DK2124638T3 - Sammensætning, der er præstationforøgende, samt anvendelse af den - Google Patents
Sammensætning, der er præstationforøgende, samt anvendelse af den Download PDFInfo
- Publication number
- DK2124638T3 DK2124638T3 DK08712839.3T DK08712839T DK2124638T3 DK 2124638 T3 DK2124638 T3 DK 2124638T3 DK 08712839 T DK08712839 T DK 08712839T DK 2124638 T3 DK2124638 T3 DK 2124638T3
- Authority
- DK
- Denmark
- Prior art keywords
- nitrate
- nitrite
- vol
- combination
- inorganic
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 24
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 103
- 229910002651 NO3 Inorganic materials 0.000 claims description 100
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 94
- 229910001959 inorganic nitrate Inorganic materials 0.000 claims description 35
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 31
- 235000013824 polyphenols Nutrition 0.000 claims description 31
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 230000036284 oxygen consumption Effects 0.000 claims description 27
- 230000009467 reduction Effects 0.000 claims description 18
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 18
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 13
- 235000013311 vegetables Nutrition 0.000 claims description 13
- 241000894006 Bacteria Species 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 230000002829 reductive effect Effects 0.000 claims description 11
- 241000124008 Mammalia Species 0.000 claims description 9
- 235000010344 sodium nitrate Nutrition 0.000 claims description 9
- 239000004317 sodium nitrate Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 230000037396 body weight Effects 0.000 claims description 7
- 150000002823 nitrates Chemical class 0.000 claims description 7
- 235000015897 energy drink Nutrition 0.000 claims description 6
- 239000003826 tablet Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 239000007937 lozenge Substances 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 230000036314 physical performance Effects 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims description 2
- 235000015218 chewing gum Nutrition 0.000 claims description 2
- YBVAXJOZZAJCLA-UHFFFAOYSA-N nitric acid nitrous acid Chemical compound ON=O.O[N+]([O-])=O YBVAXJOZZAJCLA-UHFFFAOYSA-N 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 1
- 235000011496 sports drink Nutrition 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 232
- 230000000694 effects Effects 0.000 description 33
- 238000012360 testing method Methods 0.000 description 26
- 239000001301 oxygen Substances 0.000 description 21
- 229910052760 oxygen Inorganic materials 0.000 description 21
- 239000000047 product Substances 0.000 description 21
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 20
- 150000001875 compounds Chemical class 0.000 description 19
- 229940068196 placebo Drugs 0.000 description 15
- 239000000902 placebo Substances 0.000 description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 230000015572 biosynthetic process Effects 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 14
- 235000002639 sodium chloride Nutrition 0.000 description 12
- 235000015872 dietary supplement Nutrition 0.000 description 11
- 210000003205 muscle Anatomy 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 235000013305 food Nutrition 0.000 description 10
- 238000001727 in vivo Methods 0.000 description 9
- 230000003387 muscular Effects 0.000 description 9
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 8
- 235000021537 Beetroot Nutrition 0.000 description 8
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 8
- 241000282412 Homo Species 0.000 description 8
- 241000700159 Rattus Species 0.000 description 8
- 230000001351 cycling effect Effects 0.000 description 8
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 8
- 229960000201 isosorbide dinitrate Drugs 0.000 description 8
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 8
- 210000002027 skeletal muscle Anatomy 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 7
- 244000299461 Theobroma cacao Species 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 230000004087 circulation Effects 0.000 description 7
- 235000005911 diet Nutrition 0.000 description 7
- 230000002708 enhancing effect Effects 0.000 description 7
- 235000013376 functional food Nutrition 0.000 description 7
- 230000005764 inhibitory process Effects 0.000 description 7
- 230000008811 mitochondrial respiratory chain Effects 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 6
- 244000303040 Glycyrrhiza glabra Species 0.000 description 6
- RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 description 6
- 206010021143 Hypoxia Diseases 0.000 description 6
- 241000220225 Malus Species 0.000 description 6
- 108010025915 Nitrite Reductases Proteins 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 230000000378 dietary effect Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 6
- 230000012010 growth Effects 0.000 description 6
- 235000011477 liquorice Nutrition 0.000 description 6
- 230000002438 mitochondrial effect Effects 0.000 description 6
- 230000006540 mitochondrial respiration Effects 0.000 description 6
- 230000037361 pathway Effects 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 230000009469 supplementation Effects 0.000 description 6
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 5
- 241000282472 Canis lupus familiaris Species 0.000 description 5
- 108090000365 Cytochrome-c oxidases Proteins 0.000 description 5
- 230000000975 bioactive effect Effects 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 5
- 108010002255 deoxyhemoglobin Proteins 0.000 description 5
- 108010035264 deoxymyoglobin Proteins 0.000 description 5
- 230000001419 dependent effect Effects 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 210000003470 mitochondria Anatomy 0.000 description 5
- 150000002826 nitrites Chemical class 0.000 description 5
- 230000035479 physiological effects, processes and functions Effects 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000024883 vasodilation Effects 0.000 description 5
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 235000011430 Malus pumila Nutrition 0.000 description 4
- 235000015103 Malus silvestris Nutrition 0.000 description 4
- 102000008200 Uncoupling Protein 3 Human genes 0.000 description 4
- 108010021098 Uncoupling Protein 3 Proteins 0.000 description 4
- 244000078534 Vaccinium myrtillus Species 0.000 description 4
- 241000219094 Vitaceae Species 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- 235000019270 ammonium chloride Nutrition 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 238000004364 calculation method Methods 0.000 description 4
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical group OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 235000010675 chips/crisps Nutrition 0.000 description 4
- 235000019219 chocolate Nutrition 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 235000021021 grapes Nutrition 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- -1 inorganic anions nitrate Chemical class 0.000 description 4
- 230000001404 mediated effect Effects 0.000 description 4
- 239000002840 nitric oxide donor Substances 0.000 description 4
- 235000010333 potassium nitrate Nutrition 0.000 description 4
- 239000004323 potassium nitrate Substances 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- 230000000241 respiratory effect Effects 0.000 description 4
- 230000006965 reversible inhibition Effects 0.000 description 4
- 238000012552 review Methods 0.000 description 4
- 210000003296 saliva Anatomy 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 238000012549 training Methods 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 3
- 235000005979 Citrus limon Nutrition 0.000 description 3
- 244000131522 Citrus pyriformis Species 0.000 description 3
- 108050008072 Cytochrome c oxidase subunit IV Proteins 0.000 description 3
- QQZWEECEMNQSTG-UHFFFAOYSA-N Ethyl nitrite Chemical compound CCON=O QQZWEECEMNQSTG-UHFFFAOYSA-N 0.000 description 3
- CITFYDYEWQIEPX-UHFFFAOYSA-N Flavanol Natural products O1C2=CC(OCC=C(C)C)=CC(O)=C2C(=O)C(O)C1C1=CC=C(O)C=C1 CITFYDYEWQIEPX-UHFFFAOYSA-N 0.000 description 3
- 206010019280 Heart failures Diseases 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 3
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 3
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 3
- 244000299790 Rheum rhabarbarum Species 0.000 description 3
- 235000009411 Rheum rhabarbarum Nutrition 0.000 description 3
- 244000269722 Thea sinensis Species 0.000 description 3
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 3
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 3
- 240000006909 Tilia x europaea Species 0.000 description 3
- 235000011941 Tilia x europaea Nutrition 0.000 description 3
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 3
- 108010093894 Xanthine oxidase Proteins 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 235000001046 cacaotero Nutrition 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 3
- 239000003925 fat Substances 0.000 description 3
- 235000021107 fermented food Nutrition 0.000 description 3
- 150000002206 flavan-3-ols Chemical class 0.000 description 3
- 235000011987 flavanols Nutrition 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 229960003711 glyceryl trinitrate Drugs 0.000 description 3
- 230000008821 health effect Effects 0.000 description 3
- 229960002474 hydralazine Drugs 0.000 description 3
- 208000028867 ischemia Diseases 0.000 description 3
- 239000004571 lime Substances 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 230000002107 myocardial effect Effects 0.000 description 3
- 150000004005 nitrosamines Chemical class 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 235000014571 nuts Nutrition 0.000 description 3
