DK1976532T3 - Hurtigvirkende inhibitor af mavesyresekretion - Google Patents
Hurtigvirkende inhibitor af mavesyresekretion Download PDFInfo
- Publication number
- DK1976532T3 DK1976532T3 DK07716990.2T DK07716990T DK1976532T3 DK 1976532 T3 DK1976532 T3 DK 1976532T3 DK 07716990 T DK07716990 T DK 07716990T DK 1976532 T3 DK1976532 T3 DK 1976532T3
- Authority
- DK
- Denmark
- Prior art keywords
- zinc
- gastric
- composition
- stomach
- acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/315—Zinc compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (16)
1. Farmaceutisk sammensætning til administration til maven hos en patient omfattende en effektiv mængde af mindst et farmaceutisk acceptabelt zinksalt i kombination med en protonpumpeinhibitor, eventuelt i kombination med en farmaceutisk acceptabel bærer, et additiv eller en excipiens til anvendelse til hurtigt at øge pH-værdien i mavesafterne i maven hos en patient som har behov derfor til mindst 3,0 inden for et tidsrum som ikke er mere end en time efter administration.
2. Sammensætning til anvendelse ifølge krav 1 hvor mængden af zinksalt i sammensætningen er effektiv til at øge pH-værdien i mavesafterne i maven hos patienten til mindst 3,5 inden for et tidsrum som ikke er mere end 30 minutter efter administration.
3. Sammensætning til anvendelse ifølge krav 1 eller 2 hvor mængden af zinksalt er effektiv til at øge pH-værdien i mavesafterne i maven hos patienten til mindst 4,0.
4. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-3 hvor zinksaltet er valgt fra gruppen bestående af zinkacetat, zinkascorbat, zinkbutryat, zinkcarbonat, zinkcitrat, zinkchlorid, zinkiodid, zinksulfat, zinkgluconat, zinkglycerat, zinkglycolat, zinkformat, zinklactat, zinkpicolinat, zinksalicylat, zinktartrat, zinkundecylenat, et zinkaminosyrechelat og blandinger deraf.
5. Sammensætning til anvendelse ifølge krav 4 hvor zinksaltet er valgt fra gruppen bestående af zinkacetat, zinkascorbat, zinkcitrat, zinkchlorid, zinksulfat, zinkgluconat, zinkpicolinat, et zinkaminosyrechelat eller blandinger deraf.
6. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 3 hvor zinksaltet er valgt blandt mindst to zinksalte fra gruppen bestående af zinkacetat, zinkascorbate, zinkcitrat, zinkchlorid, zinkgluconat, zinkpicolinat og et zinkaminosyrechelat.
7. Sammensætning til anvendelse ifølge kravene 1-6 hvor zinksaltet eller mindst et af zinksaltene er et zinkaminosyrechelat.
8. Sammensætning til anvendelse ifølge krav 7 hvor zinkaminosyrechelatet er valgt fra gruppen bestående af mono- og bis-chelater fra L- eller D- aminosyrer.
9. Sammensætning til anvendelse ifølge kravene 7 eller 8 hvor aminosyrechelatet er et chelat af zink med en aminosyre valgt fra gruppen bestående af L-cystein, L-cystin, L-N-acetylcystein, L-histidin, D-histidin, L-taurin, L-glycinat, L-aspartat og L-methionin.
10. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-3 hvor zinksaltet er zinkchlorid og eventuelt, mindst et yderligere zinksalt valgt blandt gruppen bestående af zinkacetat, zinkascorbat, zinkcitrat, zinkgluconat, zinkpicolinat, zinksulfat og et zinkaminosyrechelat.
11. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-10 hvor protonpumpeinhibitoren er esomeprazol, lansoprazol, omeprazol, pantoprazol, rabeprazol eller blandinger deraf.
12. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-11 hvor protonpumpeinhibitoren er en blanding af esomeprazol, lansoprazol, omeprazol, pantoprazol eller rabeprazol.
13. Sammensætning ifølge et hvilket som helst af kravene 1-11 hvor protonpumpeinhibitoren er formuleret til en langsom frigivelsesform.
14. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-13 omfattende mindst to zinksalte, idet mindst et af zinksaltene er formuleret til en øjeblikkelig frigivelsesform og mindst et zinksalt er formuleret til en langsom frigivelsesform.
15. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor sammensætningen er en væskesammensætning.
