DK194688A - DESAZA-PURIN NUCLEOSIDE DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND USING THEREOF - Google Patents

DESAZA-PURIN NUCLEOSIDE DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND USING THEREOF

Info

Publication number
DK194688A
DK194688A DK194688A DK194688A DK194688A DK 194688 A DK194688 A DK 194688A DK 194688 A DK194688 A DK 194688A DK 194688 A DK194688 A DK 194688A DK 194688 A DK194688 A DK 194688A
Authority
DK
Denmark
Prior art keywords
group
denotes
hydrogen
hydroxyl
radicals
Prior art date
Application number
DK194688A
Other languages
Danish (da)
Other versions
DK194688D0 (en
Inventor
Frank Seela
Heinz-Peter Muth
Klaus Kaiser
Werner Bourgeois
Klaus Muehlegger
Herbert Von Der Eltz
Hans-Georg Batz
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK194688D0 publication Critical patent/DK194688D0/en
Publication of DK194688A publication Critical patent/DK194688A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Novel deazapurine nucleosides of the formula I <IMAGE> in which X denotes nitrogen or a methine group, W denotes nitrogen or the group <IMAGE> R<1>, R<2>, R<3> and R<4> can be the same or different, and denote hydrogen, halogen, a lower alkyl, hydroxyl, mercapto, lower alkylthio, lower alkyloxy, aralkyl, aralkyloxy, aryloxy or an optionally mono- or disubstituted amino group, R<5> denotes hydrogen or a hydroxyl group, R<6> and R<7> each denote hydrogen or one of the two radicals R<6> and R<7> denotes halogen, a cyano, azido or an optionally mono- or disubstituted amino group, where one of the radicals R<6> and R<7> can also represent a hydroxyl group if X denotes a methine group, and R<5> and R<7> together can additionally represent a further bond between C-2' and C-3' and Y represents hydrogen, a monophosphate, diphosphate or triphosphate group, and possible tautomers and salts and nucleic acids which contain one or more compounds of the formula I as building block. The compounds according to the invention exhibit antiviral properties and can further be used in DNA sequencing, where they lead to chain termination and/or prevent band compression.
DK194688A 1987-04-10 1988-04-08 DESAZA-PURIN NUCLEOSIDE DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND USING THEREOF DK194688A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3712280 1987-04-10
DE19873739366 DE3739366A1 (en) 1987-04-10 1987-11-20 DESAZA-PURIN-NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN NUCLEIC ACID SEQUENCING AND AS AN ANTIVIRAL AGENT

Publications (2)

Publication Number Publication Date
DK194688D0 DK194688D0 (en) 1988-04-08
DK194688A true DK194688A (en) 1988-10-11

Family

ID=25854556

Family Applications (1)

Application Number Title Priority Date Filing Date
DK194688A DK194688A (en) 1987-04-10 1988-04-08 DESAZA-PURIN NUCLEOSIDE DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND USING THEREOF

Country Status (11)

Country Link
EP (1) EP0286028B1 (en)
JP (2) JPH0662663B2 (en)
KR (1) KR880012631A (en)
CN (1) CN88102038A (en)
AT (1) ATE124415T1 (en)
AU (1) AU597483B2 (en)
CA (1) CA1311201C (en)
DE (2) DE3739366A1 (en)
DK (1) DK194688A (en)
ES (1) ES2076146T3 (en)
HU (1) HU199871B (en)