- 239000006041 probiotic Substances 0.000 description 3
- 230000000529 probiotic effect Effects 0.000 description 3
- 235000018291 probiotics Nutrition 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 230000000284 resting effect Effects 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- MOZIGXHKOXEDLJ-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N MOZIGXHKOXEDLJ-WCCKRBBISA-N 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 2
- 241000976983 Anoxia Species 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 description 2
- JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 description 2
- 108010061435 Enalapril Proteins 0.000 description 2
- 240000006927 Foeniculum vulgare Species 0.000 description 2
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 2
- 240000009088 Fragaria x ananassa Species 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 2
- 229930064664 L-arginine Natural products 0.000 description 2
- 235000014852 L-arginine Nutrition 0.000 description 2
- 240000001929 Lactobacillus brevis Species 0.000 description 2
- 235000003228 Lactuca sativa Nutrition 0.000 description 2
- 240000008415 Lactuca sativa Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 239000000006 Nitroglycerin Substances 0.000 description 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 241000589597 Paracoccus denitrificans Species 0.000 description 2
- 241000734695 Recchia Species 0.000 description 2
- 235000009337 Spinacia oleracea Nutrition 0.000 description 2
- 244000300264 Spinacia oleracea Species 0.000 description 2
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 2
- 102000005773 Xanthine dehydrogenase Human genes 0.000 description 2
- 108010091383 Xanthine dehydrogenase Proteins 0.000 description 2
- 235000011054 acetic acid Nutrition 0.000 description 2
- 239000002535 acidifier Substances 0.000 description 2
- 230000007950 acidosis Effects 0.000 description 2
- 208000026545 acidosis disease Diseases 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229960005305 adenosine Drugs 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 230000007953 anoxia Effects 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 235000021016 apples Nutrition 0.000 description 2
- 210000002565 arteriole Anatomy 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000021028 berry Nutrition 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000008827 biological function Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 235000021014 blueberries Nutrition 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000004098 cellular respiration Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000001120 cytoprotective effect Effects 0.000 description 2
- 235000019221 dark chocolate Nutrition 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 235000021004 dietary regimen Nutrition 0.000 description 2
- 229960001089 dobutamine Drugs 0.000 description 2
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 description 2
- 229960000873 enalapril Drugs 0.000 description 2
- 210000003989 endothelium vascular Anatomy 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000005417 food ingredient Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 235000021384 green leafy vegetables Nutrition 0.000 description 2
- 238000005534 hematocrit Methods 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 230000001146 hypoxic effect Effects 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 230000006686 mitochondrial oxygen consumption Effects 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 238000006396 nitration reaction Methods 0.000 description 2
- 238000007034 nitrosation reaction Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 210000004738 parenchymal cell Anatomy 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000003642 reactive oxygen metabolite Substances 0.000 description 2
- 235000021067 refined food Nutrition 0.000 description 2
- 210000003079 salivary gland Anatomy 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 230000007727 signaling mechanism Effects 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- 235000021012 strawberries Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 238000012956 testing procedure Methods 0.000 description 2
- 230000000304 vasodilatating effect Effects 0.000 description 2
- 235000015192 vegetable juice Nutrition 0.000 description 2
- 239000000052 vinegar Substances 0.000 description 2
- 235000021419 vinegar Nutrition 0.000 description 2
- PGRNZHOQVAPMFX-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;2-oxopentanedioic acid Chemical compound OC(=O)CCC(=O)C(O)=O.OC(=O)[C@@H](N)CCCN=C(N)N PGRNZHOQVAPMFX-WCCKRBBISA-N 0.000 description 1
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 description 1
- 235000009434 Actinidia chinensis Nutrition 0.000 description 1