16. Sammensætning til anvendelse ifølge et hvilket som helst af de foregående krav, hvor sammensætningen er egnet til oral administration.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76259506P | 2006-01-27 | 2006-01-27 | |
US76483406P | 2006-02-03 | 2006-02-03 | |
US85089106P | 2006-10-11 | 2006-10-11 | |
PCT/US2007/001950 WO2007089511A2 (en) | 2006-01-27 | 2007-01-25 | Fast acting inhibitor of gastric acid secretion |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1976532T3 true DK1976532T3 (da) | 2016-02-01 |
Family
ID=38327882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07716990.2T DK1976532T3 (da) | 2006-01-27 | 2007-01-25 | Hurtigvirkende inhibitor af mavesyresekretion |
Country Status (15)
Country | Link |
---|---|
US (1) | US11510894B2 (da) |
EP (2) | EP2705845B1 (da) |
JP (3) | JP5469865B2 (da) |
CN (2) | CN101374526B (da) |
CA (1) | CA2635272C (da) |
DK (1) | DK1976532T3 (da) |
ES (2) | ES2609976T3 (da) |
HK (1) | HK1191861A1 (da) |
HR (1) | HRP20151437T1 (da) |
HU (1) | HUE029222T2 (da) |
PL (1) | PL1976532T3 (da) |
PT (1) | PT1976532E (da) |
RS (1) | RS54543B1 (da) |
SI (1) | SI1976532T1 (da) |
WO (1) | WO2007089511A2 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1976532T3 (pl) | 2006-01-27 | 2016-05-31 | Univ Yale | Szybko działający inhibitor wydzielania kwasu żołądkowego |
US8512761B2 (en) | 2006-01-27 | 2013-08-20 | Yale University | Fast acting inhibitor of gastric acid secretion |
EP2262492A2 (en) * | 2008-03-03 | 2010-12-22 | Amgen Inc. | Methods of treating hyperacidic disorders |
JP2010184914A (ja) * | 2009-02-13 | 2010-08-26 | Bizen Chemical Co Ltd | プロトンポンプ阻害活性を有する組成物 |
US20110038852A1 (en) * | 2009-06-10 | 2011-02-17 | 3-V Biosciences, Inc. | Antivirals that target transporters, carriers, and ion channels |
AU2010313216A1 (en) * | 2009-11-01 | 2012-06-14 | Synthetic Biologics, Inc. | Gastroretentive oral high dose zinc preparations |
CN102970992B (zh) | 2010-05-12 | 2016-07-06 | 莱姆派克斯制药公司 | 四环素组合物 |
US20140039004A1 (en) * | 2012-07-31 | 2014-02-06 | Ono Pharmaceutical Co., Ltd. | Method of treating of gastroesophageal reflux disease |
US20170209489A1 (en) * | 2014-03-31 | 2017-07-27 | Yale University | Fast acting inhibitor of gastric acid secretion with enhanced activity |
CN105232506A (zh) * | 2015-11-04 | 2016-01-13 | 温州医科大学 | 丁酸及其盐在制备治疗或预防胃溃疡药物中的应用 |
CN105769840B (zh) * | 2016-04-01 | 2018-06-29 | 温州医科大学 | 乙酸及其盐的应用 |
RU2659955C1 (ru) * | 2017-10-26 | 2018-07-04 | Галина Ильхамовна Лукина | Способ диагностики высоких гастроэзофагеальных рефлюксов |
EP3880192A1 (en) * | 2018-12-20 | 2021-09-22 | Colgate-Palmolive Company | Oral care composition comprising zinc and an amino acid for treating symptoms of a gastric disorder in the oral cavity |
CN111388436A (zh) * | 2020-04-20 | 2020-07-10 | 北京健讯医药科技有限公司 | 一种海藻酸钠咀嚼片及其制备方法 |
CN114908314B (zh) * | 2022-05-16 | 2023-11-28 | 浙江飞剑工贸有限公司 | 一种能持久微量释放金属离子的抗菌涂层及其制备方法 |
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SE393532B (sv) | 1974-05-02 | 1977-05-16 | Draco Ab | Sett att framstella en farmaceutisk zinkberedning for astadkommande av en smaklig, fordragbar, peroral zinklosning innehallande ett zinkkomplex |
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JPH07116160B2 (ja) | 1987-08-10 | 1995-12-13 | 浜理薬品工業株式会社 | 結晶性l−カルノシン亜鉛錯体およびその製造法 |
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AUPM456894A0 (en) * | 1994-03-18 | 1994-04-14 | Glyzinc Pharmaceuticals Limited | Treatment for gastric disorders |
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SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