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AU4817490A (en) * 1988-11-29 1990-06-26 Institut Fur Molekularbiologie Und Analytik (Ima) G.M.B.H. 2',3'-dideoxyribofuranosides and process for producing them
GB8902041D0 (en) * 1989-01-31 1989-03-22 Tanabe Seiyaku Co Antiviral agent and novel nucleoside
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US5721356A (en) * 1989-09-15 1998-02-24 Gensia, Inc. Orally active adenosine kinase inhibitors
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WO1991004254A1 (en) * 1989-09-19 1991-04-04 Teijin Limited PYRROLO[2,3-d]PYRIMIDINE DERIVATIVE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL PREPARATION COMPRISING THE DERIVATIVE AS ACTIVE INGREDIENT
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US5633360A (en) * 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
CA2159630A1 (en) * 1993-03-30 1994-10-13 Philip D. Cook 7-deazapurine modified oligonucleotides
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DE4438918A1 (en) * 1994-11-04 1996-05-09 Hoechst Ag Modified oligonucleotides, their preparation and their use
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
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US6004939A (en) * 1995-07-06 1999-12-21 Ctrc Research Foundation Board Of Regents Methods for modulation and inhibition of telomerase
US6054442A (en) * 1995-07-06 2000-04-25 Board Of Regents, University Of Texas System Methods and compositions for modulation and inhibition of telomerase in vitro
US6291164B1 (en) 1996-11-22 2001-09-18 Invitrogen Corporation Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate
EP0866070A1 (en) * 1997-03-20 1998-09-23 Amersham Pharmacia Biotech Inc Derivatives of 7 deaza 2' deoxy guanosine 5' triphosphate, preparation and use thereof
US6143206A (en) * 1998-06-24 2000-11-07 Tdk Corporation Organic positive temperature coefficient thermistor and manufacturing method therefor
JP3619017B2 (en) * 1998-06-24 2005-02-09 日本臓器製薬株式会社 New arabinosyladenine derivatives
US6452476B1 (en) 1999-01-28 2002-09-17 Tdk Corporation Organic positive temperature coefficient thermistor
US6093807A (en) * 1999-03-19 2000-07-25 Isis Pharmaceuticals, Inc. Sugar-modified 7-deaza-7-substituted oligonucleotides
ATE342271T1 (en) 1999-08-30 2006-11-15 Roche Diagnostics Gmbh 2-AZAPURINE COMPOUNDS AND THEIR USE
US6660845B1 (en) 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
US6756383B2 (en) 2000-09-01 2004-06-29 Chiron Corporation Heterocyclic derivatives of quinolinone benimidazoles
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JP2005538096A (en) * 2002-07-25 2005-12-15 マイジェニックス インコーポレイテッド Antiviral 7-deaza D-nucleosides and methods of use thereof
DE10238722A1 (en) 2002-08-23 2004-03-11 Bayer Ag Improving attention, concentration, cognition, learning and/or memory performance, using selective phosphodiesterase 9A inhibitors, preferably 4H-pyrazolo-(3,4-d)-pyrimidin-4-one derivatives
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DE10238724A1 (en) 2002-08-23 2004-03-04 Bayer Ag New 6-alkyl-1,5-dihydro-4H-pyrazolo-(3,4-d)-pyrimidin-4-ones useful as selective phosphodiesterase 9A inhibitors for improving attention, concentration, learning and/or memory performance
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US8044060B2 (en) 2003-05-09 2011-10-25 Boehringer Ingelheim International Gmbh 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory
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AU2006294807B2 (en) * 2005-09-26 2013-01-17 Gilead Pharmasset Llc Modified 4'-nucleosides as antiviral agents
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Also Published As

Publication number Publication date
AU597483B2 (en) 1990-05-31
DE3854060D1 (en) 1995-08-03
DE3739366A1 (en) 1988-10-27
EP0286028A2 (en) 1988-10-12
JPS63275598A (en) 1988-11-14
HUT46703A (en) 1988-11-28
EP0286028A3 (en) 1990-05-30
JP2675749B2 (en) 1997-11-12
EP0286028B1 (en) 1995-06-28
DK194688D0 (en) 1988-04-08
CA1311201C (en) 1992-12-08
HU199871B (en) 1990-03-28
ATE124415T1 (en) 1995-07-15
CN88102038A (en) 1988-10-26
JPH0748396A (en) 1995-02-21
ES2076146T3 (en) 1995-11-01
AU1439888A (en) 1988-10-13
JPH0662663B2 (en) 1994-08-17
KR880012631A (en) 1988-11-28

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