- 244000298697 Actinidia deliciosa Species 0.000 description 1
- 235000009436 Actinidia deliciosa Nutrition 0.000 description 1
- 241000186046 Actinomyces Species 0.000 description 1
- 244000291564 Allium cepa Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000208223 Anacardiaceae Species 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 235000007425 Aronia melanocarpa Nutrition 0.000 description 1
- 240000005662 Aronia melanocarpa Species 0.000 description 1
- 244000075850 Avena orientalis Species 0.000 description 1
- 235000007319 Avena orientalis Nutrition 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- 241000167854 Bourreria succulenta Species 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000002568 Capsicum frutescens Nutrition 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 235000005747 Carum carvi Nutrition 0.000 description 1
- 240000000467 Carum carvi Species 0.000 description 1
- 235000009025 Carya illinoensis Nutrition 0.000 description 1
- 244000068645 Carya illinoensis Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- 241000723382 Corylus Species 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 235000019542 Cured Meats Nutrition 0.000 description 1
- 102100025621 Cytochrome b-245 heavy chain Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010078321 Guanylate Cyclase Proteins 0.000 description 1
- 102000014469 Guanylate cyclase Human genes 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 101000688996 Homo sapiens Ski-like protein Proteins 0.000 description 1
- 235000003368 Ilex paraguariensis Nutrition 0.000 description 1
- 244000188472 Ilex paraguariensis Species 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 241000758791 Juglandaceae Species 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 241000186679 Lactobacillus buchneri Species 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 241001134659 Lactobacillus curvatus Species 0.000 description 1
- 241000186673 Lactobacillus delbrueckii Species 0.000 description 1
- 241000186840 Lactobacillus fermentum Species 0.000 description 1
- 240000002605 Lactobacillus helveticus Species 0.000 description 1
- 240000006024 Lactobacillus plantarum Species 0.000 description 1
- 241000186604 Lactobacillus reuteri Species 0.000 description 1
- 241000186612 Lactobacillus sakei Species 0.000 description 1
- 241000186869 Lactobacillus salivarius Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108010082739 NADPH Oxidase 2 Proteins 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000008753 Papaver somniferum Nutrition 0.000 description 1
- 240000001090 Papaver somniferum Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 240000001987 Pyrus communis Species 0.000 description 1
- 240000001890 Ribes hudsonianum Species 0.000 description 1
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 1
- 235000001466 Ribes nigrum Nutrition 0.000 description 1
- 241001453443 Rothia <bacteria> Species 0.000 description 1
- 235000016554 Rubus chamaemorus Nutrition 0.000 description 1
- 240000006831 Rubus chamaemorus Species 0.000 description 1
- 244000235659 Rubus idaeus Species 0.000 description 1
- 235000003942 Rubus occidentalis Nutrition 0.000 description 1
- 244000111388 Rubus occidentalis Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 244000058477 Sambucus melanocarpa Species 0.000 description 1
- 235000007052 Sambucus melanocarpa Nutrition 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 244000040738 Sesamum orientale Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 240000001717 Vaccinium macrocarpon Species 0.000 description 1
- 235000017606 Vaccinium vitis idaea Nutrition 0.000 description 1
- 244000077923 Vaccinium vitis idaea Species 0.000 description 1
- 102100033220 Xanthine oxidase Human genes 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 235000011022 black elderberry Nutrition 0.000 description 1
- 235000020279 black tea Nutrition 0.000 description 1
- 235000021029 blackberry Nutrition 0.000 description 1
- 235000020113 brazil nut Nutrition 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 230000036996 cardiovascular health Effects 0.000 description 1
- 235000020226 cashew nut Nutrition 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 235000021544 chips of chocolate Nutrition 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 229920002770 condensed tannin Polymers 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000021019 cranberries Nutrition 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000008242 dietary patterns Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- XRKMNJXYOFSTBE-UHFFFAOYSA-N disodium;iron(4+);nitroxyl anion;pentacyanide;dihydrate Chemical compound O.O.[Na+].[Na+].[Fe+4].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].O=[N-] XRKMNJXYOFSTBE-UHFFFAOYSA-N 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000019264 food flavour enhancer Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical class OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000004190 glucose uptake Effects 0.000 description 1