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FI20011403A (fi) * | 2001-06-29 | 2002-12-30 | Carbion Oy | Menetelmä ja koostumukset vatsan sairauksien hoitoon |
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WO2005009352A2 (en) * | 2003-07-17 | 2005-02-03 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositons containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof |
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CN100515491C (zh) | 2005-01-04 | 2009-07-22 | 健能隆医药技术(上海)有限公司 | 白介素-22的医药用途 |
US20060230553A1 (en) * | 2005-04-14 | 2006-10-19 | Helmut Thullen | Process for tinting, dyeing or doping of moulded components made of transparent (co)polyamides in aqueous dye bath |
US20060251722A1 (en) * | 2005-05-03 | 2006-11-09 | Novavax, Inc. | Multi-component vitamin and mineral supplement for the optimal absorption of components |
US8512761B2 (en) | 2006-01-27 | 2013-08-20 | Yale University | Fast acting inhibitor of gastric acid secretion |
PL1976532T3 (pl) | 2006-01-27 | 2016-05-31 | Univ Yale | Szybko działający inhibitor wydzielania kwasu żołądkowego |
-
2007
- 2007-01-25 PL PL07716990T patent/PL1976532T3/pl unknown
- 2007-01-25 CA CA2635272A patent/CA2635272C/en active Active
- 2007-01-25 EP EP13193624.7A patent/EP2705845B1/en active Active
- 2007-01-25 EP EP07716990.2A patent/EP1976532B1/en active Active
- 2007-01-25 CN CN2007800036618A patent/CN101374526B/zh not_active Expired - Fee Related
- 2007-01-25 DK DK07716990.2T patent/DK1976532T3/da active
- 2007-01-25 SI SI200731736T patent/SI1976532T1/sl unknown
- 2007-01-25 CN CN201310174056.4A patent/CN103463096B/zh not_active Expired - Fee Related
- 2007-01-25 RS RS20160022A patent/RS54543B1/en unknown
- 2007-01-25 ES ES13193624.7T patent/ES2609976T3/es active Active
- 2007-01-25 WO PCT/US2007/001950 patent/WO2007089511A2/en active Application Filing
- 2007-01-25 JP JP2008552394A patent/JP5469865B2/ja not_active Expired - Fee Related
- 2007-01-25 HU HUE07716990A patent/HUE029222T2/en unknown
- 2007-01-25 PT PT77169902T patent/PT1976532E/pt unknown
- 2007-01-25 US US12/086,379 patent/US11510894B2/en active Active
- 2007-01-25 ES ES07716990.2T patent/ES2562059T3/es active Active
-
2013
- 2013-08-12 JP JP2013167225A patent/JP2013241457A/ja active Pending
-
2014
- 2014-05-30 HK HK14105100.0A patent/HK1191861A1/zh not_active IP Right Cessation
-
2015
- 2015-08-06 JP JP2015155729A patent/JP6366548B2/ja not_active Expired - Fee Related
- 2015-12-30 HR HRP20151437TT patent/HRP20151437T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
US11510894B2 (en) | 2022-11-29 |
JP2009524669A (ja) | 2009-07-02 |
HRP20151437T1 (hr) | 2016-02-12 |
JP2015232016A (ja) | 2015-12-24 |
WO2007089511A2 (en) | 2007-08-09 |
ES2609976T3 (es) | 2017-04-25 |
PT1976532E (pt) | 2016-02-11 |
EP1976532A2 (en) | 2008-10-08 |
JP2013241457A (ja) | 2013-12-05 |
JP5469865B2 (ja) | 2014-04-16 |
EP2705845B1 (en) | 2016-10-05 |
ES2562059T3 (es) | 2016-03-02 |
CA2635272C (en) | 2016-11-29 |
WO2007089511A3 (en) | 2008-04-10 |
EP1976532B1 (en) | 2015-11-11 |
CA2635272A1 (en) | 2007-08-09 |
CN101374526A (zh) | 2009-02-25 |
PL1976532T3 (pl) | 2016-05-31 |
EP2705845A1 (en) | 2014-03-12 |
HUE029222T2 (en) | 2017-02-28 |
SI1976532T1 (sl) | 2016-04-29 |
US20090035393A1 (en) | 2009-02-05 |
CN103463096A (zh) | 2013-12-25 |
JP6366548B2 (ja) | 2018-08-01 |
EP1976532A4 (en) | 2010-12-15 |
HK1191861A1 (zh) | 2014-08-08 |
RS54543B1 (en) | 2016-06-30 |
CN101374526B (zh) | 2013-08-07 |
CN103463096B (zh) | 2016-03-16 |
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