DK1968635T3 - Sammensætninger og fremgangsmåder med og anvendelser af ikke-naturlige aminosyrer og polypeptider - Google Patents

Sammensætninger og fremgangsmåder med og anvendelser af ikke-naturlige aminosyrer og polypeptider Download PDF

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DK1968635T3
DK1968635T3 DK06848566.3T DK06848566T DK1968635T3 DK 1968635 T3 DK1968635 T3 DK 1968635T3 DK 06848566 T DK06848566 T DK 06848566T DK 1968635 T3 DK1968635 T3 DK 1968635T3
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amino acid
natural amino
polypeptide
amino acids
alkylene
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DK06848566.3T
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Zhenwei Miao
Thea Norman
Junjie Liu
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Ambrx Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Claims (11)

1. Polypeptid eller salt deraf, indeholdende mindst en forbindelse udvalgt fra gruppen bestående af:
hvor hvert Ra uafhængigt er udvalgt fra gruppen bestående af H, halogen, alkyl, -N02, - CN, substitueret alkyl, -N(R')2, -C(0)kR', -C(0)N(R')2, -OR' og -S(0)kR', hvor k er 1,2 eller 3; M er H eller -CH2R5; Ri er H, en aminobeskyttelsesgruppe, harpiks, aminosyre, polypeptid eller polynukleotid; R2 er OH, en esterbeskyttelsesgruppe, harpiks, aminosyre, polypeptid eller polynukleotid; R5 er L-X, hvor X er en polymer omfattende alkyl, alkenyl, alkynyl, alkoxy, alkylalkoxy, polyalkylenoxid, aryl, heteroaryl, alkaryl eller aralkyl; og L eventuelt, og når det er til stede, er en linker udvalgt fra gruppen bestående af alkylen, alkenylen, -O-, -0-(alkylen)-,-(alkylen)-0-, -C(O)-, -C(0)-(alkylen)-, -(alkylen)-C(O)-, -C(0)N(R')-, -C(0)N(R')-(alkylen)-, -(alkylen)-C(0)N(R'), -0C(0)N(R')-, -0C(0)N(R')-(alkylen)-, -(alkylen)-0C(0)N(R')-, -N(R')C(0)-, -NR’C(0)-(alkylen)-, -(alkylen)-NR’C(O)-, -S-, -S-(alkylen)-, -S(0)k- hvor k er 1, 2 eller 3, -S(0)k(alkylen)-, -C(S)-, -C(S)-(alkylen)-, - CSN(R')-, -CSN(R')-(alkylen)-, -N(R')CO-(alkylen)-, -N(R')C(0)0-, -(alkylen)-ON=CR'-, -(alkylen)-C(0)NR'-(alkylen)-, -(alkylen)-S(0)k-(alkylen eller substitueret alkylen)-S-, -(alkylen)-S-S-, -S(0)kN(R>, -N(R')C(0)N(R')-, -N(R')C(S)N(R')-, - N(R')S(0)kN(R')-, -N(R')-N=, -C(R')=N-, -C(R')=N-N(R')-, -C(R')=N-N=, -C(R')2-N=N- og -C(R')2-N(R')-N(R')-; og hvert R' uafhængigt er H, alkyl eller substitueret alkyl; hvor forbindelsen er udvalat fra aruDoen:
2. Forbindelse ifølge krav 1, hvor polymeren omfatter polyalkylenoxid.
3. Forbindelse ifølge krav 1, hvor polymeren omfatter -[(alkylen)-O-(hydrogen eller alkyl)]x, hvor x er fra 20-10.000.
4. Forbindelse ifølge krav 1, hvor polymeren er m-PEG med en molekylvægt, der ligger i området fra ca. 2 til ca. 40 KDa.
5. Fremgangsmåde til fremstilling af en forbindelse indeholdende mindst en ikke-naturlig aminosyre udvalgt fra gruppen bestående af:
hvor forbindelsen er dannet af en reduktiv alkylering af en aromatisk amino-enhed på mindst en ikke-naturlig aminosyre med mindst en reaktant omfat tende mindst en aldehydenhed, hvor R-ι, R2, R5, Ra og M er som defineret i krav 1; hvor den i det mindste ene ikke-naturliae aminosvre er udvalgt fra en gruppe:
6. Fremgangsmåde ifølge krav 5, hvorved polymeren omfatter polyalkylenox-id eller et substitueret polyalkylenoxid.
7. Fremgangsmåde ifølge krav 5, hvorved polymeren omfatter -[(alkylen eller substitueret alkyien)-0-(hydrogen, alkyl, eller substitueret alkyl)]x, hvor x er fra 20-10.000.
8. Fremgangsmåde ifølge krav 5, hvorved polymeren er m-PEG med en molekylvægt, der ligger i området fra ca. 2 til ca. 40 KDa.
9. Fremgangsmåde ifølge krav 5, hvorved den i det mindste ene aldehydenhed har strukturen, der svarer til :
hvor: R5 er som defineret i krav 1.
10. Fremgangsmåde ifølge krav 5, hvorved den ikke-naturlige aminosyre inkorporeres ved anvendelse af et translationssystem.
11. Fremgangsmåde ifølge krav 5, hvorved den ikke-naturlige aminosyre inkorporeres i polypeptidet ved anvendelse af et translationssystem og en post-translationsmodifikationssystem.
DK06848566.3T 2005-12-14 2006-12-13 Sammensætninger og fremgangsmåder med og anvendelser af ikke-naturlige aminosyrer og polypeptider DK1968635T3 (da)

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US74304005P 2005-12-14 2005-12-14
US74304105P 2005-12-14 2005-12-14
PCT/US2006/047822 WO2007070659A2 (en) 2005-12-14 2006-12-13 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides

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US (6) US20080317670A1 (da)
EP (1) EP1968635B1 (da)
JP (1) JP2009519942A (da)
KR (2) KR101423898B1 (da)
CN (2) CN105384807A (da)
AU (1) AU2006326404B2 (da)
CA (2) CA2882445A1 (da)
DK (1) DK1968635T3 (da)
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HK (1) HK1123194A1 (da)
IL (1) IL209386A (da)
NZ (2) NZ568578A (da)
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WO (1) WO2007070659A2 (da)

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