- 235000015810 grayleaf red raspberry Nutrition 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 102000054714 human SKIL Human genes 0.000 description 1
- 229920001461 hydrolysable tannin Polymers 0.000 description 1
- 238000012613 in situ experiment Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910001412 inorganic anion Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 229960003827 isosorbide mononitrate Drugs 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004066 metabolic change Effects 0.000 description 1
- 208000005135 methemoglobinemia Diseases 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 210000001700 mitochondrial membrane Anatomy 0.000 description 1
- 230000000897 modulatory effect Effects 0.000 description 1
- 230000008345 muscle blood flow Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000000626 neurodegenerative effect Effects 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 229940005654 nitrite ion Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229960002460 nitroprusside Drugs 0.000 description 1
- 230000009935 nitrosation Effects 0.000 description 1
- 230000009635 nitrosylation Effects 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000037050 permeability transition Effects 0.000 description 1
- CMFNMSMUKZHDEY-UHFFFAOYSA-M peroxynitrite Chemical compound [O-]ON=O CMFNMSMUKZHDEY-UHFFFAOYSA-M 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 125000001474 phenylpropanoid group Chemical group 0.000 description 1
- 230000010254 physiological adaptation Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000004853 protein function Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229960002181 saccharomyces boulardii Drugs 0.000 description 1
- 210000001189 slow twitch fiber Anatomy 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 229940083618 sodium nitroprusside Drugs 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000037078 sports performance Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 235000019505 tobacco product Nutrition 0.000 description 1
- 235000021404 traditional food Nutrition 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01D—COMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
- C01D9/00—Nitrates of sodium, potassium or alkali metals in general
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (9)
1. Fremgangsmåde til ikke-terapeutisk forøgelse af et pattedyrs præstation, hvor den forøgede præstation ved fysisk udøvelse ytrer sig ved reduceret oxygenforbrug (VO2), kendetegnet ved, at uorganisk nitrat, nitrit eller en kombination deraf indgives oralt, hvor dosen af nitrat andrager 0,01 - 10 mmol natriumnitrat/kg le-gemsvægt/dag, dosen af nitrit andrager 0,001 - 1 mmol/kg legemsvægt/dag, og hvor doseforholdsintervallet, når nitrat og nitrit indgives i kombination, andrager 5:1 til 100:1 (nitratmitrit), og hvor den nævnte præstation er forøget i sammenligning med pattedyrets fysiske præstation ved fravær af indgivelse af uorganisk nitrat og/eller nitrit.
2. Fremgangsmåde ifølge krav 1, hvor nitrat og/eller nitrit indgives sammen med polyphenoler.
3. Anvendelse af uorganisk nitrat eller nitrit eller en kombination deraf til ikke-terapeutisk forøgelse af et pattedyrs præstation, hvor den forøgede præstation under fysisk udøvelse ytrer sig ved formindsket oxygenforbrug (VO2), kendetegnet ved, at uorganisk nitrat, nitrit eller en kombination deraf indgives oralt, hvor dosen af nitrat andrager 0,01 - 10 mmol natriumnitrat/kg legemsvægt/dag, dosen af nitrit andrager 0,001 - 1 mmol/kg legemsvægt/dag, og hvor doseforholdsintervallet, når nitrat og nitrit indgives i kombination, andrager 5:1 til 100:1 (nitratmitrit), og hvor den nævnte præstation er forøget i sammenligning med pattedyrets fysiske præstation ved fravær af indgivelse af uorganisk nitrat og/eller nitrit.
4. Anvendelse ifølge krav 3, hvor sammensætningen foreligger i form af en væske, en pasta, en stang (barre), en kage, et pulver, et granulat, en brusetablet, en tablet, en kapsel, en pastil, en tyggegummi, en hurtig smeltende smelte-tablet eller -wafer, en sugetablet eller en spray.
5. Anvendelse ifølge krav 3 eller 4, hvor sammensætningen foreligger i form af en sportsdrik, en energidrik, en sportsstang eller -barre eller en energi-stang eller -barre.
6. Anvendelse ifølge krav 3, 4 eller 5, hvor kilden til uorganisk nitrat er udvalgt blandt et koncentrat, en ekstrakt eller en juice af nitrat-holdige grøntsager eller en uorganisk nitratsalt.
7. Anvendelse ifølge krav 3, 4, 5 eller 6, hvor den uorganiske nitrat er anvendt i kombination med polyphenoler.
8. Anvendelse ifølge krav 3, 4, 5, 6 eller 7, hvor den uorganiske nitrat er anvendt i kombination med levende bakterier, som er i stand til forøgelse af nitrat- eller nitrit-reduktion.
