DK202388A - Azabicycliske forbindelser og fremgangsmaade til fremstilling deraf - Google Patents

Azabicycliske forbindelser og fremgangsmaade til fremstilling deraf

Info

Publication number
DK202388A
DK202388A DK202388A DK202388A DK202388A DK 202388 A DK202388 A DK 202388A DK 202388 A DK202388 A DK 202388A DK 202388 A DK202388 A DK 202388A DK 202388 A DK202388 A DK 202388A
Authority
DK
Denmark
Prior art keywords
group
chem
alkyl
nitrogen
methyl
Prior art date
Application number
DK202388A
Other languages
English (en)
Other versions
DK202388D0 (da
Inventor
Michael Stewart Hadley
Paul Adran Wyman
Barry Sidney Orlek
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878709025A external-priority patent/GB8709025D0/en
Priority claimed from GB878729809A external-priority patent/GB8729809D0/en
Priority claimed from GB888804224A external-priority patent/GB8804224D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK202388D0 publication Critical patent/DK202388D0/da
Publication of DK202388A publication Critical patent/DK202388A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Recording Measured Values (AREA)
  • Luminescent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK202388A 1987-04-15 1988-04-13 Azabicycliske forbindelser og fremgangsmaade til fremstilling deraf DK202388A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878709025A GB8709025D0 (en) 1987-04-15 1987-04-15 Compounds
GB878729809A GB8729809D0 (en) 1987-12-22 1987-12-22 Novel compounds
GB888804224A GB8804224D0 (en) 1988-02-24 1988-02-24 Novel compounds

Publications (2)

Publication Number Publication Date
DK202388D0 DK202388D0 (da) 1988-04-13
DK202388A true DK202388A (da) 1988-10-16

Family

ID=27263387

Family Applications (1)

Application Number Title Priority Date Filing Date
DK202388A DK202388A (da) 1987-04-15 1988-04-13 Azabicycliske forbindelser og fremgangsmaade til fremstilling deraf

Country Status (8)

Country Link
US (2) US4971975A (da)
EP (1) EP0287356B1 (da)
JP (1) JP2651695B2 (da)
AT (1) ATE133415T1 (da)
AU (1) AU614513B2 (da)
DE (1) DE3854932T2 (da)
DK (1) DK202388A (da)
NZ (1) NZ224237A (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
DE3877470T2 (de) * 1987-09-10 1993-06-24 Merck Sharp & Dohme Oxazole und thiazole zur behandlung seniler demenz.
EP0322182A3 (en) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
GB8808926D0 (en) * 1988-04-15 1988-05-18 Beecham Group Plc Novel compounds
AU3301689A (en) * 1988-04-15 1989-10-26 Beecham Group Plc 1-azabicyclo-alkyl derivatives
EP0363085A3 (en) 1988-10-03 1991-03-27 Beecham Group Plc Novel compounds
CA2000041A1 (en) * 1988-10-13 1990-04-13 Barry S. Orlek Compounds
ATE269330T1 (de) * 1989-04-13 2004-07-15 Beecham Group Plc Chemische verbindungen
EP0402056A3 (en) * 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
GB8917957D0 (en) * 1989-08-05 1989-09-20 Beecham Group Plc Novel compounds
US5157160A (en) * 1989-08-16 1992-10-20 Beecham Group P.L.C. Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their pharmaceutical use
ATE153024T1 (de) * 1989-08-16 1997-05-15 Beecham Group Plc Azabicyclische verbindungen
DE69026197T2 (de) * 1989-10-07 1997-01-09 Beecham Group Plc Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
YU84791A (sh) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni
PT98742A (pt) * 1990-08-24 1992-07-31 Beecham Group Plc Processo para a preparacao de compostos azabicilicos
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
US5356914A (en) * 1990-10-12 1994-10-18 Beecham Group P.L.C. 1,2,5,6-tetrahydropyridine oxime derivatives
AU2782792A (en) * 1991-10-15 1993-05-21 Warner-Lambert Company Azabicyclo oxime and amine cholinergic agents and methods of treatment
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
US5679693A (en) * 1992-09-30 1997-10-21 Sanofi 1-azoniabicyclo 2.2.1!heptanes, method of preparing them and pharmaceutical compositions in which they are present
AU6010594A (en) * 1993-02-12 1994-08-29 Sankyo Company Limited Isoxazoleoxy derivative
GB9507203D0 (en) * 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
US6875774B2 (en) 2002-08-06 2005-04-05 The University Of North Carolina Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
AR049401A1 (es) 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
EP2275095A3 (en) * 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
MX2009008509A (es) 2007-02-09 2009-08-20 Astellas Pharma Inc Compuesto de anillo puenteado-aza.

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3661918A (en) * 1968-10-17 1972-05-09 Exxon Research Engineering Co Process for the preparation of bicyclic amines
JPS56156283A (en) * 1980-05-07 1981-12-02 Suntory Ltd 8-substituted pyrrolitidine and its quaternary ammonium salt
JPH0633286B2 (ja) * 1985-01-14 1994-05-02 エーザイ株式会社 セフエム誘導体
US4771051A (en) * 1985-05-17 1988-09-13 A/S Ferrosan 3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
EP0235878A3 (en) * 1986-01-16 1989-06-14 Beecham Group Plc Novel compounds
GB8630896D0 (en) 1986-12-24 1987-02-04 Merck Sharp & Dohme Oxadiazoles
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8607713D0 (en) 1986-03-27 1986-04-30 Merck Sharpe & Dohme Ltd Oxadiazoles
GB8622380D0 (en) 1986-09-17 1986-10-22 Beecham Group Plc Compounds
GB8615785D0 (en) * 1986-06-27 1986-08-06 Beecham Group Plc Compounds
GB8615784D0 (en) 1986-06-27 1986-08-06 Beecham Group Plc Compounds
DE3789039T2 (de) * 1986-06-27 1994-06-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen.
GB8812145D0 (en) 1988-05-23 1988-06-29 Merck Sharp & Dohme Therapeutic agents
GB8721342D0 (en) 1987-09-10 1987-10-14 Merk Sharp & Dohme Ltd Therapeutic agents
GB8817311D0 (en) 1988-07-20 1988-08-24 Merck Sharp & Dohme Therapeutic agents
GB8801758D0 (en) 1988-01-27 1988-02-24 Merck Sharp & Dohme Therapeutic agents
GB8801759D0 (en) 1988-01-27 1988-02-24 Merck Sharp & Dohme Therapeutic agents
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
GB8721343D0 (en) 1987-09-10 1987-10-14 Merk Sharp & Dohme Ltd Therapeutic agents
DE3877470T2 (de) * 1987-09-10 1993-06-24 Merck Sharp & Dohme Oxazole und thiazole zur behandlung seniler demenz.

Also Published As

Publication number Publication date
ATE133415T1 (de) 1996-02-15
NZ224237A (en) 1991-04-26
AU614513B2 (en) 1991-09-05
EP0287356A2 (en) 1988-10-19
US5132316A (en) 1992-07-21
EP0287356A3 (en) 1989-09-20
DK202388D0 (da) 1988-04-13
DE3854932T2 (de) 1996-06-13
US4971975A (en) 1990-11-20
EP0287356B1 (en) 1996-01-24
JP2651695B2 (ja) 1997-09-10
DE3854932D1 (de) 1996-03-07
JPS63290878A (ja) 1988-11-28
AU1455788A (en) 1988-10-27

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment