelse af høretærskel