9. Anvendelse ifølge krav 3, 4, 5, 6, 7 eller 8, hvor den uorganiske nitrat er anvendt i kombination med ethanol i en mængde mindre end 5 % (v/v), fortrinsvis mindre end 2 % (v/v), mere foretrukket imellem 0,5 - 1 % (v/v).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0700520 | 2007-02-26 | ||
SE0700729 | 2007-03-22 | ||
PCT/SE2008/050211 WO2008105730A1 (en) | 2007-02-26 | 2008-02-26 | Performance enhancing composition and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2124638T3 true DK2124638T3 (da) | 2017-03-20 |
Family
ID=39721497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08712839.3T DK2124638T3 (da) | 2007-02-26 | 2008-02-26 | Sammensætning, der er præstationforøgende, samt anvendelse af den |
Country Status (12)
Country | Link |
---|---|
US (2) | US9180140B2 (da) |
EP (2) | EP3159000A1 (da) |
JP (1) | JP2010519335A (da) |
CA (1) | CA2678093C (da) |
CY (1) | CY1118847T1 (da) |
DK (1) | DK2124638T3 (da) |
ES (1) | ES2618655T3 (da) |
HR (1) | HRP20170355T1 (da) |
HU (1) | HUE031982T2 (da) |
PL (1) | PL2124638T3 (da) |
PT (1) | PT2124638T (da) |
WO (1) | WO2008105730A1 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11759477B2 (en) | 2007-02-26 | 2023-09-19 | Heartbeet Ltd. | Compositions of nitrates and methods of use thereof |
US10842813B2 (en) | 2007-02-26 | 2020-11-24 | Heartbeet Ltd | Compositions of nitrates and methods of use thereof |
US10835555B2 (en) | 2007-02-26 | 2020-11-17 | Heartbeet Ltd | Compositions of nitrates and methods of use thereof |
US10406118B2 (en) | 2007-02-26 | 2019-09-10 | Jon Lundberg | Use of nitrites and nitrates and compositions containing these |
US10821132B2 (en) | 2007-02-26 | 2020-11-03 | Heartbeet Ltd | Compositions of nitrates and methods of use thereof |
US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
WO2009065142A2 (en) | 2007-11-15 | 2009-05-22 | Biomedical Research Foundation Of Northwest Louisiana | Use of nitrite salts in chronic ischemia |
WO2010147742A2 (en) | 2009-06-18 | 2010-12-23 | Theravasc Inc. | Use of nitrite salts in treating tissue damage |
DE102009041425B4 (de) * | 2009-08-13 | 2017-08-31 | Aeroscan Gmbh | Verfahren zur Steuerung eines Spiroergometriesystems und Spiroergometriesystem |
ES2633618T3 (es) | 2009-10-14 | 2017-09-22 | Theravasc Inc. | Formulaciones farmacéuticas de nitrito y sus usos |
HUE032165T2 (en) | 2011-04-13 | 2017-09-28 | Thermolife Int Llc | Methods of using N-actyl-beta-alanine |
BR112014003414B1 (pt) * | 2011-08-17 | 2021-09-21 | Board Of Regents, The University Of Texas System | Composição e sistema de entrega oral para aumento de níveis fisiológicos e terapêuticos de óxido nítrico |
EP2675291B1 (en) * | 2012-05-07 | 2015-10-07 | Premier Nutrition Corporation | Puree compositions having specific carbohydrate ratios and methods for using same |
BR112015019802A2 (pt) | 2013-02-20 | 2017-07-18 | Theravasc Inc | formulações farmacêuticas de nitrito e usos das mesmas |
JP6531990B2 (ja) * | 2013-02-28 | 2019-06-19 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 心肺血行動態を改善するための無機亜硝酸塩 |
WO2014201360A1 (en) * | 2013-06-13 | 2014-12-18 | The Hershey Company | Food compositions that enhance nitric oxide mediated signalling |
US11338005B2 (en) | 2013-06-28 | 2022-05-24 | Arjuna Natural Private Limited | Medicinal composition of amaranth origin for cardiovascular treatment |
AU2014300493B2 (en) | 2013-06-28 | 2020-01-16 | Arjuna Natural Private Limited | A medicinal composition of Amaranth extract origin having enriched nitrate content and a method of preparing the same |
US20160095341A1 (en) * | 2014-06-13 | 2016-04-07 | The Hershey Company | Food compositions that enhance nitric oxide mediated signalling |
JP2016032808A (ja) * | 2014-07-30 | 2016-03-10 | 株式会社サンダーアーク | 機能性飲料水及びその製造方法 |
BR112017023509B1 (pt) | 2015-05-06 | 2022-08-30 | Yara International Asa | Ração adequada para uma fêmea de mamífero monogástrico em fase de lactação e/ou gestação |
ES2959184T3 (es) | 2015-05-27 | 2024-02-21 | Vdf Futureceuticals Inc | Composiciones y métodos para aumentar el rendimiento atlético |
US11241406B2 (en) | 2015-08-28 | 2022-02-08 | Nature's Sunshine Products, Inc. | Compositions and methods for acutley raising nitric oxide levels |
US10362998B2 (en) | 2016-02-25 | 2019-07-30 | Samsung Electronics Co., Ltd. | Sensor-based detection of changes in health and ventilation threshold |
US10420514B2 (en) | 2016-02-25 | 2019-09-24 | Samsung Electronics Co., Ltd. | Detection of chronotropic incompetence |
US10172517B2 (en) | 2016-02-25 | 2019-01-08 | Samsung Electronics Co., Ltd | Image-analysis for assessing heart failure |
US11164596B2 (en) | 2016-02-25 | 2021-11-02 | Samsung Electronics Co., Ltd. | Sensor assisted evaluation of health and rehabilitation |
US11090342B2 (en) | 2016-04-11 | 2021-08-17 | President And Fellows Of Harvard College | Probiotic formulations for improving athletic performance |
CA3026639A1 (en) | 2016-06-06 | 2017-12-14 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Uses of inorganic nitrite for increasing nerve conduction velocity |
CN110461171A (zh) | 2017-03-23 | 2019-11-15 | 美生盐有限公司 | 含甜菜根的组合物 |
GB202004927D0 (en) | 2020-04-03 | 2020-05-20 | Sis Science In Sport Ltd | Compositions |
US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
CN112772789B (zh) * | 2020-12-31 | 2023-05-09 | 内江师范学院 | 石榴皮饲料用功能添加剂、制备方法及应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB962209A (en) * | 1962-04-19 | 1964-07-01 | Upjohn Co | Multi-vitamin compositions containing fluorides |
US4868179A (en) * | 1987-04-22 | 1989-09-19 | Cohn Jay N | Method of reducing mortality associated with congestive heart failure using hydralazine and isosorbide dinitrate |
EP0511587A1 (en) * | 1991-04-26 | 1992-11-04 | Takeda Chemical Industries, Ltd. | Slimming composition |
US5476847A (en) | 1994-06-29 | 1995-12-19 | Schering Corporation | Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors |
US20050036996A1 (en) * | 1996-12-24 | 2005-02-17 | Edmond Roussel | Absorbable composition containing propionic bacteria capable of releasing nitric oxide in the human or animal alimentary canal |
DE69737510T2 (de) | 1996-12-30 | 2007-12-06 | Battelle Memorial Institute, Columbus | Verwendung eines unverkapselten Antikrebs-Arzneimittels zur Herstellung einer Zubereitung zur Behandlung von Neoplasmen durch Inhalation |
US6117872A (en) * | 1998-06-23 | 2000-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity |
EP1115389B1 (en) | 1998-09-25 | 2014-03-12 | PhilERA New Zealand Limited | Fructosamine oxidase: antagonists and inhibitors |
DE19913437B4 (de) * | 1999-03-25 | 2009-05-14 | Karl Müller GmbH & Co. | Verwendung einer Umrötungsmischung |
US6465463B1 (en) * | 1999-09-08 | 2002-10-15 | Nitromed, Inc. | Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate |
EP1381582A2 (en) * | 2000-11-02 | 2004-01-21 | The Lubrizol Corporation | Stabilized energetic water in oil emulsion composition |
KR20020057695A (ko) * | 2001-01-03 | 2002-07-12 | 류경열 | 야채 종합 비타민 강정제 제조방법 |
US20030036565A1 (en) * | 2001-06-22 | 2003-02-20 | Wisconsin Alumni Research Foundation | Cancer chemopreventive agents |
SE0203817D0 (sv) | 2002-12-20 | 2002-12-20 | Jon Lundberg | New composition |
KR100492083B1 (ko) * | 2003-02-22 | 2005-06-01 | 삼성전자주식회사 | 화상형성장치의 급지 카세트 |
JP4100224B2 (ja) * | 2003-04-07 | 2008-06-11 | 大正製薬株式会社 | 飲料組成物 |
DE602004008927T2 (de) | 2003-07-09 | 2008-06-05 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Verwendung von nitritsalzen zur behandlung von kardiovaskulären erkrankungen |
WO2005097085A1 (en) * | 2004-04-08 | 2005-10-20 | Micro Nutrient, Llc | Nutrient system for individualized responsive dosing regimens |
US20050266018A1 (en) * | 2004-05-27 | 2005-12-01 | Boreyko Benson K | Nutraceutical compositions with mangosteen |
US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
WO2006110601A2 (en) * | 2005-04-07 | 2006-10-19 | Nitromed, Inc. | The genetic risk assessment in heart failure: impact of the genetic variation of nos3 |
GB0522566D0 (en) | 2005-11-04 | 2005-12-14 | Novartis Ag | Organic compounds |
US10406118B2 (en) * | 2007-02-26 | 2019-09-10 | Jon Lundberg | Use of nitrites and nitrates and compositions containing these |
US8303995B1 (en) * | 2008-06-13 | 2012-11-06 | Board Of Regents, The University Of Texas System | Nitrite formulations and their use as nitric oxide prodrugs |
-
2008
- 2008-02-26 EP EP16202454.1A patent/EP3159000A1/en active Pending
- 2008-02-26 HU HUE08712839A patent/HUE031982T2/en unknown
- 2008-02-26 ES ES08712839.3T patent/ES2618655T3/es active Active
- 2008-02-26 CA CA2678093A patent/CA2678093C/en active Active
- 2008-02-26 PL PL08712839T patent/PL2124638T3/pl unknown
- 2008-02-26 JP JP2009551970A patent/JP2010519335A/ja active Pending
- 2008-02-26 DK DK08712839.3T patent/DK2124638T3/da active
- 2008-02-26 PT PT87128393T patent/PT2124638T/pt unknown
- 2008-02-26 US US12/528,798 patent/US9180140B2/en active Active
- 2008-02-26 WO PCT/SE2008/050211 patent/WO2008105730A1/en active Application Filing
- 2008-02-26 EP EP08712839.3A patent/EP2124638B1/en active Active
-
2015
- 2015-08-20 US US14/830,937 patent/US10555968B2/en active Active
-
2017
- 2017-03-03 HR HRP20170355TT patent/HRP20170355T1/hr unknown
- 2017-03-07 CY CY20171100294T patent/CY1118847T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HUE031982T2 (en) | 2017-08-28 |
EP2124638A1 (en) | 2009-12-02 |
EP2124638A4 (en) | 2014-04-02 |
HRP20170355T1 (hr) | 2017-05-19 |
ES2618655T3 (es) | 2017-06-21 |
PT2124638T (pt) | 2017-03-13 |
JP2010519335A (ja) | 2010-06-03 |
CA2678093C (en) | 2017-10-24 |
EP3159000A1 (en) | 2017-04-26 |
WO2008105730A1 (en) | 2008-09-04 |
CY1118847T1 (el) | 2018-01-10 |
US20150352147A1 (en) | 2015-12-10 |
CA2678093A1 (en) | 2008-09-04 |
EP2124638B1 (en) | 2016-12-07 |
US9180140B2 (en) | 2015-11-10 |
US20100047344A1 (en) | 2010-02-25 |
US10555968B2 (en) | 2020-02-11 |
PL2124638T3 (pl) | 2017-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2124638T3 (da) | Sammensætning, der er præstationforøgende, samt anvendelse af den | |
AU2008219834B2 (en) | New use of nitrites and nitrates and compositions containing these | |
US11096409B2 (en) | Compositions of nitrates and methods of use thereof | |
US9446006B2 (en) | Hydroxytyrosol combinations for enhancing mitochondrial function and energy production | |
US11723917B2 (en) | Compositions of nitrates and methods of use thereof | |
US10835555B2 (en) | Compositions of nitrates and methods of use thereof | |
WO2017187033A1 (fr) | Procédé d'évaluation de la capacité d'une composition à prévenir la fatigue et les dommages musculaires; complément alimentaire et medicament | |
KR20090117762A (ko) | (-)-에피갈로카테킨 갈레이트의 신규한 용도 | |
US11759477B2 (en) | Compositions of nitrates and methods of use thereof |